Found 92 hits with Last Name = 'procter' and Initial = 'mj' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362677
(CHEMBL1939618)Show SMILES Cn1c(OCC(C)(C)C(O)=O)nnc1-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C25H24N4O4/c1-25(2,23(31)32)15-33-24-28-27-21(29(24)3)17-10-12-20(13-11-17)26-22(30)19-9-8-16-6-4-5-7-18(16)14-19/h4-14H,15H2,1-3H3,(H,26,30)(H,31,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362678
(CHEMBL1939480)Show SMILES CCC(Sc1nnc(-c2ccc(NC(=O)c3ccc(Cl)c(Cl)c3)cc2)n1C)C(O)=O Show InChI InChI=1S/C20H18Cl2N4O3S/c1-3-16(19(28)29)30-20-25-24-17(26(20)2)11-4-7-13(8-5-11)23-18(27)12-6-9-14(21)15(22)10-12/h4-10,16H,3H2,1-2H3,(H,23,27)(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362683
(CHEMBL1939476)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3cc4ccccc4s3)cc2)n1C)C(O)=O Show InChI InChI=1S/C21H18N4O3S2/c1-12(20(27)28)29-21-24-23-18(25(21)2)13-7-9-15(10-8-13)22-19(26)17-11-14-5-3-4-6-16(14)30-17/h3-12H,1-2H3,(H,22,26)(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362685
(CHEMBL1939475)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C)C(O)=O Show InChI InChI=1S/C23H20N4O3S/c1-14(22(29)30)31-23-26-25-20(27(23)2)16-9-11-19(12-10-16)24-21(28)18-8-7-15-5-3-4-6-17(15)13-18/h3-14H,1-2H3,(H,24,28)(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362675
(CHEMBL1939620)Show SMILES Cn1c(OCC(C)(C)C(N)=O)nnc1-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C25H25N5O3/c1-25(2,23(26)32)15-33-24-29-28-21(30(24)3)17-10-12-20(13-11-17)27-22(31)19-9-8-16-6-4-5-7-18(16)14-19/h4-14H,15H2,1-3H3,(H2,26,32)(H,27,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362676
(CHEMBL1939621)Show SMILES CN(C)C(=O)C(C)(C)COc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C Show InChI InChI=1S/C27H29N5O3/c1-27(2,25(34)31(3)4)17-35-26-30-29-23(32(26)5)19-12-14-22(15-13-19)28-24(33)21-11-10-18-8-6-7-9-20(18)16-21/h6-16H,17H2,1-5H3,(H,28,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362667
(CHEMBL1939631)Show SMILES CC(C)(COc1ccc(cn1)-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1)C(O)=O Show InChI InChI=1S/C27H24N2O4/c1-27(2,26(31)32)17-33-24-14-11-22(16-28-24)19-9-12-23(13-10-19)29-25(30)21-8-7-18-5-3-4-6-20(18)15-21/h3-16H,17H2,1-2H3,(H,29,30)(H,31,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362680
(CHEMBL1939478)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)n1C)C(O)=O Show InChI InChI=1S/C20H18Cl2N4O3S/c1-11(19(28)29)30-20-25-24-18(26(20)2)13-4-6-14(7-5-13)23-17(27)10-12-3-8-15(21)16(22)9-12/h3-9,11H,10H2,1-2H3,(H,23,27)(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362672
(CHEMBL1939622)Show SMILES CC(C)NC(=O)C(C)(C)COc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C Show InChI InChI=1S/C28H31N5O3/c1-18(2)29-26(35)28(3,4)17-36-27-32-31-24(33(27)5)20-12-14-23(15-13-20)30-25(34)22-11-10-19-8-6-7-9-21(19)16-22/h6-16,18H,17H2,1-5H3,(H,29,35)(H,30,34) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362667
(CHEMBL1939631)Show SMILES CC(C)(COc1ccc(cn1)-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1)C(O)=O Show InChI InChI=1S/C27H24N2O4/c1-27(2,26(31)32)17-33-24-14-11-22(16-28-24)19-9-12-23(13-10-19)29-25(30)21-8-7-18-5-3-4-6-20(18)15-21/h3-16H,17H2,1-2H3,(H,29,30)(H,31,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362673
