Found 402 hits with Last Name = 'lerner' and Initial = 'c' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fatty acid-binding protein, adipocyte
(Homo sapiens (Human)) | BDBM50197092
(CHEMBL3947458)Show InChI InChI=1S/C19H16ClNO2/c1-11(2)18-17(19(22)23)16(12-6-4-3-5-7-12)14-10-13(20)8-9-15(14)21-18/h3-11H,1-2H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Fatty acid-binding protein, adipocyte
(Homo sapiens (Human)) | BDBM50197094
(CHEMBL3941588)Show SMILES OC(=O)c1c(nc2ccc(Cl)cc2c1-c1ccccc1)N1CCCCC1 Show InChI InChI=1S/C21H19ClN2O2/c22-15-9-10-17-16(13-15)18(14-7-3-1-4-8-14)19(21(25)26)20(23-17)24-11-5-2-6-12-24/h1,3-4,7-10,13H,2,5-6,11-12H2,(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Fatty acid-binding protein, adipocyte
(Homo sapiens (Human)) | BDBM50613583
(CHEMBL5287034) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Fatty acid-binding protein, heart
(Homo sapiens (Human)) | BDBM50197091
(CHEMBL1738980)Show InChI InChI=1S/C17H12ClNO2/c1-10-15(17(20)21)16(11-5-3-2-4-6-11)13-9-12(18)7-8-14(13)19-10/h2-9H,1H3,(H,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
| 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Fatty acid-binding protein, adipocyte
(Homo sapiens (Human)) | BDBM50197091
(CHEMBL1738980)Show InChI InChI=1S/C17H12ClNO2/c1-10-15(17(20)21)16(11-5-3-2-4-6-11)13-9-12(18)7-8-14(13)19-10/h2-9H,1H3,(H,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
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| Purchase
CHEMBL
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UniChem
Similars
| PDB
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Fatty acid-binding protein, heart
(Homo sapiens (Human)) | BDBM50613583
(CHEMBL5287034) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Fatty acid-binding protein, heart
(Homo sapiens (Human)) | BDBM50197092
(CHEMBL3947458)Show InChI InChI=1S/C19H16ClNO2/c1-11(2)18-17(19(22)23)16(12-6-4-3-5-7-12)14-10-13(20)8-9-15(14)21-18/h3-11H,1-2H3,(H,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| | 380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Fatty acid-binding protein 5
(Homo sapiens (Human)) | BDBM50197094
(CHEMBL3941588)Show SMILES OC(=O)c1c(nc2ccc(Cl)cc2c1-c1ccccc1)N1CCCCC1 Show InChI InChI=1S/C21H19ClN2O2/c22-15-9-10-17-16(13-15)18(14-7-3-1-4-8-14)19(21(25)26)20(23-17)24-11-5-2-6-12-24/h1,3-4,7-10,13H,2,5-6,11-12H2,(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
| 490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Fatty acid-binding protein 5
(Homo sapiens (Human)) | BDBM50197092
(CHEMBL3947458)Show InChI InChI=1S/C19H16ClNO2/c1-11(2)18-17(19(22)23)16(12-6-4-3-5-7-12)14-10-13(20)8-9-15(14)21-18/h3-11H,1-2H3,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Fatty acid-binding protein 5
(Homo sapiens (Human)) | BDBM50613583
(CHEMBL5287034) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Fatty acid-binding protein, heart
(Homo sapiens (Human)) | BDBM50197094
(CHEMBL3941588)Show SMILES OC(=O)c1c(nc2ccc(Cl)cc2c1-c1ccccc1)N1CCCCC1 Show InChI InChI=1S/C21H19ClN2O2/c22-15-9-10-17-16(13-15)18(14-7-3-1-4-8-14)19(21(25)26)20(23-17)24-11-5-2-6-12-24/h1,3-4,7-10,13H,2,5-6,11-12H2,(H,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Fatty acid-binding protein 5
(Homo sapiens (Human)) | BDBM50197091
(CHEMBL1738980)Show InChI InChI=1S/C17H12ClNO2/c1-10-15(17(20)21)16(11-5-3-2-4-6-11)13-9-12(18)7-8-14(13)19-10/h2-9H,1H3,(H,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
