Found 8 hits with Last Name = 'hanai' and Initial = 'n' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50131110
(CHEMBL437226 | Cyclic peptide analogue)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CO)N[C@H]1CC(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)NCC(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@@H]2C(=O)N1)C(C)C)C(C)C)C(O)=O Show InChI InChI=1S/C79H120N22O22S3/c1-38(2)25-52(78(121)101-22-14-17-55(101)72(115)95-54(36-124)71(114)98-64(40(5)6)75(118)99-63(39(3)4)74(117)92-48(79(122)123)20-24-126-10)90-61(107)33-84-66(109)47(19-23-125-9)91-70(113)53(35-102)88-58-29-59(105)83-32-60(106)89-51(28-57(80)104)69(112)93-49(26-43-30-82-46-16-12-11-15-45(43)46)68(111)94-50(27-44-31-81-37-86-44)67(110)85-34-62(108)97-65(42(8)103)76(119)87-41(7)77(120)100-21-13-18-56(100)73(116)96-58/h11-12,15-16,30-31,37-42,47-56,58,63-65,82,88,102-103,124H,13-14,17-29,32-36H2,1-10H3,(H2,80,104)(H,81,86)(H,83,105)(H,84,109)(H,85,110)(H,87,119)(H,89,106)(H,90,107)(H,91,113)(H,92,117)(H,93,112)(H,94,111)(H,95,115)(H,96,116)(H,97,108)(H,98,114)(H,99,118)(H,122,123)/t41-,42+,47-,48-,49-,50+,51+,52-,53-,54-,55+,56+,58+,63-,64-,65+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase by Scintillation Proximity Assay |
Bioorg Med Chem Lett 13: 2583-6 (2003)
BindingDB Entry DOI: 10.7270/Q2KK9B5J |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50131111
(CHEMBL87258 | H-SMGLPCVVM-OH)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CO)C(C)C)C(C)C)C(O)=O Show InChI InChI=1S/C39H69N9O11S3/c1-20(2)16-26(42-29(50)17-41-33(52)24(11-14-61-7)43-32(51)23(40)18-49)38(57)48-13-9-10-28(48)35(54)45-27(19-60)34(53)46-31(22(5)6)37(56)47-30(21(3)4)36(55)44-25(39(58)59)12-15-62-8/h20-28,30-31,49,60H,9-19,40H2,1-8H3,(H,41,52)(H,42,50)(H,43,51)(H,44,55)(H,45,54)(H,46,53)(H,47,56)(H,58,59)/t23-,24-,25-,26-,27-,28-,30-,31-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase by Scintillation Proximity Assay |
Bioorg Med Chem Lett 13: 2583-6 (2003)
BindingDB Entry DOI: 10.7270/Q2KK9B5J |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50131111
(CHEMBL87258 | H-SMGLPCVVM-OH)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CO)C(C)C)C(C)C)C(O)=O Show InChI InChI=1S/C39H69N9O11S3/c1-20(2)16-26(42-29(50)17-41-33(52)24(11-14-61-7)43-32(51)23(40)18-49)38(57)48-13-9-10-28(48)35(54)45-27(19-60)34(53)46-31(22(5)6)37(56)47-30(21(3)4)36(55)44-25(39(58)59)12-15-62-8/h20-28,30-31,49,60H,9-19,40H2,1-8H3,(H,41,52)(H,42,50)(H,43,51)(H,44,55)(H,45,54)(H,46,53)(H,47,56)(H,58,59)/t23-,24-,25-,26-,27-,28-,30-,31-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesylation of v-Ki-Ras by bovine farnesyl transferase |
Bioorg Med Chem Lett 13: 2583-6 (2003)
BindingDB Entry DOI: 10.7270/Q2KK9B5J |
More data for this
Ligand-Target Pair | |
Integrin alpha-5/beta-1
(Homo sapiens (Human)) | BDBM50131112
