Found 562 hits with Last Name = 'houang' and Initial = 'e' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631495
(US20230348424, Example 78)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)C1(C)CN(C1)C(=O)C1CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631686
(US20230348424, Example 269)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)[C@]1(C)CCN(C1)C(=O)C1(F)CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631683
(1-((S)-1-acetyl-3-methylpyrrolidin-3-yl)-N-((R)-1-...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)[C@]1(C)CCN(C1)C(C)=O)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631687
(US20230348424, Example 270)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)C1(C)CN(C1)C(=O)C1CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.74 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631681
(US20230348424, Example 264)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)C1(C)CCN(C1)C(C)=O)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631684
(US20230348424, Example 267)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)C1(C)CCN(C1)C(=O)C1(F)CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.44 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631543
(US20230348424, Example 126 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(C2CC3(C2)CC(F)(F)C3)c(=O)cc1N[C@@H]1CCN(C)C[C@@H]1F)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631615
(US20230348424, Example 198)Show SMILES C[C@@H](NC(=O)c1cn([C@H]2[C@H](C)C2(F)F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(c1F)C(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.41 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631526
(US20230348424, Example 109 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2[C@@H](C)C2(F)F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631621
(US20230348424, Example 204)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@H]1CCN(C)C[C@H]1F)C12CC(C1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.61 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631496
(: N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethy...)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2CCOC[C@H]2F)c(=O)cc1NC1CCN(C)CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631559
(US20230348424, Example 142 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@H]1CCN(C)C[C@H]1F)C12CC(F)(C1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631561
(US20230348424, Example 144 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn([C@H]2CCC2(F)F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(c1F)C(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631627
(US20230348424, Example 210)Show SMILES C[C@@H](NC(=O)c1cn(C2CCC2(F)F)c(=O)cc1N[C@@H]1[C@H]2CC[C@@H]1CN(C)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631543
(US20230348424, Example 126 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(C2CC3(C2)CC(F)(F)C3)c(=O)cc1N[C@@H]1CCN(C)C[C@@H]1F)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631464
(N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)[C@@]1(C)CCOC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631620
(US20230348424, Example 203)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1CCN(C)C[C@@H]1F)C12CC(C1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631490
(1-((1R,2S)-[1,1′-bi(cyclopropan)]-2-yl)-N-((...)Show SMILES C[C@@H](NC(=O)c1cn([C@H]2C[C@@H]2C2CC2)c(=O)cc1NC1CCN(C)CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631702
(US20230348424, Example 285)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)[C@@]12C[C@@H]1COC2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631649
(US20230348424, Example 232 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)[C@]1(CCOC1)C(F)(F)F)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631724
(N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)...)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2CCOC(C)(C)C2)c(=O)cc1NC1CCN(C)CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631559
(US20230348424, Example 142 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@H]1CCN(C)C[C@H]1F)C12CC(F)(C1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631563
(US20230348424, Example 146 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn([C@H]2CCC2(F)F)c(=O)cc1NCC1(F)CN(C)C1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631612
(US20230348424, Example 195)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2[C@@H](C)C2(F)F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(c1F)C(C)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 5.44 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631520
(US20230348424, Example 103 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2CCC2(F)F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631553
(US20230348424, Example 136 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@H]1[C@H]2CC[C@@H]1CN(C)C2)C12CC(F)(C1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631600
(N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@H]1CCCn2cncc12)C1(CC1)C(F)F)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631660
