Found 286 hits with Last Name = 'han' and Initial = 'sb' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Stimulator of interferon genes protein
(Human) | BDBM50604466
(CHEMBL5201766)Show SMILES CCn1nc(C)cc1C(=O)Nc1nc2cc(cc(OC)c2n1C\C=C\Cn1c(NC(=O)c2cc(C)nn2CC)nc2cc(cc(OCCCNC(=O)OC(C)(C)C)c12)C(N)=O)C(N)=O | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.0623 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01795
BindingDB Entry DOI: 10.7270/Q2H1363K |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477923
(CHEMBL437977)Show SMILES C[C@H](CCCNS(C)(=O)=O)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H24Cl2N2O5S2/c1-14(4-3-11-22-29(2,25)26)23(19-12-17(21)6-5-15(19)13-24)30(27,28)18-9-7-16(20)8-10-18/h5-10,12,14,22,24H,3-4,11,13H2,1-2H3/t14-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM29012
(N-[(4R)-4-{[5-chloro-2-(hydroxymethyl)phenyl](4-ch...)Show SMILES C[C@H](CCCN(C)S(C)(=O)=O)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C20H26Cl2N2O5S2/c1-15(5-4-12-23(2)30(3,26)27)24(20-13-18(22)7-6-16(20)14-25)31(28,29)19-10-8-17(21)9-11-19/h6-11,13,15,25H,4-5,12,14H2,1-3H3/t15-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM29013
(4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]-N-[(...)Show SMILES C[C@H](CCCn1cnnn1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C19H21Cl2N5O3S/c1-14(3-2-10-25-13-22-23-24-25)26(19-11-17(21)5-4-15(19)12-27)30(28,29)18-8-6-16(20)7-9-18/h4-9,11,13-14,27H,2-3,10,12H2,1H3/t14-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477936
(CHEMBL252052)Show SMILES C[C@H](CCCn1nnnc1N(C)C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H26Cl2N6O3S/c1-15(5-4-12-28-21(27(2)3)24-25-26-28)29(20-13-18(23)7-6-16(20)14-30)33(31,32)19-10-8-17(22)9-11-19/h6-11,13,15,30H,4-5,12,14H2,1-3H3/t15-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477922
(CHEMBL252051)Show SMILES C[C@H](CCCn1nnnc1C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H23Cl2N5O3S/c1-14(4-3-11-26-15(2)23-24-25-26)27(20-12-18(22)6-5-16(20)13-28)31(29,30)19-9-7-17(21)8-10-19/h5-10,12,14,28H,3-4,11,13H2,1-2H3/t14-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477915
(CHEMBL252846)Show SMILES C[C@H](CCCn1ccnn1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H22Cl2N4O3S/c1-15(3-2-11-25-12-10-23-24-25)26(20-13-18(22)5-4-16(20)14-27)30(28,29)19-8-6-17(21)7-9-19/h4-10,12-13,15,27H,2-3,11,14H2,1H3/t15-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50125393
(CHEMBL57014)Show SMILES CCCCN(C)C(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)C(O)(O)c1ccccc1 Show InChI InChI=1S/C13H11N5/c14-12-15-8-16-13(18-12)17-11-6-5-9-3-1-2-4-10(9)7-11/h1-8H,(H3,14,15,16,17,18) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase activity in H4 human neuroglioma cells by measuring amyloid beta production |
Bioorg Med Chem Lett 14: 1917-21 (2004)
BindingDB Entry DOI: 10.7270/Q2TT4T4K |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50223758
(CHEMBL58925)Show SMILES CCCCN(C)C(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)c1ccccc1 |r| Show InChI InChI=1S/C28H45N3O4/c1-5-6-17-31(4)28(35)24(19-21-13-9-7-10-14-21)30-26(33)23(18-20(2)3)29-27(34)25(32)22-15-11-8-12-16-22/h8,11-12,15-16,20-21,23-25,32H,5-7,9-10,13-14,17-19H2,1-4H3,(H,29,34)(H,30,33)/t23-,24-,25-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase activity in H4 human neuroglioma cells by measuring amyloid beta production |
Bioorg Med Chem Lett 14: 1917-21 (2004)
BindingDB Entry DOI: 10.7270/Q2TT4T4K |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477917
(CHEMBL253295)Show SMILES C[C@H](CCCN1CCCS1(=O)=O)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H26Cl2N2O5S2/c1-16(4-2-11-24-12-3-13-31(24,27)28)25(21-14-19(23)6-5-17(21)15-26)32(29,30)20-9-7-18(22)8-10-20/h5-10,14,16,26H,2-4,11-13,15H2,1H3/t16-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477945
