Found 49 hits with Last Name = 'tian' and Initial = 'hz' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50463715
(CHEMBL4243470)Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc(C)nc3noc(N)c23)c1 Show InChI InChI=1S/C21H19N5O2/c1-12-4-3-5-16(10-12)25-21(27)24-15-8-6-14(7-9-15)17-11-13(2)23-20-18(17)19(22)28-26-20/h3-11H,22H2,1-2H3,(H2,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human KDR using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463712
(CHEMBL4247248)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C21H15ClF3N5O2/c1-10-8-14(17-18(26)32-30-19(17)27-10)11-2-4-12(5-3-11)28-20(31)29-13-6-7-16(22)15(9-13)21(23,24)25/h2-9H,26H2,1H3,(H2,28,29,31) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463715
(CHEMBL4243470)Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc(C)nc3noc(N)c23)c1 Show InChI InChI=1S/C21H19N5O2/c1-12-4-3-5-16(10-12)25-21(27)24-15-8-6-14(7-9-15)17-11-13(2)23-20-18(17)19(22)28-26-20/h3-11H,22H2,1-2H3,(H2,24,25,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463707
(CHEMBL4237289)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3cccc(Cl)c3)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C20H16ClN5O2/c1-11-9-16(17-18(22)28-26-19(17)23-11)12-5-7-14(8-6-12)24-20(27)25-15-4-2-3-13(21)10-15/h2-10H,22H2,1H3,(H2,24,25,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM21079
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50463715
(CHEMBL4243470)Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc(C)nc3noc(N)c23)c1 Show InChI InChI=1S/C21H19N5O2/c1-12-4-3-5-16(10-12)25-21(27)24-15-8-6-14(7-9-15)17-11-13(2)23-20-18(17)19(22)28-26-20/h3-11H,22H2,1-2H3,(H2,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463709
(CHEMBL4240969)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C21H16F3N5O2/c1-11-9-16(17-18(25)31-29-19(17)26-11)12-5-7-14(8-6-12)27-20(30)28-15-4-2-3-13(10-15)21(22,23)24/h2-10H,25H2,1H3,(H2,27,28,30) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50463709
(CHEMBL4240969)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C21H16F3N5O2/c1-11-9-16(17-18(25)31-29-19(17)26-11)12-5-7-14(8-6-12)27-20(30)28-15-4-2-3-13(10-15)21(22,23)24/h2-10H,25H2,1H3,(H2,27,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human KDR using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50079534
(CHEMBL3417325)Show SMILES CN1CCC(CC1)NC(=O)c1ccc(Nc2ncc(Br)c(NC3CCCC3)n2)cc1 Show InChI InChI=1S/C22H29BrN6O/c1-29-12-10-18(11-13-29)26-21(30)15-6-8-17(9-7-15)27-22-24-14-19(23)20(28-22)25-16-4-2-3-5-16/h6-9,14,16,18H,2-5,10-13H2,1H3,(H,26,30)(H2,24,25,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Lanzhou University
Curated by ChEMBL
| Assay Description
Inhibition of Aurora A in human HeLa cells after 12 hrs by ELISA method |
Eur J Med Chem 95: 174-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.044
BindingDB Entry DOI: 10.7270/Q2R78GXS |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50463709
(CHEMBL4240969)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C21H16F3N5O2/c1-11-9-16(17-18(25)31-29-19(17)26-11)12-5-7-14(8-6-12)27-20(30)28-15-4-2-3-13(10-15)21(22,23)24/h2-10H,25H2,1H3,(H2,27,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50463712
(CHEMBL4247248)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C21H15ClF3N5O2/c1-10-8-14(17-18(26)32-30-19(17)27-10)11-2-4-12(5-3-11)28-20(31)29-13-6-7-16(22)15(9-13)21(23,24)25/h2-9H,26H2,1H3,(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463705
