Found 123 hits with Last Name = 'tontsch-grunt' and Initial = 'u' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50279238
((Z)-3-({4-[N-Acetyl-(3-dimethylaminopropyl)-amino]...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C30H32N4O4/c1-20(35)34(18-8-17-33(2)3)24-14-12-23(13-15-24)31-28(21-9-6-5-7-10-21)27-25-16-11-22(30(37)38-4)19-26(25)32-29(27)36/h5-7,9-16,19,27H,8,17-18H2,1-4H3,(H,32,36) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR3 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50279080
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50279267
((Z)-3-({4-[N-Acetyl-(2-dimethylaminoethyl)-amino]-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H30N4O4/c1-19(34)33(17-16-32(2)3)23-13-11-22(12-14-23)30-27(20-8-6-5-7-9-20)26-24-15-10-21(29(36)37-4)18-25(24)31-28(26)35/h5-15,18,26H,16-17H2,1-4H3,(H,31,35) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR3 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50279080
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR3 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50279236
((Z)-3-({4-[(2-Imidazol-1-yl-acetyl)methylamino]-ph...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)Cn3ccnc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H25N5O4/c1-33(25(35)17-34-15-14-30-18-34)22-11-9-21(10-12-22)31-27(19-6-4-3-5-7-19)26-23-13-8-20(29(37)38-2)16-24(23)32-28(26)36/h3-16,18,26H,17H2,1-2H3,(H,32,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50279237
((Z)-3-{[4-(N-Acetyl-dimethylcarbamoylmethyl-amino)...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CC(=O)N(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H28N4O5/c1-18(34)33(17-25(35)32(2)3)22-13-11-21(12-14-22)30-27(19-8-6-5-7-9-19)26-23-15-10-20(29(37)38-4)16-24(23)31-28(26)36/h5-16,26H,17H2,1-4H3,(H,31,36) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR3 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50279082
((Z)-6-Nitro-3-[phenyl-(4-piperidin-1-ylmethyl-phen...)Show SMILES [O-][N+](=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1 |w:9.9| Show InChI InChI=1S/C27H26N4O3/c32-27-25(23-14-13-22(31(33)34)17-24(23)29-27)26(20-7-3-1-4-8-20)28-21-11-9-19(10-12-21)18-30-15-5-2-6-16-30/h1,3-4,7-14,17,25H,2,5-6,15-16,18H2,(H,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50279236
((Z)-3-({4-[(2-Imidazol-1-yl-acetyl)methylamino]-ph...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)Cn3ccnc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H25N5O4/c1-33(25(35)17-34-15-14-30-18-34)22-11-9-21(10-12-22)31-27(19-6-4-3-5-7-19)26-23-13-8-20(29(37)38-2)16-24(23)32-28(26)36/h3-16,18,26H,17H2,1-2H3,(H,32,36) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR3 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50279238
((Z)-3-({4-[N-Acetyl-(3-dimethylaminopropyl)-amino]...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C30H32N4O4/c1-20(35)34(18-8-17-33(2)3)24-14-12-23(13-15-24)31-28(21-9-6-5-7-10-21)27-25-16-11-22(30(37)38-4)19-26(25)32-29(27)36/h5-7,9-16,19,27H,8,17-18H2,1-4H3,(H,32,36) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human PDGFRalpha |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50279267
((Z)-3-({4-[N-Acetyl-(2-dimethylaminoethyl)-amino]-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H30N4O4/c1-19(34)33(17-16-32(2)3)23-13-11-22(12-14-23)30-27(20-8-6-5-7-9-20)26-24-15-10-21(29(36)37-4)18-25(24)31-28(26)35/h5-15,18,26H,16-17H2,1-4H3,(H,31,35) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human PDGFRalpha |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50279236
((Z)-3-({4-[(2-Imidazol-1-yl-acetyl)methylamino]-ph...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)Cn3ccnc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H25N5O4/c1-33(25(35)17-34-15-14-30-18-34)22-11-9-21(10-12-22)31-27(19-6-4-3-5-7-19)26-23-13-8-20(29(37)38-2)16-24(23)32-28(26)36/h3-16,18,26H,17H2,1-2H3,(H,32,36) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human PDGFRalpha |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50279237
((Z)-3-{[4-(N-Acetyl-dimethylcarbamoylmethyl-amino)...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CC(=O)N(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H28N4O5/c1-18(34)33(17-25(35)32(2)3)22-13-11-21(12-14-22)30-27(19-8-6-5-7-9-19)26-23-15-10-20(29(37)38-4)16-24(23)31-28(26)36/h5-16,26H,17H2,1-4H3,(H,31,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50279238
((Z)-3-({4-[N-Acetyl-(3-dimethylaminopropyl)-amino]...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C30H32N4O4/c1-20(35)34(18-8-17-33(2)3)24-14-12-23(13-15-24)31-28(21-9-6-5-7-10-21)27-25-16-11-22(30(37)38-4)19-26(25)32-29(27)36/h5-7,9-16,19,27H,8,17-18H2,1-4H3,(H,32,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50279237
