Compile Data Set for Download or QSAR

Found 272 hits with Last Name = 'nemecek' and Initial = 'c'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532763 (CHEMBL4593634) Show SMILES O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(NC5CCOCC5)nn34)cc2s1 Show InChI InChI=1S/C24H29N9O3S2/c34-22(25-7-8-32-9-13-36-14-10-32)28-23-27-18-2-1-17(15-19(18)38-23)37-24-30-29-21-4-3-20(31-33(21)24)26-16-5-11-35-12-6-16/h1-4,15-16H,5-14H2,(H,26,31)(H2,25,27,28,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532762 (CHEMBL4513820) Show SMILES O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(NC5CC5)nn34)cc2s1 Show InChI InChI=1S/C22H25N9O2S2/c32-20(23-7-8-30-9-11-33-12-10-30)26-21-25-16-4-3-15(13-17(16)35-21)34-22-28-27-19-6-5-18(29-31(19)22)24-14-1-2-14/h3-6,13-14H,1-2,7-12H2,(H,24,29)(H2,23,25,26,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532756 (CHEMBL4466644) Show SMILES O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(NC5CCCCC5)nn34)cc2s1 Show InChI InChI=1S/C25H31N9O2S2/c35-23(26-10-11-33-12-14-36-15-13-33)29-24-28-19-7-6-18(16-20(19)38-24)37-25-31-30-22-9-8-21(32-34(22)25)27-17-4-2-1-3-5-17/h6-9,16-17H,1-5,10-15H2,(H,27,32)(H2,26,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532762 (CHEMBL4513820) Show SMILES O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(NC5CC5)nn34)cc2s1 Show InChI InChI=1S/C22H25N9O2S2/c32-20(23-7-8-30-9-11-33-12-10-30)26-21-25-16-4-3-15(13-17(16)35-21)34-22-28-27-19-6-5-18(29-31(19)22)24-14-1-2-14/h3-6,13-14H,1-2,7-12H2,(H,24,29)(H2,23,25,26,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532756 (CHEMBL4466644) Show SMILES O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(NC5CCCCC5)nn34)cc2s1 Show InChI InChI=1S/C25H31N9O2S2/c35-23(26-10-11-33-12-14-36-15-13-33)29-24-28-19-7-6-18(16-20(19)38-24)37-25-31-30-22-9-8-21(32-34(22)25)27-17-4-2-1-3-5-17/h6-9,16-17H,1-5,10-15H2,(H,27,32)(H2,26,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532763 (CHEMBL4593634) Show SMILES O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(NC5CCOCC5)nn34)cc2s1 Show InChI InChI=1S/C24H29N9O3S2/c34-22(25-7-8-32-9-13-36-14-10-32)28-23-27-18-2-1-17(15-19(18)38-23)37-24-30-29-21-4-3-20(31-33(21)24)26-16-5-11-35-12-6-16/h1-4,15-16H,5-14H2,(H,26,31)(H2,25,27,28,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532758 (CHEMBL4470877) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)CCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C26H24FN7O2S2/c27-18-5-3-17(4-6-18)20-9-10-23-30-31-26(34(23)32-20)37-19-7-8-21-22(16-19)38-25(28-21)29-24(35)2-1-11-33-12-14-36-15-13-33/h3-10,16H,1-2,11-15H2,(H,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISA				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532743 (CHEMBL4527749) Show SMILES CCN1CCC(CCNC(=O)Nc2nc3ccc(Sc4nnc5ccc(nn45)-c4cccs4)cc3s2)CC1 Show InChI InChI=1S/C26H28N8OS3/c1-2-33-13-10-17(11-14-33)9-12-27-24(35)29-25-28-19-6-5-18(16-22(19)38-25)37-26-31-30-23-8-7-20(32-34(23)26)21-4-3-15-36-21/h3-8,15-17H,2,9-14H2,1H3,(H2,27,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532764 (CHEMBL4551712) Show SMILES O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(OC5CCCCC5)nn34)cc2s1 Show InChI InChI=1S/C25H30N8O3S2/c34-23(26-10-11-32-12-14-35-15-13-32)28-24-27-19-7-6-18(16-20(19)38-24)37-25-30-29-21-8-9-22(31-33(21)25)36-17-4-2-1-3-5-17/h6-9,16-17H,1-5,10-15H2,(H2,26,27,28,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532768 (CHEMBL4541666) Show SMILES O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(Oc5ccccc5)nn34)cc2s1 Show InChI