Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50586288 (CHEMBL5070753) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to PPARgamma (unknown origin) by lanthascreen TR-FRET assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00715 BindingDB Entry DOI: 10.7270/Q2H135XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50030474 (Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to PPARgamma (unknown origin) by lanthascreen TR-FRET assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00715 BindingDB Entry DOI: 10.7270/Q2H135XX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM147253 (US8957093, 73) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to PPARgamma (unknown origin) by lanthascreen TR-FRET assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00715 BindingDB Entry DOI: 10.7270/Q2H135XX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50586288 (CHEMBL5070753) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of PPARgamma (unknown origin) phosphorylation at pS273 residue | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00715 BindingDB Entry DOI: 10.7270/Q2H135XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM147253 (US8957093, 73) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of PPARgamma (unknown origin) phosphorylation at pS273 residue | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00715 BindingDB Entry DOI: 10.7270/Q2H135XX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50030474 (Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of PPARgamma (unknown origin) phosphorylation at pS273 residue | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00715 BindingDB Entry DOI: 10.7270/Q2H135XX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cytochrome P450 2C9 (Homo sapiens (Human)) | BDBM50586288 (CHEMBL5070753) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human CYP2C9 preincubated for 10 mins followed by NADPH addition and measured at 20 to 50 mins by LC-MS/MS analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00715 BindingDB Entry DOI: 10.7270/Q2H135XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor SOX-18 (Mus musculus (Mouse)) | BDBM223293 (Sm4 | US20240002326, Compound Sm4) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.75E+4 | n/a | n/a | n/a | n/a | 7.5 | 37 |
The University of Queensland | Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha... | Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor SOX-18 (Mus musculus (Mouse)) | BDBM223299 (Sm14 | US20240002326, Compound Sm14) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
The University of Queensland | Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha... | Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor SOX-18 (Mus musculus (Mouse)) | BDBM22971 (2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.63E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
The University of Queensland | Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha... | Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor SOX-18 (Mus musculus (Mouse)) | BDBM17636 (2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.20E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
The University of Queensland | Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha... | Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor SOX-18 (Mus musculus (Mouse)) | BDBM223295 (Sm8 | US20240002326, Compound Sm8) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.27E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
The University of Queensland | Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha... | Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor SOX-18 (Mus musculus (Mouse)) | BDBM50259931 (6-Tridecylsalicylic acid (Sm2) | 6-tridecyl phenol...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.41E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
The University of Queensland | Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha... | Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor SOX-18 (Mus musculus (Mouse)) | BDBM223292 (6-Undecylsalicylic acid (Sm1) | US20240002326, Com...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.48E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
The University of Queensland | Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha... | Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor SOX-18 (Mus musculus (Mouse)) | BDBM85507 (CAS_4394-00-7 | NSC_4488 | Niflumic acid | Niflumi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 3.75E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
The University of Queensland | Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha... | Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor SOX-18 (Mus musculus (Mouse)) | BDBM223298 (Sm13 | US20240002326, Compound Sm13) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.81E+5 | n/a | n/a | n/a | n/a | 7.5 | 37 |
The University of Queensland | Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha... | Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor SOX-18 (Mus musculus (Mouse)) | BDBM223294 (Sm5) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.11E+6 | n/a | n/a | n/a | n/a | 7.5 | 37 |
The University of Queensland | Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha... | Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor SOX-18 (Mus musculus (Mouse)) | BDBM223297 (Sm12 | US20240002326, Compound Sm12) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.88E+6 | n/a | n/a | n/a | n/a | 7.5 | 37 |
The University of Queensland | Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha... | Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription factor SOX-18 (Mus musculus (Mouse)) | BDBM223296 (Sm11 | US20240002326, Compound Sm11) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.80E+6 | n/a | n/a | n/a | n/a | 7.5 | 37 |
The University of Queensland | Assay Description The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha... | Cell Chem Biol 24: 346-359 (2017) Article DOI: 10.1016/j.chembiol.2017.01.003 BindingDB Entry DOI: 10.7270/Q2MP5252 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50030474 (Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at Gal4-fused PPARgamma (unknown origin) expressed in human U2OS cells co-transfected with pSG5 expression vector preincubated for 4... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00715 BindingDB Entry DOI: 10.7270/Q2H135XX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50586288 (CHEMBL5070753) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at Gal4-fused PPARgamma (unknown origin) expressed in human U2OS cells co-transfected with pSG5 expression vector preincubated for 4... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00715 BindingDB Entry DOI: 10.7270/Q2H135XX | |||||||||||
More data for this Ligand-Target Pair |