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UniChem
Similars
| | >2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50397965
(CHEMBL2180789)Show SMILES FC(F)(F)Oc1cccc(c1)-n1ccc(=O)c(n1)-c1ccnn1-c1ccccc1 Show InChI InChI=1S/C20H13F3N4O2/c21-20(22,23)29-16-8-4-7-15(13-16)26-12-10-18(28)19(25-26)17-9-11-24-27(17)14-5-2-1-3-6-14/h1-13H | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
| PDB
| n/a | n/a | 0.0190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50613581
(CHEMBL5286395)Show SMILES FC(F)(F)Oc1cccc(c1)-c1c[nH]c(=O)c(c1)-c1ccnn1-c1ccccc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0630 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50613582
(CHEMBL5288570)Show SMILES FC(F)(F)Oc1cccc(c1)-c1c[nH]c(=O)c(n1)-c1ccnn1-c1ccccc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.102 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239752
(Roche-Dataset for PDE10A, Compound 308 | US9394311...)Show SMILES Cc1cc(Cl)c(C)n2nc(\C=C\c3nc(N4CCCC4)n(C)n3)nc12 Show InChI InChI=1S/C17H20ClN7/c1-11-10-13(18)12(2)25-16(11)19-14(22-25)6-7-15-20-17(23(3)21-15)24-8-4-5-9-24/h6-7,10H,4-5,8-9H2,1-3H3/b7-6+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239785
(Roche-Dataset for PDE10A, Compound 522 | US9394311...)Show SMILES Cc1c(Cl)cc(Cl)c2nc(CCc3n[nH]c(n3)N3CCCC3)nn12 Show InChI InChI=1S/C15H17Cl2N7/c1-9-10(16)8-11(17)14-18-13(22-24(9)14)5-4-12-19-15(21-20-12)23-6-2-3-7-23/h8H,2-7H2,1H3,(H,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.220 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239837
(Roche-Dataset for PDE10A, Compound 146 | US9394311...)Show SMILES COCCOc1cc(Cl)c(C)n2nc(CCc3nc(nn3C)N3CCCC3)nc12 Show InChI InChI=1S/C19H26ClN7O2/c1-13-14(20)12-15(29-11-10-28-3)18-21-16(23-27(13)18)6-7-17-22-19(24-25(17)2)26-8-4-5-9-26/h12H,4-11H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.230 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239812
(Roche-Dataset for PDE10A, Compound 227 | US9394311...)Show SMILES Cc1c(Cl)cc(OC(F)F)c2nc(CCc3nc(nn3C)N3CCCC3)nn12 Show InChI InChI=1S/C17H20ClF2N7O/c1-10-11(18)9-12(28-16(19)20)15-21-13(23-27(10)15)5-6-14-22-17(24-25(14)2)26-7-3-4-8-26/h9,16H,3-8H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.230 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239755
(Roche-Dataset for PDE10A, Compound 359 | US9394311...)Show InChI InChI=1S/C17H22ClN7/c1-11-10-13(18)12(2)25-16(11)19-14(21-25)6-7-15-20-17(22-23(15)3)24-8-4-5-9-24/h10H,4-9H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
US Patent
| n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239826
(Roche-Dataset for PDE10A, Compound 244 | US9394311...)Show SMILES Cc1cnc(C)c2nc(CCc3nc(nn3-c3ccccc3)N3CCCC3)nn12 Show InChI InChI=1S/C21H24N8/c1-15-14-22-16(2)20-23-18(25-28(15)20)10-11-19-24-21(27-12-6-7-13-27)26-29(19)17-8-4-3-5-9-17/h3-5,8-9,14H,6-7,10-13H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.290 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239755
(Roche-Dataset for PDE10A, Compound 359 | US9394311...)Show InChI InChI=1S/C17H22ClN7/c1-11-10-13(18)12(2)25-16(11)19-14(21-25)6-7-15-20-17(22-23(15)3)24-8-4-5-9-24/h10H,4-9H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239840
(Roche-Dataset for PDE10A, Compound 47 | US9394311,...)Show SMILES Cc1c(Cl)cc(c2nc(CCc3nc(nn3C3CCOCC3)N3CCCC3)nn12)C(F)(F)F Show InChI InChI=1S/C21H25ClF3N7O/c1-13-16(22)12-15(21(23,24)25)19-26-17(28-31(13)19)4-5-18-27-20(30-8-2-3-9-30)29-32(18)14-6-10-33-11-7-14/h12,14H,2-11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239838