((Z)-3-{[4-(N-Acetyl-dimethylcarbamoylmethyl-amino)...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CC(=O)N(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H28N4O5/c1-18(34)33(17-25(35)32(2)3)22-13-11-21(12-14-22)30-27(19-8-6-5-7-9-19)26-23-15-10-20(29(37)38-4)16-24(23)31-28(26)36/h5-16,26H,17H2,1-4H3,(H,31,36) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human PDGFRalpha |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50279045
((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C(=O)N(C)C)cc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C28H28N4O4/c1-31(2)28(35)32(3)17-18-10-13-21(14-11-18)29-25(19-8-6-5-7-9-19)24-22-15-12-20(27(34)36-4)16-23(22)30-26(24)33/h5-16,24H,17H2,1-4H3,(H,30,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR3 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50279268
((Z)-3-({4-[(2-Dimethylaminoethyl)-methanesulfonyl-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)S(C)(=O)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C28H30N4O5S/c1-31(2)16-17-32(38(4,35)36)22-13-11-21(12-14-22)29-26(19-8-6-5-7-9-19)25-23-15-10-20(28(34)37-3)18-24(23)30-27(25)33/h5-15,18,25H,16-17H2,1-4H3,(H,30,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR3 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50279269
((Z)-3-({4-[(3-Dimethylaminopropyl)-methyl-carbamoy...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)C(=O)N(C)CCN(C)C)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H30N4O4/c1-32(2)16-17-33(3)28(35)20-10-13-22(14-11-20)30-26(19-8-6-5-7-9-19)25-23-15-12-21(29(36)37-4)18-24(23)31-27(25)34/h5-15,18,25H,16-17H2,1-4H3,(H,31,34) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human PDGFRalpha |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50279267
((Z)-3-({4-[N-Acetyl-(2-dimethylaminoethyl)-amino]-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H30N4O4/c1-19(34)33(17-16-32(2)3)23-13-11-22(12-14-23)30-27(20-8-6-5-7-9-20)26-24-15-10-21(29(36)37-4)18-25(24)31-28(26)35/h5-15,18,26H,16-17H2,1-4H3,(H,31,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50279268
((Z)-3-({4-[(2-Dimethylaminoethyl)-methanesulfonyl-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)S(C)(=O)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C28H30N4O5S/c1-31(2)16-17-32(38(4,35)36)22-13-11-21(12-14-22)29-26(19-8-6-5-7-9-19)25-23-15-10-20(28(34)37-3)18-24(23)30-27(25)33/h5-15,18,25H,16-17H2,1-4H3,(H,30,33) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human PDGFRalpha |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50279080
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR3 |
Cancer Res 68: 4774-82 (2008)
Article DOI: 10.1158/0008-5472.CAN-07-6307 BindingDB Entry DOI: 10.7270/Q26M3715 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Mus musculus) | BDBM50279080
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) | PDB MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
| Assay Description Inhibition of mouse GST-fused VEGFR2 expressed in Sf9 insect cells after 20 mins by scintillation counting |
Cancer Res 68: 4774-82 (2008)
Article DOI: 10.1158/0008-5472.CAN-07-6307 BindingDB Entry DOI: 10.7270/Q26M3715 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50279080
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
| Assay Description Inhibition of human Lck |
Cancer Res 68: 4774-82 (2008)
Article DOI: 10.1158/0008-5472.CAN-07-6307 BindingDB Entry DOI: 10.7270/Q26M3715 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50279080
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human Lck |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50279238
((Z)-3-({4-[N-Acetyl-(3-dimethylaminopropyl)-amino]...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C30H32N4O4/c1-20(35)34(18-8-17-33(2)3)24-14-12-23(13-15-24)31-28(21-9-6-5-7-10-21)27-25-16-11-22(30(37)38-4)19-26(25)32-29(27)36/h5-7,9-16,19,27H,8,17-18H2,1-4H3,(H,32,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50279267
((Z)-3-({4-[N-Acetyl-(2-dimethylaminoethyl)-amino]-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H30N4O4/c1-19(34)33(17-16-32(2)3)23-13-11-22(12-14-23)30-27(20-8-6-5-7-9-20)26-24-15-10-21(29(36)37-4)18-25(24)31-28(26)35/h5-15,18,26H,16-17H2,1-4H3,(H,31,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50279080
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human PDGFRalpha |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50279045
