Compile Data Set for Download or QSAR

Found 69 hits with Last Name = 'tang' and Initial = 'gh'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291300 (CHEMBL4168752) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6@H]-1-[#8]-c2cc(-[#8])ccc2-c2oc3c4-[#6]=[#6]C([#6])([#6])[#8]-c4cc(-[#8])c3c(=O)c12 |r,c:18| Show InChI InChI=1S/C25H22O6/c1-12(2)9-19-21-22(28)20-16(27)11-18-15(7-8-25(3,4)31-18)23(20)30-24(21)14-6-5-13(26)10-17(14)29-19/h5-11,19,26-27H,1-4H3/t19-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50519233 (CHEMBL4533719) Show SMILES [H][C@@]12OC(=O)C(CCC(=O)\C(C)=C\C[C@H]1C(C)=C)=C2 |r,c:18,t:11| Show InChI InChI=1S/C15H18O3/c1-9(2)12-6-4-10(3)13(16)7-5-11-8-14(12)18-15(11)17/h4,8,12,14H,1,5-7H2,2-3H3/b10-4+/t12-,14-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-Sen University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged TGFbeta1 receptor (80 to end residues) expressed in baculovirus infected Sf9 insect cells using...				J Med Chem 62: 7961-7975 (2019) Article DOI: 10.1021/acs.jmedchem.9b00708 BindingDB Entry DOI: 10.7270/Q24J0JHQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291298 (CHEMBL4171877) Show SMILES [#6]-[#8]-[#6]-1-[#6]C([#6])([#6])[#8]-c2cc(-[#8])c3c(oc(c(-[#6]\[#6]=[#6](\[#6])-[#6])c3=O)-c3ccc(-[#8])cc3-[#8])c-12 Show InChI InChI=1S/C26H28O7/c1-13(2)6-8-16-23(30)21-18(29)11-19-22(20(31-5)12-26(3,4)33-19)25(21)32-24(16)15-9-7-14(27)10-17(15)28/h6-7,9-11,20,27-29H,8,12H2,1-5H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291293 (CHEMBL4170837) Show SMILES CC1(C)Oc2ccc(c(O)c2C=C1)-c1cc(=O)c2c(O)cc3OC(C)(C)C=Cc3c2o1 |c:12,28| Show InChI InChI=1S/C25H22O6/c1-24(2)9-7-14-18(30-24)6-5-13(22(14)28)19-11-16(26)21-17(27)12-20-15(23(21)29-19)8-10-25(3,4)31-20/h5-12,27-28H,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291296 (CHEMBL4168522) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc(-[#8])c2c1oc1-c3ccc(-[#8])cc3-[#8]-[#6](\[#6]=[#6](\[#6])-[#6])-c1c2=O Show InChI InChI=1S/C25H24O6/c1-12(2)5-7-15-17(27)11-18(28)21-23(29)22-20(9-13(3)4)30-19-10-14(26)6-8-16(19)25(22)31-24(15)21/h5-6,8-11,20,26-28H,7H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human))	BDBM50041010 (BAY-736691 | CHEMBL1513993) Show SMILES C[C@H](Cc1nc2n(ncc2c(=O)[nH]1)-c1ccccc1Cl)C(F)(F)F Show InChI InChI=1S/C15H12ClF3N4O/c1-8(15(17,18)19)6-12-21-13-9(14(24)22-12)7-20-23(13)11-5-3-2-4-10(11)16/h2-5,7-8H,6H2,1H3,(H,21,22,24)/t8-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of recombinant PDE9A2 catalytic domain (unknown origin) expressed in Escherichia coli BL21 using [3H]cGMP as substrate after 15 mins by li...				J Nat Prod 77: 2651-7 (2014) Article DOI: 10.1021/np500528u BindingDB Entry DOI: 10.7270/Q2N87CDV
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human))	BDBM50041010 (BAY-736691 | CHEMBL1513993) Show SMILES C[C@H](Cc1nc2n(ncc2c(=O)[nH]1)-c1ccccc1Cl)C(F)(F)F Show InChI InChI=1S/C15H12ClF3N4O/c1-8(15(17,18)19)6-12-21-13-9(14(24)22-12)7-20-23(13)11-5-3-2-4-10(11)16/h2-5,7-8H,6H2,1H3,(H,21,22,24)/t8-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE9A2 using [3H]cGMP as substrate by scintillation proximity assay				J Nat Prod 77: 2651-7 (2014) Article DOI: 10.1021/np500528u BindingDB Entry DOI: 10.7270/Q2N87CDV
