Compile Data Set for Download or QSAR

Found 161 hits with Last Name = 'prasanna' and Initial = 'g'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430984 (US10550102, Example 40-1 (-)) Show SMILES CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(CC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC |r| Show InChI InChI=1S/C39H46N4O4/c1-4-9-35(44)38(45)42-20-18-27(19-21-42)30-17-14-25(22-26(30)5-2)23-29-16-15-28-10-7-11-31(37(28)29)33-12-8-13-36(41-33)43-34(6-3)32(24-40-43)39(46)47/h7-8,10-14,17,22,24,27,29,35,44H,4-6,9,15-16,18-21,23H2,1-3H3,(H,46,47)/t29?,35-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430985 (Example 60-A. (+-)-Ethyl 1-(6-(3-((4-(1-cyclopropy...) Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C3CC3)c12)C(O)=O Show InChI InChI=1S/C34H37N5O2/c1-21-19-25(23-15-17-38(18-16-23)26-11-12-26)10-13-29(21)36-31-14-9-24-5-3-6-27(33(24)31)30-7-4-8-32(37-30)39-22(2)28(20-35-39)34(40)41/h3-8,10,13,19-20,23,26,31,36H,9,11-12,14-18H2,1-2H3,(H,40,41)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.30	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430986 (US10550102, Example 40-1 (+)) Show SMILES CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(CC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC |r| Show InChI InChI=1S/C39H46N4O4/c1-4-9-35(44)38(45)42-20-18-27(19-21-42)30-17-14-25(22-26(30)5-2)23-29-16-15-28-10-7-11-31(37(28)29)33-12-8-13-36(41-33)43-34(6-3)32(24-40-43)39(46)47/h7-8,10-14,17,22,24,27,29,35,44H,4-6,9,15-16,18-21,23H2,1-3H3,(H,46,47)/t29?,35-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430987 (US10550102, Example 61. b). (enantiomer-1) | US105...) Show SMILES OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C(F)(F)F)C3CCN(CC3)C(=O)C3CC3)c12 Show InChI InChI=1S/C35H31F6N5O3/c36-34(37,38)25-17-22(19-13-15-45(16-14-19)32(47)21-7-8-21)10-11-27(25)43-28-12-9-20-3-1-4-23(30(20)28)26-5-2-6-29(44-26)46-31(35(39,40)41)24(18-42-46)33(48)49/h1-6,10-11,17-19,21,28,43H,7-9,12-16H2,(H,48,49)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430988 (US10550102, Example 40-2 (-)) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)[C@H](C)O)c12)C(O)=O |r| Show InChI InChI=1S/C36H40N4O4/c1-4-32-30(36(43)44)21-37-40(32)33-10-6-9-31(38-33)29-8-5-7-25-11-14-28(34(25)29)20-26-12-13-27(19-22(26)2)24-15-17-39(18-16-24)35(42)23(3)41/h5-10,12-13,19,21,23-24,28,41H,4,11,14-18,20H2,1-3H3,(H,43,44)/t23-,28?/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430987 (US10550102, Example 61. b). (enantiomer-1) | US105...) Show SMILES OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C(F)(F)F)C3CCN(CC3)C(=O)C3CC3)c12 Show InChI InChI=1S/C35H31F6N5O3/c36-34(37,38)25-17-22(19-13-15-45(16-14-19)32(47)21-7-8-21)10-11-27(25)43-28-12-9-20-3-1-4-23(30(20)28)26-5-2-6-29(44-26)46-31(35(39,40)41)24(18-42-46)33(48)49/h1-6,10-11,17-19,21,28,43H,7-9,12-16H2,(H,48,49)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430990 (US10550102, Example 40-2 (+)) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)[C@H](C)O)c12)C(O)=O |r| Show InChI InChI=1S/C36H40N4O4/c1-4-32-30(36(43)44)21-37-40(32)33-10-6-9-31(38-33)29-8-5-7-25-11-14-28(34(25)29)20-26-12-13-27(19-22(26)2)24-15-17-39(18-16-24)35(42)23(3)41/h5-10,12-13,19,21,23-24,28,41H,4,11,14-18,20H2,1-3H3,(H,43,44)/t23-,28?