(CHEMBL4242710)Show SMILES Nc1onc2nc(cc(-c3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C26H17ClF3N5O2/c27-20-11-10-17(12-19(20)26(28,29)30)33-25(36)32-16-8-6-14(7-9-16)18-13-21(15-4-2-1-3-5-15)34-24-22(18)23(31)37-35-24/h1-13H,31H2,(H2,32,33,36) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50463707
(CHEMBL4237289)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3cccc(Cl)c3)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C20H16ClN5O2/c1-11-9-16(17-18(22)28-26-19(17)23-11)12-5-7-14(8-6-12)24-20(27)25-15-4-2-3-13(21)10-15/h2-10H,22H2,1H3,(H2,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human KDR using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM21079
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human KDR using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463716
(CHEMBL4240512)Show SMILES C\C=C/C(=O)Nc1ccc(NC(=O)Nc2ccc(cc2)-c2cc(C)nc3noc(N)c23)cc1C Show InChI InChI=1S/C25H24N6O3/c1-4-5-21(32)30-20-11-10-18(12-14(20)2)29-25(33)28-17-8-6-16(7-9-17)19-13-15(3)27-24-22(19)23(26)34-31-24/h4-13H,26H2,1-3H3,(H,30,32)(H2,28,29,33)/b5-4- | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463713
(CHEMBL4238294)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3ccc(NC(=O)C(=C)CN4CCOCC4)c(C)c3)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C29H31N7O4/c1-17-14-22(8-9-24(17)34-28(37)18(2)16-36-10-12-39-13-11-36)33-29(38)32-21-6-4-20(5-7-21)23-15-19(3)31-27-25(23)26(30)40-35-27/h4-9,14-15H,2,10-13,16,30H2,1,3H3,(H,34,37)(H2,32,33,38) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50463707
(CHEMBL4237289)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3cccc(Cl)c3)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C20H16ClN5O2/c1-11-9-16(17-18(22)28-26-19(17)23-11)12-5-7-14(8-6-12)24-20(27)25-15-4-2-3-13(21)10-15/h2-10H,22H2,1H3,(H2,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50079535
(CHEMBL3417327)Show SMILES COc1cc(ccc1Nc1ncc(F)c(NC2CCCC2)n1)C(=O)NC1CCN(C)CC1 Show InChI InChI=1S/C23H31FN6O2/c1-30-11-9-17(10-12-30)27-22(31)15-7-8-19(20(13-15)32-2)28-23-25-14-18(24)21(29-23)26-16-5-3-4-6-16/h7-8,13-14,16-17H,3-6,9-12H2,1-2H3,(H,27,31)(H2,25,26,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Lanzhou University
Curated by ChEMBL
| Assay Description
Inhibition of Aurora A in human HeLa cells after 12 hrs by ELISA method |
Eur J Med Chem 95: 174-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.044
BindingDB Entry DOI: 10.7270/Q2R78GXS |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463706
(CHEMBL4251080)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3ccccc3Cl)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C20H16ClN5O2/c1-11-10-14(17-18(22)28-26-19(17)23-11)12-6-8-13(9-7-12)24-20(27)25-16-5-3-2-4-15(16)21/h2-10H,22H2,1H3,(H2,24,25,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM21079
(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 Show InChI InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50463717
(CHEMBL4243899)Show SMILES Nc1onc2nc(cc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C25H18FN5O2/c26-17-7-4-8-19(13-17)29-25(32)28-18-11-9-15(10-12-18)20-14-21(16-5-2-1-3-6-16)30-24-22(20)23(27)33-31-24/h1-14H,27H2,(H2,28,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human KDR using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463711
(CHEMBL4241470)Show SMILES Nc1onc2nc(cc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C25H18ClN5O2/c26-17-7-4-8-19(13-17)29-25(32)28-18-11-9-15(10-12-18)20-14-21(16-5-2-1-3-6-16)30-24-22(20)23(27)33-31-24/h1-14H,27H2,(H2,28,29,32) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 128 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50463708