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50110208 (4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1...) Show SMILES NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCOc2c1)-c1ccccn1 Show InChI InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-Sen University Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal GST-tagged TGFbeta1 receptor (80 to end residues) expressed in baculovirus infected Sf9 insect cells using...				J Med Chem 62: 7961-7975 (2019) Article DOI: 10.1021/acs.jmedchem.9b00708 BindingDB Entry DOI: 10.7270/Q24J0JHQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50008731 (CHEMBL3235992) Show SMILES [H][C@@]1([#6]-[#6@@H](\[#6]=[#6](\[#6])-[#6])-c2c(-[#8]1)c1ccccc1n(-[#6])c2=O)\[#6]=[#6]\c1c(-[#8]-[#6])cc(-[#8]-[#6])c2ccc(=O)oc12 |r| Show InChI InChI=1S/C30H29NO6/c1-17(2)14-18-15-19(36-29-20-8-6-7-9-23(20)31(3)30(33)27(18)29)10-11-21-24(34-4)16-25(35-5)22-12-13-26(32)37-28(21)22/h6-14,16,18-19H,15H2,1-5H3/b11-10+/t18-,19+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413aa) expressed in Escherichia coli strain BL21 after 15 mins by liquid scintillation counting in...				J Nat Prod 77: 955-62 (2014) Article DOI: 10.1021/np401040d BindingDB Entry DOI: 10.7270/Q2HQ41GQ
					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM8961 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...) Show SMILES Nc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human AChE by Ellman's assay				J Nat Prod 72: 1151-4 (2009) Article DOI: 10.1021/np9001515 BindingDB Entry DOI: 10.7270/Q22807ND
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291299 (CHEMBL4176617) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6@@H]-1-[#8]-c2cc(-[#8])ccc2-c2oc3c4-[#6]=[#6]C([#6])([#6])[#8]-c4cc(-[#8])c3c(=O)c12 |r,c:18| Show InChI InChI=1S/C25H22O6/c1-12(2)9-19-21-22(28)20-16(27)11-18-15(7-8-25(3,4)31-18)23(20)30-24(21)14-6-5-13(26)10-17(14)29-19/h5-11,19,26-27H,1-4H3/t19-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291327 (CHEBI:68023 | Cudraflavone C) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc2oc(-c3ccc(-[#8])cc3-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c(=O)c2c1-[#8] Show InChI InChI=1S/C25H26O6/c1-13(2)5-8-16-20(28)12-21-22(23(16)29)24(30)18(9-6-14(3)4)25(31-21)17-10-7-15(26)11-19(17)27/h5-7,10-12,26-29H,8-9H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291292 (CHEMBL4167451) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]C1([#6])[#8]-c2ccc(c(-[#8])c2-[#6]=[#6]1)-c1oc2cc(-[#8])cc(-[#8])c2c(=O)c1-[#6]\[#6]=[#6](\[#6])-[#6] |c:17| Show InChI InChI=1S/C30H32O6/c1-17(2)7-6-13-30(5)14-12-20-24(36-30)11-10-21(27(20)33)29-22(9-8-18(3)4)28(34)26-23(32)15-19(31)16-25(26)35-29/h7-8,10-12,14-16,31-33H,6,9,13H2,1-5H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human))	