Compile Data Set for Download or QSAR

Found 1691 hits with Last Name = 'harikrishnan' and Initial = 'ls'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM412734 (N-(3-fluoropyridin-4-yl)-2-(6-methylpyridin-2-yl)-...) Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1 Show InChI InChI=1S/C17H13FN6/c1-10-3-2-4-14(21-10)17-23-15-11(5-8-20-15)16(24-17)22-13-6-7-19-9-12(13)18/h2-9H,1H3,(H2,19,20,22,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase UniChem	Article PubMed	0.140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assay				Bioorg Med Chem 26: 1026-1034 (2018) Article DOI: 10.1016/j.bmc.2018.01.014 BindingDB Entry DOI: 10.7270/Q27M0BHV
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50454871 (CHEMBL4209835) Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncc2F)c2nc[nH]c2n1 Show InChI InChI=1S/C16H12FN7/c1-9-3-2-4-12(21-9)14-23-15-13(19-8-20-15)16(24-14)22-11-5-6-18-7-10(11)17/h2-8H,1H3,(H2,18,19,20,22,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assay				Bioorg Med Chem 26: 1026-1034 (2018) Article DOI: 10.1016/j.bmc.2018.01.014 BindingDB Entry DOI: 10.7270/Q27M0BHV
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM412755 (N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1 Show InChI InChI=1S/C19H14F3N7O/c1-10(30)25-15-9-11(5-7-23-15)26-17-12-6-8-24-16(12)28-18(29-17)13-3-2-4-14(27-13)19(20,21)22/h2-9H,1H3,(H3,23,24,25,26,28,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem	Article PubMed	0.150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assay				Bioorg Med Chem 26: 1026-1034 (2018) Article DOI: 10.1016/j.bmc.2018.01.014 BindingDB Entry DOI: 10.7270/Q27M0BHV
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM412745 (N-(3-fluoropyridin-4-yl)-2-(6-(trifluoromethyl)pyr...) Show SMILES Fc1cnccc1Nc1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F Show InChI InChI=1S/C17H10F4N6/c18-10-8-22-6-5-11(10)25-15-9-4-7-23-14(9)26-16(27-15)12-2-1-3-13(24-12)17(19,20)21/h1-8H,(H2,22,23,25,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PDB UniChem	PDB Article PubMed	0.220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assay				Bioorg Med Chem 26: 1026-1034 (2018) Article DOI: 10.1016/j.bmc.2018.01.014 BindingDB Entry DOI: 10.7270/Q27M0BHV
					More data for this Ligand-Target Pair				3D Structure (crystal)
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406730 (N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2...) Show SMILES CC(=O)Nc1cc(Nc2nc(nn3cccc23)-c2cccc(n2)C(F)F)ccn1 Show InChI InChI=1S/C19H15F2N7O/c1-11(29)23-16-10-12(7-8-22-16)24-19-15-6-3-9-28(15)27-18(26-19)14-5-2-4-13(25-14)17(20)21/h2-10,17H,1H3,(H2,22,23,24,26,27,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406730 (N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2...) Show SMILES CC(=O)Nc1cc(Nc2nc(nn3cccc23)-c2cccc(n2)C(F)F)ccn1 Show InChI InChI=1S/C19H15F2N7O/c1-11(29)23-16-10-12(7-8-22-16)24-19-15-6-3-9-28(15)27-18(26-19)14-5-2-4-13(25-14)17(20)21/h2-10,17H,1H3,(H2,22,23,24,26,27,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM407009 (N-(4-{[5-(morpholin-4-ylmethyl)-2-(pyridin-2-yl)py...) Show SMILES CC(=O)Nc1cc(Nc2nc(nn3ccc(CN4CCOCC4)c23)-c2ccccn2)ccn1 Show InChI InChI=1S/C23H24N8O2/c1-16(32)26-20-14-18(5-8-25-20)27-23-21-17(15-30-10-12-33-13-11-30)6-9-31(21)29-22(28-23)19-4-2-3-7-24-19/h2-9,14H,10-13,15H2,1H3,(H2,25,26,27,28,29,32)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406793 (N-{5-[(4,4-difluoropiperidin-1-yl)methyl]-2-(6-met...) Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncc2F)c2c(CN3CCC(F)(F)CC3)ccn2n1 Show InChI InChI=1S/C23H22F3N7/c1-15-3-2-4-19(28-15)21-30-22(29-18-5-9-27-13-17(18)24)20-16(6-10-33(20)31-21)14-32-11-7-23(25,26)8-12-32/h2-6,9-10,13H,7-8,11-12,14H2,1H3,(H,27,29,30,31)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406951 (1-({[2-(5-fluoropyridin-2-yl)-4-[(3-fluoropyridin-...) Show SMILES CC(C)(O)CNCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccc(F)cn1 Show InChI InChI=1S/C21H21F2N7O/c1-21(2,31)12-25-9-13-6-8-30-18(13)20(27-16-5-7-24-11-15(16)23)28-19(29-30)17-4-3-14(22)10-26-17/h3-8,10-11,25,31H,9,12H2,1-2H3,(H,24,27,28,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.25	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412735 (2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyri...) Show SMILES FC(F)c1cccc(n1)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1 Show InChI InChI=1S/C17H11F3N6/c18-10-8-21-6-5-11(10)24-16-9-4-7-22-15(9)25-17(26-16)13-3-1-2-12(23-13)14(19)20/h1-8,14H,(H2,21,22,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412768 (N-(3-fluoropyridin-4-yl)-5-methyl-2-(6-methylpyrid...) Show SMILES Cc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(C)n1 Show InChI InChI=1S/C18H15FN6/c1-10-8-21-17-15(10)18(23-13-6-7-20-9-12(13)19)25-16(24-17)14-5-3-4-11(2)22-14/h3-9H,1-2H3,(H2,20,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM407012 ((3-{[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-...) Show SMILES OCC1(CNCc2ccn3nc(nc(Nc4ccncc4F)c23)-c2ccccn2)COC1 Show InChI InChI=1S/C22H22FN7O2/c23-16-10-24-7-4-17(16)27-21-19-15(9-25-11-22(12-31)13-32-14-22)5-8-30(19)29-20(28-21)18-3-1-2-6-26-18/h1-8,10,25,31H,9,11-14H2,(H,24,27,28,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.25	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412743 (N-(3-fluoropyridin-4-yl)-2-(pyridin-2-yl)-7H-pyrro...) Show SMILES Fc1cnccc1Nc1nc(nc2[nH]ccc12)-c1ccccn1 Show InChI InChI=1S/C16H11FN6/c17-11-9-18-7-5-12(11)21-15-10-4-8-20-14(10)22-16(23-15)13-3-1-2-6-19-13/h1-9H,(H2,18,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406957 (3-fluoro-N-(5-{[(1-methylcyclobutyl)amino]methyl}-...) Show SMILES CC1(CNCc2ccn3nc(nc(Nc4ccncc4F)c23)-c2ccccn2)CCC1 Show InChI InChI=1S/C23H24FN7/c1-23(8-4-9-23)15-26-13-16-7-12-31-20(16)22(28-18-6-11-25-14-17(18)24)29-21(30-31)19-5-2-3-10-27-19/h2-3,5-7,10-12,14,26H,4,8-9,13,15H2,1H3,(H,25,28,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM407043 (2-[(3R)-3-hydroxypyrrolidin-1-yl]-N-[4-({2-[6-(tri...) Show SMILES O[C@@H]1CCN(CC(=O)Nc2cc(Nc3nc(nn4cccc34)-c3cccc(n3)C(F)(F)F)ccn2)C1 |r| Show InChI InChI=1S/C23H21F3N8O2/c24-23(25,26)18-5-1-3-16(29-18)21-31-22(17-4-2-9-34(17)32-21)28-14-6-8-27-19(11-14)30-20(36)13-33-10-7-15(35)12-33/h1-6,8-9,11,15,35H,7,10,12-13H2,(H2,27,28,30,31,32,36)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM407051 (N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]pyrrolo[...) Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)C3CC3)c2)c2cccn2n1 Show InChI InChI=1S/C21H16F3N7O/c22-21(23,24)16-5-1-3-14(27-16)18-29-19(15-4-2-10-31(15)30-18)26-13-8-9-25-17(11-13)28-20(32)12-6-7-12/h1-5,8-12H,6-7H2,(H2,25,26,28,29,30,32)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412766 (N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...) Show SMILES CC(=O)Nc1nccc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)c1F Show InChI InChI=1S/C19H14F3N7O/c1-9(30)25-19-14(20)11(6-8-24-19)27-17-10-5-7-23-16(10)28-18(29-17)13-4-2-3-12(26-13)15(21)22/h2-8,15H,1H3,(H3,23,24,25,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406787 (3-chloro-N-[2-(6-fluoropyridin-2-yl)pyrrolo[2,1-f]...) Show SMILES Fc1cccc(n1)-c1nc(Nc2ccncc2Cl)c2cccn2n1 Show InChI InChI=1S/C16H10ClFN6/c17-10-9-19-7-6-11(10)21-16-13-4-2-8-24(13)23-15(22-16)12-3-1-5-14(18)20-12/h1-9H,(H,19,21,22,23)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.390	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406741 (N-[4-({5-[(4,4-difluoropiperidin-1-yl)methyl]-2-(p...) Show SMILES CC(=O)Nc1cc(Nc2nc(nn3ccc(CN4CCC(F)(F)CC4)c23)-c2ccccn2)ccn1 Show InChI InChI=1S/C24H24F2N8O/c1-16(35)29-20-14-18(5-10-28-20)30-23-21-17(15-33-12-7-24(25,26)8-13-33)6-11-34(21)32-22(31-23)19-4-2-3-9-27-19/h2-6,9-11,14H,7-8,12-13,15H2,1H3,(H2,28,29,30,31,32,35)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM407010 (N-(5-{[(2H-1,3-benzodioxol-5-ylmethyl)amino]methyl...) Show SMILES Fc1cnccc1Nc1nc(nn2ccc(CNCc3ccc4OCOc4c3)c12)-c1ccccn1 Show InChI InChI=1S/C25H20FN7O2/c26-18-14-27-9-6-19(18)30-25-23-17(13-28-12-16-4-5-21-22(11-16)35-15-34-21)7-10-33(23)32-24(31-25)20-3-1-2-8-29-20/h1-11,14,28H,12-13,15H2,(H,27,30,31,32)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412738 (2-(pyrrolidin-1-yl)-N-(4-((2-(6-(trifluoromethyl)p...) Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)CN3CCCC3)c2)c2cc[nH]c2n1 Show InChI InChI=1S/C23H21F3N8O/c24-23(25,26)17-5-3-4-16(30-17)22-32-20-15(7-9-28-20)21(33-22)29-14-6-8-27-18(12-14)31-19(35)13-34-10-1-2-11-34/h3-9,12H,1-2,10-11,13H2,(H3,27,28,29,31,32,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406783 (N-{2-[6-(difluoromethyl)-5-fluoropyridin-2-yl]pyrr...) Show SMILES FC(F)c1nc(ccc1F)-c1nc(Nc2ccncc2F)c2cccn2n1 Show InChI InChI=1S/C17H10F4N6/c18-9-3-4-12(23-14(9)15(20)21)16-25-17(13-2-1-7-27(13)26-16)24-11-5-6-22-8-10(11)19/h1-8,15H,(H,22,24,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406991 (3-[4-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-...) Show SMILES Oc1cccc(c1)N1CCN(Cc2ccn3nc(nc(Nc4ccncc4F)c23)-c2ccccn2)CC1 Show InChI InChI=1S/C27H25FN8O/c28-22-17-29-10-7-23(22)31-27-25-19(8-11-36(25)33-26(32-27)24-6-1-2-9-30-24)18-34-12-14-35(15-13-34)20-4-3-5-21(37)16-20/h1-11,16-17,37H,12-15,18H2,(H,29,31,32,33)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406968 ((3S)-1-({4-[(3-fluoropyridin-4-yl)amino]-2-(6-meth...) Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncc2F)c2c(CN3CC[C@H](O)C3)ccn2n1 |r| Show InChI InChI=1S/C22H22FN7O/c1-14-3-2-4-19(25-14)21-27-22(26-18-5-8-24-11-17(18)23)20-15(6-10-30(20)28-21)12-29-9-7-16(31)13-29/h2-6,8,10-11,16,31H,7,9,12-13H2,1H3,(H,24,26,27,28)/t16-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.490	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406990 (4-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-...) Show SMILES CC(O)CCNCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccccn1 Show InChI