(CHEMBL1939624)Show SMILES CN(C)CCNC(=O)C(C)(C)COc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C Show InChI InChI=1S/C29H34N6O3/c1-29(2,27(37)30-16-17-34(3)4)19-38-28-33-32-25(35(28)5)21-12-14-24(15-13-21)31-26(36)23-11-10-20-8-6-7-9-22(20)18-23/h6-15,18H,16-17,19H2,1-5H3,(H,30,37)(H,31,36) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362666
(CHEMBL1939628)Show SMILES Cc1cc(NC(=O)c2ccc3ccccc3c2)ccc1-c1ccc(OCC(C)(C)C(O)=O)nc1 Show InChI InChI=1S/C28H26N2O4/c1-18-14-23(30-26(31)21-9-8-19-6-4-5-7-20(19)15-21)11-12-24(18)22-10-13-25(29-16-22)34-17-28(2,3)27(32)33/h4-16H,17H2,1-3H3,(H,30,31)(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362665
(CHEMBL1939632)Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1)C(O)=O Show InChI InChI=1S/C28H25NO4/c1-28(2,27(31)32)18-33-25-15-11-21(12-16-25)20-9-13-24(14-10-20)29-26(30)23-8-7-19-5-3-4-6-22(19)17-23/h3-17H,18H2,1-2H3,(H,29,30)(H,31,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 102 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362665
(CHEMBL1939632)Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1)C(O)=O Show InChI InChI=1S/C28H25NO4/c1-28(2,27(31)32)18-33-25-15-11-21(12-16-25)20-9-13-24(14-10-20)29-26(30)23-8-7-19-5-3-4-6-22(19)17-23/h3-17H,18H2,1-2H3,(H,29,30)(H,31,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 102 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362671
(CHEMBL1939623)Show SMILES Cn1c(OCC(C)(C)C(=O)Nc2ccccc2)nnc1-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C31H29N5O3/c1-31(2,29(38)33-25-11-5-4-6-12-25)20-39-30-35-34-27(36(30)3)22-15-17-26(18-16-22)32-28(37)24-14-13-21-9-7-8-10-23(21)19-24/h4-19H,20H2,1-3H3,(H,32,37)(H,33,38) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362669
(CHEMBL1939625)Show SMILES Cc1cc(NC(=O)c2ccc3ccccc3c2)ccc1-c1cnc(OCC(C)(C)C(O)=O)nc1 Show InChI InChI=1S/C27H25N3O4/c1-17-12-22(30-24(31)20-9-8-18-6-4-5-7-19(18)13-20)10-11-23(17)21-14-28-26(29-15-21)34-16-27(2,3)25(32)33/h4-15H,16H2,1-3H3,(H,30,31)(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362670
(CHEMBL1939627)Show SMILES Cc1cc(NC(=O)c2ccc3ccccc3c2)ccc1-c1cnc(OCC(C)(C)C(O)=O)cn1 Show InChI InChI=1S/C27H25N3O4/c1-17-12-21(30-25(31)20-9-8-18-6-4-5-7-19(18)13-20)10-11-22(17)23-14-29-24(15-28-23)34-16-27(2,3)26(32)33/h4-15H,16H2,1-3H3,(H,30,31)(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362666
(CHEMBL1939628)Show SMILES Cc1cc(NC(=O)c2ccc3ccccc3c2)ccc1-c1ccc(OCC(C)(C)C(O)=O)nc1 Show InChI InChI=1S/C28H26N2O4/c1-18-14-23(30-26(31)21-9-8-19-6-4-5-7-20(19)15-21)11-12-24(18)22-10-13-25(29-16-22)34-17-28(2,3)27(32)33/h4-16H,17H2,1-3H3,(H,30,31)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 125 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362687
(CHEMBL1939474)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3ccc(C)cc3)cc2)n1C)C(O)=O Show InChI InChI=1S/C20H20N4O3S/c1-12-4-6-15(7-5-12)18(25)21-16-10-8-14(9-11-16)17-22-23-20(24(17)3)28-13(2)19(26)27/h4-11,13H,1-3H3,(H,21,25)(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362679
(CHEMBL1939617)Show SMILES CC(Oc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C)C(O)=O Show InChI InChI=1S/C23H20N4O4/c1-14(22(29)30)31-23-26-25-20(27(23)2)16-9-11-19(12-10-16)24-21(28)18-8-7-15-5-3-4-6-17(15)13-18/h3-14H,1-2H3,(H,24,28)(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 144 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362674