BDBM50291300 (CHEMBL4168752) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6@H]-1-[#8]-c2cc(-[#8])ccc2-c2oc3c4-[#6]=[#6]C([#6])([#6])[#8]-c4cc(-[#8])c3c(=O)c12 |r,c:18| Show InChI InChI=1S/C25H22O6/c1-12(2)9-19-21-22(28)20-16(27)11-18-15(7-8-25(3,4)31-18)23(20)30-24(21)14-6-5-13(26)10-17(14)29-19/h5-11,19,26-27H,1-4H3/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE1B2 catalytic domain (10 to 487 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50242015 (CHEMBL518543 | Kuwanon C, 4 | kuwanon C) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc(-[#8])c2c1oc(-c1ccc(-[#8])cc1-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c2=O Show InChI InChI=1S/C25H26O6/c1-13(2)5-8-17-20(28)12-21(29)22-23(30)18(9-6-14(3)4)24(31-25(17)22)16-10-7-15(26)11-19(16)27/h5-7,10-12,26-29H,8-9H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human))	BDBM50291300 (CHEMBL4168752) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6@H]-1-[#8]-c2cc(-[#8])ccc2-c2oc3c4-[#6]=[#6]C([#6])([#6])[#8]-c4cc(-[#8])c3c(=O)c12 |r,c:18| Show InChI InChI=1S/C25H22O6/c1-12(2)9-19-21-22(28)20-16(27)11-18-15(7-8-25(3,4)31-18)23(20)30-24(21)14-6-5-13(26)10-17(14)29-19/h5-11,19,26-27H,1-4H3/t19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE9A2 catalytic domain (181 to 506 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291297 (CHEMBL4164003) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-1-[#8]-c2cc(-[#8])ccc2-c2oc3cc(-[#8])cc(-[#8])c3c(=O)c12 Show InChI InChI=1S/C20H16O6/c1-9(2)5-15-18-19(24)17-13(23)6-11(22)8-16(17)26-20(18)12-4-3-10(21)7-14(12)25-15/h3-8,15,21-23H,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50291300 (CHEMBL4168752) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6@H]-1-[#8]-c2cc(-[#8])ccc2-c2oc3c4-[#6]=[#6]C([#6])([#6])[#8]-c4cc(-[#8])c3c(=O)c12 |r,c:18| Show InChI InChI=1S/C25H22O6/c1-12(2)9-19-21-22(28)20-16(27)11-18-15(7-8-25(3,4)31-18)23(20)30-24(21)14-6-5-13(26)10-17(14)29-19/h5-11,19,26-27H,1-4H3/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE5A1 catalytic domain (535 to 860 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50291300 (CHEMBL4168752) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6@H]-1-[#8]-c2cc(-[#8])ccc2-c2oc3c4-[#6]=[#6]C([#6])([#6])[#8]-c4cc(-[#8])c3c(=O)c12 |r,c:18| Show InChI InChI=1S/C25H22O6/c1-12(2)9-19-21-22(28)20-16(27)11-18-15(7-8-25(3,4)31-18)23(20)30-24(21)14-6-5-13(26)10-17(14)29-19/h5-11,19,26-27H,1-4H3/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE10A2 catalytic domain (448 to 789 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 min...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50291300 (CHEMBL4168752) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6@H]-1-[#8]-c2cc(-[#8])ccc2-c2oc3c4-[#6]=[#6]C([#6])([#6])[#8]-c4cc(-[#8])c3c(=O)c12 |r,c:18| Show InChI InChI=1S/C25H22O6/c1-12(2)9-19-21-22(28)20-16(27)11-18-15(7-8-25(3,4)31-18)23(20)30-24(21)14-6-5-13(26)10-17(14)29-19/h5-11,19,26-27H,1-4H3/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE2A3 catalytic domain (222 to 904 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413aa) expressed in Escherichia coli strain BL21 after 15 mins by liquid scintillation counting in...				