InChI=1S/C25H24N8O3S2/c34-23(26-10-11-32-12-14-35-15-13-32)28-24-27-19-7-6-18(16-20(19)38-24)37-25-30-29-21-8-9-22(31-33(21)25)36-17-4-2-1-3-5-17/h1-9,16H,10-15H2,(H2,26,27,28,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532768 (CHEMBL4541666) Show SMILES O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(Oc5ccccc5)nn34)cc2s1 Show InChI InChI=1S/C25H24N8O3S2/c34-23(26-10-11-32-12-14-35-15-13-32)28-24-27-19-7-6-18(16-20(19)38-24)37-25-30-29-21-8-9-22(31-33(21)25)36-17-4-2-1-3-5-17/h1-9,16H,10-15H2,(H2,26,27,28,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532758 (CHEMBL4470877) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)CCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C26H24FN7O2S2/c27-18-5-3-17(4-6-18)20-9-10-23-30-31-26(34(23)32-20)37-19-7-8-21-22(16-19)38-25(28-21)29-24(35)2-1-11-33-12-14-36-15-13-33/h3-10,16H,1-2,11-15H2,(H,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISA				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532764 (CHEMBL4551712) Show SMILES O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(OC5CCCCC5)nn34)cc2s1 Show InChI InChI=1S/C25H30N8O3S2/c34-23(26-10-11-32-12-14-35-15-13-32)28-24-27-19-7-6-18(16-20(19)38-24)37-25-30-29-21-8-9-22(31-33(21)25)36-17-4-2-1-3-5-17/h6-9,16-17H,1-5,10-15H2,(H2,26,27,28,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532743 (CHEMBL4527749) Show SMILES CCN1CCC(CCNC(=O)Nc2nc3ccc(Sc4nnc5ccc(nn45)-c4cccs4)cc3s2)CC1 Show InChI InChI=1S/C26H28N8OS3/c1-2-33-13-10-17(11-14-33)9-12-27-24(35)29-25-28-19-6-5-18(16-22(19)38-25)37-26-31-30-23-8-7-20(32-34(23)26)21-4-3-15-36-21/h3-8,15-17H,2,9-14H2,1H3,(H2,27,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532760 (CHEMBL4457387) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)C5CC5)sc4c3)n2n1 Show InChI InChI=1S/C22H15FN6OS2/c23-14-5-3-12(4-6-14)16-9-10-19-26-27-22(29(19)28-16)31-15-7-8-17-18(11-15)32-21(24-17)25-20(30)13-1-2-13/h3-11,13H,1-2H2,(H,24,25,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532752 (CHEMBL4459929) Show SMILES CCN(CC)CCNC(=O)Nc1nc2ccc(Sc3nnc4ccc(nn34)-c3ccc(F)cc3)cc2s1 Show InChI InChI=1S/C25H25FN8OS2/c1-3-33(4-2)14-13-27-23(35)29-24-28-20-10-9-18(15-21(20)37-24)36-25-31-30-22-12-11-19(32-34(22)25)16-5-7-17(26)8-6-16/h5-12,15H,3-4,13-14H2,1-2H3,(H2,27,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532753 (CHEMBL4472923) Show SMILES Fc1cccc(Oc2ccc3nnc(Sc4ccc5nc(NC(=O)NCCN6CCOCC6)sc5c4)n3n2)c1 Show InChI InChI=1S/C25H23FN8O3S2/c26-16-2-1-3-17(14-16)37-22-7-6-21-30-31-25(34(21)32-22)38-18-4-5-19-20(15-18)39-24(28-19)29-23(35)27-8-9-33-10-12-36-13-11-33/h1-7,14-15H,8-13H2,(H2,27,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532753 (CHEMBL4472923) Show SMILES Fc1cccc(Oc2ccc3nnc(Sc4ccc5nc(NC(=O)NCCN6CCOCC6)sc5c4)n3n2)c1 Show InChI InChI=1S/C25H23FN8O3S2/c26-16-2-1-3-17(14-16)37-22-7-6-21-30-31-25(34(21)32-22)38-18-4-5-19-20(15-18)39-24(28-19)29-23(35)27-8-9-33-10-12-36-13-11-33/h1-7,14-15H,8-13H2,(H2,27,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532750 (CHEMBL4462907) Show SMILES CCOc1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C21H24N8O3S2/c1-2-32-18-6-5-17-25-26-21(29(17)27-18)33-14-3-4-15-16(13-14)34-20(23-15)24-19(30)22-7-8-28-9-11-31-12-10-28/h3-6,13H,2,7-12H2,1H3,(H2,22,23,24,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532760 (CHEMBL4457387) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)C5CC5)sc4c3)n2n1 Show InChI InChI=1S/C22H15FN6OS2/c23-14-5-3-12(4-6-14)16-9-10-19-26-27-22(29(19)28-16)31-15-7-8-17-18(11-15)32-21(24-17)25-20(30)13-1-2-13/h3-11,13H,1-2H2,(H,24,25,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532750 (CHEMBL4462907) Show SMILES