(CHEMBL1939619)Show SMILES Cn1c(CCC(O)=O)nnc1-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C23H20N4O3/c1-27-20(12-13-21(28)29)25-26-22(27)16-8-10-19(11-9-16)24-23(30)18-7-6-15-4-2-3-5-17(15)14-18/h2-11,14H,12-13H2,1H3,(H,24,30)(H,28,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 167 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362671
(CHEMBL1939623)Show SMILES Cn1c(OCC(C)(C)C(=O)Nc2ccccc2)nnc1-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C31H29N5O3/c1-31(2,29(38)33-25-11-5-4-6-12-25)20-39-30-35-34-27(36(30)3)22-15-17-26(18-16-22)32-28(37)24-14-13-21-9-7-8-10-23(21)19-24/h4-19H,20H2,1-3H3,(H,32,37)(H,33,38) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362684
(CHEMBL1939477)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3ccc(Cl)c(Cl)c3)cc2)n1C)C(O)=O Show InChI InChI=1S/C19H16Cl2N4O3S/c1-10(18(27)28)29-19-24-23-16(25(19)2)11-3-6-13(7-4-11)22-17(26)12-5-8-14(20)15(21)9-12/h3-10H,1-2H3,(H,22,26)(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362682
(CHEMBL1939473)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3ccccc3)cc2)n1C)C(O)=O Show InChI InChI=1S/C19H18N4O3S/c1-12(18(25)26)27-19-22-21-16(23(19)2)13-8-10-15(11-9-13)20-17(24)14-6-4-3-5-7-14/h3-12H,1-2H3,(H,20,24)(H,25,26) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362668
(CHEMBL1939626)Show SMILES Cc1cc(NC(=O)c2ccc3ccccc3c2)ccc1-c1ccc(OCC(C)(C)C(O)=O)nn1 Show InChI InChI=1S/C27H25N3O4/c1-17-14-21(28-25(31)20-9-8-18-6-4-5-7-19(18)15-20)10-11-22(17)23-12-13-24(30-29-23)34-16-27(2,3)26(32)33/h4-15H,16H2,1-3H3,(H,28,31)(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 373 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362669
(CHEMBL1939625)Show SMILES Cc1cc(NC(=O)c2ccc3ccccc3c2)ccc1-c1cnc(OCC(C)(C)C(O)=O)nc1 Show InChI InChI=1S/C27H25N3O4/c1-17-12-22(30-24(31)20-9-8-18-6-4-5-7-19(18)13-20)10-11-23(17)21-14-28-26(29-15-21)34-16-27(2,3)25(32)33/h4-15H,16H2,1-3H3,(H,30,31)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 433 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362676
(CHEMBL1939621)Show SMILES CN(C)C(=O)C(C)(C)COc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C Show InChI InChI=1S/C27H29N5O3/c1-27(2,25(34)31(3)4)17-35-26-30-29-23(32(26)5)19-12-14-22(15-13-19)28-24(33)21-11-10-18-8-6-7-9-20(18)16-21/h6-16H,17H2,1-5H3,(H,28,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362688
(CHEMBL1939630)Show SMILES Cc1cc(NC(=O)c2ccc3ccccc3c2)ccc1-c1ccc(OCC(C)(C)C(O)=O)cc1 Show InChI InChI=1S/C29H27NO4/c1-19-16-24(30-27(31)23-9-8-20-6-4-5-7-22(20)17-23)12-15-26(19)21-10-13-25(14-11-21)34-18-29(2,3)28(32)33/h4-17H,18H2,1-3H3,(H,30,31)(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362668
(CHEMBL1939626)Show SMILES Cc1cc(NC(=O)c2ccc3ccccc3c2)ccc1-c1ccc(OCC(C)(C)C(O)=O)nn1 Show InChI InChI=1S/C27H25N3O4/c1-17-14-21(28-25(31)20-9-8-18-6-4-5-7-19(18)15-20)10-11-22(17)23-12-13-24(30-29-23)34-16-27(2,3)26(32)33/h4-15H,16H2,1-3H3,(H,28,31)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 709 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362686
(CHEMBL1939479)Show SMILES Cn1c(SC(C(O)=O)c2ccccc2)nnc1-c1ccc(NC(=O)c2ccc(Cl)c(Cl)c2)cc1 Show InChI InChI=1S/C24H18Cl2N4O3S/c1-30-21(28-29-24(30)34-20(23(32)33)14-5-3-2-4-6-14)15-7-10-17(11-8-15)27-22(31)16-9-12-18(25)19(26)13-16/h2-13,20H,1H3,(H,27,31)(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362677
(CHEMBL1939618)Show SMILES Cn1c(OCC(C)(C)C(O)=O)nnc1-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C25H24N4O4/c1-25(2,23(31)32)15-33-24-28-27-21(29(24)3)17-10-12-20(13-11-17)26-22(30)19-9-8-16-6-4-5-7-18(16)14-19/h4-14H,15H2,1-3H3,(H,26,30)(H,31,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362681
