Found 378 hits with Last Name = 'nagao' and Initial = 's' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058752
(CHEMBL3335630)Show SMILES COCCOCc1ccc(CN2CCN(Cc3ccc(cc3)C(=O)Nc3ccc(cc3)C#CC34CC5CC(CC(C5)C3)C4)[C@@H](C)C2)cn1 |r,THB:32:33:36:40.38.39,38:37:34:40.39.41,38:39:36.37.42:34,41:39:36:42.33.34,41:33:36:40.38.39| Show InChI InChI=1S/C41H50N4O3/c1-30-26-44(27-33-7-12-39(42-25-33)29-48-18-17-47-2)15-16-45(30)28-32-3-8-37(9-4-32)40(46)43-38-10-5-31(6-11-38)13-14-41-22-34-19-35(23-41)21-36(20-34)24-41/h3-12,25,30,34-36H,15-24,26-29H2,1-2H3,(H,43,46)/t30-,34?,35?,36?,41?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571009
(CHEMBL4865592)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)CC4CCN(C)CC4)c3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.650 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571017
(CHEMBL4852684)Show SMILES CC(C)n1cc(C(=O)Nc2cc(F)c(Oc3ccnc(NC(=O)N4CCC(CC4)N4CCN(C)CC4)c3)cc2F)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.760 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571010
(CHEMBL4848604)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)CC4CCN(C)CC4)c3)cc2F)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571019
(CHEMBL4845957)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)C4CC4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058757
(CHEMBL3335423)Show SMILES O=C(Nc1ccc(cc1)C#CC12CC3CC(CC(C3)C1)C2)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1 |THB:10:11:14:18.16.17,16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| Show InChI InChI=1S/C36H40N4O/c41-35(33-7-3-28(4-8-33)25-39-14-16-40(17-15-39)26-29-2-1-13-37-24-29)38-34-9-5-27(6-10-34)11-12-36-21-30-18-31(22-36)20-32(19-30)23-36/h1-10,13,24,30-32H,14-23,25-26H2,(H,38,41) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.970 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058753
(CHEMBL3335427)Show SMILES COCc1ccc(CN2CCN(Cc3ccc(cc3)C(=O)Nc3ccc(cc3)C#CC34CC5CC(CC(C5)C3)C4)[C@@H](C)C2)cn1 |r,THB:29:30:33:37.35.36,35:34:31:37.36.38,35:36:33.34.39:31,38:36:33:39.30.31,38:30:33:37.35.36| Show InChI InChI=1S/C39H46N4O2/c1-28-24-42(25-31-7-12-37(27-45-2)40-23-31)15-16-43(28)26-30-3-8-35(9-4-30)38(44)41-36-10-5-29(6-11-36)13-14-39-20-32-17-33(21-39)19-34(18-32)22-39/h3-12,23,28,32-34H,15-22,24-27H2,1-2H3,(H,41,44)/t28-,32?,33?,34?,39?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571012
(CHEMBL4867696)Show SMILES CN1CCC(CC(=O)Nc2cc(Oc3ccc(NC(=O)c4cn(C5CCCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)ccn2)CC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571018
(CHEMBL4849679)Show SMILES CN1CCN(CC1)C1CCN(CC1)C(=O)Nc1cc(Oc2cc(F)c(NC(=O)c3cc4C(=O)CCCc4n(-c4ccccc4)c3=O)cc2F)ccn1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571028
(CHEMBL4853815)Show SMILES CN1CCN(CC1)C1CCN(CC1)C(=O)Nc1cc(Oc2ccc(NC(=O)c3cn(C4CCCC4)c(=O)n(-c4ccc(F)cc4)c3=O)cc2)ncn1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571952
(CHEMBL4858396)Show SMILES CN1CCC(CN2CCc3c(C2)ncnc3Oc2ccc(NC(=O)c3cn(CC4CC4)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)CC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Axl (unknown origin) by cell free assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128247
BindingDB Entry DOI: 10.7270/Q2BC43BR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571017
(CHEMBL4852684)Show SMILES CC(C)n1cc(C(=O)Nc2cc(F)c(Oc3ccnc(NC(=O)N4CCC(CC4)N4CCN(C)CC4)c3)cc2F)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human Axl expressed in mouse BaF3 cells assessed as reduction in cell viability incubated for 2 days by cell titer glo assa... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571025
(CHEMBL4846932)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N4CCC(CC4)N4CCN(C)CC4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571020
(CHEMBL4867664)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N4CCC4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571025
(CHEMBL4846932)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N4CCC(CC4)N4CCN(C)CC4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Axl (unknown origin) by cell free assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128247
