Compile Data Set for Download or QSAR

Found 191 hits with Last Name = 'kamei' and Initial = 'k'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252902 (US9464076, 54) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(N)c4ccccc4n3)c(C)c12 Show InChI InChI=1S/C23H21N3O3S/c1-12-20-14(11-29-3)8-9-15(13(2)27)22(20)30-21(12)23(28)26-19-10-17(24)16-6-4-5-7-18(16)25-19/h4-10H,11H2,1-3H3,(H3,24,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0540	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252906 (US9464076, 58) Show SMILES COCc1ccc(C(=O)C(C)(C)C)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12 |r| Show InChI InChI=1S/C31H35N3O4S/c1-18-26-19(17-38-5)10-11-23(29(36)31(2,3)4)28(26)39-27(18)30(37)33-25-14-20(15-34-13-12-21(35)16-34)22-8-6-7-9-24(22)32-25/h6-11,14,21,35H,12-13,15-17H2,1-5H3,(H,32,33,37)/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0850	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252947 (US9464076, 99) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(F)C3)c(C)c12 Show InChI InChI=1S/C27H24FN3O4S/c1-14-23-16(13-35-3)7-8-18(15(2)32)25(23)36-24(14)26(33)30-22-10-9-19-20(5-4-6-21(19)29-22)27(34)31-11-17(28)12-31/h4-10,17H,11-13H2,1-3H3,(H,29,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252941 (US9464076, 93) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(O)=O)c(C)c12 Show InChI InChI=1S/C24H20N2O5S/c1-12-20-14(11-31-3)7-8-15(13(2)27)22(20)32-21(12)23(28)26-19-10-9-16-17(24(29)30)5-4-6-18(16)25-19/h4-10H,11H2,1-3H3,(H,29,30)(H,25,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252949 (US9464076, 101) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(O)C3)c(C)c12 Show InChI InChI=1S/C27H25N3O5S/c1-14-23-16(13-35-3)7-8-18(15(2)31)25(23)36-24(14)26(33)29-22-10-9-19-20(5-4-6-21(19)28-22)27(34)30-11-17(32)12-30/h4-10,17,32H,11-13H2,1-3H3,(H,28,29,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252961 (US9464076, 113) Show SMILES COCc1cccc2nc(NC(=O)c3sc4c(ccc(CO)c4c3C)C(C)=O)ccc12 Show InChI InChI=1S/C24H22N2O4S/c1-13-21-15(11-27)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-16(12-30-3)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252887 (US9464076, 116 | US9464076, 39 | US9464076, 40 | U...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12 |r| Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50167871 (3-Chloro-4-{4-[5-(4-methyl-pyrimidin-2-yl)-3,4-dih...) Show SMILES Cc1ccnc(n1)C1=CN(CCCCN2C(Cl)=COc3ccccc3C2=O)CCC1 |c:17,t:8| Show InChI InChI=1S/C23H25ClN4O2/c1-17-10-11-25-22(26-17)18-7-6-13-27(15-18)12-4-5-14-28-21(24)16-30-20-9-3-2-8-19(20)23(28)29/h2-3,8-11,15-16H,4-7,12-14H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.185	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Suntory Biomedical Research Co., Ltd Curated by ChEMBL					Assay Description Inhibitory concentration against 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]-8-OH-DPAT as radioligand				Bioorg Med Chem Lett 15: 2990-3 (2005) Article DOI: 10.1016/j.bmcl.2005.04.059 BindingDB Entry DOI: 10.7270/Q21Z456V
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252946 (US9464076, 98) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CCC3)c(C)c12 Show InChI InChI=1S/C27H25N3O4S/c1-15-23-17(14-34-3)8-9-18(16(2)31)25(23)35-24(15)26(32)29-22-11-10-19-20(6-4-7-21(19)28-22)27(33)30-12-5-13-30/h4,6-11H,5,12-14H2,1-3H3,(H,28,29,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.210	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252950 (US9464076, 102 | US9464076, 103 | US9464076, 104 |...