(CHEMBL1305904)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3ccccc3C)cc2)n1C)C(O)=O Show InChI InChI=1S/C20H20N4O3S/c1-12-6-4-5-7-16(12)18(25)21-15-10-8-14(9-11-15)17-22-23-20(24(17)3)28-13(2)19(26)27/h4-11,13H,1-3H3,(H,21,25)(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362670
(CHEMBL1939627)Show SMILES Cc1cc(NC(=O)c2ccc3ccccc3c2)ccc1-c1cnc(OCC(C)(C)C(O)=O)cn1 Show InChI InChI=1S/C27H25N3O4/c1-17-12-21(30-25(31)20-9-8-18-6-4-5-7-19(18)13-20)10-11-22(17)23-14-29-24(15-28-23)34-16-27(2,3)26(32)33/h4-15H,16H2,1-3H3,(H,30,31)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362672
(CHEMBL1939622)Show SMILES CC(C)NC(=O)C(C)(C)COc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C Show InChI InChI=1S/C28H31N5O3/c1-18(2)29-26(35)28(3,4)17-36-27-32-31-24(33(27)5)20-12-14-23(15-13-20)30-25(34)22-11-10-19-8-6-7-9-21(19)16-22/h6-16,18H,17H2,1-5H3,(H,29,35)(H,30,34) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50362689
(CHEMBL1939629)Show SMILES Cc1cc(NC(=O)c2ccc3ccccc3c2)ccc1-c1ccc(OCC(C)(C)C(O)=O)cn1 Show InChI InChI=1S/C28H26N2O4/c1-18-14-22(30-26(31)21-9-8-19-6-4-5-7-20(19)15-21)10-12-24(18)25-13-11-23(16-29-25)34-17-28(2,3)27(32)33/h4-16H,17H2,1-3H3,(H,30,31)(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362674
(CHEMBL1939619)Show SMILES Cn1c(CCC(O)=O)nnc1-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C23H20N4O3/c1-27-20(12-13-21(28)29)25-26-22(27)16-8-10-19(11-9-16)24-23(30)18-7-6-15-4-2-3-5-17(15)14-18/h2-11,14H,12-13H2,1H3,(H,24,30)(H,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362673
(CHEMBL1939624)Show SMILES CN(C)CCNC(=O)C(C)(C)COc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C Show InChI InChI=1S/C29H34N6O3/c1-29(2,27(37)30-16-17-34(3)4)19-38-28-33-32-25(35(28)5)21-12-14-24(15-13-21)31-26(36)23-11-10-20-8-6-7-9-22(20)18-23/h6-15,18H,16-17,19H2,1-5H3,(H,30,37)(H,31,36) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362675
(CHEMBL1939620)Show SMILES Cn1c(OCC(C)(C)C(N)=O)nnc1-c1ccc(NC(=O)c2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C25H25N5O3/c1-25(2,23(26)32)15-33-24-29-28-21(30(24)3)17-10-12-20(13-11-17)27-22(31)19-9-8-16-6-4-5-7-18(16)14-19/h4-14H,15H2,1-3H3,(H2,26,32)(H,27,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362679
(CHEMBL1939617)Show SMILES CC(Oc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C)C(O)=O Show InChI InChI=1S/C23H20N4O4/c1-14(22(29)30)31-23-26-25-20(27(23)2)16-9-11-19(12-10-16)24-21(28)18-8-7-15-5-3-4-6-17(15)13-18/h3-14H,1-2H3,(H,24,28)(H,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362680
(CHEMBL1939478)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)n1C)C(O)=O Show InChI InChI=1S/C20H18Cl2N4O3S/c1-11(19(28)29)30-20-25-24-18(26(20)2)13-4-6-14(7-5-13)23-17(27)10-12-3-8-15(21)16(22)9-12/h3-9,11H,10H2,1-2H3,(H,23,27)(H,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362687
(CHEMBL1939474)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3ccc(C)cc3)cc2)n1C)C(O)=O Show InChI InChI=1S/C20H20N4O3S/c1-12-4-6-15(7-5-12)18(25)21-16-10-8-14(9-11-16)17-22-23-20(24(17)3)28-13(2)19(26)27/h4-11,13H,1-3H3,(H,21,25)(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362678
