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Compile Data Set for Download or QSAR

Found 404 hits with Last Name = 'paraselli' and Initial = 'p'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526479
PNG
(US11186566, Compound 18)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(O[C@H]3C[C@H]3C(F)(F)F)n2)C(C)(C)C1 |r|
PDB

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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526481
PNG
(US11186566, Compound 20)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2O)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526491
PNG
(US11186566, Compound 30 | US11186566, Compound 36)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC3C(C)(C)C3(C)C)n2)C(C)(C)C1 |r|
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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526500
PNG
(US11186566, Compound 39)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(O[C@H]3C[C@H]4CC[C@@H]3C4)n2)C(C)(C)C1 |r,THB:26:27:33:30.31|
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UniProtKB/SwissProt

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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526502
PNG
(US11186566, Compound 41)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC(C3CC3)C3CC3)n2)C(C)(C)C1 |r|
PDB

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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526505
PNG
(US11186566, Compound 44)
Show SMILES C[C@@H]1CN(c2cc(ncc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
PDB

UniProtKB/SwissProt

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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526507
PNG
(US11186566, Compound 46)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)N[S@@](=N)(=O)c2ccccc2)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526510
PNG
(US11186566, Compound 49)
Show SMILES COc1cccc(c1)S(=O)(=O)NC(=O)c1ccc(nc1N1C[C@@H](C)CC1(C)C)-n1ccc(OCC2(CC2)C(F)(F)F)n1 |r|
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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526512
PNG
(US11186566, Compound 51)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2cccc(F)c2)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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UniProtKB/SwissProt

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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526515
PNG
(US11186566, Compound 54)
Show SMILES COc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(nc1N1C[C@@H](C)CC1(C)C)-n1ccc(OCC2(CC2)C(F)(F)F)n1 |r|
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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526518
PNG
(US11186566, Compound 57)
Show SMILES COc1ccc(c(C)c1)S(=O)(=O)NC(=O)c1ccc(nc1N1C[C@@H](C)CC1(C)C)-n1ccc(OCC2(CC2)C(F)(F)F)n1 |r|
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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526520
PNG
(US11186566, Compound 59)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2cccc(F)c2)-n2ccc(OCC3(CCC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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UniProtKB/SwissProt

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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526523
PNG
(US11186566, Compound 63 | US11186566, Compound 64)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC3C4(CC4)C33CC3)n2)C(C)(C)C1 |r|
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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526475
PNG
(US11186566, Compound 14)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
PDB

UniProtKB/SwissProt

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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526493
PNG
(US11186566, Compound 32)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2nc(OCCC3(CC3)C(F)(F)F)cc2F)C(C)(C)C1 |r|
PDB

UniProtKB/SwissProt

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n/an/an/an/a 40n/an/an/an/a


TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526468
PNG
(US11186566, Compound 5)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2cccc(F)c2)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526504
PNG
(US11186566, Compound 43)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2Cl)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526502
PNG
(US11186566, Compound 41)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC(C3CC3)C3CC3)n2)C(C)(C)C1 |r|
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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526500
PNG
(US11186566, Compound 39)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(O[C@H]3C[C@H]4CC[C@@H]3C4)n2)C(C)(C)C1 |r,THB:26:27:33:30.31|
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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526474
PNG
(US11186566, Compound 13)
Show SMILES COc1ccc(c(OC)c1)S(=O)(=O)NC(=O)c1ccc(nc1N1C[C@@H](C)CC1(C)C)-n1ccc(OCC2(CC2)C(F)(F)F)n1 |r|
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n/an/an/an/a 110n/an/an/an/a


TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526488
PNG
(US11186566, Compound 27)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccc(cc2)C#N)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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n/an/an/an/a 270n/an/an/an/a


TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526483
PNG
(US11186566, Compound 22)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccc(O)cc2)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526464
PNG
(US11186566, Compound 1 | US11186566, Compound 17)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<100n/an/an/an/a


TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526465
PNG
((R)—N-(Phenylsulfonyl)-6-(3-(2-(1-(trifluorom...)
Show SMILES C[C@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526466
PNG
((S)—N-((4-Hydroxy-3-methoxyphenyl)sulfonyl)-6...)
Show SMILES COc1cc(ccc1O)S(=O)(=O)NC(=O)c1ccc(nc1Cl)-n1ccc(OCCC2(CC2)C(F)(F)F)n1
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Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526467
PNG
(US11186566, Compound 4)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2C)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526468
PNG
(US11186566, Compound 5)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2cccc(F)c2)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526469
PNG
(US11186566, Compound 8)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2C)-n2ccc(OCC3C4(CC4)C33CC3)n2)C(C)(C)C1 |r|
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Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526470
PNG
(US11186566, Compound 9)
Show SMILES CC1(C)CC(CO)CN1c1nc(ccc1C(=O)NS(=O)(=O)c1ccccc1)-n1ccc(OCCC2(CC2)C(F)(F)F)n1
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UniProtKB/SwissProt

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TBA

Assay Description
The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526471
PNG
(US11186566, Compound 10)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC3(CCC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526472
PNG
(US11186566, Compound 11)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccc(cc2C)C#N)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526473
PNG
(US11186566, Compound 12)
Show SMILES COc1cc(C)ccc1S(=O)(=O)NC(=O)c1ccc(nc1N1C[C@@H](C)CC1(C)C)-n1ccc(OCC2(CC2)C(F)(F)F)n1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526474
PNG
(US11186566, Compound 13)
Show SMILES COc1ccc(c(OC)c1)S(=O)(=O)NC(=O)c1ccc(nc1N1C[C@@H](C)CC1(C)C)-n1ccc(OCC2(CC2)C(F)(F)F)n1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526475
PNG
(US11186566, Compound 14)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


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BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526476
PNG
(US11186566, Compound 15)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2C)-n2ccc(OCC3C(C)(C)C3(C)C)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526477
PNG
(US11186566, Compound 16)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2cccc(F)c2)-n2ccc(OCC3C(C)(C)C3(C)C)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526464
PNG
(US11186566, Compound 1 | US11186566, Compound 17)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526480
PNG
(US11186566, Compound 19)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(O[C@H]3C[C@@H]3C(F)(F)F)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526482
PNG
(US11186566, Compound 21)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2cccc(O)c2)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526483
PNG
(US11186566, Compound 22)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccc(O)cc2)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526484
PNG
(US11186566, Compound 23)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2C)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526485
PNG
(US11186566, Compound 24)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccc(C)cc2)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


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BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526486
PNG
(US11186566, Compound 25)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2cccc(c2)C#N)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526487
PNG
(US11186566, Compound 26)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2C#N)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526488
PNG
(US11186566, Compound 27)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccc(cc2)C#N)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526489
PNG
(US11186566, Compound 28)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2cccc(C)c2)-n2ccc(OCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526490
PNG
(US11186566, Compound 29)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(COC3(C)CC3)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526491
PNG
(US11186566, Compound 30 | US11186566, Compound 36)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2ccc(OCC3C(C)(C)C3(C)C)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526492
PNG
(US11186566, Compound 31)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccc(O)cc2)-n2ccc(OCCC3(CC3)C(F)(F)F)n2)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator [1-507,509-1480]


(Homo sapiens (Human))
BDBM526493
PNG
(US11186566, Compound 32)
Show SMILES C[C@@H]1CN(c2nc(ccc2C(=O)NS(=O)(=O)c2ccccc2)-n2nc(OCCC3(CC3)C(F)(F)F)cc2F)C(C)(C)C1 |r|
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The assay utilizes fluorescent voltage sensing dyes to measure changes in membrane potential using a fluorescent plate reader (e.g., FLIPR III, Molec...


Citation and Details

BindingDB Entry DOI: 10.7270/Q22R3VVH
More data for this
Ligand-Target Pair
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