Found 4 hits with Last Name = 'lauchli' and Initial = 'r' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50495959
(CHEMBL3121667)Show SMILES Fc1ccccc1-c1nc2ccn(Cc3cc(no3)-c3ccc(cc3C(F)(F)F)C(F)(F)F)cc2n1 Show InChI InChI=1S/C24H13F7N4O/c25-18-4-2-1-3-16(18)22-32-19-7-8-35(12-21(19)33-22)11-14-10-20(34-36-14)15-6-5-13(23(26,27)28)9-17(15)24(29,30)31/h1-10,12H,11H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research & Development
Curated by ChEMBL
| Assay Description Inhibition of human ERG expressed in CHO cells |
J Med Chem 57: 1964-75 (2014)
Article DOI: 10.1021/jm401337x BindingDB Entry DOI: 10.7270/Q2DZ0C9K |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50461671
(GS-333126 | GS-9190 | Tegobuvir)Show SMILES Fc1ccccc1-c1nc2ccn(Cc3ccc(nn3)-c3ccc(cc3C(F)(F)F)C(F)(F)F)cc2n1 Show InChI InChI=1S/C25H14F7N5/c26-19-4-2-1-3-17(19)23-33-21-9-10-37(13-22(21)34-23)12-15-6-8-20(36-35-15)16-7-5-14(24(27,28)29)11-18(16)25(30,31)32/h1-11,13H,12H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research & Development
Curated by ChEMBL
| Assay Description Inhibition of human ERG expressed in CHO cells |
J Med Chem 57: 1964-75 (2014)
Article DOI: 10.1021/jm401337x BindingDB Entry DOI: 10.7270/Q2DZ0C9K |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50495960
(CHEMBL3121666)Show SMILES Fc1cccc(-c2nc3cnn(Cc4cc(no4)-c4ccc(cc4C(F)(F)F)C(F)(F)F)cc3n2)c1F Show InChI InChI=1S/C23H11F8N5O/c24-16-3-1-2-14(20(16)25)21-33-18-8-32-36(10-19(18)34-21)9-12-7-17(35-37-12)13-5-4-11(22(26,27)28)6-15(13)23(29,30)31/h1-8,10H,9H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <5.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research & Development
Curated by ChEMBL
| Assay Description Inhibition of human ERG expressed in HEK293 cells |
J Med Chem 57: 1964-75 (2014)
Article DOI: 10.1021/jm401337x BindingDB Entry DOI: 10.7270/Q2DZ0C9K |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50495958
(CHEMBL3121684)Show SMILES Fc1cccc(-c2nc3cnn(Cc4ccc(nc4)-c4ccc(cc4C(F)(F)F)C(F)(F)F)cc3n2)c1F Show InChI InChI=1S/C25H13F8N5/c26-18-3-1-2-16(22(18)27)23-36-20-10-35-38(12-21(20)37-23)11-13-4-7-19(34-9-13)15-6-5-14(24(28,29)30)8-17(15)25(31,32)33/h1-10,12H,11H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 7.94E+3 | n/a | n/a | n/a | n/a |
GlaxoSmithKline Research & Development
Curated by ChEMBL
| Assay Description Inhibition of human ERG by patch-clamp technique |
J Med Chem 57: 1964-75 (2014)
Article DOI: 10.1021/jm401337x BindingDB Entry DOI: 10.7270/Q2DZ0C9K |
More data for this Ligand-Target Pair | |