(CHEMBL4238195)Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc(nc3noc(N)c23)-c2ccccc2)c1 Show InChI InChI=1S/C26H21N5O2/c1-16-6-5-9-20(14-16)29-26(32)28-19-12-10-17(11-13-19)21-15-22(18-7-3-2-4-8-18)30-25-23(21)24(27)33-31-25/h2-15H,27H2,1H3,(H2,28,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human KDR using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50463713
(CHEMBL4238294)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3ccc(NC(=O)C(=C)CN4CCOCC4)c(C)c3)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C29H31N7O4/c1-17-14-22(8-9-24(17)34-28(37)18(2)16-36-10-12-39-13-11-36)33-29(38)32-21-6-4-20(5-7-21)23-15-19(3)31-27-25(23)26(30)40-35-27/h4-9,14-15H,2,10-13,16,30H2,1,3H3,(H,34,37)(H2,32,33,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 167 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human KDR using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463720
(CHEMBL4238538)Show SMILES COc1ccc(NC(=O)Nc2ccc(cc2)-c2cc(nc3noc(N)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C26H21N5O3/c1-33-20-13-11-19(12-14-20)29-26(32)28-18-9-7-16(8-10-18)21-15-22(17-5-3-2-4-6-17)30-25-23(21)24(27)34-31-25/h2-15H,27H2,1H3,(H2,28,29,32) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 177 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50463712
(CHEMBL4247248)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C21H15ClF3N5O2/c1-10-8-14(17-18(26)32-30-19(17)27-10)11-2-4-12(5-3-11)28-20(31)29-13-6-7-16(22)15(9-13)21(23,24)25/h2-9H,26H2,1H3,(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 177 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human KDR using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463708
(CHEMBL4238195)Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc(nc3noc(N)c23)-c2ccccc2)c1 Show InChI InChI=1S/C26H21N5O2/c1-16-6-5-9-20(14-16)29-26(32)28-19-12-10-17(11-13-19)21-15-22(18-7-3-2-4-8-18)30-25-23(21)24(27)33-31-25/h2-15H,27H2,1H3,(H2,28,29,32) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 191 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50463711
(CHEMBL4241470)Show SMILES Nc1onc2nc(cc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C25H18ClN5O2/c26-17-7-4-8-19(13-17)29-25(32)28-18-11-9-15(10-12-18)20-14-21(16-5-2-1-3-6-16)30-24-22(20)23(27)33-31-24/h1-14H,27H2,(H2,28,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 259 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human KDR using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50004205
(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 261 | n/a | n/a | n/a | n/a | n/a | n/a |
Lanzhou University
Curated by ChEMBL
| Assay Description
Inhibition of Aurora A in human HeLa cells after 12 hrs by ELISA method |
Eur J Med Chem 95: 174-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.044
BindingDB Entry DOI: 10.7270/Q2R78GXS |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50463705
(CHEMBL4242710)Show SMILES Nc1onc2nc(cc(-c3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C26H17ClF3N5O2/c27-20-11-10-17(12-19(20)26(28,29)30)33-25(36)32-16-8-6-14(7-9-16)18-13-21(15-4-2-1-3-5-15)34-24-22(18)23(31)37-35-24/h1-13H,31H2,(H2,32,33,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463714
(CHEMBL4245698)Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cc(nc3noc(N)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C26H21N5O2/c1-16-7-11-19(12-8-16)28-26(32)29-20-13-9-17(10-14-20)21-15-22(18-5-3-2-4-6-18)30-25-23(21)24(27)33-31-25/h2-15H,27H2,1H3,(H2,28,29,32) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 311 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50079535