InChI=1S/C21H22FN7O/c1-14(30)5-9-23-12-15-7-11-29-19(15)21(26-17-6-10-24-13-16(17)22)27-20(28-29)18-4-2-3-8-25-18/h2-4,6-8,10-11,13-14,23,30H,5,9,12H2,1H3,(H,24,26,27,28)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412739 (2-(4-methylpiperazin-1-yl)-N-(4-((2-(6-(trifluorom...) Show SMILES CN1CCN(CC(=O)Nc2cc(Nc3nc(nc4[nH]ccc34)-c3cccc(n3)C(F)(F)F)ccn2)CC1 Show InChI InChI=1S/C24H24F3N9O/c1-35-9-11-36(12-10-35)14-20(37)32-19-13-15(5-7-28-19)30-22-16-6-8-29-21(16)33-23(34-22)17-3-2-4-18(31-17)24(25,26)27/h2-8,13H,9-12,14H2,1H3,(H3,28,29,30,32,33,34,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.530	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM412745 (N-(3-fluoropyridin-4-yl)-2-(6-(trifluoromethyl)pyr...) Show SMILES Fc1cnccc1Nc1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F Show InChI InChI=1S/C17H10F4N6/c18-10-8-22-6-5-11(10)25-15-9-4-7-23-14(9)26-16(27-15)12-2-1-3-13(24-12)17(19,20)21/h1-8H,(H2,22,23,25,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PDB UniChem	PDB Article PubMed	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect cells after 1 hr by HTRF assay				Bioorg Med Chem 26: 1026-1034 (2018) Article DOI: 10.1016/j.bmc.2018.01.014 BindingDB Entry DOI: 10.7270/Q27M0BHV
					More data for this Ligand-Target Pair				3D Structure (crystal)
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412745 (N-(3-fluoropyridin-4-yl)-2-(6-(trifluoromethyl)pyr...) Show SMILES Fc1cnccc1Nc1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F Show InChI InChI=1S/C17H10F4N6/c18-10-8-22-6-5-11(10)25-15-9-4-7-23-14(9)26-16(27-15)12-2-1-3-13(24-12)17(19,20)21/h1-8H,(H2,22,23,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PDB UniChem	PDB US Patent	n/a	n/a	0.560	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair				3D Structure (crystal)
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406959 (1-({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin-2-y...) Show SMILES OC1CCN(Cc2ccn3nc(nc(Nc4ccncc4F)c23)-c2ccccn2)CC1 Show InChI InChI=1S/C22H22FN7O/c23-17-13-24-9-4-18(17)26-22-20-15(14-29-10-6-16(31)7-11-29)5-12-30(20)28-21(27-22)19-3-1-2-8-25-19/h1-5,8-9,12-13,16,31H,6-7,10-11,14H2,(H,24,26,27,28)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM407017 (3-fluoro-N-[2-(pyridin-2-yl)-5-({[2-(pyridin-2-yl)...) Show SMILES CC(C)(NCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccccn1)c1ccccn1 Show InChI InChI=1S/C25H23FN8/c1-25(2,21-8-4-6-12-29-21)30-15-17-10-14-34-22(17)24(31-19-9-13-27-16-18(19)26)32-23(33-34)20-7-3-5-11-28-20/h3-14,16,30H,15H2,1-2H3,(H,27,31,32,33)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406721 (3-chloro-N-[2-(5-fluoropyridin-2-yl)pyrrolo[2,1-f]...) Show SMILES Fc1ccc(nc1)-c1nc(Nc2ccncc2Cl)c2cccn2n1 Show InChI InChI=1S/C16H10ClFN6/c17-11-9-19-6-5-12(11)21-16-14-2-1-7-24(14)23-15(22-16)13-4-3-10(18)8-20-13/h1-9H,(H,19,21,22,23)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406967 ((3S)-1-({2-[6-(difluoromethyl)pyridin-2-yl]-4-[(3-...) Show SMILES O[C@H]1CCN(Cc2ccn3nc(nc(Nc4ccncc4F)c23)-c2cccc(n2)C(F)F)C1 |r| Show InChI InChI=1S/C22H20F3N7O/c23-15-10-26-7-4-16(15)28-22-19-13(11-31-8-6-14(33)12-31)5-9-32(19)30-21(29-22)18-3-1-2-17(27-18)20(24)25/h1-5,7,9-10,14,20,33H,6,8,11-12H2,(H,26,28,29,30)/t14-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412773 (N-methyl-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H...) Show SMILES CN(c1ccncc1)c1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F