/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430991 (Example 62-A. (+-)-Ethyl 1-(6-(3-((tert-butoxycarb...) Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ncc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O Show InChI InChI=1S/C34H36N6O3/c1-20-17-25(22-13-15-39(16-14-22)33(41)24-9-10-24)18-35-32(20)38-29-12-11-23-5-3-6-26(31(23)29)28-7-4-8-30(37-28)40-21(2)27(19-36-40)34(42)43/h3-8,17-19,22,24,29H,9-16H2,1-2H3,(H,35,38)(H,42,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430992 (US10550102, Example 40-3 (-)) Show SMILES CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(CC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)c(C)c1 |r| Show InChI InChI=1S/C38H44N4O4/c1-4-8-34(43)37(44)41-19-17-25(18-20-41)28-15-14-27(24(3)21-28)22-29-16-13-26-9-6-10-30(36(26)29)32-11-7-12-35(40-32)42-33(5-2)31(23-39-42)38(45)46/h6-7,9-12,14-15,21,23,25,29,34,43H,4-5,8,13,16-20,22H2,1-3H3,(H,45,46)/t29?,34-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	49	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430993 (US10550102, Example 63a) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)n3)c12)C(O)=O Show InChI InChI=1S/C36H40N6O3/c1-3-28-25(22-17-19-41(20-18-22)35(43)24-11-12-24)14-16-32(38-28)39-30-15-13-23-7-5-8-26(34(23)30)29-9-6-10-33(40-29)42-31(4-2)27(21-37-42)36(44)45/h5-10,14,16,21-22,24,30H,3-4,11-13,15,17-20H2,1-2H3,(H,38,39)(H,44,45)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430994 (US10550102, Example 40-3 (+)) Show SMILES CCC[C@H](O)C(=O)N1CCC(CC1)c1ccc(CC2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)c(C)c1 |r| Show InChI InChI=1S/C38H44N4O4/c1-4-8-34(43)37(44)41-19-17-25(18-20-41)28-15-14-27(24(3)21-28)22-29-16-13-26-9-6-10-30(36(26)29)32-11-7-12-35(40-32)42-33(5-2)31(23-39-42)38(45)46/h6-7,9-12,14-15,21,23,25,29,34,43H,4-5,8,13,16-20,22H2,1-3H3,(H,45,46)/t29?,34-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430995 (US10550102, Example 63b) Show SMILES CCOC(=O)c1cnn(c1CC)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(C4CCN(CC4)C(=O)C4CC4)c(CC)n3)c12 Show InChI InChI=1S/C38H44N6O3/c1-4-30-27(24-19-21-43(22-20-24)37(45)26-13-14-26)16-18-34(40-30)41-32-17-15-25-9-7-10-28(36(25)32)31-11-8-12-35(42-31)44-33(5-2)29(23-39-44)38(46)47-6-3/h7-12,16,18,23-24,26,32H,4-6,13-15,17,19-22H2,1-3H3,(H,40,41)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430996 (US10550102, Example 41. b). (-)) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(C4CCN(CC4)C(=O)OC)c(CC)c3)c12)C(O)=O Show InChI InChI=1S/C36H40N4O4/c1-4-24-20-23(12-15-28(24)25-16-18-39(19-17-25)36(43)44-3)21-27-14-13-26-8-6-9-29(34(26)27)31-10-7-11-33(38-31)40-32(5-2)30(22-37-40)35(41)42/h6-12,15,20,22,25,27H,4-5,13-14,16-19,21H2,1-3H3,(H,41,42)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430997 (US10550102, Example 64-1) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OCc4ccccc4)c(CC)c3)c12)C(O)=O |r| Show InChI InChI=1S/C41H42N4O5/c1-3-28-24-31(17-18-32(28)29-20-22-44(23-21-29)41(48)49-26-27-10-6-5-7-11-27)50-37-19-16-30-12-8-13-33(39(30)37)35-14-9-15-38(43-35)45-36(4-2)34(25-42-45)40(46)47/h5-15,17-18,24-25,29,37H,3-4,16,19-23,26H2,1-2H3,(H,46,47)/t37-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430998 (US10550102, Example 41. b). (+)) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(C4CCN(CC4)C(=O)OC)c(CC)c3)c12)C(O)=O Show InChI InChI=1S/C36H40N4O4/c1-4-24-20-23(12-15-28(24)25-16-18-39(19-17-25)36(43)44-3)21-27-14-13-26-8-6-9-29(34(26)27)31-10-7-11-33(38-31)40-32(5-2)30(22-37-40)35(41)42/h6-12,15,20,22,25,27H,4-5,13-14,16-19,21H2,1-3H3,(H,41,42)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430999 (US10550102, Example 64-2) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OCC(C)C)c(CC)c3)c12)C(O)=O |r| Show InChI InChI=1S/C38H44N4O5/c1-5-25-21-28(14-15-29(25)26-17-19-41(20-18-26)38(45)46-23-24(3)4)47-34-16-13-27-9-7-10-30(36(27)34)32-11-8-12-35(40-32)42-33(6-2)31(22-39-42)37(43)44/h7-12,14-15,21-22,24,26,34H,5-6,13,16-20,23H2,1-4H3,(H,43,44)/t34-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM431000 (US10550102, Example 42. b). (-)) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)OC)c12)C(O)=O Show InChI InChI=1S/C35H38N4O4/c1-4-31-29(34(40)41)21-36-39(31)32-10-6-9-30(37-32)28-8-5-7-24-11-14-27(33(24)28)20-25-12-13-26(19-22(25)2)23-15-17-38(18-16-23)35(42)43-3/h5-10,12-13,19,21,23,27H,4,11,14-18,20H2,1-3H3,(H,40,41)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	93	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM431001 (US10550102, Example 64-3) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OC(C)C)c(CC)c3)c12)C(O)=O |r| Show InChI InChI=1S/C37H42N4O5/c1-5-24-21-27(14-15-28(24)25-17-19-40(20-18-25)37(44)45-23(3)4)46-33-16-13-26-9-7-10-29(35(26)33)31-11-8-12-34(39-31)41-32(6-2)30(22-38-41)36(42)43/h7-12,14-15,21-23,25,33H,5-6,13,16-20H2,1-4H3,(H,42,43)/t33-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM431002 (US10550102, Example 42. b). (+)) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Cc3ccc(cc3C)C3CCN(CC3)C(=O)OC)c12)C(O)=O Show InChI InChI=1S/C35H38N4O4/c1-4-31-29(34(40)41)21-36-39(31)32-10-6-9-30(37-32)28-8-5-7-24-11-14-27(33(24)28)20-25-12-13-26(19-22(25)2)23-15-17-38(18-16-23)35(42)43-3/h5-10,12-13,19,21,23,27H,4,11,14-18,20H2,1-3H3,(H,40,41)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM431003 (US10550102, Example 64-4) Show SMILES CCCOC(=O)N1CCC(CC1)c1ccc(O[C@H]2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2CC)cc1CC |r| Show InChI InChI=1S/C37H42N4O5/c1-4-21-45-37(44)40-19-17-25(18-20-40)28-15-14-27(22-24(28)5-2)46-33-16-13-26-9-7-10-29(35(26)33)31-11-8-12-34(39-31)41-32(6-3)30(23-38-41)36(42)43/h7-12,14-15,22-23,25,33H,4-6,13,16-21H2,1-3H3,(H,42,43)/t33-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM431004 (US10550102, Example 43 (+)) Show SMILES Cc1cc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c2c(c1)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F Show InChI InChI=1S/C36H36F3N5O3/c1-20-16-25-9-11-30(41-28-10-8-24(18-21(28)2)22-12-14-43(15-13-22)34(45)23-6-7-23)32(25)26(17-20)29-4-3-5-31(42-29)44-33(36(37,38)39)27(19-40-44)35(46)47/h3-5,8,10,16-19,22-23,30,41H,6-7,9,11-15H2,1-2H3,(H,46,47)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM431005 (US10550102, Example 64-5) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OCC=C)c(CC)c3)c12)C(O)=O |r| Show InChI