(Roche-Dataset for PDE10A, Compound 208 | US9394311...)Show SMILES Cc1c(Cl)cc(OC2CCOCC2)c2nc(CCc3nc(nn3C)N3CCCC3)nn12 Show InChI InChI=1S/C21H28ClN7O2/c1-14-16(22)13-17(31-15-7-11-30-12-8-15)20-23-18(25-29(14)20)5-6-19-24-21(26-27(19)2)28-9-3-4-10-28/h13,15H,3-12H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.360 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239822
(Roche-Dataset for PDE10A, Compound 158 | US9394311...)Show SMILES Cc1c(Cl)cc(c2nc(CCc3nc(N4CCCC4)n(C)n3)nn12)C(F)(F)F Show InChI InChI=1S/C17H19ClF3N7/c1-10-12(18)9-11(17(19,20)21)15-22-13(25-28(10)15)5-6-14-23-16(26(2)24-14)27-7-3-4-8-27/h9H,3-8H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239793
(Roche-Dataset for PDE10A, Compound 313 | US9394311...)Show SMILES COc1cc(Cl)c(C)n2nc(CCc3nc(nn3C)N3CCCC3)nc12 Show InChI InChI=1S/C17H22ClN7O/c1-11-12(18)10-13(26-3)16-19-14(21-25(11)16)6-7-15-20-17(22-23(15)2)24-8-4-5-9-24/h10H,4-9H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239799
(Roche-Dataset for PDE10A, Compound 135 | US9394311...)Show SMILES Cc1c(Br)cc(c2nc(CCc3nc(nn3C)N3CCCC3)nn12)C(F)(F)F Show InChI InChI=1S/C17H19BrF3N7/c1-10-12(18)9-11(17(19,20)21)15-22-13(24-28(10)15)5-6-14-23-16(25-26(14)2)27-7-3-4-8-27/h9H,3-8H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.480 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM317168
((E)-8-Isopropoxy-2,3-dimethyl-6-(2-(1-methyl-3-(py...)Show SMILES CC(C)Oc1cc(\C=C\c2nc(nn2C)N2CCCC2)nn2c(C)c(C)nc12 Show InChI InChI=1S/C20H27N7O/c1-13(2)28-17-12-16(23-27-15(4)14(3)21-19(17)27)8-9-18-22-20(24-25(18)5)26-10-6-7-11-26/h8-9,12-13H,6-7,10-11H2,1-5H3/b9-8+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.493 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM... |
US Patent US9617271 (2017)
BindingDB Entry DOI: 10.7270/Q2N58PFC |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239786
(Roche-Dataset for PDE10A, Compound 157 | US9394311...)Show SMILES Cc1c(Cl)cc(c2nc(CCc3nc(nn3C)N3CCCC3)nn12)C(F)(F)F Show InChI InChI=1S/C17H19ClF3N7/c1-10-12(18)9-11(17(19,20)21)15-22-13(24-28(10)15)5-6-14-23-16(25-26(14)2)27-7-3-4-8-27/h9H,3-8H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239815
(Roche-Dataset for PDE10A, Compound 119 | US9394311...)Show SMILES Cc1c(Cl)cc(OCC(F)(F)F)c2nc(CCc3nc(nn3C)N3CCCC3)nn12 Show InChI InChI=1S/C18H21ClF3N7O/c1-11-12(19)9-13(30-10-18(20,21)22)16-23-14(25-29(11)16)5-6-15-24-17(26-27(15)2)28-7-3-4-8-28/h9H,3-8,10H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239823
(Roche-Dataset for PDE10A, Compound 206 | US9394311...)Show SMILES Cc1c(Cl)cc(OC(F)F)c2nc(CCc3nc(N4CCCC4)n(C)n3)nn12 Show InChI InChI=1S/C17H20ClF2N7O/c1-10-11(18)9-12(28-16(19)20)15-21-13(24-27(10)15)5-6-14-22-17(25(2)23-14)26-7-3-4-8-26/h9,16H,3-8H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.550 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239753
(Roche-Dataset for PDE10A, Compound 374 | US9394311...)Show SMILES Cc1cc(Cl)c(C)n2nc(CCc3nc(N4CCCC4)n(C)n3)nc12 Show InChI InChI=1S/C17H22ClN7/c1-11-10-13(18)12(2)25-16(11)19-14(22-25)6-7-15-20-17(23(3)21-15)24-8-4-5-9-24/h10H,4-9H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM317193
(7-Cyclobutyl-2,3-dimethyl-6-((1-methyl-3-(pyrrolid...)Show SMILES Cc1nc2cc(C3CCC3)c(nn2c1C)C#Cc1nc(nn1C)N1CCCC1 Show InChI InChI=1S/C21H25N7/c1-14-15(2)28-20(22-14)13-17(16-7-6-8-16)18(24-28)9-10-19-23-21(25-26(19)3)27-11-4-5-12-27/h13,16H,4-8,11-12H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM... |