(CHEMBL429838)Show SMILES C[C@H](CCCn1ncnn1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H21Cl2N5O3S/c1-14(3-2-10-25-23-13-22-24-25)26(19-11-17(21)5-4-15(19)12-27)30(28,29)18-8-6-16(20)7-9-18/h4-9,11,13-14,27H,2-3,10,12H2,1H3/t14-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477932
(CHEMBL253091)Show SMILES C[C@H](CCCNC(=O)[C@H](O)c1ccccc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C26H28Cl2N2O5S/c1-18(6-5-15-29-26(33)25(32)19-7-3-2-4-8-19)30(24-16-22(28)10-9-20(24)17-31)36(34,35)23-13-11-21(27)12-14-23/h2-4,7-14,16,18,25,31-32H,5-6,15,17H2,1H3,(H,29,33)/t18-,25-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477939
(CHEMBL253092)Show SMILES C[C@H](CCCNC(=O)[C@@H](O)c1ccccc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C26H28Cl2N2O5S/c1-18(6-5-15-29-26(33)25(32)19-7-3-2-4-8-19)30(24-16-22(28)10-9-20(24)17-31)36(34,35)23-13-11-21(27)12-14-23/h2-4,7-14,16,18,25,31-32H,5-6,15,17H2,1H3,(H,29,33)/t18-,25+/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50553808
(CHEMBL4788217)Show SMILES ONC(=O)CCCCCCN1C(=O)\C(=C2/Nc3ccccc3/C/2=N\O)c2cc(Cl)ccc12 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of HDAC in human HeLa nuclear extract using fluoroscence-labeled acetylated peptide as substrate by fluorometric assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127537
BindingDB Entry DOI: 10.7270/Q27P931S |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477933
(CHEMBL253041)Show SMILES C[C@H](CCCN1CCOCC1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H28Cl2N2O4S/c1-17(3-2-10-25-11-13-30-14-12-25)26(22-15-20(24)5-4-18(22)16-27)31(28,29)21-8-6-19(23)7-9-21/h4-9,15,17,27H,2-3,10-14,16H2,1H3/t17-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50553810
(CHEMBL4746933)Show SMILES ONC(=O)CCCCCCN1C(=O)\C(=C2/Nc3ccccc3/C/2=N\O)c2cc(Br)ccc12 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of HDAC in human HeLa nuclear extract using fluoroscence-labeled acetylated peptide as substrate by fluorometric assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127537
BindingDB Entry DOI: 10.7270/Q27P931S |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50476941
(CHEMBL233363)Show SMILES C[C@H](CCc1ccccc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C23H23Cl2NO3S/c1-17(7-8-18-5-3-2-4-6-18)26(23-15-21(25)10-9-19(23)16-27)30(28,29)22-13-11-20(24)12-14-22/h2-6,9-15,17,27H,7-8,16H2,1H3/t17-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISA |
Bioorg Med Chem Lett 17: 4432-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.022
BindingDB Entry DOI: 10.7270/Q2708465 |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50132321
(CHEMBL298738)Show SMILES CC(C)C[C@H](NC(=O)Cc1ccc2ccccc2c1)C(=O)N[C@@H](CC1CCCCC1)[C@H](O)Cc1ccccc1C(=O)NC(C)(C)C |r| Show InChI InChI=1S/C20H22N5O5P/c1-30-14-6-2-4-12(8-14)18-17-19(21)22-11-23-20(17)25(24-18)13-5-3-7-15(9-13)31(28,29)10-16(26)27/h2,4-5,8-9,11,14H,3,6-7,10H2,1H3,(H,26,27)(H,28,29)(H2,21,22,23) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase activity in H4 human neuroglioma cells by measuring amyloid beta production |
Bioorg Med Chem Lett 14: 1917-21 (2004)
BindingDB Entry DOI: 10.7270/Q2TT4T4K |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477943
(CHEMBL437405)Show SMILES C[C@H](CCCn1cncn1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H22Cl2N4O3S/c1-15(3-2-10-25-14-23-13-24-25)26(20-11-18(22)5-4-16(20)12-27)30(28,29)19-8-6-17(21)7-9-19/h4-9,11,13-15,27H,2-3,10,12H2,1H3/t15-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50553797
(CHEMBL4781628)Show SMILES Cc1ccc2N(Cc3ccc(cc3)C(=O)NO)C(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c2c1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of HDAC in human HeLa nuclear extract using fluoroscence-labeled acetylated peptide as substrate by fluorometric assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127537
BindingDB Entry DOI: 10.7270/Q27P931S |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50553805