InChI=1S/C37H40N4O5/c1-4-21-45-37(44)40-19-17-25(18-20-40)28-15-14-27(22-24(28)5-2)46-33-16-13-26-9-7-10-29(35(26)33)31-11-8-12-34(39-31)41-32(6-3)30(23-38-41)36(42)43/h4,7-12,14-15,22-23,25,33H,1,5-6,13,16-21H2,2-3H3,(H,42,43)/t33-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM431006 (US10550102, Example 43 (-)) Show SMILES Cc1cc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c2c(c1)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F Show InChI InChI=1S/C36H36F3N5O3/c1-20-16-25-9-11-30(41-28-10-8-24(18-21(28)2)22-12-14-43(15-13-22)34(45)23-6-7-23)32(25)26(17-20)29-4-3-5-31(42-29)44-33(36(37,38)39)27(19-40-44)35(46)47/h3-5,8,10,16-19,22-23,30,41H,6-7,9,11-15H2,1-2H3,(H,46,47)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM431007 (US10550102, Example 64-6) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OCC4CC4)c(CC)c3)c12)C(O)=O |r| Show InChI InChI=1S/C38H42N4O5/c1-3-25-21-28(14-15-29(25)26-17-19-41(20-18-26)38(45)46-23-24-11-12-24)47-34-16-13-27-7-5-8-30(36(27)34)32-9-6-10-35(40-32)42-33(4-2)31(22-39-42)37(43)44/h5-10,14-15,21-22,24,26,34H,3-4,11-13,16-20,23H2,1-2H3,(H,43,44)/t34-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.40	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM431008 (US10550102, Example 44 (+)) Show SMILES Cc1c(cnn1-c1cccc(c1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O Show InChI InChI=1S/C36H38N4O3/c1-22-19-27(24-15-17-39(18-16-24)35(41)26-9-10-26)12-13-32(22)38-33-14-11-25-5-4-8-30(34(25)33)28-6-3-7-29(20-28)40-23(2)31(21-37-40)36(42)43/h3-8,12-13,19-21,24,26,33,38H,9-11,14-18H2,1-2H3,(H,42,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM431009 (US10550102, Example 64-7) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)C(=O)OC)c(CC)c3)c12)C(O)=O |r| Show InChI InChI=1S/C35H38N4O5/c1-4-22-20-25(13-14-26(22)23-16-18-38(19-17-23)35(42)43-3)44-31-15-12-24-8-6-9-27(33(24)31)29-10-7-11-32(37-29)39-30(5-2)28(21-36-39)34(40)41/h6-11,13-14,20-21,23,31H,4-5,12,15-19H2,1-3H3,(H,40,41)/t31-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM431010 (US10550102, Example 44 (-)) Show SMILES Cc1c(cnn1-c1cccc(c1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O Show InChI InChI=1S/C36H38N4O3/c1-22-19-27(24-15-17-39(18-16-24)35(41)26-9-10-26)12-13-32(22)38-33-14-11-25-5-4-8-30(34(25)33)28-6-3-7-29(20-28)40-23(2)31(21-37-40)36(42)43/h3-8,12-13,19-21,24,26,33,38H,9-11,14-18H2,1-2H3,(H,42,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	9.90	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM431011 (US10550102, Example 64-8) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CC[C@H](Oc3ccc(C4CCN(CC4)S(C)(=O)=O)c(CC)c3)c12)C(O)=O |r| Show InChI InChI=1S/C34H38N4O5S/c1-4-22-20-25(13-14-26(22)23-16-18-37(19-17-23)44(3,41)42)43-31-15-12-24-8-6-9-27(33(24)31)29-10-7-11-32(36-29)38-30(5-2)28(21-35-38)34(39)40/h6-11,13-14,20-21,23,31H,4-5,12,15-19H2,1-3H3,(H,39,40)/t31-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430635 (US10550102, Example (-)-1. b)) Show SMILES Cc1cc(ccc1OC1CCc2cccc(c12)-c1cccc(c1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1 Show InChI InChI=1S/C36H34F3N3O4/c1-21-18-25(22-14-16-41(17-15-22)34(43)24-8-9-24)11-12-30(21)46-31-13-10-23-4-3-7-28(32(23)31)26-5-2-6-27(19-26)42-33(36(37,38)39)29(20-40-42)35(44)45/h2-7,11-12,18-20,22,24,31H,8-10,13-17H2,1H3,(H,44,45)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430642 (US10550102, Example 7a) Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O Show InChI InChI=1S/C35H37N5O3/c1-21-19-26(23-15-17-39(18-16-23)34(41)25-9-10-25)12-13-29(21)37-31-14-11-24-5-3-6-27(33(24)31)30-7-4-8-32(38-30)40-22(2)28(20-36-40)35(42)43/h3-8,12-13,19-20,23,25,31,37H,9-11,14-18H2,1-2H3,(H,42,43)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430649 (US10550102, Example (+)-1. b)) Show SMILES Cc1cc(ccc1OC1CCc2cccc(c12)-c1cccc(c1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1 Show InChI InChI=1S/C36H34F3N3O4/c1-21-18-25(22-14-16-41(17-15-22)34(43)24-8-9-24)11-12-30(21)46-31-13-10-23-4-3-7-28(32(23)31)26-5-2-6-27(19-26)42-33(36(37,38)39)29(20-40-42)35(44)45/h2-7,11-12,18-20,22,24,31H,8-10,13-17H2,1H3,(H,44,45)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430673 (US10550102, Example 7b) Show SMILES CCOC(=O)c1cnn(c1C)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12 Show InChI InChI=1S/C37H41N5O3/c1-4-45-37(44)30-22-38-42(24(30)3)34-10-6-9-32(40-34)29-8-5-7-26-13-16-33(35(26)29)39-31-15-14-28(21-23(31)2)25-17-19-41(20-18-25)36(43)27-11-12-27/h5-10,14-15,21-22,25,27,33,39H,4,11-13,16-20H2,1-3H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430678 (Example 2-A. (+)-(S)-Ethyl-1-(3-(3-(4-(1-(cyclopro...) Show SMILES Cc1c(cnn1-c1cccc(c1)-c1cccc2CC[C@H](Oc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O |r| Show InChI InChI=1S/C36H37N3O4/c1-22-19-27(24-15-17-38(18-16-24)35(40)26-9-10-26)12-13-32(22)43-33-14-11-25-5-4-8-30(34(25)33)28-6-3-7-29(20-28)39-23(2)31(21-37-39)36(41)42/h3-8,12-13,19-21,24,26,33H,9-11,14-18H2,1-2H3,(H,41,42)/t33-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430679 (US10550102, Example (-)-8. b)) Show SMILES Cc1cc(ccc1NC1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1 Show InChI InChI=1S/C35H34F3N5O3/c1-20-18-24(21-14-16-42(17-15-21)33(44)23-8-9-23)11-12-27(20)40-29-13-10-22-4-2-5-25(31(22)29)28-6-3-7-30(41-28)43-32(35(36,37)38)26(19-39-43)34(45)46/h2-7,11-12,18-19,21,23,29,40H,8-10,13-17H2,1H3,(H,45,46)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	53	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430739 (US10550102, Example 3a) Show SMILES Cc1cc(ccc1OC1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1 Show InChI InChI=1S/C35H33F3N4O4/c1-20-18-24(21-14-16-41(17-15-21)33(43)23-8-9-23)11-12-28(20)46-29-13-10-22-4-2-5-25(31(22)29)27-6-3-7-30(40-27)42-32(35(36,37)38)26(19-39-42)34(44)45/h2-7,11-12,18-19,21,23,29H,8-10,13-17H2,1H3,(H,44,45)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430740 (US10550102, Example (+)-8. b)) Show SMILES Cc1cc(ccc1NC1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC1)C(=O)C1CC1 Show InChI InChI=1S/C35H34F3N5O3/c1-20-18-24(21-14-16-42(17-15-21)33(44)23-8-9-23)11-12-27(20)40-29-13-10-22-4-2-5-25(31(22)29)28-6-3-7-30(41-28)43-32(35(36,37)38)26(19-39-43)34(45)46/h2-7,11-12,18-19,21,23,29,40H,8-10,13-17H2,1H3,(H,45,46)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430859 (US10550102, Example 3b) Show SMILES CCOC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Oc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12 Show