Compile Data Set for Download or QSAR

Found 107 hits with Last Name = 'riegler' and Initial = 'e'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545768 (CHEMBL4641127) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCNC(C)=O)C1 |r| Show InChI InChI=1S/C26H33Cl2N7O/c1-16-25-26(35(32-16)17(2)22-7-6-21(27)11-23(22)28)31-24(12-30-25)34-14-20(15-34)19-5-4-9-33(13-19)10-8-29-18(3)36/h6-7,11-12,17,19-20H,4-5,8-10,13-15H2,1-3H3,(H,29,36)/t17-,19+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545779 (CHEMBL4642563) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCO)C1 |r| Show InChI InChI=1S/C24H29Cl2N7O2/c1-14(18-5-4-17(25)9-19(18)26)33-24-22(21(30-33)23(27)35)28-10-20(29-24)32-12-16(13-32)15-3-2-6-31(11-15)7-8-34/h4-5,9-10,14-16,34H,2-3,6-8,11-13H2,1H3,(H2,27,35)/t14-,15+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545782 (CHEMBL4637695) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(=O)N(C)C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCO)C1 |r| Show InChI InChI=1S/C26H33Cl2N7O2/c1-16(20-7-6-19(27)11-21(20)28)35-25-23(24(31-35)26(37)32(2)3)29-12-22(30-25)34-14-18(15-34)17-5-4-8-33(13-17)9-10-36/h6-7,11-12,16-18,36H,4-5,8-10,13-15H2,1-3H3/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545769 (CHEMBL4645325) Show SMILES CC(C)C(=O)NCCN1CCC[C@@H](C1)C1CN(C1)c1cnc2c(C)nn([C@H](C)c3ccc(Cl)cc3Cl)c2n1 |r| Show InChI InChI=1S/C28H37Cl2N7O/c1-17(2)28(38)31-9-11-35-10-5-6-20(14-35)21-15-36(16-21)25-13-32-26-18(3)34-37(27(26)33-25)19(4)23-8-7-22(29)12-24(23)30/h7-8,12-13,17,19-21H,5-6,9-11,14-16H2,1-4H3,(H,31,38)/t19-,20+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545771 (CHEMBL4639600) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(Cc2cnc[nH]2)C1 |r| Show InChI InChI=1S/C26H27Cl2N9/c1-16(21-5-4-19(27)7-22(21)28)37-26-25(23(8-29)34-37)31-10-24(33-26)36-12-18(13-36)17-3-2-6-35(11-17)14-20-9-30-15-32-20/h4-5,7,9-10,15-18H,2-3,6,11-14H2,1H3,(H,30,32)/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545778 (CHEMBL4637143) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCO)C1 |r| Show InChI InChI=1S/C24H27Cl2N7O/c1-15(19-5-4-18(25)9-20(19)26)33-24-23(21(10-27)30-33)28-11-22(29-24)32-13-17(14-32)16-3-2-6-31(12-16)7-8-34/h4-5,9,11,15-17,34H,2-3,6-8,12-14H2,1H3/t15-,16+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545762 (CHEMBL4647117) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCCS(C)(=O)=O)C1 |r| Show InChI InChI=1S/C26H34Cl2N6O2S/c1-17-25-26(34(31-17)18(2)22-8-7-21(27)12-23(22)28)30-24(13-29-25)33-15-20(16-33)19-6-4-9-32(14-19)10-5-11-37(3,35)36/h7-8,12-13,18-20H,4-6,9-11,14-16H2,1-3H3/t18-,19+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545770 (CHEMBL4641595) Show SMILES COC(=O)NCCN1CCC[C@@H](C1)C1CN(C1)c1cnc2c(C)nn([C@H](C)c3ccc(Cl)cc3Cl)c2n1 |r| Show InChI InChI=1S/C26H33Cl2N7O2/c1-16-24-25(35(32-16)17(2)21-7-6-20(27)11-22(21)28)31-23(12-30-24)34-14-19(15-34)18-5-4-9-33(13-18)10-8-29-26(36)37-3/h6-7,11-12,17-19H,4-5,8-10,13-15H2,1-3H3,(H,29,36)/t17-,18+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545777 (CHEMBL4634054) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCO)C1 |r| Show InChI