(CHEMBL4791243)Show SMILES COc1ccc2N(Cc3ccc(\C=C\C(=O)NO)cc3)C(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c2c1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of HDAC in human HeLa nuclear extract using fluoroscence-labeled acetylated peptide as substrate by fluorometric assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127537
BindingDB Entry DOI: 10.7270/Q27P931S |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50476940
(CHEMBL233362)Show SMILES CCC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C18H21Cl2NO3S/c1-3-4-13(2)21(18-11-16(20)6-5-14(18)12-22)25(23,24)17-9-7-15(19)8-10-17/h5-11,13,22H,3-4,12H2,1-2H3/t13-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50476940
(CHEMBL233362)Show SMILES CCC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C18H21Cl2NO3S/c1-3-4-13(2)21(18-11-16(20)6-5-14(18)12-22)25(23,24)17-9-7-15(19)8-10-17/h5-11,13,22H,3-4,12H2,1-2H3/t13-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISA |
Bioorg Med Chem Lett 17: 4432-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.022
BindingDB Entry DOI: 10.7270/Q2708465 |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50476939
(CHEMBL233364)Show SMILES CCCC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H23Cl2NO3S/c1-3-4-5-14(2)22(19-12-17(21)7-6-15(19)13-23)26(24,25)18-10-8-16(20)9-11-18/h6-12,14,23H,3-5,13H2,1-2H3/t14-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISA |
Bioorg Med Chem Lett 17: 4432-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.022
BindingDB Entry DOI: 10.7270/Q2708465 |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477929
(CHEMBL253283)Show SMILES C[C@H](CCCNC=O)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H22Cl2N2O4S/c1-14(3-2-10-22-13-25)23(19-11-17(21)5-4-15(19)12-24)28(26,27)18-8-6-16(20)7-9-18/h4-9,11,13-14,24H,2-3,10,12H2,1H3,(H,22,25)/t14-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477925
(CHEMBL251856)Show SMILES C[C@H](CCCn1nnc(n1)N(C)C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H26Cl2N6O3S/c1-15(5-4-12-28-25-21(24-26-28)27(2)3)29(20-13-18(23)7-6-16(20)14-30)33(31,32)19-10-8-17(22)9-11-19/h6-11,13,15,30H,4-5,12,14H2,1-3H3/t15-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50223762
(CHEMBL417588)Show SMILES CCCCN(C)C(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)Cc1cc(F)cc(F)c1 Show InChI InChI=1S/C28H43F2N3O3/c1-5-6-12-33(4)28(36)25(16-20-10-8-7-9-11-20)32-27(35)24(13-19(2)3)31-26(34)17-21-14-22(29)18-23(30)15-21/h14-15,18-20,24-25H,5-13,16-17H2,1-4H3,(H,31,34)(H,32,35)/t24-,25-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase activity in H4 human neuroglioma cells by measuring amyloid beta production |
Bioorg Med Chem Lett 14: 1917-21 (2004)
BindingDB Entry DOI: 10.7270/Q2TT4T4K |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477921
(CHEMBL404294)Show SMILES C[C@H](CCCn1nnc(C)n1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H23Cl2N5O3S/c1-14(4-3-11-26-24-15(2)23-25-26)27(20-12-18(22)6-5-16(20)13-28)31(29,30)19-9-7-17(21)8-10-19/h5-10,12,14,28H,3-4,11,13H2,1-2H3/t14-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Stimulator of interferon genes protein
(Human) | BDBM50509049
(CHEMBL4440744)Show SMILES CCn1nc(C)cc1C(=O)\N=c1/[nH]c2cc(ccc2n1CCCCn1c2ccc(cc2[nH]\c1=N/C(=O)c1cc(C)nn1CC)C(N)=O)C(N)=O Show InChI InChI=1S/C34H38N12O4/c1-5-45-27(15-19(3)41-45)31(49)39-33-37-23-17-21(29(35)47)9-11-25(23)43(33)13-7-8-14-44-26-12-10-22(30(36)48)18-24(26)38-34(44)40-32(50)28-16-20(4)42-46(28)6-2/h9-12,15-18H,5-8,13-14H2,1-4H3,(H2,35,47)(H2,36,48)(H,37,39,49)(H,38,40,50) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01795
BindingDB Entry DOI: 10.7270/Q2H1363K |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477937