US Patent US9617271 (2017)
BindingDB Entry DOI: 10.7270/Q2N58PFC |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239769
(Roche-Dataset for PDE10A, Compound 357 | US9394311...)Show SMILES Cc1c(Cl)cc(Cl)c2nc(CCc3nc(nn3C)N3CCCC3)nn12 Show InChI InChI=1S/C16H19Cl2N7/c1-10-11(17)9-12(18)15-19-13(21-25(10)15)5-6-14-20-16(22-23(14)2)24-7-3-4-8-24/h9H,3-8H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.630 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239778
(Roche-Dataset for PDE10A, Compound 97 | US9394311,...)Show SMILES COc1ccc(Cn2nc(nc2CCc2nc3c(Cl)cc(Cl)c(C)n3n2)N2CCCC2)cc1 Show InChI InChI=1S/C23H25Cl2N7O/c1-15-18(24)13-19(25)22-26-20(28-32(15)22)9-10-21-27-23(30-11-3-4-12-30)29-31(21)14-16-5-7-17(33-2)8-6-16/h5-8,13H,3-4,9-12,14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.720 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239851
(Roche-Dataset for PDE10A, Compound 127 | US9394311...)Show SMILES Cc1c(Cl)cc(c2nc(CCc3nc(nn3C3CC3)N3CCCC3)nn12)C(F)(F)F Show InChI InChI=1S/C19H21ClF3N7/c1-11-14(20)10-13(19(21,22)23)17-24-15(26-29(11)17)6-7-16-25-18(28-8-2-3-9-28)27-30(16)12-4-5-12/h10,12H,2-9H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.720 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239786
(Roche-Dataset for PDE10A, Compound 157 | US9394311...)Show SMILES Cc1c(Cl)cc(c2nc(CCc3nc(nn3C)N3CCCC3)nn12)C(F)(F)F Show InChI InChI=1S/C17H19ClF3N7/c1-10-12(18)9-11(17(19,20)21)15-22-13(24-28(10)15)5-6-14-23-16(25-26(14)2)27-7-3-4-8-27/h9H,3-8H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.720 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239825
(US9394311, 108)Show InChI InChI=1S/C16H18N8/c1-11-10-17-12(2)15-18-13(20-24(11)15)6-7-14-19-16(21-22(14)3)23-8-4-5-9-23/h10H,4-5,8-9H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239808
(US9394311, 91)Show SMILES Cc1c(Cl)cc(c2nc(nn12)C#Cc1nc(nn1C)N1CCCC1)C(F)(F)F Show InChI InChI=1S/C17H15ClF3N7/c1-10-12(18)9-11(17(19,20)21)15-22-13(24-28(10)15)5-6-14-23-16(25-26(14)2)27-7-3-4-8-27/h9H,3-4,7-8H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.880 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239849
(Roche-Dataset for PDE10A, Compound 187 | US9394311...)Show SMILES Cc1c(Cl)cc(C(F)F)c2nc(CCc3nc(nn3C)N3CCCC3)nn12 Show InChI InChI=1S/C17H20ClF2N7/c1-10-12(18)9-11(15(19)20)16-21-13(23-27(10)16)5-6-14-22-17(24-25(14)2)26-7-3-4-8-26/h9,15H,3-8H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.890 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM317189
(8-Cyclobutyl-2,3-dimethyl-6-((1-methyl-3-(pyrrolid...)Show SMILES Cc1nc2c(cc(nn2c1C)C#Cc1nc(nn1C)N1CCCC1)C1CCC1 Show InChI InChI=1S/C21H25N7/c1-14-15(2)28-20(22-14)18(16-7-6-8-16)13-17(24-28)9-10-19-23-21(25-26(19)3)27-11-4-5-12-27/h13,16H,4-8,11-12H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM... |
US Patent US9617271 (2017)
BindingDB Entry DOI: 10.7270/Q2N58PFC |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239744
(US9394311, 27)Show InChI InChI=1S/C16H20ClN7/c1-11-12(17)5-7-15-18-13(20-24(11)15)6-8-14-19-16(21-22(14)2)23-9-3-4-10-23/h5,7H,3-4,6,8-10H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.980 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM317188