BindingDB Entry DOI: 10.7270/Q2BC43BR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571021
(CHEMBL4849099)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N4CCCC4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571016
(CHEMBL4864389)Show SMILES CN1CCC(CC(=O)Nc2cc(Oc3cc(F)c(NC(=O)c4cc5C(=O)CCCc5n(-c5ccccc5)c4=O)cc3F)ccn2)CC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571951
(CHEMBL4864780)Show SMILES CN1CCC(CN2CCc3c(C2)ncnc3Oc2ccc(NC(=O)c3cn(CC4CCC4)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)CC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Axl (unknown origin) by cell free assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128247
BindingDB Entry DOI: 10.7270/Q2BC43BR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571011
(CHEMBL4865438)Show SMILES CN1CCC(CC(=O)Nc2cc(Oc3ccc(NC(=O)c4cn(C5CC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)ccn2)CC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058754
(CHEMBL3335426)Show SMILES C[C@H]1CN(Cc2cccnc2)CCN1Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C#CC12CC3CC(CC(C3)C1)C2 |r,THB:31:32:35:39.37.38,37:36:33:39.38.40,37:38:35.36.41:33,40:38:35:41.32.33,40:32:35:39.37.38| Show InChI InChI=1S/C37H42N4O/c1-27-24-40(25-30-3-2-14-38-23-30)15-16-41(27)26-29-4-8-34(9-5-29)36(42)39-35-10-6-28(7-11-35)12-13-37-20-31-17-32(21-37)19-33(18-31)22-37/h2-11,14,23,27,31-33H,15-22,24-26H2,1H3,(H,39,42)/t27-,31?,32?,33?,37?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571953
(CHEMBL4860541)Show SMILES CN1CCC(CN2CCc3c(C2)ncnc3Oc2ccc(NC(=O)c3cn(C4CCCC4)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)CC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Axl (unknown origin) by cell free assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128247
BindingDB Entry DOI: 10.7270/Q2BC43BR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571933
(CHEMBL4878216)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(Cc34)C(=O)C3CC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Axl (unknown origin) by cell free assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128247
BindingDB Entry DOI: 10.7270/Q2BC43BR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571012
(CHEMBL4867696)Show SMILES CN1CCC(CC(=O)Nc2cc(Oc3ccc(NC(=O)c4cn(C5CCCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)ccn2)CC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human Axl expressed in mouse BaF3 cells assessed as reduction in cell viability incubated for 2 days by cell titer glo assa... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058760
(CHEMBL3335421)Show SMILES O=C(Nc1ccc(cc1)C#CC1CCCCC1)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1 Show InChI InChI=1S/C32H36N4O/c37-32(34-31-16-12-27(13-17-31)9-8-26-5-2-1-3-6-26)30-14-10-28(11-15-30)24-35-19-21-36(22-20-35)25-29-7-4-18-33-23-29/h4,7,10-18,23,26H,1-3,5-6,19-22,24-25H2,(H,34,37) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM50571017
(CHEMBL4852684)Show SMILES CC(C)n1cc(C(=O)Nc2cc(F)c(Oc3ccnc(NC(=O)N4CCC(CC4)N4CCN(C)CC4)c3)cc2F)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human Mer expressed in mouse BaF3 cells assessed as reduction in cell viability incubated for 2 days by cell titer glo assa... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058766
(CHEMBL3335415)Show SMILES C[C@H]1CN(Cc2cccnc2)CCN1Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C26H27F3N4O/c1-19-16-32(17-21-3-2-12-30-15-21)13-14-33(19)18-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142338
(US8933099, 112)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C[C@H](C)O)CC2)c1)C(=O)NC |r| Show InChI InChI=1S/C34H41N5O6/c1-4-43-17-18-44-30-21-29-27(12-16-39(29)34(42)35-3)19-31(30)45-28-9-13-36-32(20-28)37-33(41)26-7-5-24(6-8-26)25-10-14-38(15-11-25)22-23(2)40/h5-9,12-13,16,19-21,23,25,40H,4,10-11,14-15,17-18,22H2,1-3H3,(H,35,42)(H,36,37,41)/t23-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571932
(CHEMBL4865150)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(Cc34)C(=O)CC3CCN(C)CC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Axl (unknown origin) by cell free assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128247