InChI InChI=1S/C37H37F3N4O4/c1-3-47-36(46)28-21-41-44(34(28)37(38,39)40)32-9-5-8-29(42-32)27-7-4-6-24-12-15-31(33(24)27)48-30-14-13-26(20-22(30)2)23-16-18-43(19-17-23)35(45)25-10-11-25/h4-9,13-14,20-21,23,25,31H,3,10-12,15-19H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.90	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430860 (US10550102, Example 9. b). (-)) Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O Show InChI InChI=1S/C34H35N5O3/c1-21-28(34(41)42)20-35-39(21)31-7-3-6-29(37-31)27-5-2-4-24-12-15-30(32(24)27)36-26-13-10-22(11-14-26)23-16-18-38(19-17-23)33(40)25-8-9-25/h2-7,10-11,13-14,20,23,25,30,36H,8-9,12,15-19H2,1H3,(H,41,42)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	184	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430861 (US10550102, Example 4a) Show SMILES OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Oc3ccc4CN(Cc5ccccn5)CCc4c3)c12 Show InChI InChI=1S/C34H28F3N5O3/c35-34(36,37)32-27(33(43)44)18-39-42(32)30-9-4-8-28(40-30)26-7-3-5-21-11-13-29(31(21)26)45-25-12-10-23-19-41(16-14-22(23)17-25)20-24-6-1-2-15-38-24/h1-10,12,15,17-18,29H,11,13-14,16,19-20H2,(H,43,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430862 (US10550102, Example 9. b). (+)) Show SMILES Cc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O Show InChI InChI=1S/C34H35N5O3/c1-21-28(34(41)42)20-35-39(21)31-7-3-6-29(37-31)27-5-2-4-24-12-15-30(32(24)27)36-26-13-10-22(11-14-26)23-16-18-38(19-17-23)33(40)25-8-9-25/h2-7,10-11,13-14,20,23,25,30,36H,8-9,12,15-19H2,1H3,(H,41,42)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430863 (US10550102, Example 4b) Show SMILES CCOC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Oc3ccc4CN(Cc5ccccn5)CCc4c3)c12 Show InChI InChI=1S/C36H32F3N5O3/c1-2-46-35(45)29-20-41-44(34(29)36(37,38)39)32-11-6-10-30(42-32)28-9-5-7-23-13-15-31(33(23)28)47-27-14-12-25-21-43(18-16-24(25)19-27)22-26-8-3-4-17-40-26/h3-12,14,17,19-20,31H,2,13,15-16,18,21-22H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	116	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430864 (US10550102, Example 10a) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12)C(O)=O Show InChI InChI=1S/C36H39N5O3/c1-3-32-28(36(43)44)21-37-41(32)33-9-5-8-30(39-33)27-7-4-6-24-12-15-31(34(24)27)38-29-14-13-26(20-22(29)2)23-16-18-40(19-17-23)35(42)25-10-11-25/h4-9,13-14,20-21,23,25,31,38H,3,10-12,15-19H2,1-2H3,(H,43,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430865 (US10550102, Example 5-1) Show SMILES Cc1cc2CCC(Oc3ccc4CN(Cc5ccccn5)CCc4c3)c2c(c1)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F Show InChI InChI=1S/C35H30F3N5O3/c1-21-15-23-9-11-30(46-26-10-8-24-19-42(14-12-22(24)17-26)20-25-5-2-3-13-39-25)32(23)27(16-21)29-6-4-7-31(41-29)43-33(35(36,37)38)28(18-40-43)34(44)45/h2-8,10,13,15-18,30H,9,11-12,14,19-20H2,1H3,(H,44,45)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	39	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430866 (US10550102, Example 10b) Show SMILES CCOC(=O)c1cnn(c1CC)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c12 Show InChI InChI=1S/C38H43N5O3/c1-4-34-30(38(45)46-5-2)23-39-43(34)35-11-7-10-32(41-35)29-9-6-8-26-14-17-33(36(26)29)40-31-16-15-28(22-24(31)3)25-18-20-42(21-19-25)37(44)27-12-13-27/h6-11,15-16,22-23,25,27,33,40H,4-5,12-14,17-21H2,1-3H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	