J Nat Prod 77: 955-62 (2014) Article DOI: 10.1021/np401040d BindingDB Entry DOI: 10.7270/Q2HQ41GQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 amino acids) expressed in Escherichia coli strain BL21 after 15 mins using [3H]-cAMP by liquid...				J. Nat. Prod. 77: 1928-36 (2014) Article DOI: 10.1021/np500394d BindingDB Entry DOI: 10.7270/Q20866X7
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50240972 (5,7-Dihydroxy-2-(4-hydroxy-phenyl)-8-(3-methyl-but...) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])cc(-[#8])c2c1oc(cc2=O)-c1ccc(-[#8])cc1 Show InChI InChI=1S/C20H18O5/c1-11(2)3-8-14-15(22)9-16(23)19-17(24)10-18(25-20(14)19)12-4-6-13(21)7-5-12/h3-7,9-10,21-23H,8H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291295 (CHEMBL4160605) Show SMILES CC1(C)CCc2c3OC(C)(C)C=Cc3c3oc(cc(=O)c3c2O1)-c1ccc(O)cc1O |c:11| Show InChI InChI=1S/C25H24O6/c1-24(2)9-7-15-21(30-24)16-8-10-25(3,4)31-23(16)20-18(28)12-19(29-22(15)20)14-6-5-13(26)11-17(14)27/h5-7,9,11-12,26-27H,8,10H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	870	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50242014 (CHEMBL464006 | Morusin | Morusin, 3 | TCMDC-124149...) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-c1c(oc2c3-[#6]=[#6]C([#6])([#6])[#8]-c3cc(-[#8])c2c1=O)-c1ccc(-[#8])cc1-[#8] |c:10| Show InChI InChI=1S/C25H24O6/c1-13(2)5-7-17-22(29)21-19(28)12-20-16(9-10-25(3,4)31-20)24(21)30-23(17)15-8-6-14(26)11-18(15)27/h5-6,8-12,26-28H,7H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50008737 (CHEMBL529210) Show SMILES COc1cc2ccc(=O)oc2c2C=CC(C)(C)Oc12 |c:13| Show InChI InChI=1S/C15H14O4/c1-15(2)7-6-10-13-9(4-5-12(16)18-13)8-11(17-3)14(10)19-15/h4-8H,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413aa) expressed in Escherichia coli strain BL21 after 15 mins by liquid scintillation counting in...				J Nat Prod 77: 955-62 (2014) Article DOI: 10.1021/np401040d BindingDB Entry DOI: 10.7270/Q2HQ41GQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2				J. Nat. Prod. 77: 1928-36 (2014) Article DOI: 10.1021/np500394d BindingDB Entry DOI: 10.7270/Q20866X7
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291290 (CHEMBL4173326) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-c1cc(-[#6@@H]-2-[#6]-[#6](=O)-c3c(-[#8])cc(-[#8])cc3-[#8]-2)c(-[#8])cc1-[#8] |r| Show InChI InChI=1S/C25H28O6/c1-14(2)5-4-6-15(3)7-8-16-9-18(20(28)12-19(16)27)23-13-22(30)25-21(29)10-17(26)11-24(25)31-23/h5,7,9-12,23,26-29H,4,6,8,13H2,1-3H3/b15-7+/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50044116 (CHEMBL3331578) Show SMILES CCCCC[C@H](OC(C)=O)\C=C\[C@H]1[C@@H](C[C@H](OC(C)=O)[C@@H]1C\C=C/CCCC(=O)OC)OC(C)=O |r| Show InChI InChI=1S/C27H42O8/c1-6-7-10-13-22(33-19(2)28)16-17-24-23(14-11-8-9-12-15-27(31)32-5)25(34-20(3)29)18-26(24)35-21(4)30/h8,11,16-17,22-26H,6-7,9-10,12-15,18H2,1-5H3/b11-8-,17-16+/t22-,23+,24+,25-,26+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 amino acids) expressed in Escherichia coli strain BL21 after 15 mins using [3H]-cAMP by liquid...				