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12 Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.220	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252886 (US9464076, 38) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@H](O)C4)c4ccccc4n3)c(C)c12 |r| Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.230	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252957 (US9464076, 109 | US9464076, 110 | US9464076, 111 |...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CS(C)(=O)=O)cccc4n3)c(C)c12 Show InChI InChI=1S/C25H24N2O5S2/c1-14-22-16(12-32-3)8-9-18(15(2)28)24(22)33-23(14)25(29)27-21-11-10-19-17(13-34(4,30)31)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.230	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252945 (US9464076, 97) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N(C)C)c(C)c12 Show InChI InChI=1S/C26H25N3O4S/c1-14-22-16(13-33-5)9-10-17(15(2)30)24(22)34-23(14)25(31)28-21-12-11-18-19(26(32)29(3)4)7-6-8-20(18)27-21/h6-12H,13H2,1-5H3,(H,27,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252950 (US9464076, 102 | US9464076, 103 | US9464076, 104 |...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12 Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.290	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252883 (US9464076, 35) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCC(O)C4)c4ccccc4n3)c(C)c12 Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.290	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252950 (US9464076, 102 | US9464076, 103 | US9464076, 104 |...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12 Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252907 (US9464076, 59) Show SMILES COCc1ccc(C(=O)C(C)C)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12 |r| Show InChI InChI=1S/C30H33N3O4S/c1-17(2)27(35)23-10-9-19(16-37-4)26-18(3)28(38-29(23)26)30(36)32-25-13-20(14-33-12-11-21(34)15-33)22-7-5-6-8-24(22)31-25/h5-10,13,17,21,34H,11-12,14-16H2,1-4H3,(H,31,32,36)/t21-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.310	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252950 (US9464076, 102 | US9464076, 103 | US9464076, 104 |...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12 Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.310	n/a	n/a	n/a	n/a	7.5	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252944 (US9464076, 96) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CCN(C)CC3)c(C)c12 Show InChI InChI=1S/C29H30N4O4S/c1-17-25-19(16-37-4)8-9-20(18(2)34)27(25)38-26(17)28(35)31-24-11-10-21-22(6-5-7-23(21)30-24)29(36)33-14-12-32(3)13-15-33/h5-11H,12-16H2,1-4H3,(H,30,31,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.310	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252925 (US9464076, 119 | US9464076, 120 | US9464076, 77 | ...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CO)cccc4n3)c(C)c12 Show InChI InChI=1S/C24H22N2O4S/c1-13-21-16(12-30-3)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-15(11-27)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252887 (US9464076, 116 | US9464076, 39 | US9464076, 40 | U...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12 |r| Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.350	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252884 (US9464076, 36) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCC(O)CC4)c4ccccc4n3)c(C)c12 Show InChI InChI=1S/C29H31N3O4S/c1-17-26-19(16-36-3)8-9-22(18(2)33)28(26)37-27(17)29(35)31-25-14-20(15-32-12-10-21(34)11-13-32)23-6-4-5-7-24(23)30-25/h4-9,14,21,34H,10-13,15-16H2,1-3H3,(H,30,31,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.350	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252937 (US9464076, 89) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)CCC(O)=O)cccc4n3)c(C)c12 Show InChI InChI=1S/C28H26N2O7S/c1-15-25-18(13-36-3)7-8-19(16(2)31)27(25)38-26(15)28(35)30-22-10-9-20-17(5-4-6-21(20)29-22)14-37-24(34)12-11-23(32)33/h4-10H,11-14H2,1-3H3,(H,32,33)(H,29,30,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252915 (US9464076, 117 | US9464076, 118 | US9464076, 67 | ...