49	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430867 (US10550102, Example 5-2) Show SMILES Cc1cc2CCC(Oc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c2c(c1)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F Show InChI InChI=1S/C36H35F3N4O4/c1-20-16-25-9-11-30(47-29-10-8-24(18-21(29)2)22-12-14-42(15-13-22)34(44)23-6-7-23)32(25)26(17-20)28-4-3-5-31(41-28)43-33(36(37,38)39)27(19-40-43)35(45)46/h3-5,8,10,16-19,22-23,30H,6-7,9,11-15H2,1-2H3,(H,45,46)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430868 (US10550102, Example 11-1) Show SMILES Cc1cc2CCC(Nc3ccc(cc3C)C3CCN(CC3)C(=O)C3CC3)c2c(c1)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F Show InChI InChI=1S/C36H36F3N5O3/c1-20-16-25-9-11-30(41-28-10-8-24(18-21(28)2)22-12-14-43(15-13-22)34(45)23-6-7-23)32(25)26(17-20)29-4-3-5-31(42-29)44-33(36(37,38)39)27(19-40-44)35(46)47/h3-5,8,10,16-19,22-23,30,41H,6-7,9,11-15H2,1-2H3,(H,46,47)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430869 (US10550102, Example 5-3) Show SMILES CCc1cc(O[C@H]2CCc3cccc(c23)-c2cccc(n2)-n2ncc(C(O)=O)c2C(F)(F)F)ccc1C1CCN(CC1)C(=O)C1CC1 |r| Show InChI InChI=1S/C36H35F3N4O4/c1-2-21-19-25(12-13-26(21)22-15-17-42(18-16-22)34(44)24-9-10-24)47-30-14-11-23-5-3-6-27(32(23)30)29-7-4-8-31(41-29)43-33(36(37,38)39)28(20-40-43)35(45)46/h3-8,12-13,19-20,22,24,30H,2,9-11,14-18H2,1H3,(H,45,46)/t30-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430870 (US10550102, Example 11-2) Show SMILES OC(=O)c1cnn(c1C(F)(F)F)-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3)C3CCN(CC3)C(=O)C3CC3)c12 Show InChI InChI=1S/C34H32F3N5O3/c35-34(36,37)31-26(33(44)45)19-38-42(31)29-6-2-5-27(40-29)25-4-1-3-22-11-14-28(30(22)25)39-24-12-9-20(10-13-24)21-15-17-41(18-16-21)32(43)23-7-8-23/h1-6,9-10,12-13,19,21,23,28,39H,7-8,11,14-18H2,(H,44,45)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430871 (US10550102, Example 5-4) Show SMILES Cc1cc(ccc1O[C@H]1CCc2cccc(c12)-c1cccc(n1)-n1ncc(C(O)=O)c1C(F)(F)F)C1CCN(CC(F)(F)F)CC1 |r| Show InChI InChI=1S/C33H30F6N4O3/c1-19-16-22(20-12-14-42(15-13-20)18-32(34,35)36)9-10-26(19)46-27-11-8-21-4-2-5-23(29(21)27)25-6-3-7-28(41-25)43-30(33(37,38)39)24(17-40-43)31(44)45/h2-7,9-10,16-17,20,27H,8,11-15,18H2,1H3,(H,44,45)/t27-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1/beta-1 (Homo sapiens (Human))	BDBM430872 (US10550102, Example 11-3) Show SMILES CCc1c(cnn1-c1cccc(n1)-c1cccc2CCC(Nc3ccc(cc3C)C3CCN(CC(F)(F)F)CC3)c12)C(O)=O Show InChI InChI=1S/C34H36F3N5O2/c1-3-30-26(33(43)44)19-38-42(30)31-9-5-8-28(40-31)25-7-4-6-23-10-13-29(32(23)25)39-27-12-11-24(18-21(27)2)22-14-16-41(17-15-22)20-34(35,36)37/h4-9,11-12,18-19,22,29,39H,3,10,13-17,20H2,1-2H3,(H,43,44)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.40	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description Chinese hamster ovary (CHO) cells overexpressing soluble guanylate cyclase were generated to test the effect of sGC activators in a cellular context....				US Patent US10550102 (2020) BindingDB Entry DOI: 10.7270/Q2PC34SQ
					More data for this Ligand-Target Pair

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