J. Nat. Prod. 77: 1928-36 (2014) Article DOI: 10.1021/np500394d BindingDB Entry DOI: 10.7270/Q20866X7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50008738 (CHEMBL3235994) Show SMILES COc1cc2ccc(=O)oc2c2CCC(C)(C)Oc12 Show InChI InChI=1S/C15H16O4/c1-15(2)7-6-10-13-9(4-5-12(16)18-13)8-11(17-3)14(10)19-15/h4-5,8H,6-7H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413aa) expressed in Escherichia coli strain BL21 after 15 mins by liquid scintillation counting in...				J Nat Prod 77: 955-62 (2014) Article DOI: 10.1021/np401040d BindingDB Entry DOI: 10.7270/Q2HQ41GQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50008732 (5-Methoxyseselin | CHEMBL479894) Show SMILES COc1cc2OC(C)(C)C=Cc2c2oc(=O)ccc12 |c:9| Show InChI InChI=1S/C15H14O4/c1-15(2)7-6-10-12(19-15)8-11(17-3)9-4-5-13(16)18-14(9)10/h4-8H,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413aa) expressed in Escherichia coli strain BL21 after 15 mins by liquid scintillation counting in...				J Nat Prod 77: 955-62 (2014) Article DOI: 10.1021/np401040d BindingDB Entry DOI: 10.7270/Q2HQ41GQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291307 (CHEMBL4174381) Show SMILES CC(C)(C=C)c1cc(c(O)cc1O)-c1cc(=O)c2c(O)cc(O)cc2o1 Show InChI InChI=1S/C20H18O6/c1-4-20(2,3)12-7-11(13(22)8-14(12)23)17-9-16(25)19-15(24)5-10(21)6-18(19)26-17/h4-9,21-24H,1H2,2-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.88E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291289 (CHEMBL4162628) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])cc(-[#6@@H]-2-[#6]-[#6](=O)-c3c(-[#8])cc(-[#8])cc3-[#8]-2)c1-[#8] |r| Show InChI InChI=1S/C30H36O6/c1-17(2)7-6-8-19(5)10-12-22-29(34)20(11-9-18(3)4)13-23(30(22)35)26-16-25(33)28-24(32)14-21(31)15-27(28)36-26/h7,9-10,13-15,26,31-32,34-35H,6,8,11-12,16H2,1-5H3/b19-10+/t26-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50008736 (CHEMBL3235993) Show SMILES COc1cc2OC(C)(C)CCc2c2oc(=O)ccc12 Show InChI InChI=1S/C15H16O4/c1-15(2)7-6-10-12(19-15)8-11(17-3)9-4-5-13(16)18-14(9)10/h4-5,8H,6-7H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413aa) expressed in Escherichia coli strain BL21 after 15 mins by liquid scintillation counting in...				J Nat Prod 77: 955-62 (2014) Article DOI: 10.1021/np401040d BindingDB Entry DOI: 10.7270/Q2HQ41GQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291291 (CHEMBL4168945) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])ccc(-[#6@@H]-2-[#6]-[#6](=O)-c3c(-[#8])cc(-[#8])cc3-[#8]-2)c1-[#8] |r| Show InChI InChI=1S/C25H28O6/c1-14(2)5-4-6-15(3)7-8-17-19(27)10-9-18(25(17)30)22-13-21(29)24-20(28)11-16(26)12-23(24)31-22/h5,7,9-12,22,26-28,30H,4,6,8,13H2,1-3H3/b15-7+/t22-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50008739 (CHEMBL3235995) Show SMILES CC1(C)Oc2c(O)cc3ccc(=O)oc3c2C=C1 |c:18| Show InChI InChI=1S/C14H12O4/c1-14(2)6-5-9-12-8(3-4-11(16)17-12)7-10(15)13(9)18-14/h3-7,15H,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413aa) expressed in Escherichia coli strain BL21 after 15 mins by liquid scintillation counting in...				