InChI=1S/C24H30Cl2N6O/c1-15-23-24(32(29-15)16(2)20-6-5-19(25)10-21(20)26)28-22(11-27-23)31-13-18(14-31)17-4-3-7-30(12-17)8-9-33/h5-6,10-11,16-18,33H,3-4,7-9,12-14H2,1-2H3/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545781 (CHEMBL4633133) Show SMILES CNC(=O)c1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(cnc12)N1CC(C1)[C@H]1CCCN(CCO)C1 |r| Show InChI InChI=1S/C25H31Cl2N7O2/c1-15(19-6-5-18(26)10-20(19)27)34-24-22(23(31-34)25(36)28-2)29-11-21(30-24)33-13-17(14-33)16-4-3-7-32(12-16)8-9-35/h5-6,10-11,15-17,35H,3-4,7-9,12-14H2,1-2H3,(H,28,36)/t15-,16+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545773 (CHEMBL4633494) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCC#N)C1 |r| Show InChI InChI=1S/C25H26Cl2N8/c1-16(20-6-5-19(26)10-21(20)27)35-25-24(22(11-29)32-35)30-12-23(31-25)34-14-18(15-34)17-4-2-8-33(13-17)9-3-7-28/h5-6,10,12,16-18H,2-4,8-9,13-15H2,1H3/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545759 (CHEMBL4647188) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCNS(C)(=O)=O)C1 |r| Show InChI InChI=1S/C25H33Cl2N7O2S/c1-16-24-25(34(31-16)17(2)21-7-6-20(26)11-22(21)27)30-23(12-28-24)33-14-19(15-33)18-5-4-9-32(13-18)10-8-29-37(3,35)36/h6-7,11-12,17-19,29H,4-5,8-10,13-15H2,1-3H3/t17-,18+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545760 (CHEMBL4636749) Show SMILES CC(C)S(=O)(=O)NCCN1CCC[C@@H](C1)C1CN(C1)c1cnc2c(C)nn([C@H](C)c3ccc(Cl)cc3Cl)c2n1 |r| Show InChI InChI=1S/C27H37Cl2N7O2S/c1-17(2)39(37,38)31-9-11-34-10-5-6-20(14-34)21-15-35(16-21)25-13-30-26-18(3)33-36(27(26)32-25)19(4)23-8-7-22(28)12-24(23)29/h7-8,12-13,17,19-21,31H,5-6,9-11,14-16H2,1-4H3/t19-,20+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545778 (CHEMBL4637143) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCO)C1 |r| Show InChI InChI=1S/C24H27Cl2N7O/c1-15(19-5-4-18(25)9-20(19)26)33-24-23(21(10-27)30-33)28-11-22(29-24)32-13-17(14-32)16-3-2-6-31(12-16)7-8-34/h4-5,9,11,15-17,34H,2-3,6-8,12-14H2,1H3/t15-,16+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 additi...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545766 (CHEMBL4645037) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CC(O)=O)C1 |r| Show InChI InChI=1S/C24H25Cl2N7O2/c1-14(18-5-4-17(25)7-19(18)26)33-24-23(20(8-27)30-33)28-9-21(29-24)32-11-16(12-32)15-3-2-6-31(10-15)13-22(34)35/h4-5,7,9,14-16H,2-3,6,10-13H2,1H3,(H,34,35)/t14-,15+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545779 (CHEMBL4642563) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCO)C1 |r| Show InChI InChI=1S/C24H29Cl2N7O2/c1-14(18-5-4-17(25)9-19(18)26)33-24-22(21(30-33)23(27)35)28-10-20(29-24)32-12-16(13-32)15-3-2-6-31(11-15)7-8-34/h4-5,9-10,14-16,34H,2-3,6-8,11-13H2,1H3,(H2,27,35)/t14-,15+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545776 (CHEMBL4641873) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCCO)C1 |r| Show InChI InChI=1S/C25H32Cl2N6O/c1-16-24-25(33(30-16)17(2)21-7-6-20(26)11-22(21)27)29-23(12-28-24)32-14-19(15-32)18-5-3-8-31(13-18)9-4-10-34/h6-7,11-12,17-19,34H,3-5,8-10,13-15H2,1-2H3/t17-,18+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Mus musculus)	BDBM50545778 (CHEMBL4637143) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCO)C1 |r| Show InChI InChI=1S/C24H27Cl2N7O/c1-15(19-5-4-18(25)9-20(19)26)33-24-23(21(10-27)30-33)28-11-22(29-24)32-13-17(14-32)16-3-2-6-31(12-16)7-8-34/h4-5,9,11,15-17,34H,2-3,6-8,12-14H2,1H3/t15-,16+/m1/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 additi...