Found 3 hits with Last Name = 'moorthy' and Initial = 'd' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histone deacetylase 8
(Homo sapiens (Human)) | BDBM19149
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Birla Institute of Technology
Curated by ChEMBL
| Assay Description Inhibition of human HDAC8 |
Bioorg Med Chem Lett 20: 3906-10 (2010)
Article DOI: 10.1016/j.bmcl.2010.05.020 BindingDB Entry DOI: 10.7270/Q2TD9Z97 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Histone deacetylase 8
(Homo sapiens (Human)) | BDBM50321384
(CHEMBL1169978 | N-hydroxy-4-(2-(2-hydroxybenzylide...)Show SMILES ONC(=O)N1CCN(CC1)C(=S)NN=Cc1ccccc1O |w:14.15| Show InChI InChI=1S/C13H17N5O3S/c19-11-4-2-1-3-10(11)9-14-15-13(22)18-7-5-17(6-8-18)12(20)16-21/h1-4,9,19,21H,5-8H2,(H,15,22)(H,16,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.37E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Birla Institute of Technology
Curated by ChEMBL
| Assay Description Inhibition of human HDAC8 |
Bioorg Med Chem Lett 20: 3906-10 (2010)
Article DOI: 10.1016/j.bmcl.2010.05.020 BindingDB Entry DOI: 10.7270/Q2TD9Z97 |
More data for this Ligand-Target Pair | |
Histone deacetylase 8
(Homo sapiens (Human)) | BDBM50321385
(4-(2-(4-chlorobenzylidene)hydrazinecarbonothioyl)-...)Show SMILES ONC(=O)N1CCN(CC1)C(=S)NN=Cc1ccc(Cl)cc1 |w:14.15| Show InChI InChI=1S/C13H16ClN5O2S/c14-11-3-1-10(2-4-11)9-15-16-13(22)19-7-5-18(6-8-19)12(20)17-21/h1-4,9,21H,5-8H2,(H,16,22)(H,17,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Birla Institute of Technology
Curated by ChEMBL
| Assay Description Inhibition of human HDAC8 |
Bioorg Med Chem Lett 20: 3906-10 (2010)
Article DOI: 10.1016/j.bmcl.2010.05.020 BindingDB Entry DOI: 10.7270/Q2TD9Z97 |
More data for this Ligand-Target Pair | |