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Compile Data Set for Download or QSAR

Found 12 hits with Last Name = 'ohkubo' and Initial = 'y'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin G/H synthase 2


(Ovis aries (Sheep))
BDBM11639
PNG
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
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n/an/a 560n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric method


Bioorg Med Chem 23: 6807-14 (2015)


Article DOI: 10.1016/j.bmc.2015.10.007
BindingDB Entry DOI: 10.7270/Q22N543P
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))
BDBM17638
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
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n/an/a 790n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ovine COX-1 using arachidonic acid after 5 mins by colorimetric method


Bioorg Med Chem 23: 6807-14 (2015)


Article DOI: 10.1016/j.bmc.2015.10.007
BindingDB Entry DOI: 10.7270/Q22N543P
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Ovis aries (Sheep))
BDBM50056999
PNG
(CHEMBL56367 | nimesulide)
Show SMILES CS(=O)(=O)Nc1ccc(cc1Oc1ccccc1)[N+]([O-])=O
Show InChI InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3
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n/an/a 1.92E+3n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric method


Bioorg Med Chem 23: 6807-14 (2015)


Article DOI: 10.1016/j.bmc.2015.10.007
BindingDB Entry DOI: 10.7270/Q22N543P
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Ovis aries (Sheep))
BDBM50128688
PNG
(CHEMBL3628727)
Show SMILES COc1ccc(Oc2cc(ccc2NS(C)(=O)=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C14H14N2O6S/c1-21-11-4-6-12(7-5-11)22-14-9-10(16(17)18)3-8-13(14)15-23(2,19)20/h3-9,15H,1-2H3
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n/an/a 2.31E+3n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric method


Bioorg Med Chem 23: 6807-14 (2015)


Article DOI: 10.1016/j.bmc.2015.10.007
BindingDB Entry DOI: 10.7270/Q22N543P
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Ovis aries (Sheep))
BDBM17638
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
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n/an/a 1.18E+4n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric method


Bioorg Med Chem 23: 6807-14 (2015)


Article DOI: 10.1016/j.bmc.2015.10.007
BindingDB Entry DOI: 10.7270/Q22N543P
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))
BDBM50056999
PNG
(CHEMBL56367 | nimesulide)
Show SMILES CS(=O)(=O)Nc1ccc(cc1Oc1ccccc1)[N+]([O-])=O
Show InChI InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ovine COX-1 using arachidonic acid after 5 mins by colorimetric method


Bioorg Med Chem 23: 6807-14 (2015)


Article DOI: 10.1016/j.bmc.2015.10.007
BindingDB Entry DOI: 10.7270/Q22N543P
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))
BDBM11639
PNG
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ovine COX-1 using arachidonic acid after 5 mins by colorimetric method


Bioorg Med Chem 23: 6807-14 (2015)


Article DOI: 10.1016/j.bmc.2015.10.007
BindingDB Entry DOI: 10.7270/Q22N543P
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Ovis aries (Sheep))
BDBM50128691
PNG
(CHEMBL3628630)
Show SMILES COc1cccc(Oc2cc(ccc2NS(C)(=O)=O)[N+]([O-])=O)c1
Show InChI InChI=1S/C14H14N2O6S/c1-21-11-4-3-5-12(9-11)22-14-8-10(16(17)18)6-7-13(14)15-23(2,19)20/h3-9,15H,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric method


Bioorg Med Chem 23: 6807-14 (2015)


Article DOI: 10.1016/j.bmc.2015.10.007
BindingDB Entry DOI: 10.7270/Q22N543P
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))
BDBM50128688
PNG
(CHEMBL3628727)
Show SMILES COc1ccc(Oc2cc(ccc2NS(C)(=O)=O)[N+]([O-])=O)cc1
Show InChI InChI=1S/C14H14N2O6S/c1-21-11-4-6-12(7-5-11)22-14-9-10(16(17)18)3-8-13(14)15-23(2,19)20/h3-9,15H,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ovine COX-1 using arachidonic acid after 5 mins by colorimetric method


Bioorg Med Chem 23: 6807-14 (2015)


Article DOI: 10.1016/j.bmc.2015.10.007
BindingDB Entry DOI: 10.7270/Q22N543P
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))
BDBM50128691
PNG
(CHEMBL3628630)
Show SMILES COc1cccc(Oc2cc(ccc2NS(C)(=O)=O)[N+]([O-])=O)c1
Show InChI InChI=1S/C14H14N2O6S/c1-21-11-4-3-5-12(9-11)22-14-8-10(16(17)18)6-7-13(14)15-23(2,19)20/h3-9,15H,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ovine COX-1 using arachidonic acid after 5 mins by colorimetric method


Bioorg Med Chem 23: 6807-14 (2015)


Article DOI: 10.1016/j.bmc.2015.10.007
BindingDB Entry DOI: 10.7270/Q22N543P
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 1


(Ovis aries (Sheep))
BDBM50128748
PNG
(CHEMBL3628629)
Show SMILES COc1ccccc1Oc1cc(ccc1NS(C)(=O)=O)[N+]([O-])=O
Show InChI InChI=1S/C14H14N2O6S/c1-21-12-5-3-4-6-13(12)22-14-9-10(16(17)18)7-8-11(14)15-23(2,19)20/h3-9,15H,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ovine COX-1 using arachidonic acid after 5 mins by colorimetric method


Bioorg Med Chem 23: 6807-14 (2015)


Article DOI: 10.1016/j.bmc.2015.10.007
BindingDB Entry DOI: 10.7270/Q22N543P
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Ovis aries (Sheep))
BDBM50128748
PNG
(CHEMBL3628629)
Show SMILES COc1ccccc1Oc1cc(ccc1NS(C)(=O)=O)[N+]([O-])=O
Show InChI InChI=1S/C14H14N2O6S/c1-21-12-5-3-4-6-13(12)22-14-9-10(16(17)18)7-8-11(14)15-23(2,19)20/h3-9,15H,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tohoku Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric method


Bioorg Med Chem 23: 6807-14 (2015)


Article DOI: 10.1016/j.bmc.2015.10.007
BindingDB Entry DOI: 10.7270/Q22N543P
More data for this
Ligand-Target Pair