BindingDB Entry DOI: 10.7270/Q2BC43BR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571945
(CHEMBL4866147)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CCc34)C3CCN(CC4CC4)CC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Axl (unknown origin) by cell free assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128247
BindingDB Entry DOI: 10.7270/Q2BC43BR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571022
(CHEMBL4864028)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N4CC(O)C4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571943
(CHEMBL4848465)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CC5CCN(C)CC5)CCc34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Axl (unknown origin) by cell free assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128247
BindingDB Entry DOI: 10.7270/Q2BC43BR |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142348
(US8933099, 114)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C)CC2)c1)C(=O)NC Show InChI InChI=1S/C32H37N5O5/c1-4-40-17-18-41-28-21-27-25(12-16-37(27)32(39)33-2)19-29(28)42-26-9-13-34-30(20-26)35-31(38)24-7-5-22(6-8-24)23-10-14-36(3)15-11-23/h5-9,12-13,16,19-21,23H,4,10-11,14-15,17-18H2,1-3H3,(H,33,39)(H,34,35,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571947
(CHEMBL4850929)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CCc34)C3CN(C)C3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Axl (unknown origin) by cell free assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128247
BindingDB Entry DOI: 10.7270/Q2BC43BR |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142347
(US8933099, 109)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CC(C)(C)O)CC2)c1)C(=O)NC Show InChI InChI=1S/C35H43N5O6/c1-5-44-18-19-45-30-22-29-27(13-17-40(29)34(42)36-4)20-31(30)46-28-10-14-37-32(21-28)38-33(41)26-8-6-24(7-9-26)25-11-15-39(16-12-25)23-35(2,3)43/h6-10,13-14,17,20-22,25,43H,5,11-12,15-16,18-19,23H2,1-4H3,(H,36,42)(H,37,38,41) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM50571932
(CHEMBL4865150)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(Cc34)C(=O)CC3CCN(C)CC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Mer (unknown origin) by cell free assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128247
BindingDB Entry DOI: 10.7270/Q2BC43BR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM50571933
(CHEMBL4878216)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(Cc34)C(=O)C3CC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Mer (unknown origin) by cell free assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128247
BindingDB Entry DOI: 10.7270/Q2BC43BR |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM50571019
(CHEMBL4845957)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)C4CC4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Mer using biotinylated peptide as substrate incubated for 1 hr by TR-FRET analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142339
(US8933099, 113)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(CC)CC2)c1)C(=O)NC Show InChI InChI=1S/C33H39N5O5/c1-4-37-15-11-24(12-16-37)23-6-8-25(9-7-23)32(39)36-31-21-27(10-14-35-31)43-30-20-26-13-17-38(33(40)34-3)28(26)22-29(30)42-19-18-41-5-2/h6-10,13-14,17,20-22,24H,4-5,11-12,15-16,18-19H2,1-3H3,(H,34,40)(H,35,36,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571015
(CHEMBL4862542)Show SMILES CN1CCC(CC(=O)Nc2cc(Oc3ccc(NC(=O)c4cc5C(=O)CCCc5n(-c5ccccc5)c4=O)c(F)c3)ccn2)CC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysis |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142337
(US8933099, 111)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCN(C[C@@H](C)O)CC2)c1)C(=O)NC |r| Show InChI InChI=1S/C34H41N5O6/c1-4-43-17-18-44-30-21-29-27(12-16-39(29)34(42)35-3)19-31(30)45-28-9-13-36-32(20-28)37-33(41)26-7-5-24(6-8-26)25-10-14-38(15-11-25)22-23(2)40/h5-9,12-13,16,19-21,23,25,40H,4,10-11,14-15,17-18,22H2,1-3H3,(H,35,42)(H,36,37,41)/t23-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571940