(CHEMBL410280 | Cyclic peptide analogue)Show SMILES CC(C)[C@H](NC(=O)[C@H]1CC(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)NCC(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@@H]2C(=O)N1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(O)=O Show InChI InChI=1S/C75H109N25O26/c1-33(2)58(70(121)98-59(36(5)102)69(120)85-29-54(107)89-42(14-9-17-80-75(77)78)61(112)83-28-55(108)91-47(24-57(110)111)65(116)95-48(31-101)73(124)100-19-11-15-49(100)67(118)88-35(4)74(125)126)97-66(117)46-23-52(105)82-27-53(106)90-45(22-51(76)104)64(115)92-43(20-38-25-81-41-13-8-7-12-40(38)41)63(114)93-44(21-39-26-79-32-86-39)62(113)84-30-56(109)96-60(37(6)103)71(122)87-34(3)72(123)99-18-10-16-50(99)68(119)94-46/h7-8,12-13,25-26,32-37,42-50,58-60,81,101-103H,9-11,14-24,27-31H2,1-6H3,(H2,76,104)(H,79,86)(H,82,105)(H,83,112)(H,84,113)(H,85,120)(H,87,122)(H,88,118)(H,89,107)(H,90,106)(H,91,108)(H,92,115)(H,93,114)(H,94,119)(H,95,116)(H,96,109)(H,97,117)(H,98,121)(H,110,111)(H,125,126)(H4,77,78,80)/t34-,35-,36+,37+,42-,43-,44+,45+,46+,47-,48-,49+,50+,58-,59-,60+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of mouse melanoma B16-F10 cell adhesion to fibronectin |
Bioorg Med Chem Lett 13: 2583-6 (2003)
BindingDB Entry DOI: 10.7270/Q2KK9B5J |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50131110
(CHEMBL437226 | Cyclic peptide analogue)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CO)N[C@H]1CC(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)NCC(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@@H]2C(=O)N1)C(C)C)C(C)C)C(O)=O Show InChI InChI=1S/C79H120N22O22S3/c1-38(2)25-52(78(121)101-22-14-17-55(101)72(115)95-54(36-124)71(114)98-64(40(5)6)75(118)99-63(39(3)4)74(117)92-48(79(122)123)20-24-126-10)90-61(107)33-84-66(109)47(19-23-125-9)91-70(113)53(35-102)88-58-29-59(105)83-32-60(106)89-51(28-57(80)104)69(112)93-49(26-43-30-82-46-16-12-11-15-45(43)46)68(111)94-50(27-44-31-81-37-86-44)67(110)85-34-62(108)97-65(42(8)103)76(119)87-41(7)77(120)100-21-13-18-56(100)73(116)96-58/h11-12,15-16,30-31,37-42,47-56,58,63-65,82,88,102-103,124H,13-14,17-29,32-36H2,1-10H3,(H2,80,104)(H,81,86)(H,83,105)(H,84,109)(H,85,110)(H,87,119)(H,89,106)(H,90,107)(H,91,113)(H,92,117)(H,93,112)(H,94,111)(H,95,115)(H,96,116)(H,97,108)(H,98,114)(H,99,118)(H,122,123)/t41-,42+,47-,48-,49-,50+,51+,52-,53-,54-,55+,56+,58+,63-,64-,65+/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of mouse melanoma B16-F10 cell adhesion to fibronectin |
Bioorg Med Chem Lett 13: 2583-6 (2003)
BindingDB Entry DOI: 10.7270/Q2KK9B5J |
More data for this
Ligand-Target Pair | |
Integrin alpha-5/beta-1
(Homo sapiens (Human)) | BDBM50131113