(CHEMBL1939480)Show SMILES CCC(Sc1nnc(-c2ccc(NC(=O)c3ccc(Cl)c(Cl)c3)cc2)n1C)C(O)=O Show InChI InChI=1S/C20H18Cl2N4O3S/c1-3-16(19(28)29)30-20-25-24-17(26(20)2)11-4-7-13(8-5-11)23-18(27)12-6-9-14(21)15(22)10-12/h4-10,16H,3H2,1-2H3,(H,23,27)(H,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 2
(Homo sapiens (Human)) | BDBM50362682
(CHEMBL1939473)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3ccccc3)cc2)n1C)C(O)=O Show InChI InChI=1S/C19H18N4O3S/c1-12(18(25)26)27-19-22-21-16(23(19)2)13-8-10-15(11-9-13)20-17(24)14-6-4-3-5-7-14/h3-12H,1-2H3,(H,20,24)(H,25,26) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminus FLAG-tagged DGAT2 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362681
(CHEMBL1305904)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3ccccc3C)cc2)n1C)C(O)=O Show InChI InChI=1S/C20H20N4O3S/c1-12-6-4-5-7-16(12)18(25)21-15-10-8-14(9-11-15)17-22-23-20(24(17)3)28-13(2)19(26)27/h4-11,13H,1-3H3,(H,21,25)(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362683
(CHEMBL1939476)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3cc4ccccc4s3)cc2)n1C)C(O)=O Show InChI InChI=1S/C21H18N4O3S2/c1-12(20(27)28)29-21-24-23-18(25(21)2)13-7-9-15(10-8-13)22-19(26)17-11-14-5-3-4-6-16(14)30-17/h3-12H,1-2H3,(H,22,26)(H,27,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362684
(CHEMBL1939477)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3ccc(Cl)c(Cl)c3)cc2)n1C)C(O)=O Show InChI InChI=1S/C19H16Cl2N4O3S/c1-10(18(27)28)29-19-24-23-16(25(19)2)11-3-6-13(7-4-11)22-17(26)12-5-8-14(20)15(21)9-12/h3-10H,1-2H3,(H,22,26)(H,27,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362685
(CHEMBL1939475)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3ccc4ccccc4c3)cc2)n1C)C(O)=O Show InChI InChI=1S/C23H20N4O3S/c1-14(22(29)30)31-23-26-25-20(27(23)2)16-9-11-19(12-10-16)24-21(28)18-8-7-15-5-3-4-6-17(15)13-18/h3-14H,1-2H3,(H,24,28)(H,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362686
(CHEMBL1939479)Show SMILES Cn1c(SC(C(O)=O)c2ccccc2)nnc1-c1ccc(NC(=O)c2ccc(Cl)c(Cl)c2)cc1 Show InChI InChI=1S/C24H18Cl2N4O3S/c1-30-21(28-29-24(30)34-20(23(32)33)14-5-3-2-4-6-14)15-7-10-17(11-8-15)27-22(31)16-9-12-18(25)19(26)13-16/h2-13,20H,1H3,(H,27,31)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Mus musculus (mouse)) | BDBM50362682
(CHEMBL1939473)Show SMILES CC(Sc1nnc(-c2ccc(NC(=O)c3ccccc3)cc2)n1C)C(O)=O Show InChI InChI=1S/C19H18N4O3S/c1-12(18(25)26)27-19-22-21-16(23(19)2)13-8-10-15(11-9-13)20-17(24)14-6-4-3-5-7-14/h3-12H,1-2H3,(H,20,24)(H,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Prosidion Ltd
Curated by ChEMBL
| Assay Description
Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells |
Bioorg Med Chem Lett 22: 824-8 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.050
BindingDB Entry DOI: 10.7270/Q2R211V4 |
More data for this
Ligand-Target Pair | |
Hexokinase-4
(Rattus norvegicus) | BDBM50161688
(3-(5-Chloro-thiazol-2-yl)-1-(4-methanesulfonyl-phe...)Show SMILES CS(=O)(=O)c1ccc(cc1)N(Cc1cccs1)C(=O)Nc1ncc(Cl)s1 Show InChI InChI=1S/C16H14ClN3O3S3/c1-26(22,23)13-6-4-11(5-7-13)20(10-12-3-2-8-24-12)16(21)19-15-18-9-14(17)25-15/h2-9H,10H2,1H3,(H,18,19,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a |
OSI Pharmaceuticals
Curated by ChEMBL
| Assay Description
Effective concentration for glucokinase activation with 5 mM glucose |
Bioorg Med Chem Lett 15: 1501-4 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.083
BindingDB Entry DOI: 10.7270/Q2HT2NVC |
More data for this
Ligand-Target Pair | |
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