(CHEMBL3417327)Show SMILES COc1cc(ccc1Nc1ncc(F)c(NC2CCCC2)n1)C(=O)NC1CCN(C)CC1 Show InChI InChI=1S/C23H31FN6O2/c1-30-11-9-17(10-12-30)27-22(31)15-7-8-19(20(13-15)32-2)28-23-25-14-18(24)21(29-23)26-16-5-3-4-6-16/h7-8,13-14,16-17H,3-6,9-12H2,1-2H3,(H,27,31)(H2,25,26,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 395 | n/a | n/a | n/a | n/a | n/a | n/a |
Lanzhou University
Curated by ChEMBL
| Assay Description
Inhibition of Aurora B in human HeLa cells after 12 hrs by ELISA method |
Eur J Med Chem 95: 174-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.044
BindingDB Entry DOI: 10.7270/Q2R78GXS |
More data for this
Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50079534
(CHEMBL3417325)Show SMILES CN1CCC(CC1)NC(=O)c1ccc(Nc2ncc(Br)c(NC3CCCC3)n2)cc1 Show InChI InChI=1S/C22H29BrN6O/c1-29-12-10-18(11-13-29)26-21(30)15-6-8-17(9-7-15)27-22-24-14-19(23)20(28-22)25-16-4-2-3-5-16/h6-9,14,16,18H,2-5,10-13H2,1H3,(H,26,30)(H2,24,25,27,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Lanzhou University
Curated by ChEMBL
| Assay Description
Inhibition of Aurora B in human HeLa cells after 12 hrs by ELISA method |
Eur J Med Chem 95: 174-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.044
BindingDB Entry DOI: 10.7270/Q2R78GXS |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463719
(CHEMBL4244708)Show SMILES C\C=C/C(=O)Nc1ccc(NC(=O)Nc2ccc(cc2)-c2cc(C)nc3noc(N)c23)cc1 Show InChI InChI=1S/C24H22N6O3/c1-3-4-20(31)27-16-9-11-18(12-10-16)29-24(32)28-17-7-5-15(6-8-17)19-13-14(2)26-23-21(19)22(25)33-30-23/h3-13H,25H2,1-2H3,(H,27,31)(H2,28,29,32)/b4-3- | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 438 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463710
(CHEMBL4245241)Show SMILES Nc1onc2nc(cc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C25H18FN5O2/c26-17-8-12-19(13-9-17)29-25(32)28-18-10-6-15(7-11-18)20-14-21(16-4-2-1-3-5-16)30-24-22(20)23(27)33-31-24/h1-14H,27H2,(H2,28,29,32) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 449 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Aurora kinase B
(Homo sapiens (Human)) | BDBM50004205
(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 453 | n/a | n/a | n/a | n/a | n/a | n/a |
Lanzhou University
Curated by ChEMBL
| Assay Description
Inhibition of Aurora B in human HeLa cells after 12 hrs by ELISA method |
Eur J Med Chem 95: 174-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.03.044
BindingDB Entry DOI: 10.7270/Q2R78GXS |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50463713
(CHEMBL4238294)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3ccc(NC(=O)C(=C)CN4CCOCC4)c(C)c3)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C29H31N7O4/c1-17-14-22(8-9-24(17)34-28(37)18(2)16-36-10-12-39-13-11-36)33-29(38)32-21-6-4-20(5-7-21)23-15-19(3)31-27-25(23)26(30)40-35-27/h4-9,14-15H,2,10-13,16,30H2,1,3H3,(H,34,37)(H2,32,33,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463717
(CHEMBL4243899)Show SMILES Nc1onc2nc(cc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C25H18FN5O2/c26-17-7-4-8-19(13-17)29-25(32)28-18-11-9-15(10-12-18)20-14-21(16-5-2-1-3-6-16)30-24-22(20)23(27)33-31-24/h1-14H,27H2,(H2,28,29,32) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 565 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50463706
(CHEMBL4251080)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3ccccc3Cl)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C20H16ClN5O2/c1-11-10-14(17-18(22)28-26-19(17)23-11)12-6-8-13(9-7-12)24-20(27)25-16-5-3-2-4-15(16)21/h2-10H,22H2,1H3,(H2,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human KDR using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50463705