(CHEMBL410479 | Cyclic peptide analogue)Show SMILES CC(C)[C@H](N[C@H]1CC(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)NCC(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@@H]2C(=O)N1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O Show InChI InChI=1S/C91H133N29O28/c1-41(2)71(114-64-32-65(126)99-35-66(127)108-58(30-63(92)125)81(139)110-56(28-49-33-98-53-16-11-10-15-52(49)53)80(138)111-57(29-50-34-96-40-103-50)78(136)101-38-69(130)116-74(47(9)123)88(146)106-45(7)89(147)119-25-13-19-62(119)84(142)115-64)86(144)112-55(27-48-20-22-51(124)23-21-48)79(137)105-44(6)76(134)117-72(42(3)4)87(145)118-73(46(8)122)85(143)102-37-67(128)107-54(17-12-24-97-91(94)95)77(135)100-36-68(129)109-59(31-70(131)132)82(140)113-60(39-121)90(148)120-26-14-18-61(120)83(141)104-43(5)75(93)133/h10-11,15-16,20-23,33-34,40-47,54-62,64,71-74,98,114,121-124H,12-14,17-19,24-32,35-39H2,1-9H3,(H2,92,125)(H2,93,133)(H,96,103)(H,99,126)(H,100,135)(H,101,136)(H,102,143)(H,104,141)(H,105,137)(H,106,146)(H,107,128)(H,108,127)(H,109,129)(H,110,139)(H,111,138)(H,112,144)(H,113,140)(H,115,142)(H,116,130)(H,117,134)(H,118,145)(H,131,132)(H4,94,95,97)/t43-,44-,45-,46+,47+,54-,55-,56-,57+,58+,59-,60-,61+,62+,64+,71-,72-,73-,74+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 8.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of mouse melanoma B16-F10 cell adhesion to fibronectin |
Bioorg Med Chem Lett 13: 2583-6 (2003)
BindingDB Entry DOI: 10.7270/Q2KK9B5J |
More data for this
Ligand-Target Pair | |
Integrin alpha-5/beta-1
(Homo sapiens (Human)) | BDBM50131108
(CHEMBL402695 | H-VYAVTGRGDSPA-NH2)Show SMILES CC(C)[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O Show InChI InChI=1S/C51H82N16O17/c1-23(2)38(52)47(81)63-31(18-28-12-14-29(70)15-13-28)44(78)60-26(6)42(76)65-39(24(3)4)49(83)66-40(27(7)69)48(82)58-21-35(71)61-30(10-8-16-56-51(54)55)43(77)57-20-36(72)62-32(19-37(73)74)45(79)64-33(22-68)50(84)67-17-9-11-34(67)46(80)59-25(5)41(53)75/h12-15,23-27,30-34,38-40,68-70H,8-11,16-22,52H2,1-7H3,(H2,53,75)(H,57,77)(H,58,82)(H,59,80)(H,60,78)(H,61,71)(H,62,72)(H,63,81)(H,64,79)(H,65,76)(H,66,83)(H,73,74)(H4,54,55,56)/t25-,26-,27+,30-,31-,32-,33-,34+,38-,39-,40-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of mouse melanoma B16-F10 cell adhesion to fibronectin |
Bioorg Med Chem Lett 13: 2583-6 (2003)
BindingDB Entry DOI: 10.7270/Q2KK9B5J |
More data for this
Ligand-Target Pair | |
Integrin alpha-5/beta-1
(Homo sapiens (Human)) | BDBM50131109
((S)-3-[2-((S)-2-{2-[(2S,3R)-2-((S)-2-Amino-3-methy...)Show SMILES CC(C)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O Show InChI InChI=1S/C34H58N12O14/c1-15(2)25(35)30(56)45-26(17(4)48)31(57)40-13-22(49)42-18(7-5-9-38-34(36)37)27(53)39-12-23(50)43-19(11-24(51)52)28(54)44-20(14-47)32(58)46-10-6-8-21(46)29(55)41-16(3)33(59)60/h15-21,25-26,47-48H,5-14,35H2,1-4H3,(H,39,53)(H,40,57)(H,41,55)(H,42,49)(H,43,50)(H,44,54)(H,45,56)(H,51,52)(H,59,60)(H4,36,37,38)/t16-,17+,18-,19-,20-,21-,25-,26-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.10E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesylation of v-Ki-Ras by bovine farnesyl transferase |
Bioorg Med Chem Lett 13: 2583-6 (2003)
BindingDB Entry DOI: 10.7270/Q2KK9B5J |
More data for this
Ligand-Target Pair | |
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