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC)cccc4n3)c(C)c12 Show InChI InChI=1S/C25H24N2O4S/c1-14-22-17(13-31-4)8-9-18(15(2)28)24(22)32-23(14)25(29)27-21-11-10-19-16(12-30-3)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.380	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252913 (US9464076, 65) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CN5CC(O)C5)cccc4n3)c(C)c12 Show InChI InChI=1S/C27H27N3O4S/c1-15-24-18(14-34-3)7-8-20(16(2)31)26(24)35-25(15)27(33)29-23-10-9-21-17(5-4-6-22(21)28-23)11-30-12-19(32)13-30/h4-10,19,32H,11-14H2,1-3H3,(H,28,29,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.390	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252887 (US9464076, 116 | US9464076, 39 | US9464076, 40 | U...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12 |r| Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.410	n/a	n/a	n/a	n/a	7.5	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252886 (US9464076, 38) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@H](O)C4)c4ccccc4n3)c(C)c12 |r| Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.420	n/a	n/a	n/a	n/a	7.5	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252948 (US9464076, 100) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(F)(F)C3)c(C)c12 Show InChI InChI=1S/C27H23F2N3O4S/c1-14-22-16(11-36-3)7-8-17(15(2)33)24(22)37-23(14)25(34)31-21-10-9-18-19(5-4-6-20(18)30-21)26(35)32-12-27(28,29)13-32/h4-10H,11-13H2,1-3H3,(H,30,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.420	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252894 (US9464076, 46) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCC(F)CC4)c4ccccc4n3)c(C)c12 Show InChI InChI=1S/C29H30FN3O3S/c1-17-26-19(16-36-3)8-9-22(18(2)34)28(26)37-27(17)29(35)32-25-14-20(15-33-12-10-21(30)11-13-33)23-6-4-5-7-24(23)31-25/h4-9,14,21H,10-13,15-16H2,1-3H3,(H,31,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.440	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252903 (US9464076, 55) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(N(C)C)c4ccccc4n3)c(C)c12 Show InChI InChI=1S/C25H25N3O3S/c1-14-22-16(13-31-5)10-11-17(15(2)29)24(22)32-23(14)25(30)27-21-12-20(28(3)4)18-8-6-7-9-19(18)26-21/h6-12H,13H2,1-5H3,(H,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.450	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252866 (US9464076, 18) Show SMILES CC(C)C(=O)c1cccc2c(C)c(sc12)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O Show InChI InChI=1S/C26H26N2O3S/c1-14(2)22(29)18-11-8-10-16-15(3)23(32-24(16)18)25(30)28-21-13-19(26(4,5)31)17-9-6-7-12-20(17)27-21/h6-14,31H,1-5H3,(H,27,28,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.470	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50097342 (3-Chloro-4-[4-(3',6'-dihydro-2'H-[2,4']bipyridinyl...) Show SMILES ClC1=COc2ccccc2C(=O)N1CCCCN1CCC(=CC1)c1ccccn1 |c:22,t:1| Show InChI InChI=1S/C23H24ClN3O2/c24-22-17-29-21-9-2-1-7-19(21)23(28)27(22)14-6-5-13-26-15-10-18(11-16-26)20-8-3-4-12-25-20/h1-4,7-10,12,17H,5-6,11,13-16H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Biomedical Research Limited Curated by ChEMBL					Assay Description Binding affinity of the compound to 5-hydroxytryptamine 1A receptor of rat hippocampus with [3H]-8-OH-DPAT as radioligand				Bioorg Med Chem Lett 11: 595-8 (2001) BindingDB Entry DOI: 10.7270/Q2P26XDB