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545768 (CHEMBL4641127) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCNC(C)=O)C1 |r| Show InChI InChI=1S/C26H33Cl2N7O/c1-16-25-26(35(32-16)17(2)22-7-6-21(27)11-23(22)28)31-24(12-30-25)34-14-20(15-34)19-5-4-9-33(13-19)10-8-29-18(3)36/h6-7,11-12,17,19-20H,4-5,8-10,13-15H2,1-3H3,(H,29,36)/t17-,19+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545767 (CHEMBL4640439) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCC(N)=O)C1 |r| Show InChI InChI=1S/C25H31Cl2N7O/c1-15-24-25(34(31-15)16(2)20-6-5-19(26)10-21(20)27)30-23(11-29-24)33-13-18(14-33)17-4-3-8-32(12-17)9-7-22(28)35/h5-6,10-11,16-18H,3-4,7-9,12-14H2,1-2H3,(H2,28,35)/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545765 (CHEMBL4639418) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCC(O)=O)C1 |r| Show InChI InChI=1S/C25H27Cl2N7O2/c1-15(19-5-4-18(26)9-20(19)27)34-25-24(21(10-28)31-34)29-11-22(30-25)33-13-17(14-33)16-3-2-7-32(12-16)8-6-23(35)36/h4-5,9,11,15-17H,2-3,6-8,12-14H2,1H3,(H,35,36)/t15-,16+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545778 (CHEMBL4637143) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCO)C1 |r| Show InChI InChI=1S/C24H27Cl2N7O/c1-15(19-5-4-18(25)9-20(19)26)33-24-23(21(10-27)30-33)28-11-22(29-24)32-13-17(14-32)16-3-2-6-31(12-16)7-8-34/h4-5,9,11,15-17,34H,2-3,6-8,12-14H2,1H3/t15-,16+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545769 (CHEMBL4645325) Show SMILES CC(C)C(=O)NCCN1CCC[C@@H](C1)C1CN(C1)c1cnc2c(C)nn([C@H](C)c3ccc(Cl)cc3Cl)c2n1 |r| Show InChI InChI=1S/C28H37Cl2N7O/c1-17(2)28(38)31-9-11-35-10-5-6-20(14-35)21-15-36(16-21)25-13-32-26-18(3)34-37(27(26)33-25)19(4)23-8-7-22(29)12-24(23)30/h7-8,12-13,17,19-21H,5-6,9-11,14-16H2,1-4H3,(H,31,38)/t19-,20+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545778 (CHEMBL4637143) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCO)C1 |r| Show InChI InChI=1S/C24H27Cl2N7O/c1-15(19-5-4-18(25)9-20(19)26)33-24-23(21(10-27)30-33)28-11-22(29-24)32-13-17(14-32)16-3-2-6-31(12-16)7-8-34/h4-5,9,11,15-17,34H,2-3,6-8,12-14H2,1H3/t15-,16+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL17-mediated chemotaxis preincubated for 30 mins followed by CCL17 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545763 (CHEMBL4638846) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCCC(O)=O)C1 |r| Show InChI InChI=1S/C26H32Cl2N6O2/c1-16-25-26(34(31-16)17(2)21-8-7-20(27)11-22(21)28)30-23(12-29-25)33-14-19(15-33)18-5-3-9-32(13-18)10-4-6-24(35)36/h7-8,11-12,17-19H,3-6,9-10,13-15H2,1-2H3,(H,35,36)/t17-,18+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545777 (CHEMBL4634054) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCO)C1 |r| Show InChI InChI=1S/C24H30Cl2N6O/c1-15-23-24(32(29-15)16(2)20-6-5-19(25)10-21(20)26)28-22(11-27-23)31-13-18(14-31)17-4-3-7-30(12-17)8-9-33/h5-6,10-11,16-18,33H,3-4,7-9,12-14H2,1-2H3/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545761 (CHEMBL4633920) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCS(C)(=O)=O)C1 |r| Show InChI