Found 85 hits with Last Name = 'parrish' and Initial = 'ke' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552696
(CHEMBL4778959)Show SMILES CN1CCC(CC1)c1noc(n1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552697
(CHEMBL4780798)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(no4)C45CCN(CC4)CC5)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 3
(Homo sapiens (Human)) | BDBM50552697
(CHEMBL4780798)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(no4)C45CCN(CC4)CC5)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.460 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of GLK (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552695
(CHEMBL4789200)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(no4)-c4ccncc4)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552691
(CHEMBL4750822)Show SMILES CC(C)c1noc(n1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552692
(CHEMBL4759406)Show SMILES CC(C)(C)c1noc(n1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 3
(Homo sapiens (Human)) | BDBM50552696
(CHEMBL4778959)Show SMILES CN1CCC(CC1)c1noc(n1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of GLK (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552690
(CHEMBL4758114)Show SMILES CCc1noc(n1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552698
(CHEMBL4779496)Show SMILES Cc1nnc(o1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552693
(CHEMBL4784181)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(no4)C4CC4)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552702
(CHEMBL4748154)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552699
(CHEMBL4784784)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnc(o4)C4CC4)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552689
(CHEMBL4790192)Show SMILES Cc1noc(n1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552681
(CHEMBL4761884)Show SMILES CNC(=O)c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552688
(CHEMBL4748045)Show SMILES CCOC(=O)c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552684
(CHEMBL4749598)Show SMILES CCCNC(=O)c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552700
(CHEMBL4741772)Show SMILES CN1CCC(CC1)c1nnc(o1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552682
(CHEMBL4745378)Show SMILES CCNC(=O)c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552686
(CHEMBL4776227)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(C(N)=O)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552701
(CHEMBL4758887)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnc(o4)C45CCN(CC4)CC5)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552697
(CHEMBL4780798)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(no4)C45CCN(CC4)CC5)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 in anti-CD3/anti-CD28-stimulated human T-cells assessed as inhibition of SLP76 phosphorylation preincubated for 1 hr followed by a... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM209597
(US9546153, ex. 145 | US9546153, ex. 146)Show SMILES CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H](CO)c1ccccc1 |r| Show InChI InChI=1S/C22H21N5O2S/c1-23-22(29)16-11-24-21(26-15-7-8-17-20(9-15)30-13-25-17)10-18(16)27-19(12-28)14-5-3-2-4-6-14/h2-11,13,19,28H,12H2,1H3,(H,23,29)(H2,24,26,27)/t19-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of IRAK4 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552680
(CHEMBL4793633)Show SMILES CCc1cc(Nc2ncc(C(=O)NC)c(N[C@H](CO)c3ccccc3)n2)ccc1C#N |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552694
(CHEMBL4758572)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(no4)-c4ccc(F)cc4)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552683
(CHEMBL4761304)Show SMILES CC(C)NC(=O)c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552696
(CHEMBL4778959)Show SMILES CN1CCC(CC1)c1noc(n1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 in anti-CD3/anti-CD28-stimulated human T-cells assessed as inhibition of SLP76 phosphorylation preincubated for 1 hr followed by a... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM50552680
(CHEMBL4793633)Show SMILES CCc1cc(Nc2ncc(C(=O)NC)c(N[C@H](CO)c3ccccc3)n2)ccc1C#N |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of IRAK4 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 3
(Homo sapiens (Human)) | BDBM50552695
(CHEMBL4789200)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(no4)-c4ccncc4)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of GLK (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 3
(Homo sapiens (Human)) | BDBM50552691
(CHEMBL4750822)Show SMILES CC(C)c1noc(n1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of GLK (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 3
(Homo sapiens (Human)) | BDBM50552692
(CHEMBL4759406)Show SMILES CC(C)(C)c1noc(n1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of GLK (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM50552698
(CHEMBL4779496)Show SMILES Cc1nnc(o1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of IRAK4 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 3
(Homo sapiens (Human)) | BDBM50552693
(CHEMBL4784181)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(no4)C4CC4)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of GLK (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM50552681
(CHEMBL4761884)Show SMILES CNC(=O)c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of IRAK4 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM50552702
(CHEMBL4748154)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of IRAK4 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 3
(Homo sapiens (Human)) | BDBM50552690
(CHEMBL4758114)Show SMILES CCc1noc(n1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of GLK (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 3
(Homo sapiens (Human)) | BDBM50552688
(CHEMBL4748045)Show SMILES CCOC(=O)c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of GLK (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 3
(Homo sapiens (Human)) | BDBM50552681
(CHEMBL4761884)Show SMILES CNC(=O)c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of GLK (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 3
(Homo sapiens (Human)) | BDBM50552698
(CHEMBL4779496)Show SMILES Cc1nnc(o1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of GLK (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 3
(Homo sapiens (Human)) | BDBM50552689
(CHEMBL4790192)Show SMILES Cc1noc(n1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of GLK (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM209597
(US9546153, ex. 145 | US9546153, ex. 146)Show SMILES CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1N[C@H](CO)c1ccccc1 |r| Show InChI InChI=1S/C22H21N5O2S/c1-23-22(29)16-11-24-21(26-15-7-8-17-20(9-15)30-13-25-17)10-18(16)27-19(12-28)14-5-3-2-4-6-14/h2-11,13,19,28H,12H2,1H3,(H,23,29)(H2,24,26,27)/t19-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM50552697
(CHEMBL4780798)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nc(no4)C45CCN(CC4)CC5)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of IRAK4 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 3
(Homo sapiens (Human)) | BDBM50552684
(CHEMBL4749598)Show SMILES CCCNC(=O)c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of GLK (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 3
(Homo sapiens (Human)) | BDBM50552702
(CHEMBL4748154)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of GLK (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM50552699
(CHEMBL4784784)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnc(o4)C4CC4)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of IRAK4 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 3
(Homo sapiens (Human)) | BDBM50552699
(CHEMBL4784784)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnc(o4)C4CC4)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of GLK (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 1
(Homo sapiens (Human)) | BDBM50552691
(CHEMBL4750822)Show SMILES CC(C)c1noc(n1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB
NCI pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of HPK1 in anti-CD3/anti-CD28-stimulated human T-cells assessed as inhibition of SLP76 phosphorylation preincubated for 1 hr followed by a... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM50552686
(CHEMBL4776227)Show SMILES CC1(C)OC(=O)c2ccc(Nc3ncc(C(N)=O)c(N[C@H](CO)c4ccccc4)n3)cc12 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of IRAK4 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM50552684
(CHEMBL4749598)Show SMILES CCCNC(=O)c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of IRAK4 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM50552700
(CHEMBL4741772)Show SMILES CN1CCC(CC1)c1nnc(o1)-c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of IRAK4 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM50552682
(CHEMBL4745378)Show SMILES CCNC(=O)c1cnc(Nc2ccc3C(=O)OC(C)(C)c3c2)nc1N[C@H](CO)c1ccccc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of IRAK4 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00660 BindingDB Entry DOI: 10.7270/Q2DN48N7 |
More data for this Ligand-Target Pair | |