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252943 (US9464076, 95) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CCOCC3)c(C)c12 Show InChI InChI=1S/C28H27N3O5S/c1-16-24-18(15-35-3)7-8-19(17(2)32)26(24)37-25(16)27(33)30-23-10-9-20-21(5-4-6-22(20)29-23)28(34)31-11-13-36-14-12-31/h4-10H,11-15H2,1-3H3,(H,29,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.480	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252895 (US9464076, 47) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC(O)C4)c4ccccc4n3)c(C)c12 Show InChI InChI=1S/C27H27N3O4S/c1-15-24-17(14-34-3)8-9-20(16(2)31)26(24)35-25(15)27(33)29-23-10-18(11-30-12-19(32)13-30)21-6-4-5-7-22(21)28-23/h4-10,19,32H,11-14H2,1-3H3,(H,28,29,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.490	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252950 (US9464076, 102 | US9464076, 103 | US9464076, 104 |...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12 Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252893 (US9464076, 45) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](F)C4)c4ccccc4n3)c(C)c12 |r| Show InChI InChI=1S/C28H28FN3O3S/c1-16-25-18(15-35-3)8-9-21(17(2)33)27(25)36-26(16)28(34)31-24-12-19(13-32-11-10-20(29)14-32)22-6-4-5-7-23(22)30-24/h4-9,12,20H,10-11,13-15H2,1-3H3,(H,30,31,34)/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252885 (US9464076, 37) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CCCC(O)C4)c4ccccc4n3)c(C)c12 Show InChI InChI=1S/C29H31N3O4S/c1-17-26-19(16-36-3)10-11-22(18(2)33)28(26)37-27(17)29(35)31-25-13-20(14-32-12-6-7-21(34)15-32)23-8-4-5-9-24(23)30-25/h4-5,8-11,13,21,34H,6-7,12,14-16H2,1-3H3,(H,30,31,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252924 (US9464076, 76) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(C)O)c(C)c12 Show InChI InChI=1S/C25H24N2O4S/c1-13-22-16(12-31-4)8-9-18(15(3)29)24(22)32-23(13)25(30)27-21-11-10-19-17(14(2)28)6-5-7-20(19)26-21/h5-11,14,28H,12H2,1-4H3,(H,26,27,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.530	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252920 (US9464076, 72) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COCCO)cccc4n3)c(C)c12 Show InChI InChI=1S/C26H26N2O5S/c1-15-23-18(13-32-3)7-8-19(16(2)30)25(23)34-24(15)26(31)28-22-10-9-20-17(14-33-12-11-29)5-4-6-21(20)27-22/h4-10,29H,11-14H2,1-3H3,(H,27,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.540	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252950 (US9464076, 102 | US9464076, 103 | US9464076, 104 |...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12 Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.570	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252935 (US9464076, 87) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COP(O)(O)=O)cccc4n3)c(C)c12 Show InChI InChI=1S/C24H23N2O7PS/c1-13-21-16(11-32-3)7-8-17(14(2)27)23(21)35-22(13)24(28)26-20-10-9-18-15(12-33-34(29,30)31)5-4-6-19(18)25-20/h4-10H,11-12H2,1-3H3,(H,25,26,28)(H2,29,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252915 (US9464076, 117 | US9464076, 118 | US9464076, 67 | ...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC)cccc4n3)c(C)c12 Show InChI InChI=1S/C25H24N2O4S/c1-14-22-17(13-31-4)8-9-18(15(2)28)24(22)32-23(14)25(29)27-21-11-10-19-16(12-30-3)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.610	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252957 (US9464076, 109 | US9464076, 110 | US9464076, 111 |...