InChI=1S/C25H32Cl2N6O2S/c1-16-24-25(33(30-16)17(2)21-7-6-20(26)11-22(21)27)29-23(12-28-24)32-14-19(15-32)18-5-4-8-31(13-18)9-10-36(3,34)35/h6-7,11-12,17-19H,4-5,8-10,13-15H2,1-3H3/t17-,18+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545758 (CHEMBL4643609) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCS(N)(=O)=O)C1 |r| Show InChI InChI=1S/C24H31Cl2N7O2S/c1-15-23-24(33(30-15)16(2)20-6-5-19(25)10-21(20)26)29-22(11-28-23)32-13-18(14-32)17-4-3-7-31(12-17)8-9-36(27,34)35/h5-6,10-11,16-18H,3-4,7-9,12-14H2,1-2H3,(H2,27,34,35)/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545764 (CHEMBL4643158) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCC(O)=O)C1 |r| Show InChI InChI=1S/C25H30Cl2N6O2/c1-15-24-25(33(30-15)16(2)20-6-5-19(26)10-21(20)27)29-22(11-28-24)32-13-18(14-32)17-4-3-8-31(12-17)9-7-23(34)35/h5-6,10-11,16-18H,3-4,7-9,12-14H2,1-2H3,(H,34,35)/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545771 (CHEMBL4639600) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(Cc2cnc[nH]2)C1 |r| Show InChI InChI=1S/C26H27Cl2N9/c1-16(21-5-4-19(27)7-22(21)28)37-26-25(23(8-29)34-37)31-10-24(33-26)36-12-18(13-36)17-3-2-6-35(11-17)14-20-9-30-15-32-20/h4-5,7,9-10,15-18H,2-3,6,11-14H2,1H3,(H,30,32)/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545776 (CHEMBL4641873) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCCO)C1 |r| Show InChI InChI=1S/C25H32Cl2N6O/c1-16-24-25(33(30-16)17(2)21-7-6-20(26)11-22(21)27)29-23(12-28-24)32-14-19(15-32)18-5-3-8-31(13-18)9-4-10-34/h6-7,11-12,17-19,34H,3-5,8-10,13-15H2,1-2H3/t17-,18+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545760 (CHEMBL4636749) Show SMILES CC(C)S(=O)(=O)NCCN1CCC[C@@H](C1)C1CN(C1)c1cnc2c(C)nn([C@H](C)c3ccc(Cl)cc3Cl)c2n1 |r| Show InChI InChI=1S/C27H37Cl2N7O2S/c1-17(2)39(37,38)31-9-11-34-10-5-6-20(14-34)21-15-35(16-21)25-13-30-26-18(3)33-36(27(26)32-25)19(4)23-8-7-22(28)12-24(23)29/h7-8,12-13,17,19-21,31H,5-6,9-11,14-16H2,1-4H3/t19-,20+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	115	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545783 (CHEMBL4649666) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)C1CCCN(CCS(N)(=O)=O)C1 |r| Show InChI InChI=1S/C24H31Cl2N7O2S/c1-15-23-24(33(30-15)16(2)20-6-5-19(25)10-21(20)26)29-22(11-28-23)32-13-18(14-32)17-4-3-7-31(12-17)8-9-36(27,34)35/h5-6,10-11,16-18H,3-4,7-9,12-14H2,1-2H3,(H2,27,34,35)/t16-,17?/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	121	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545770 (CHEMBL4641595) Show SMILES COC(=O)NCCN1CCC[C@@H](C1)C1CN(C1)c1cnc2c(C)nn([C@H](C)c3ccc(Cl)cc3Cl)c2n1 |r| Show InChI InChI=1S/C26H33Cl2N7O2/c1-16-24-25(35(32-16)17(2)21-7-6-20(27)11-22(21)28)31-23(12-30-24)34-14-19(15-34)18-5-4-9-33(13-18)10-8-29-26(36)37-3/h6-7,11-12,17-19H,4-5,8-10,13-15H2,1-3H3,(H,29,36)/t17-,18+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	133	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545759 (CHEMBL4647188) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCNS(C)(=O)=O)C1 |r| Show InChI InChI=1S/C25H33Cl2N7O2S/c1-16-24-25(34(31-16)17(2)21-7-6-20(26)11-22(21)27)30-23(12-28-24)33-14-19(15-33)18-5-4-9-32(13-18)10-8-29-37(3,35)36/h6-7,11-12,17-19,29H,4-5,8-10,13-15H2,1-3H3/t17-,18+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	136	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545767 (CHEMBL4640439) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCC(N)=O)C1 |r| Show InChI InChI=1S/C25H31Cl2N7O/c1-15-24-25(34(31-15)16(2)20-6-5-19(26)10-21(20)27)30-23(11-29-24)33-13-18(14-33)17-4-3-8-32(12-17)9-7-22(28)35/h5-6,10-11,16-18H,3-4,7-9,12-14H2,1-2H3,(H2,28,35)/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	247	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545762 (CHEMBL4647117) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCCS(C)(=O)=O)C1 |r| Show InChI InChI=1S/C26H34Cl2N6O2S/c1-17-25-26(34(31-17)18(2)22-8-7-21(27)12-23(22)28)30-24(13-29-25)33-15-20(16-33)19-6-4-9-32(14-19)10-5-11-37(3,35)36/h7-8,12-13,18-20H,4-6,9-11,14-16H2,1-3H3/t18-,19+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	259	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545764 (CHEMBL4643158) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCC(O)=O)C1 |r| Show InChI InChI=1S/C25H30Cl2N6O2/c1-15-24-25(33(30-15)16(2)20-6-5-19(26)10-21(20)27)29-22(11-28-24)32-13-18(14-32)17-4-3-8-31(12-17)9-7-23(34)35/h5-6,10-11,16-18H,3-4,7-9,12-14H2,1-2H3,(H,34,35)/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545775 (CHEMBL4640909) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCC(F)(F)F)C1 |r| Show InChI InChI=1S/C25H26Cl2F3N7/c1-15(19-5-4-18(26)9-20(19)27)37-24-23(21(10-31)34-37)32-11-22(33-24)36-13-17(14-36)16-3-2-7-35(12-16)8-6-25(28,29)30/h4-5,9,11,15-17H,2-3,6-8,12-14H2,1H3/t15-,16+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545782 (CHEMBL4637695) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(=O)N(C)C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCO)C1 |r| Show InChI InChI=1S/C26H33Cl2N7O2/c1-16(20-7-6-19(27)11-21(20)28)35-25-23(24(31-35)26(37)32(2)3)29-12-22(30-25)34-14-18(15-34)17-5-4-8-33(13-17)9-10-36/h6-7,11-12,16-18,36H,4-5,8-10,13-15H2,1-3H3/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	379	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545765 (CHEMBL4639418) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCC(O)=O)C1 |r| Show InChI InChI=1S/C25H27Cl2N7O2/c1-15(19-5-4-18(26)9-20(19)27)34-25-24(21(10-28)31-34)29-11-22(30-25)33-13-17(14-33)16-3-2-7-32(12-16)8-6-23(35)36/h4-5,9,11,15-17H,2-3,6-8,12-14H2,1H3,(H,35,36)/t15-,16+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	409	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545781 (CHEMBL4633133) Show SMILES CNC(=O)c1nn([C@H](C)c2ccc(Cl)cc2Cl)c2nc(cnc12)N1CC(C1)[C@H]1CCCN(CCO)C1 |r| Show InChI InChI=1S/C25H31Cl2N7O2/c1-15(19-6-5-18(26)10-20(19)27)34-24-22(23(31-34)25(36)28-2)29-11-21(30-24)33-13-17(14-33)16-4-3-7-32(12-16)8-9-35/h5-6,10-11,15-17,35H,3-4,7-9,12-14H2,1-2H3,(H,28,36)/t15-,16+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	446	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545784 (CHEMBL4642090) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@@H]1CCCN(CCS(N)(=O)=O)C1 |r| Show InChI InChI=1S/C24H31Cl2N7O2S/c1-15-23-24(33(30-15)16(2)20-6-5-19(25)10-21(20)26)29-22(11-28-23)32-13-18(14-32)17-4-3-7-31(12-17)8-9-36(27,34)35/h5-6,10-11,16-18H,3-4,7-9,12-14H2,1-2H3,(H2,27,34,35)/t16-,17-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	455	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545774 (CHEMBL4644412) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCC(F)(F)F)C1 |r| Show InChI InChI=1S/C25H29Cl2F3N6/c1-15-23-24(36(33-15)16(2)20-6-5-19(26)10-21(20)27)32-22(11-31-23)35-13-18(14-35)17-4-3-8-34(12-17)9-7-25(28,29)30/h5-6,10-11,16-18H,3-4,7-9,12-14H2,1-2H3/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	505	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545773 (CHEMBL4633494) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCC#N)C1 |r| Show InChI InChI=1S/C25H26Cl2N8/c1-16(20-6-5-19(26)10-21(20)27)35-25-24(22(11-29)32-35)30-12-23(31-25)34-14-18(15-34)17-4-2-8-33(13-17)9-3-7-28/h5-6,10,12,16-18H,2-4,8-9,13-15H2,1H3/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	523	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545763 (CHEMBL4638846) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCCC(O)=O)C1 |r| Show InChI InChI=1S/C26H32Cl2N6O2/c1-16-25-26(34(31-16)17(2)21-8-7-20(27)11-22(21)28)30-23(12-29-25)33-14-19(15-33)18-5-3-9-32(13-18)10-4-6-24(35)36/h7-8,11-12,17-19H,3-6,9-10,13-15H2,1-2H3,(H,35,36)/t17-,18+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	559	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545761 (CHEMBL4633920) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCS(C)(=O)=O)C1 |r| Show InChI InChI=1S/C25H32Cl2N6O2S/c1-16-24-25(33(30-16)17(2)21-7-6-20(26)11-22(21)27)29-23(12-28-24)32-14-19(15-32)18-5-4-8-31(13-18)9-10-36(3,34)35/h6-7,11-12,17-19H,4-5,8-10,13-15H2,1-3H3/t17-,18+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	575	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545756 (CHEMBL4643066) Show SMILES CCOC(=O)CN1CCCC(C1)C1CN(C1)c1cnc2c(C)nn([C@H](C)c3ccc(Cl)cc3Cl)c2n1 |r| Show InChI InChI=1S/C26H32Cl2N6O2/c1-4-36-24(35)15-32-9-5-6-18(12-32)19-13-33(14-19)23-11-29-25-16(2)31-34(26(25)30-23)17(3)21-8-7-20(27)10-22(21)28/h7-8,10-11,17-19H,4-6,9,12-15H2,1-3H3/t17-,18?/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	596	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545758 (CHEMBL4643609) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CCS(N)(=O)=O)C1 |r| Show InChI InChI=1S/C24H31Cl2N7O2S/c1-15-23-24(33(30-15)16(2)20-6-5-19(25)10-21(20)26)29-22(11-28-23)32-13-18(14-32)17-4-3-7-31(12-17)8-9-36(27,34)35/h5-6,10-11,16-18H,3-4,7-9,12-14H2,1-2H3,(H2,27,34,35)/t16-,17+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	717	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair
C-C chemokine receptor type 4 (Homo sapiens (Human))	BDBM50545766 (CHEMBL4645037) Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC(C1)[C@H]1CCCN(CC(O)=O)C1 |r| Show InChI InChI=1S/C24H25Cl2N7O2/c1-14(18-5-4-17(25)7-19(18)26)33-24-23(20(8-27)30-33)28-9-21(29-24)32-11-16(12-32)15-3-2-6-31(10-15)13-22(34)35/h4-5,7,9,14-16H,2-3,6,10-13H2,1H3,(H,34,35)/t14-,15+/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	775	n/a	n/a	n/a	n/a	n/a	n/a
RAPT Therapeutics Curated by ChEMBL					Assay Description Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis preincubated for 30 mins followed by CCL22 ad...				J Med Chem 63: 8584-8607 (2020) Article DOI: 10.1021/acs.jmedchem.0c00988 BindingDB Entry DOI: 10.7270/Q2DZ0CW6
					More data for this Ligand-Target Pair

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