J Nat Prod 77: 955-62 (2014) Article DOI: 10.1021/np401040d BindingDB Entry DOI: 10.7270/Q2HQ41GQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291294 (CHEMBL4160223) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]C1([#6])[#8]-c2cc(-[#8])c(cc2-[#6]=[#6]1)-[#6]-1-[#6]-[#6](=O)-c2c(-[#8])cc(-[#8])cc2-[#8]-1 |c:17| Show InChI InChI=1S/C25H26O6/c1-14(2)5-4-7-25(3)8-6-15-9-17(18(27)12-21(15)31-25)22-13-20(29)24-19(28)10-16(26)11-23(24)30-22/h5-6,8-12,22,26-28H,4,7,13H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50044119 (CHEMBL3331573) Show SMILES CCC(CC[C@H](OC(=O)[C@](OC)(c1ccccc1)C(F)(F)F)\C=C\[C@H]1[C@@H](C[C@H](OC(=O)[C@](OC)(c2ccccc2)C(F)(F)F)[C@@H]1C\C=C/CCCC(=O)OC)OC(C)=O)OC(C)=O |r| Show InChI InChI=1S/C45H54F6O12/c1-7-33(60-29(2)52)24-25-34(62-40(55)42(58-5,44(46,47)48)31-18-12-10-13-19-31)26-27-36-35(22-16-8-9-17-23-39(54)57-4)38(28-37(36)61-30(3)53)63-41(56)43(59-6,45(49,50)51)32-20-14-11-15-21-32/h8,10-16,18-21,26-27,33-38H,7,9,17,22-25,28H2,1-6H3/b16-8-,27-26+/t33?,34-,35+,36+,37+,38-,42+,43+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 amino acids) expressed in Escherichia coli strain BL21 after 15 mins using [3H]-cAMP by liquid...				J. Nat. Prod. 77: 1928-36 (2014) Article DOI: 10.1021/np500394d BindingDB Entry DOI: 10.7270/Q20866X7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50044125 (CHEMBL3331559) Show SMILES CCC(CC[C@H](OC(C)=O)\C=C\[C@H]1[C@@H](C[C@H](OC(C)=O)[C@@H]1C\C=C/CCCC(=O)OC)OC(C)=O)OC(C)=O |r| Show InChI InChI=1S/C29H44O10/c1-7-23(36-19(2)30)14-15-24(37-20(3)31)16-17-26-25(12-10-8-9-11-13-29(34)35-6)27(38-21(4)32)18-28(26)39-22(5)33/h8,10,16-17,23-28H,7,9,11-15,18H2,1-6H3/b10-8-,17-16+/t23?,24-,25+,26+,27-,28+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 amino acids) expressed in Escherichia coli strain BL21 after 15 mins using [3H]-cAMP by liquid...				J. Nat. Prod. 77: 1928-36 (2014) Article DOI: 10.1021/np500394d BindingDB Entry DOI: 10.7270/Q20866X7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291303 (CHEMBL4176273) Show SMILES CC(C)C[C@H]1Oc2cc(O)ccc2-c2oc3c4CCC(C)(C)Oc4cc(O)c3c(=O)c12 |r| Show InChI InChI=1S/C25H26O6/c1-12(2)9-19-21-22(28)20-16(27)11-18-15(7-8-25(3,4)31-18)23(20)30-24(21)14-6-5-13(26)10-17(14)29-19/h5-6,10-12,19,26-27H,7-9H2,1-4H3/t19-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.35E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50044118 (CHEMBL3331576) Show SMILES CCCCC[C@H](OC(C)=O)\C=C\[C@H]1[C@H](O)C[C@H](OC(C)=O)[C@@H]1C\C=C/CCCC(=O)OC |r| Show InChI InChI=1S/C25H40O7/c1-5-6-9-12-20(31-18(2)26)15-16-21-22(24(17-23(21)28)32-19(3)27)13-10-7-8-11-14-25(29)30-4/h7,10,15-16,20-24,28H,5-6,8-9,11-14,17H2,1-4H3/b10-7-,16-15+/t20-,21+,22+,23+,24-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 amino acids) expressed in Escherichia coli strain BL21 after 15 mins using [3H]-cAMP by liquid...				