CCOc1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C21H24N8O3S2/c1-2-32-18-6-5-17-25-26-21(29(17)27-18)33-14-3-4-15-16(13-14)34-20(23-15)24-19(30)22-7-8-28-9-11-31-12-10-28/h3-6,13H,2,7-12H2,1H3,(H2,22,23,24,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532752 (CHEMBL4459929) Show SMILES CCN(CC)CCNC(=O)Nc1nc2ccc(Sc3nnc4ccc(nn34)-c3ccc(F)cc3)cc2s1 Show InChI InChI=1S/C25H25FN8OS2/c1-3-33(4-2)14-13-27-23(35)29-24-28-20-10-9-18(15-21(20)37-24)36-25-31-30-22-12-11-19(32-34(22)25)16-5-7-17(26)8-6-16/h5-12,15H,3-4,13-14H2,1-2H3,(H2,27,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532757 (CHEMBL4461070) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C25H23FN8O2S2/c26-17-3-1-16(2-4-17)19-7-8-22-30-31-25(34(22)32-19)37-18-5-6-20-21(15-18)38-24(28-20)29-23(35)27-9-10-33-11-13-36-14-12-33/h1-8,15H,9-14H2,(H2,27,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532759 (CHEMBL4576381) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)CC5CC5)sc4c3)n2n1 Show InChI InChI=1S/C23H17FN6OS2/c24-15-5-3-14(4-6-15)17-9-10-20-27-28-23(30(20)29-17)32-16-7-8-18-19(12-16)33-22(25-18)26-21(31)11-13-1-2-13/h3-10,12-13H,1-2,11H2,(H,25,26,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532760 (CHEMBL4457387) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)C5CC5)sc4c3)n2n1 Show InChI InChI=1S/C22H15FN6OS2/c23-14-5-3-12(4-6-14)16-9-10-19-26-27-22(29(19)28-16)31-15-7-8-17-18(11-15)32-21(24-17)25-20(30)13-1-2-13/h3-11,13H,1-2H2,(H,24,25,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISA				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532757 (CHEMBL4461070) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C25H23FN8O2S2/c26-17-3-1-16(2-4-17)19-7-8-22-30-31-25(34(22)32-19)37-18-5-6-20-21(15-18)38-24(28-20)29-23(35)27-9-10-33-11-13-36-14-12-33/h1-8,15H,9-14H2,(H2,27,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532760 (CHEMBL4457387) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)C5CC5)sc4c3)n2n1 Show InChI InChI=1S/C22H15FN6OS2/c23-14-5-3-12(4-6-14)16-9-10-19-26-27-22(29(19)28-16)31-15-7-8-17-18(11-15)32-21(24-17)25-20(30)13-1-2-13/h3-11,13H,1-2H2,(H,24,25,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISA				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532759 (CHEMBL4576381) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)CC5CC5)sc4c3)n2n1 Show InChI InChI=1S/C23H17FN6OS2/c24-15-5-3-14(4-6-15)17-9-10-20-27-28-23(30(20)29-17)32-16-7-8-18-19(12-16)33-22(25-18)26-21(31)11-13-1-2-13/h3-10,12-13H,1-2,11H2,(H,25,26,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532766 (CHEMBL4448572) Show SMILES COCCNC(=O)Nc1nc2cc(OS(=O)(=O)c3c(F)cccc3F)ccc2[nH]1 Show InChI InChI=1S/C17H16F2N4O5S/c1-27-8-7-20-17(24)23-16-21-13-6-5-10(9-14(13)22-16)28-29(25,26)15-11(18)3-2-4-12(15)19/h2-6,9H,7-8H2,1H3,(H3,20,21,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532757 (CHEMBL4461070) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C25H23FN8O2S2/c26-17-3-1-16(2-4-17)19-7-8-22-30-31-25(34(22)32-19)37-18-5-6-20-21(15-18)38-24(28-20)29-23(35)27-9-10-33-11-13-36-14-12-33/h1-8,15H,9-14H2,(H2,27,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISA				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532744 (CHEMBL4472716) Show SMILES CCCCOc1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C23H28N8O3S2/c1-2-3-12-34-20-7-6-19-27-28-23(31(19)29-20)35-16-4-5-17-18(15-16)36-22(25-17)26-21(32)24-8-9-30-10-13-33-14-11-30/h4-7,15H,2-3,8-14H2,1H3,(H2,24,25,26,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532744 (CHEMBL4472716) Show SMILES CCCCOc1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C23H28N8O3S2/c1-2-3-12-34-20-7-6-19-27-28-23(31(19)29-20)35-16-4-5-17-18(15-16)36-22(25-17)26-21(32)24-8-9-30-10-13-33-14-11-30/h4-7,15H,2-3,8-14H2,1H3,(H2,24,25,26,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532757 (CHEMBL4461070) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C25H23FN8O2S2/c26-17-3-1-16(2-4-17)19-7-8-22-30-31-25(34(22)32-19)37-18-5-6-20-21(15-18)38-24(28-20)29-23(35)27-9-10-33-11-13-36-14-12-33/h1-8,15H,9-14H2,(H2,27,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of phosphorylated MET in human MKN45 cells assessed as reduction in pMET Y1230/1234/1235 level incubated for 1 hr by ELISA				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532766 (CHEMBL4448572) Show SMILES COCCNC(=O)Nc1nc2cc(OS(=O)(=O)c3c(F)cccc3F)ccc2[nH]1 Show InChI InChI=1S/C17H16F2N4O5S/c1-27-8-7-20-17(24)23-16-21-13-6-5-10(9-14(13)22-16)28-29(25,26)15-11(18)3-2-4-12(15)19/h2-6,9H,7-8H2,1H3,(H3,20,21,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532758 (CHEMBL4470877) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)CCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C26H24FN7O2S2/c27-18-5-3-17(4-6-18)20-9-10-23-30-31-26(34(23)32-20)37-19-7-8-21-22(16-19)38-25(28-21)29-24(35)2-1-11-33-12-14-36-15-13-33/h3-10,16H,1-2,11-15H2,(H,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM50532766 (CHEMBL4448572) Show SMILES COCCNC(=O)Nc1nc2cc(OS(=O)(=O)c3c(F)cccc3F)ccc2[nH]1 Show InChI InChI=1S/C17H16F2N4O5S/c1-27-8-7-20-17(24)23-16-21-13-6-5-10(9-14(13)22-16)28-29(25,26)15-11(18)3-2-4-12(15)19/h2-6,9H,7-8H2,1H3,(H3,20,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of CDK9 (unknown origin)				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM50532766 (CHEMBL4448572) Show SMILES COCCNC(=O)Nc1nc2cc(OS(=O)(=O)c3c(F)cccc3F)ccc2[nH]1 Show InChI InChI=1S/C17H16F2N4O5S/c1-27-8-7-20-17(24)23-16-21-13-6-5-10(9-14(13)22-16)28-29(25,26)15-11(18)3-2-4-12(15)19/h2-6,9H,7-8H2,1H3,(H3,20,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of CDK9 (unknown origin)				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532757 (CHEMBL4461070) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C25H23FN8O2S2/c26-17-3-1-16(2-4-17)19-7-8-22-30-31-25(34(22)32-19)37-18-5-6-20-21(15-18)38-24(28-20)29-23(35)27-9-10-33-11-13-36-14-12-33/h1-8,15H,9-14H2,(H2,27,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of phosphorylated MET M1250T mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532754 (CHEMBL4460814) Show SMILES O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(OC5CCCC5)nn34)cc2s1 Show InChI InChI=1S/C24H28N8O3S2/c33-22(25-9-10-31-11-13-34-14-12-31)27-23-26-18-6-5-17(15-19(18)37-23)36-24-29-28-20-7-8-21(30-32(20)24)35-16-3-1-2-4-16/h5-8,15-16H,1-4,9-14H2,(H2,25,26,27,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532757 (CHEMBL4461070) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C25H23FN8O2S2/c26-17-3-1-16(2-4-17)19-7-8-22-30-31-25(34(22)32-19)37-18-5-6-20-21(15-18)38-24(28-20)29-23(35)27-9-10-33-11-13-36-14-12-33/h1-8,15H,9-14H2,(H2,27,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of phosphorylated MET M1250T mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptid...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532758 (CHEMBL4470877) Show SMILES Fc1ccc(cc1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)CCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C26H24FN7O2S2/c27-18-5-3-17(4-6-18)20-9-10-23-30-31-26(34(23)32-20)37-19-7-8-21-22(16-19)38-25(28-21)29-24(35)2-1-11-33-12-14-36-15-13-33/h3-10,16H,1-2,11-15H2,(H,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532754 (CHEMBL4460814) Show SMILES O=C(NCCN1CCOCC1)Nc1nc2ccc(Sc3nnc4ccc(OC5CCCC5)nn34)cc2s1 Show InChI InChI=1S/C24H28N8O3S2/c33-22(25-9-10-31-11-13-34-14-12-31)27-23-26-18-6-5-17(15-19(18)37-23)36-24-29-28-20-7-8-21(30-32(20)24)35-16-3-1-2-4-16/h5-8,15-16H,1-4,9-14H2,(H2,25,26,27,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50340502 (CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...) Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-aventis Curated by ChEMBL					Assay Description Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expressed in baculovirus-SF21 cell system preincubated for 60 mins by tim...				Bioorg Med Chem Lett 21: 2224-8 (2011) Article DOI: 10.1016/j.bmcl.2011.03.003 BindingDB Entry DOI: 10.7270/Q2CC11PK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50340502 (CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...) Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-aventis Curated by ChEMBL					Assay Description Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells by ELISA				Bioorg Med Chem Lett 21: 2224-8 (2011) Article DOI: 10.1016/j.bmcl.2011.03.003 BindingDB Entry DOI: 10.7270/Q2CC11PK
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50340502 (CHEMBL1762178 | N-(4-((5,5-dimethyl-2,4-dioxo-3-(4...) Show SMILES CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c2ccc(SC(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C20H19F3N4O3S/c1-12(28)25-16-10-13(8-9-24-16)11-26-18(30)27(17(29)19(26,2)3)14-4-6-15(7-5-14)31-20(21,22)23/h4-10H,11H2,1-3H3,(H,24,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-aventis Curated by ChEMBL					Assay Description Inhibition of autophosphosphorylation of human IGF1R expressed in IGF1-stimulated MCF7 cells preincubated for 60 mins by ELISA				Bioorg Med Chem Lett 21: 2224-8 (2011) Article DOI: 10.1016/j.bmcl.2011.03.003 BindingDB Entry DOI: 10.7270/Q2CC11PK
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532755 (CHEMBL4448029) Show SMILES Nc1nc2ccc(Sc3nnc4ccc(nn34)-c3ccc(F)cc3)cc2s1 Show InChI InChI=1S/C18H11FN6S2/c19-11-3-1-10(2-4-11)13-7-8-16-22-23-18(25(16)24-13)26-12-5-6-14-15(9-12)27-17(20)21-14/h1-9H,(H2,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532767 (CHEMBL4453878) Show SMILES COC(=O)Nc1nc2cc(Sc3nnc4ccc(nn34)-c3ccc(F)cc3)ccc2[nH]1 Show InChI InChI=1S/C20H14FN7O2S/c1-30-20(29)24-18-22-15-7-6-13(10-16(15)23-18)31-19-26-25-17-9-8-14(27-28(17)19)11-2-4-12(21)5-3-11/h2-10H,1H3,(H2,22,23,24,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532767 (CHEMBL4453878) Show SMILES COC(=O)Nc1nc2cc(Sc3nnc4ccc(nn34)-c3ccc(F)cc3)ccc2[nH]1 Show InChI InChI=1S/C20H14FN7O2S/c1-30-20(29)24-18-22-15-7-6-13(10-16(15)23-18)31-19-26-25-17-9-8-14(27-28(17)19)11-2-4-12(21)5-3-11/h2-10H,1H3,(H2,22,23,24,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532755 (CHEMBL4448029) Show SMILES Nc1nc2ccc(Sc3nnc4ccc(nn34)-c3ccc(F)cc3)cc2s1 Show InChI InChI=1S/C18H11FN6S2/c19-11-3-1-10(2-4-11)13-7-8-16-22-23-18(25(16)24-13)26-12-5-6-14-15(9-12)27-17(20)21-14/h1-9H,(H2,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50532747 (CHEMBL4537541) Show SMILES Fc1cccc(c1)-c1ccc2nnc(Sc3ccc4nc(NC(=O)NCCN5CCOCC5)sc4c3)n2n1 Show InChI InChI=1S/C25H23FN8O2S2/c26-17-3-1-2-16(14-17)19-6-7-22-30-31-25(34(22)32-19)37-18-4-5-20-21(15-18)38-24(28-20)29-23(35)27-8-9-33-10-12-36-13-11-33/h1-7,14-15H,8-13H2,(H2,27,28,29,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi-Aventis Germany GmbH Curated by ChEMBL					Assay Description Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...				J Med Chem 59: 7066-74 (2016) Article DOI: 10.1021/acs.jmedchem.6b00280 BindingDB Entry DOI: 10.7270/Q2WM1HW4
					More data for this Ligand-Target Pair

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