(CHEMBL4859147)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4CN(CCc34)C(=O)CC3CCN(C)CC3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Axl (unknown origin) by cell free assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128247
BindingDB Entry DOI: 10.7270/Q2BC43BR |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142258
(US8933099, 24)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CCNCC2)c1)C(=O)NC Show InChI InChI=1S/C31H35N5O5/c1-3-39-16-17-40-27-20-26-24(11-15-36(26)31(38)32-2)18-28(27)41-25-10-14-34-29(19-25)35-30(37)23-6-4-21(5-7-23)22-8-12-33-13-9-22/h4-7,10-11,14-15,18-20,22,33H,3,8-9,12-13,16-17H2,1-2H3,(H,32,38)(H,34,35,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor 2
(Homo sapiens (Human)) | BDBM142256
(US8933099, 22 | US9951047, Compound (I))Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12 Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Mer
(Homo sapiens (Human)) | BDBM50571012
(CHEMBL4867696)Show SMILES CN1CCC(CC(=O)Nc2cc(Oc3ccc(NC(=O)c4cn(C5CCCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)ccn2)CC1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human Mer expressed in mouse BaF3 cells assessed as reduction in cell viability incubated for 2 days by cell titer glo assa... |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116137
BindingDB Entry DOI: 10.7270/Q2PV6Q46 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142325
(US8933099, 91)Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C[C@H](C)O)CC4)c3)c(OCCOC)cc12 |r| Show InChI InChI=1S/C33H39N5O6/c1-22(39)21-37-13-9-24(10-14-37)23-4-6-25(7-5-23)32(40)36-31-19-27(8-12-35-31)44-30-18-26-11-15-38(33(41)34-2)28(26)20-29(30)43-17-16-42-3/h4-8,11-12,15,18-20,22,24,39H,9-10,13-14,16-17,21H2,1-3H3,(H,34,41)(H,35,36,40)/t22-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142333
(US8933099, 103)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(cc2)C2CN(C2)C(C)C)c1)C(=O)NC Show InChI InChI=1S/C32H37N5O5/c1-5-40-14-15-41-28-18-27-24(11-13-37(27)32(39)33-4)16-29(28)42-26-10-12-34-30(17-26)35-31(38)23-8-6-22(7-9-23)25-19-36(20-25)21(2)3/h6-13,16-18,21,25H,5,14-15,19-20H2,1-4H3,(H,33,39)(H,34,35,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142341
(US8933099, 99)Show SMILES CCOCCOc1cc2n(ccc2cc1Oc1ccnc(NC(=O)c2ccc(CN3CCC[C@H]3CO)s2)c1)C(=O)NC |r| Show InChI InChI=1S/C30H35N5O6S/c1-3-39-13-14-40-25-17-24-20(9-12-35(24)30(38)31-2)15-26(25)41-22-8-10-32-28(16-22)33-29(37)27-7-6-23(42-27)18-34-11-4-5-21(34)19-36/h6-10,12,15-17,21,36H,3-5,11,13-14,18-19H2,1-2H3,(H,31,38)(H,32,33,37)/t21-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor 2
(Homo sapiens (Human)) | BDBM142255
(US8933099, 21)Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C)CC4)c3)c(OCCOC)cc12 Show InChI InChI=1S/C31H35N5O5/c1-32-31(38)36-15-11-24-18-28(27(20-26(24)36)40-17-16-39-3)41-25-8-12-33-29(19-25)34-30(37)23-6-4-21(5-7-23)22-9-13-35(2)14-10-22/h4-8,11-12,15,18-20,22H,9-10,13-14,16-17H2,1-3H3,(H,32,38)(H,33,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase receptor UFO
(Homo sapiens (Human)) | BDBM50571955
(CHEMBL4860402)Show SMILES CN1CCC(CN2CCc3c(C2)ncnc3Oc2ccc(NC(=O)c3cn(C4CCCC4)c(=O)n(-c4ccc(C)cn4)c3=O)cc2F)CC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Axl (unknown origin) by cell free assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128247
BindingDB Entry DOI: 10.7270/Q2BC43BR |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM142359
(US8933099, 125)Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C[C@@H](C)O)CC4)c3)c(OCCCOC)cc12 |r| Show InChI InChI=1S/C34H41N5O6/c1-23(40)22-38-14-10-25(11-15-38)24-5-7-26(8-6-24)33(41)37-32-20-28(9-13-36-32)45-31-19-27-12-16-39(34(42)35-2)29(27)21-30(31)44-18-4-17-43-3/h5-9,12-13,16,19-21,23,25,40H,4,10-11,14-15,17-18,22H2,1-3H3,(H,35,42)(H,36,37,41)/t23-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd.
US Patent
| Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b... |
US Patent US8933099 (2015)
BindingDB Entry DOI: 10.7270/Q28S4NMG |
More data for this
Ligand-Target Pair | |
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