(CHEMBL253727)Show SMILES C[C@H](CCCN(C)C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H26Cl2N2O3S/c1-15(5-4-12-23(2)3)24(20-13-18(22)7-6-16(20)14-25)28(26,27)19-10-8-17(21)9-11-19/h6-11,13,15,25H,4-5,12,14H2,1-3H3/t15-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477940
(CHEMBL252305)Show SMILES COCC(=O)NCCC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H26Cl2N2O5S/c1-15(4-3-11-24-21(27)14-30-2)25(20-12-18(23)6-5-16(20)13-26)31(28,29)19-9-7-17(22)8-10-19/h5-10,12,15,26H,3-4,11,13-14H2,1-2H3,(H,24,27)/t15-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50476947
(CHEMBL394661)Show SMILES CC(CCCF)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C18H20Cl2FNO3S/c1-13(3-2-10-21)22(18-11-16(20)5-4-14(18)12-23)26(24,25)17-8-6-15(19)7-9-17/h4-9,11,13,23H,2-3,10,12H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISA |
Bioorg Med Chem Lett 17: 4432-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.022
BindingDB Entry DOI: 10.7270/Q2708465 |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50553809
(CHEMBL4756818)Show SMILES ONC(=O)CCCCCCN1C(=O)\C(=C2/Nc3ccccc3/C/2=N\O)c2cccc(Cl)c12 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of HDAC in human HeLa nuclear extract using fluoroscence-labeled acetylated peptide as substrate by fluorometric assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127537
BindingDB Entry DOI: 10.7270/Q27P931S |
More data for this
Ligand-Target Pair | |
Histone deacetylase 6
(Homo sapiens (Human)) | BDBM50553792
(CHEMBL4797488)Show SMILES ONC(=O)c1ccc(CN2C(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c3ccccc23)cc1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of HDAC6 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127537
BindingDB Entry DOI: 10.7270/Q27P931S |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477942
(CHEMBL252303)Show SMILES C[C@H](CCCNC(C)=O)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H24Cl2N2O4S/c1-14(4-3-11-23-15(2)26)24(20-12-18(22)6-5-16(20)13-25)29(27,28)19-9-7-17(21)8-10-19/h5-10,12,14,25H,3-4,11,13H2,1-2H3,(H,23,26)/t14-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477912
(CHEMBL253296)Show SMILES C[C@H](CCCNS(=O)(=O)c1ccccc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C24H26Cl2N2O5S2/c1-18(6-5-15-27-34(30,31)22-7-3-2-4-8-22)28(24-16-21(26)10-9-19(24)17-29)35(32,33)23-13-11-20(25)12-14-23/h2-4,7-14,16,18,27,29H,5-6,15,17H2,1H3/t18-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477927
(CHEMBL252304)Show SMILES C[C@H](CCCNC(=O)CO)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H24Cl2N2O5S/c1-14(3-2-10-23-20(27)13-26)24(19-11-17(22)5-4-15(19)12-25)30(28,29)18-8-6-16(21)7-9-18/h4-9,11,14,25-26H,2-3,10,12-13H2,1H3,(H,23,27)/t14-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477918
(CHEMBL403739)Show SMILES C[C@H](CCCn1ccnc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23Cl2N3O3S/c1-16(3-2-11-25-12-10-24-15-25)26(21-13-19(23)5-4-17(21)14-27)30(28,29)20-8-6-18(22)7-9-20/h4-10,12-13,15-16,27H,2-3,11,14H2,1H3/t16-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50476919
(CHEMBL232948)Show SMILES CC(C1CCC1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H21Cl2NO3S/c1-13(14-3-2-4-14)22(19-11-17(21)6-5-15(19)12-23)26(24,25)18-9-7-16(20)8-10-18/h5-11,13-14,23H,2-4,12H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISA |
Bioorg Med Chem Lett 17: 4432-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.022
BindingDB Entry DOI: 10.7270/Q2708465 |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477916
(CHEMBL252645)Show SMILES C[C@H](CCCn1nccn1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H22Cl2N4O3S/c1-15(3-2-12-25-23-10-11-24-25)26(20-13-18(22)5-4-16(20)14-27)30(28,29)19-8-6-17(21)7-9-19/h4-11,13,15,27H,2-3,12,14H2,1H3/t15-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50125395
(CHEMBL57259)Show SMILES CC(C)C[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](CC1CCCCC1)C(=O)N(C)CC(C)C Show InChI InChI=1S/C9H9N5/c10-8-11-6-12-9(14-8)13-7-4-2-1-3-5-7/h1-6H,(H3,10,11,12,13,14) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of gamma-secretase activity in H4 human neuroglioma cells by measuring amyloid beta production |