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CS(C)(=O)=O)cccc4n3)c(C)c12 Show InChI InChI=1S/C25H24N2O5S2/c1-14-22-16(12-32-3)8-9-18(15(2)28)24(22)33-23(14)25(29)27-21-11-10-19-17(13-34(4,30)31)6-5-7-20(19)26-21/h5-11H,12-13H2,1-4H3,(H,26,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.610	n/a	n/a	n/a	n/a	7.5	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252925 (US9464076, 119 | US9464076, 120 | US9464076, 77 | ...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(CO)cccc4n3)c(C)c12 Show InChI InChI=1S/C24H22N2O4S/c1-13-21-16(12-30-3)7-8-17(14(2)28)23(21)31-22(13)24(29)26-20-10-9-18-15(11-27)5-4-6-19(18)25-20/h4-10,27H,11-12H2,1-3H3,(H,25,26,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.640	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252887 (US9464076, 116 | US9464076, 39 | US9464076, 40 | U...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3cc(CN4CC[C@@H](O)C4)c4ccccc4n3)c(C)c12 |r| Show InChI InChI=1S/C28H29N3O4S/c1-16-25-18(15-35-3)8-9-21(17(2)32)27(25)36-26(16)28(34)30-24-12-19(13-31-11-10-20(33)14-31)22-6-4-5-7-23(22)29-24/h4-9,12,20,33H,10-11,13-15H2,1-3H3,(H,29,30,34)/t20-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.650	n/a	n/a	n/a	n/a	7.5	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252869 (US9464076, 21) Show SMILES Cc1c(sc2c(cccc12)C(=O)C1CCC1)C(=O)Nc1cc(c2ccccc2n1)C(C)(C)O Show InChI InChI=1S/C27H26N2O3S/c1-15-17-11-7-12-19(23(30)16-8-6-9-16)25(17)33-24(15)26(31)29-22-14-20(27(2,3)32)18-10-4-5-13-21(18)28-22/h4-5,7,10-14,16,32H,6,8-9H2,1-3H3,(H,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.670	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252950 (US9464076, 102 | US9464076, 103 | US9464076, 104 |...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12 Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	7.5	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252950 (US9464076, 102 | US9464076, 103 | US9464076, 104 |...) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(cccc4n3)C(=O)N3CC(C3)OC)c(C)c12 Show InChI InChI=1S/C28H27N3O5S/c1-15-24-17(14-35-3)8-9-19(16(2)32)26(24)37-25(15)27(33)30-23-11-10-20-21(6-5-7-22(20)29-23)28(34)31-12-18(13-31)36-4/h5-11,18H,12-14H2,1-4H3,(H,29,30,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.730	n/a	n/a	n/a	n/a	7.5	n/a
Daiichi Sankyo Company, Limited US Patent					Assay Description Inhibitory activity-1 assay: To a solution containing 20 mM Tris-HCl (pH 7.5), 1 mM MgCl2, 100 μM EDTA, 330 μg/ml bovine serum albumin, 50 ...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252939 (US9464076, 91) Show SMILES COCc1ccc(C(C)=O)c2sc(C(=O)Nc3ccc4c(COC(=O)[C@@H](N)CO)cccc4n3)c(C)c12 |r| Show InChI InChI=1S/C27H27N3O6S/c1-14-23-17(12-35-3)7-8-18(15(2)32)25(23)37-24(14)26(33)30-22-10-9-19-16(5-4-6-21(19)29-22)13-36-27(34)20(28)11-31/h4-10,20,31H,11-13,28H2,1-3H3,(H,29,30,33)/t20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	0.740	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) (Homo sapiens (Human))	BDBM252919 (US9464076, 71) Show SMILES COCCOCc1cccc2nc(NC(=O)c3sc4c(ccc(COC)c4c3C)C(C)=O)ccc12 Show InChI InChI=1S/C27H28N2O5S/c1-16-24-19(14-33-4)8-9-20(17(2)30)26(24)35-25(16)27(31)29-23-11-10-21-18(15-34-13-12-32-3)6-5-7-22(21)28-23/h5-11H,12-15H2,1-4H3,(H,28,29,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.75	n/a	n/a	n/a	n/a	7.5	4
Daiichi Sankyo Company, Limited US Patent					Assay Description A human acute lymphoblastic lymphoma T cell line MOLT-4 (which can be purchased under ATCC No. CRL-1582 from ATCC) was cultured in an RPMI1640 medium...				US Patent US9464076 (2016) BindingDB Entry DOI: 10.7270/Q2JS9PC4
					More data for this Ligand-Target Pair

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