(US20230348424, Example 243 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2CCOC[C@H]2F)c(=O)cc1N[C@@H]1[C@H]2C[C@@H]1CN(C)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631561
(US20230348424, Example 144 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn([C@H]2CCC2(F)F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(c1F)C(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631568
(US20230348424, Example 151 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)[C@@]1(C)CCOC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631634
((R)-1- (bicyclo[1.1.1]pentan-1- yl)-N-(1-(3- (difl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1NC1CCN(C)CC1)C12CC(C1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631458
(: (R)-N-(1-(3-(difluoromethyl)-2-fluorophenyl)ethy...)Show SMILES C[C@@H](NC(=O)c1cn(C2CCOCC2)c(=O)cc1NC1CCN(C)CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631709
(US20230348424, Example 292)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)[C@]1(CCOC1)C1CC1)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM50605601
(CHEMBL5184138)Show SMILES Fc1cccc(COCc2ccc3S[C@@H](COc3c2)c2c[nH]c(=O)c(=O)[nH]2)c1 |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00118
BindingDB Entry DOI: 10.7270/Q2MG7TK7 |
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631545
(N-((R)-1-(3- (difluoromethyl)-2- fluorophenyl)ethy...)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2CCOC[C@H]2F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631524
(N-((R)-1-(3- (difluoromethyl)-2- fluorophenyl)ethy...)Show SMILES C[C@@H](NC(=O)c1cn(C2CC3(CC3)C2)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631534
(US20230348424, Example 117 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn([C@H]2CC22CCC2)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631551
(US20230348424, Example 134 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@H]1[C@H]2CC[C@@H]1CN(C)C2)C12CC(C1)C2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM50605597
(CHEMBL5204161)Show SMILES C[C@]1(COc2cc(ccc2S1)C(F)(F)F)c1c[nH]c(=O)c(=O)[nH]1 |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00118
BindingDB Entry DOI: 10.7270/Q2MG7TK7 |
More data for this
Ligand-Target Pair | |
D-amino-acid oxidase
(Homo sapiens (Human)) | BDBM50605598
(CHEMBL5188193)Show SMILES C[C@]1(COc2cc(Cl)ccc2S1)c1c[nH]c(=O)c(=O)[nH]1 |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00118
BindingDB Entry DOI: 10.7270/Q2MG7TK7 |
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631651
(US20230348424, Example 234 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)[C@]1(CCOC1)C(F)(F)F)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631707
(: 1-((1S,5S)-3-oxabicyclo[3.1.0]hexan-1-yl)-N-((R)...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)[C@@]12C[C@@H]1COC2)c1cccc(c1F)C(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631624
(1-cyclobutyl-N-((R)-1-(2- fluoro-3- (trifluorometh...)Show SMILES C[C@@H](NC(=O)c1cn(C2CCC2)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(c1F)C(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631694
(US20230348424, Example 277 | US20230348424, Exampl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@H]1CCNC2(CC2)C1)C1(CC1)C(F)F)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 9.46 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631728
(N-((R)-1-(3-(difluoromethyl)-2-fluorophenyl)ethyl)...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1CCN(C)C2(CC2)C1)C1(CC1)C(F)F)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631489
(1-((1S,2R)-[1,1′-bi(cyclopropan)]-2-yl)-N-((...)Show SMILES C[C@@H](NC(=O)c1cn([C@H]2C[C@@H]2C2CC2)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631704
(US20230348424, Example 287)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)[C@@]12C[C@@H]1COC2)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 9.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631616
(US20230348424, Example 199)Show SMILES C[C@@H](NC(=O)c1cn([C@@H]2CC2(F)F)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(c1F)C(F)(F)F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 10.1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631648
(N-((R)-1-(3- (difluoromethyl)-2- fluorophenyl)ethy...)Show SMILES C[C@@H](NC(=O)c1cn(C2CC3(C2)CC(F)(F)C3)c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)c1cccc(C(F)F)c1F | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Son of sevenless homolog 1 [564-1049]/GTPase KRas [G12C]
(Homo sapiens (Human)) | BDBM631501
(N-((R)-1-(3-(difluoromethyl)- 2-fluorophenyl)ethyl...)Show SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1CN2CCC1CC2)C1(CC1)C(F)F)c1cccc(C(F)F)c1F |wD:13.13,1.0,(-3.33,1.16,;-2,1.92,;-.67,1.16,;-.67,-.38,;-2,-1.16,;.67,-1.16,;2,-.38,;3.33,-1.16,;3.33,-2.7,;4.67,-3.46,;2,-3.46,;.67,-2.7,;-.67,-3.46,;-.67,-5,;.67,-5.77,;.67,-7.31,;-.67,-8.08,;-2,-7.31,;-2,-5.77,;-.75,-5.79,;-.39,-7.17,;4.67,-.38,;6,-1.15,;6,.39,;3.58,.7,;4.35,2.04,;2.09,.31,;-2,3.46,;-.67,4.24,;-.67,5.78,;-2,6.54,;-3.33,5.78,;-4.67,6.54,;-4.67,8.08,;-6,5.78,;-3.33,4.24,;-4.67,3.46,)| | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
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