J. Nat. Prod. 77: 1928-36 (2014) Article DOI: 10.1021/np500394d BindingDB Entry DOI: 10.7270/Q20866X7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291305 (CHEMBL4170952) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6@H]-1-[#8]-c2cc(-[#8]-[#6](-[#6])=O)ccc2-c2oc3c4-[#6]=[#6]C([#6])([#6])[#8]-c4cc(-[#8])c3c(=O)c12 |r,c:21| Show InChI InChI=1S/C27H24O7/c1-13(2)10-21-23-24(30)22-18(29)12-20-17(8-9-27(4,5)34-20)25(22)33-26(23)16-7-6-15(31-14(3)28)11-19(16)32-21/h6-12,21,29H,1-5H3/t21-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50291306 (CHEMBL4163032) Show SMILES [#6]-[#8]-c1ccc-2c(-[#8]-[#6@H](\[#6]=[#6](\[#6])-[#6])-c3c-2oc2c4-[#6]=[#6]C([#6])([#6])[#8]-c4cc(-[#8])c2c3=O)c1 |r,c:19| Show InChI InChI=1S/C26H24O6/c1-13(2)10-20-22-23(28)21-17(27)12-19-16(8-9-26(3,4)32-19)24(21)31-25(22)15-7-6-14(29-5)11-18(15)30-20/h6-12,20,27H,1-5H3/t20-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 residues) expressed in Escherichia coli strain BL21 using [3H]cAMP as substrate after 15 mins ...				Eur J Med Chem 144: 758-766 (2018) Article DOI: 10.1016/j.ejmech.2017.12.057 BindingDB Entry DOI: 10.7270/Q2TT4TG2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50044117 (CHEMBL3331577) Show SMILES CCCCC[C@H](OC(C)=O)\C=C\[C@H]1[C@@H](C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OC)OC(C)=O |r| Show InChI InChI=1S/C25H40O7/c1-5-6-9-12-20(31-18(2)26)15-16-22-21(23(28)17-24(22)32-19(3)27)13-10-7-8-11-14-25(29)30-4/h7,10,15-16,20-24,28H,5-6,8-9,11-14,17H2,1-4H3/b10-7-,16-15+/t20-,21+,22+,23-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 amino acids) expressed in Escherichia coli strain BL21 after 15 mins using [3H]-cAMP by liquid...				J. Nat. Prod. 77: 1928-36 (2014) Article DOI: 10.1021/np500394d BindingDB Entry DOI: 10.7270/Q20866X7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50008744 (CHEMBL3236000) Show SMILES COC1=CC(=O)c2cc(C)cc(c2C1=O)-c1c(OC)cc(OC)c2ccc(=O)oc12 |t:2,(47.77,-52.9,;47.78,-51.36,;46.45,-50.58,;46.45,-49.04,;45.11,-48.26,;45.11,-46.72,;43.78,-49.03,;42.44,-48.27,;41.11,-49.04,;39.78,-48.27,;41.11,-50.58,;42.44,-51.36,;43.77,-50.58,;45.1,-51.35,;45.1,-52.89,;42.44,-54.07,;41.11,-54.83,;39.77,-54.06,;39.77,-52.52,;41.11,-56.37,;42.44,-57.14,;42.45,-58.68,;41.12,-59.46,;43.77,-56.36,;45.1,-57.12,;46.43,-56.36,;46.42,-54.82,;47.76,-54.05,;45.09,-54.05,;43.77,-54.82,)| Show InChI InChI=1S/C23H18O7/c1-11-7-13-15(24)9-18(29-4)22(26)20(13)14(8-11)21-17(28-3)10-16(27-2)12-5-6-19(25)30-23(12)21/h5-10H,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413aa) expressed in Escherichia coli strain BL21 after 15 mins by liquid scintillation counting in...				J Nat Prod 77: 955-62 (2014) Article DOI: 10.1021/np401040d BindingDB Entry DOI: 10.7270/Q2HQ41GQ