Bioorg Med Chem Lett 14: 1917-21 (2004)
BindingDB Entry DOI: 10.7270/Q2TT4T4K |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477941
(CHEMBL403841)Show SMILES CCC(=O)NCCC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H26Cl2N2O4S/c1-3-21(27)24-12-4-5-15(2)25(20-13-18(23)7-6-16(20)14-26)30(28,29)19-10-8-17(22)9-11-19/h6-11,13,15,26H,3-5,12,14H2,1-2H3,(H,24,27)/t15-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50476912
(CHEMBL231714)Show InChI InChI=1S/C15H15Cl2NO3S/c1-2-18(15-9-13(17)4-3-11(15)10-19)22(20,21)14-7-5-12(16)6-8-14/h3-9,19H,2,10H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISA |
Bioorg Med Chem Lett 17: 4432-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.022
BindingDB Entry DOI: 10.7270/Q2708465 |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477914
(CHEMBL252694)Show SMILES CC(C)C(=O)NCCC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H28Cl2N2O4S/c1-15(2)22(28)25-12-4-5-16(3)26(21-13-19(24)7-6-17(21)14-27)31(29,30)20-10-8-18(23)9-11-20/h6-11,13,15-16,27H,4-5,12,14H2,1-3H3,(H,25,28)/t16-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Histone deacetylase
(Homo sapiens (Human)) | BDBM50553807
(CHEMBL4781515)Show SMILES ONC(=O)CCCCCCN1C(=O)\C(=C2/Nc3ccccc3/C/2=N\O)c2cc(F)ccc12 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of HDAC in human HeLa nuclear extract using fluoroscence-labeled acetylated peptide as substrate by fluorometric assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127537
BindingDB Entry DOI: 10.7270/Q27P931S |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50476953
(CHEMBL232949)Show SMILES CC(C1CCCC1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H23Cl2NO3S/c1-14(15-4-2-3-5-15)23(20-12-18(22)7-6-16(20)13-24)27(25,26)19-10-8-17(21)9-11-19/h6-12,14-15,24H,2-5,13H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISA |
Bioorg Med Chem Lett 17: 4432-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.022
BindingDB Entry DOI: 10.7270/Q2708465 |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50476922
(CHEMBL391377)Show SMILES C[C@H](CC=C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C18H19Cl2NO3S/c1-3-4-13(2)21(18-11-16(20)6-5-14(18)12-22)25(23,24)17-9-7-15(19)8-10-17/h3,5-11,13,22H,1,4,12H2,2H3/t13-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISA |
Bioorg Med Chem Lett 17: 4432-6 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.022
BindingDB Entry DOI: 10.7270/Q2708465 |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477920
(CHEMBL404295)Show SMILES C[C@H](CCCn1nnnc1-c1ccccc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C25H25Cl2N5O3S/c1-18(6-5-15-31-25(28-29-30-31)19-7-3-2-4-8-19)32(24-16-22(27)10-9-20(24)17-33)36(34,35)23-13-11-21(26)12-14-23/h2-4,7-14,16,18,33H,5-6,15,17H2,1H3/t18-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50477924
(CHEMBL428941)Show SMILES C[C@H](CCCNC(=O)c1ccccc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C25H26Cl2N2O4S/c1-18(6-5-15-28-25(31)19-7-3-2-4-8-19)29(24-16-22(27)10-9-20(24)17-30)34(32,33)23-13-11-21(26)12-14-23/h2-4,7-14,16,18,30H,5-6,15,17H2,1H3,(H,28,31)/t18-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels |
Bioorg Med Chem Lett 18: 175-8 (2008)
Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B |
More data for this
Ligand-Target Pair | |
Histone deacetylase 6
(Homo sapiens (Human)) | BDBM50553794
(CHEMBL4777783)Show SMILES ONC(=O)c1ccc(CN2C(=O)\C(=C3/Nc4ccccc4/C/3=N\O)c3cc(Cl)ccc23)cc1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of HDAC6 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2020.127537
BindingDB Entry DOI: 10.7270/Q27P931S |
More data for this
Ligand-Target Pair | |
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