Show InChI InChI=1S/C18H13F3N6/c1-27(11-5-8-22-9-6-11)17-12-7-10-23-15(12)25-16(26-17)13-3-2-4-14(24-13)18(19,20)21/h2-10H,1H3,(H,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50337332 (2-(4-chlorophenyl)-1-(4-(4-(5-methyl-1H-pyrazol-3-...) Show SMILES Cc1cc(Nc2nc(nn3cccc23)N2CCN(CC2)C(=O)Cc2ccc(Cl)cc2)[nH]n1 Show InChI InChI=1S/C22H23ClN8O/c1-15-13-19(27-26-15)24-21-18-3-2-8-31(18)28-22(25-21)30-11-9-29(10-12-30)20(32)14-16-4-6-17(23)7-5-16/h2-8,13H,9-12,14H2,1H3,(H2,24,25,26,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. Curated by ChEMBL					Assay Description Inhibition of JAK2 after 60 mins				Bioorg Med Chem Lett 21: 1425-8 (2011) Article DOI: 10.1016/j.bmcl.2011.01.022 BindingDB Entry DOI: 10.7270/Q2MG7PRT
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412775 (3-chloro-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H...) Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccncc2Cl)c2cc[nH]c2n1 Show InChI InChI=1S/C17H10ClF3N6/c18-10-8-22-6-5-11(10)25-15-9-4-7-23-14(9)26-16(27-15)12-2-1-3-13(24-12)17(19,20)21/h1-8H,(H2,22,23,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM407046 (2-[(2-hydroxy-2-methylpropyl)amino]-N-[4-({2-[6-(t...) Show SMILES CC(C)(O)CNCC(=O)Nc1cc(Nc2nc(nn3cccc23)-c2cccc(n2)C(F)(F)F)ccn1 Show InChI InChI=1S/C23H23F3N8O2/c1-22(2,36)13-27-12-19(35)31-18-11-14(8-9-28-18)29-21-16-6-4-10-34(16)33-20(32-21)15-5-3-7-17(30-15)23(24,25)26/h3-11,27,36H,12-13H2,1-2H3,(H2,28,29,31,32,33,35)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412746 (2-(5-fluoro-6-methylpyridin-2-yl)-N-(3-fluoropyrid...) Show SMILES Cc1nc(ccc1F)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1 Show InChI InChI=1S/C17H12F2N6/c1-9-11(18)2-3-14(22-9)17-24-15-10(4-7-21-15)16(25-17)23-13-5-6-20-8-12(13)19/h2-8H,1H3,(H2,20,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412747 (2-(6-(difluoromethyl)pyridin-2-yl)-4-(1H-pyrrolo[3...) Show SMILES FC(F)c1cccc(n1)-c1nc(-n2ccc3cnccc23)c2cc[nH]c2n1 Show InChI InChI=1S/C19H12F2N6/c20-16(21)13-2-1-3-14(24-13)18-25-17-12(4-8-23-17)19(26-18)27-9-6-11-10-22-7-5-15(11)27/h1-10,16H,(H,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412774 (3-(trifluoromethyl)-N-{2-[6-(trifluoromethyl)pyrid...) Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccncc2C(F)(F)F)c2cc[nH]c2n1 Show InChI InChI=1S/C18H10F6N6/c19-17(20,21)10-8-25-6-5-11(10)28-15-9-4-7-26-14(9)29-16(30-15)12-2-1-3-13(27-12)18(22,23)24/h1-8H,(H2,25,26,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412755 (N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1 Show InChI InChI=1S/C19H14F3N7O/c1-10(30)25-15-9-11(5-7-23-15)26-17-12-6-8-24-16(12)28-18(29-17)13-3-2-4-14(27-13)19(20,21)22/h2-9H,1H3,(H3,23,24,25,26,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.670	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406956 (1-{2-[({4-[(3-fluoropyridin-4-yl)amino]-2-(pyridin...) Show SMILES OC1(CCNCc2ccn3nc(nc(Nc4ccncc4F)c23)-c2ccccn2)CCCC1 Show InChI InChI=1S/C24H26FN7O/c25-18-16-26-12-6-19(18)29-23-21-17(15-27-13-10-24(33)8-2-3-9-24)7-14-32(21)31-22(30-23)20-5-1-4-11-28-20/h1,4-7,11-12,14,16,27,33H,2-3,8-10,13,15H2,(H,26,29,30,31)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412734 (N-(3-fluoropyridin-4-yl)-2-(6-methylpyridin-2-yl)-...) Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1 Show InChI InChI=1S/C17H13FN6/c1-10-3-2-4-14(21-10)17-23-15-11(5-8-20-15)16(24-17)22-13-6-7-19-9-12(13)18/h2-9H,1H3,(H2,19,20,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412751 (N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)c(F)cn1 Show InChI InChI=1S/C19H14F3N7O/c1-9(30)25-15-7-14(11(20)8-24-15)27-18-10-5-6-23-17(10)28-19(29-18)13-4-2-3-12(26-13)16(21)22/h2-8,16H,1H3,(H3,23,24,25,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.710	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406734 (N-(3-fluoropyridin-4-yl)-2-(4-(trifluoromethyl)thi...) Show SMILES Fc1cnccc1Nc1nc(nn2cccc12)-c1nc(cs1)C(F)(F)F Show InChI InChI=1S/C15H8F4N6S/c16-8-6-20-4-3-9(8)21-12-10-2-1-5-25(10)24-13(23-12)14-22-11(7-26-14)15(17,18)19/h1-7H,(H,20,21,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.720	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412759 (N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...) Show SMILES CCC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1 Show InChI InChI=1S/C20H16F3N7O/c1-2-16(31)28-15-10-11(6-8-24-15)26-18-12-7-9-25-17(12)29-19(30-18)13-4-3-5-14(27-13)20(21,22)23/h3-10H,2H2,1H3,(H3,24,25,26,28,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.740	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412778 (N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]-5-{[(2-h...) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]cc(CNCC(C)(C)O)c23)-c2cccc(n2)C(F)F)ccn1 Show InChI InChI=1S/C24H26F2N8O2/c1-13(35)30-18-9-15(7-8-28-18)31-23-19-14(10-27-12-24(2,3)36)11-29-22(19)33-21(34-23)17-6-4-5-16(32-17)20(25)26/h4-9,11,20,27,36H,10,12H2,1-3H3,(H3,28,29,30,31,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406958 (3-fluoro-N-(5-{[(4-methyloxan-4-yl)amino]methyl}-2...) Show SMILES CC1(CCOCC1)NCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccccn1 Show InChI InChI=1S/C23H24FN7O/c1-23(7-12-32-13-8-23)27-14-16-6-11-31-20(16)22(28-18-5-10-25-15-17(18)24)29-21(30-31)19-4-2-3-9-26-19/h2-6,9-11,15,27H,7-8,12-14H2,1H3,(H,25,28,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.760	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM406977 (3-fluoro-N-[2-(3-fluoro-6-methylpyridin-2-yl)pyrro...) Show SMILES Cc1ccc(F)c(n1)-c1nc(Nc2ccncc2F)c2cccn2n1 Show InChI InChI=1S/C17H12F2N6/c1-10-4-5-11(18)15(21-10)17-23-16(14-3-2-8-25(14)24-17)22-13-6-7-20-9-12(13)19/h2-9H,1H3,(H,20,22,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.760	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10336761 (2019) BindingDB Entry DOI: 10.7270/Q2M90C2R
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412752 (US10399987, Example 17 | methyl (4-((2-(6-(difluor...) Show SMILES COC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)ccn1 Show InChI InChI=1S/C19H15F2N7O2/c1-30-19(29)26-14-9-10(5-7-22-14)24-17-11-6-8-23-16(11)27-18(28-17)13-4-2-3-12(25-13)15(20)21/h2-9,15H,1H3,(H3,22,23,24,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412741 (2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyri...) Show SMILES Cc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(n1)C(F)F Show InChI InChI=1S/C18H13F3N6/c1-9-7-23-17-14(9)18(25-11-5-6-22-8-10(11)19)27-16(26-17)13-4-2-3-12(24-13)15(20)21/h2-8,15H,1H3,(H2,22,23,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair

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