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human))	BDBM50041016 (CHEMBL3355396) Show SMILES COc1ccccc1\C=C\[C@H]1OC[C@H](C\C=C\c2c(OC)cccc2OC)[C@H](O1)c1c(OC)cccc1OC |r| Show InChI InChI=1S/C32H36O7/c1-33-25-14-7-6-11-22(25)19-20-30-38-21-23(12-8-13-24-26(34-2)15-9-16-27(24)35-3)32(39-30)31-28(36-4)17-10-18-29(31)37-5/h6-11,13-20,23,30,32H,12,21H2,1-5H3/b13-8+,20-19+/t23-,30-,32-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of recombinant PDE9A2 catalytic domain (unknown origin) expressed in Escherichia coli BL21 using [3H]cGMP as substrate after 15 mins by li...				J Nat Prod 77: 2651-7 (2014) Article DOI: 10.1021/np500528u BindingDB Entry DOI: 10.7270/Q2N87CDV
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50044120 (CHEMBL3331572) Show SMILES CCC(CC[C@H](OC(=O)[C@@](OC)(c1ccccc1)C(F)(F)F)\C=C\[C@H]1[C@@H](C[C@H](OC(=O)[C@@](OC)(c2ccccc2)C(F)(F)F)[C@@H]1C\C=C/CCCC(=O)OC)OC(C)=O)OC(C)=O |r| Show InChI InChI=1S/C45H54F6O12/c1-7-33(60-29(2)52)24-25-34(62-40(55)42(58-5,44(46,47)48)31-18-12-10-13-19-31)26-27-36-35(22-16-8-9-17-23-39(54)57-4)38(28-37(36)61-30(3)53)63-41(56)43(59-6,45(49,50)51)32-20-14-11-15-21-32/h8,10-16,18-21,26-27,33-38H,7,9,17,22-25,28H2,1-6H3/b16-8-,27-26+/t33?,34-,35+,36+,37+,38-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDE4D2 catalytic domain (86 to 413 amino acids) expressed in Escherichia coli strain BL21 after 15 mins using [3H]-cAMP by liquid...				J. Nat. Prod. 77: 1928-36 (2014) Article DOI: 10.1021/np500394d BindingDB Entry DOI: 10.7270/Q20866X7
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human))	BDBM50041015 (CHEMBL3355397) Show SMILES COc1ccccc1\C=C\C[C@H]1CO[C@@H](O[C@@H]1c1ccccc1OC)\C=C\c1ccccc1OC |r| Show InChI InChI=1S/C30H32O5/c1-31-26-16-7-4-11-22(26)13-10-14-24-21-34-29(20-19-23-12-5-8-17-27(23)32-2)35-30(24)25-15-6-9-18-28(25)33-3/h4-13,15-20,24,29-30H,14,21H2,1-3H3/b13-10+,20-19+/t24-,29-,30-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of recombinant PDE9A2 catalytic domain (unknown origin) expressed in Escherichia coli BL21 using [3H]cGMP as substrate after 15 mins by li...				J Nat Prod 77: 2651-7 (2014) Article DOI: 10.1021/np500528u BindingDB Entry DOI: 10.7270/Q2N87CDV
					More data for this Ligand-Target Pair
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human))	BDBM50041011 (CHEMBL3355401) Show SMILES COc1ccccc1\C=C\C[C@@H]1CO[C@H](O[C@H]1c1ccccc1OC)\C=C\c1ccccc1OC |r| Show InChI InChI=1S/C30H32O5/c1-31-26-16-7-4-11-22(26)13-10-14-24-21-34-29(20-19-23-12-5-8-17-27(23)32-2)35-30(24)25-15-6-9-18-28(25)33-3/h4-13,15-20,24,29-30H,14,21H2,1-3H3/b13-10+,20-19+/t24-,29-,30-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of recombinant PDE9A2 catalytic domain (unknown origin) expressed in Escherichia coli BL21 using [3H]cGMP as substrate after 15 mins by li...				J Nat Prod 77: 2651-7 (2014) Article DOI: 10.1021/np500528u BindingDB Entry DOI: 10.7270/Q2N87CDV
					More data for this Ligand-Target Pair

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