(8-Cyclopropyl-2,3-dimethyl-6-((1-methyl-3-(pyrroli...)Show SMILES Cc1nc2c(cc(nn2c1C)C#Cc1nc(nn1C)N1CCCC1)C1CC1 Show InChI InChI=1S/C20H23N7/c1-13-14(2)27-19(21-13)17(15-6-7-15)12-16(23-27)8-9-18-22-20(24-25(18)3)26-10-4-5-11-26/h12,15H,4-7,10-11H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM... |
US Patent US9617271 (2017)
BindingDB Entry DOI: 10.7270/Q2N58PFC |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM317186
(8-Isopropyl-2,3-dimethyl-6-((1-methyl-3-(pyrrolidi...)Show SMILES CC(C)c1cc(nn2c(C)c(C)nc12)C#Cc1nc(nn1C)N1CCCC1 Show InChI InChI=1S/C20H25N7/c1-13(2)17-12-16(23-27-15(4)14(3)21-19(17)27)8-9-18-22-20(24-25(18)5)26-10-6-7-11-26/h12-13H,6-7,10-11H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM... |
US Patent US9617271 (2017)
BindingDB Entry DOI: 10.7270/Q2N58PFC |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM317182
(N,2,3-Trimethyl-6-((1-methyl-3-(pyrrolidin-1-yl)-1...)Show SMILES CNC(=O)c1cc(nn2c(C)c(C)nc12)C#Cc1nc(nn1C)N1CCCC1 Show InChI InChI=1S/C19H22N8O/c1-12-13(2)27-17(21-12)15(18(28)20-3)11-14(23-27)7-8-16-22-19(24-25(16)4)26-9-5-6-10-26/h11H,5-6,9-10H2,1-4H3,(H,20,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM... |
US Patent US9617271 (2017)
BindingDB Entry DOI: 10.7270/Q2N58PFC |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM317167
(8-Isopropoxy-2,3-dimethyl-6-((1-methyl-3-(pyrrolid...)Show SMILES CC(C)Oc1cc(nn2c(C)c(C)nc12)C#Cc1nc(nn1C)N1CCCC1 Show InChI InChI=1S/C20H25N7O/c1-13(2)28-17-12-16(23-27-15(4)14(3)21-19(17)27)8-9-18-22-20(24-25(18)5)26-10-6-7-11-26/h12-13H,6-7,10-11H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM... |
US Patent US9617271 (2017)
BindingDB Entry DOI: 10.7270/Q2N58PFC |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM317159
(2,3,7-Trimethyl-6-((1-methyl-3-(pyrrolidin-1-yl)-1...)Show InChI InChI=1S/C18H21N7/c1-12-11-17-19-13(2)14(3)25(17)21-15(12)7-8-16-20-18(22-23(16)4)24-9-5-6-10-24/h11H,5-6,9-10H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM... |
US Patent US9617271 (2017)
BindingDB Entry DOI: 10.7270/Q2N58PFC |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM317151
((E)-8-methoxy-3-methyl-6-(2-(1-methyl-3-(pyrrolidi...)Show SMILES COc1cc(\C=C\c2nc(nn2C)N2CCCC2)nn2c(C)c(nc12)C(F)(F)F Show InChI InChI=1S/C18H20F3N7O/c1-11-15(18(19,20)21)23-16-13(29-3)10-12(24-28(11)16)6-7-14-22-17(25-26(14)2)27-8-4-5-9-27/h6-7,10H,4-5,8-9H2,1-3H3/b7-6+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM... |
US Patent US9617271 (2017)
BindingDB Entry DOI: 10.7270/Q2N58PFC |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239788
(Roche-Dataset for PDE10A, Compound 338 | US9394311...)Show SMILES Cc1c(Cl)cc(Br)c2nc(CCc3nc(nn3C)N3CCCC3)nn12 Show InChI InChI=1S/C16H19BrClN7/c1-10-12(18)9-11(17)15-19-13(21-25(10)15)5-6-14-20-16(22-23(14)2)24-7-3-4-8-24/h9H,3-8H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.01 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM239789
(Roche-Dataset for PDE10A, Compound 272 | US9394311...)Show SMILES Cc1c(Br)cc(Cl)c2nc(CCc3nc(nn3C)N3CCCC3)nn12 Show InChI InChI=1S/C16H19BrClN7/c1-10-11(17)9-12(18)15-19-13(21-25(10)15)5-6-14-20-16(22-23(14)2)24-7-3-4-8-24/h9H,3-8H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.22 | n/a | n/a | n/a | n/a | n/a | 25 |
Hoffmann-La Roche Inc.
US Patent
| Assay Description
The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M... |
US Patent US9394311 (2016)
BindingDB Entry DOI: 10.7270/Q27D2T2H |
More data for this
Ligand-Target Pair | |
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