(CHEMBL4242710)Show SMILES Nc1onc2nc(cc(-c3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C26H17ClF3N5O2/c27-20-11-10-17(12-19(20)26(28,29)30)33-25(36)32-16-8-6-14(7-9-16)18-13-21(15-4-2-1-3-5-15)34-24-22(18)23(31)37-35-24/h1-13H,31H2,(H2,32,33,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 685 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human KDR using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50463710
(CHEMBL4245241)Show SMILES Nc1onc2nc(cc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C25H18FN5O2/c26-17-8-12-19(13-9-17)29-25(32)28-18-10-6-15(7-11-18)20-14-21(16-4-2-1-3-5-16)30-24-22(20)23(27)33-31-24/h1-14H,27H2,(H2,28,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 696 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human KDR using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50463706
(CHEMBL4251080)Show SMILES Cc1cc(-c2ccc(NC(=O)Nc3ccccc3Cl)cc2)c2c(N)onc2n1 Show InChI InChI=1S/C20H16ClN5O2/c1-11-10-14(17-18(22)28-26-19(17)23-11)12-6-8-13(9-7-12)24-20(27)25-16-5-3-2-4-15(16)21/h2-10H,22H2,1H3,(H2,24,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50463718
(CHEMBL4249500)Show SMILES Nc1onc2nc(cc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C25H19N5O2/c26-23-22-20(15-21(29-24(22)30-32-23)17-7-3-1-4-8-17)16-11-13-19(14-12-16)28-25(31)27-18-9-5-2-6-10-18/h1-15H,26H2,(H2,27,28,31) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human FLT3 using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50463708
(CHEMBL4238195)Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc(nc3noc(N)c23)-c2ccccc2)c1 Show InChI InChI=1S/C26H21N5O2/c1-16-6-5-9-20(14-16)29-26(32)28-19-12-10-17(11-13-19)21-15-22(18-7-3-2-4-8-18)30-25-23(21)24(27)33-31-25/h2-15H,27H2,1H3,(H2,28,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50463714
(CHEMBL4245698)Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cc(nc3noc(N)c23)-c2ccccc2)cc1 Show InChI InChI=1S/C26H21N5O2/c1-16-7-11-19(12-8-16)28-26(32)29-20-13-9-17(10-14-20)21-15-22(18-5-3-2-4-6-18)30-25-23(21)24(27)33-31-25/h2-15H,27H2,1H3,(H2,28,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50463711
(CHEMBL4241470)Show SMILES Nc1onc2nc(cc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C25H18ClN5O2/c26-17-7-4-8-19(13-17)29-25(32)28-18-11-9-15(10-12-18)20-14-21(16-5-2-1-3-6-16)30-24-22(20)23(27)33-31-24/h1-14H,27H2,(H2,28,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50463717
(CHEMBL4243899)Show SMILES Nc1onc2nc(cc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C25H18FN5O2/c26-17-7-4-8-19(13-17)29-25(32)28-18-11-9-15(10-12-18)20-14-21(16-5-2-1-3-6-16)30-24-22(20)23(27)33-31-24/h1-14H,27H2,(H2,28,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50463718
(CHEMBL4249500)Show SMILES Nc1onc2nc(cc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C25H19N5O2/c26-23-22-20(15-21(29-24(22)30-32-23)17-7-3-1-4-8-17)16-11-13-19(14-12-16)28-25(31)27-18-9-5-2-6-10-18/h1-15H,26H2,(H2,27,28,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50463710
(CHEMBL4245241)Show SMILES Nc1onc2nc(cc(-c3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c12)-c1ccccc1 Show InChI InChI=1S/C25H18FN5O2/c26-17-8-12-19(13-9-17)29-25(32)28-18-10-6-15(7-11-18)20-14-21(16-4-2-1-3-5-16)30-24-22(20)23(27)33-31-24/h1-14H,27H2,(H2,28,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Inhibition of human PDGFRbeta using biotin labeled substrate after 1 hr by HTFR assay |
Bioorg Med Chem 26: 4735-4744 (2018)
Article DOI: 10.1016/j.bmc.2018.08.013
BindingDB Entry DOI: 10.7270/Q208680Z |
More data for this
Ligand-Target Pair | |
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