((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C(=O)N(C)C)cc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C28H28N4O4/c1-31(2)28(35)32(3)17-18-10-13-21(14-11-18)29-25(19-8-6-5-7-9-19)24-22-15-12-20(27(34)36-4)16-23(22)30-26(24)33/h5-16,24H,17H2,1-4H3,(H,30,33) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human PDGFRalpha |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50279080
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
| Assay Description Inhibition of human GST-fused VEGFR2 expressed in Sf9 insect cells after 20 mins by scintillation counting |
Cancer Res 68: 4774-82 (2008)
Article DOI: 10.1158/0008-5472.CAN-07-6307 BindingDB Entry DOI: 10.7270/Q26M3715 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50279268
((Z)-3-({4-[(2-Dimethylaminoethyl)-methanesulfonyl-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)S(C)(=O)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C28H30N4O5S/c1-31(2)16-17-32(38(4,35)36)22-13-11-21(12-14-22)29-26(19-8-6-5-7-9-19)25-23-15-10-20(28(34)37-3)18-24(23)30-27(25)33/h5-15,18,25H,16-17H2,1-4H3,(H,30,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50279269
((Z)-3-({4-[(3-Dimethylaminopropyl)-methyl-carbamoy...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)C(=O)N(C)CCN(C)C)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H30N4O4/c1-32(2)16-17-33(3)28(35)20-10-13-22(14-11-20)30-26(19-8-6-5-7-9-19)25-23-15-12-21(29(36)37-4)18-24(23)31-27(25)34/h5-15,18,25H,16-17H2,1-4H3,(H,31,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50279298
((Z)-3-({4-[2-(4-Methylpiperazin-1-yl)acetylamino]-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(NC(=O)CN4CCN(C)CC4)cc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C30H31N5O4/c1-34-14-16-35(17-15-34)19-26(36)31-22-9-11-23(12-10-22)32-28(20-6-4-3-5-7-20)27-24-13-8-21(30(38)39-2)18-25(24)33-29(27)37/h3-13,18,27H,14-17,19H2,1-2H3,(H,31,36)(H,33,37) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR3 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50279268
((Z)-3-({4-[(2-Dimethylaminoethyl)-methanesulfonyl-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)S(C)(=O)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C28H30N4O5S/c1-31(2)16-17-32(38(4,35)36)22-13-11-21(12-14-22)29-26(19-8-6-5-7-9-19)25-23-15-10-20(28(34)37-3)18-24(23)30-27(25)33/h5-15,18,25H,16-17H2,1-4H3,(H,30,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50279080
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human Flt3 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50279080
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
| Assay Description Inhibition of human Flt3 |
Cancer Res 68: 4774-82 (2008)
Article DOI: 10.1158/0008-5472.CAN-07-6307 BindingDB Entry DOI: 10.7270/Q26M3715 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50279270
((Z)-3-[(4-Dimethylaminomethyl-phenylamino)-phenyl-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C)cc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C26H25N3O3/c1-29(2)16-17-9-12-20(13-10-17)27-24(18-7-5-4-6-8-18)23-21-14-11-19(26(31)32-3)15-22(21)28-25(23)30/h4-15,23H,16H2,1-3H3,(H,28,30) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human PDGFRalpha |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50279238
((Z)-3-({4-[N-Acetyl-(3-dimethylaminopropyl)-amino]...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C30H32N4O4/c1-20(35)34(18-8-17-33(2)3)24-14-12-23(13-15-24)31-28(21-9-6-5-7-10-21)27-25-16-11-22(30(37)38-4)19-26(25)32-29(27)36/h5-7,9-16,19,27H,8,17-18H2,1-4H3,(H,32,36) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR1 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50279198
((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H29N3O3/c1-35-29(34)22-12-15-24-25(18-22)31-28(33)26(24)27(21-8-4-2-5-9-21)30-23-13-10-20(11-14-23)19-32-16-6-3-7-17-32/h2,4-5,8-15,18,26H,3,6-7,16-17,19H2,1H3,(H,31,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR3 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50279080
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR1 |
Cancer Res 68: 4774-82 (2008)
Article DOI: 10.1158/0008-5472.CAN-07-6307 BindingDB Entry DOI: 10.7270/Q26M3715 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50279267
((Z)-3-({4-[N-Acetyl-(2-dimethylaminoethyl)-amino]-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H30N4O4/c1-19(34)33(17-16-32(2)3)23-13-11-22(12-14-23)30-27(20-8-6-5-7-9-20)26-24-15-10-21(29(36)37-4)18-25(24)31-28(26)35/h5-15,18,26H,16-17H2,1-4H3,(H,31,35) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR1 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50279198
((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H29N3O3/c1-35-29(34)22-12-15-24-25(18-22)31-28(33)26(24)27(21-8-4-2-5-9-21)30-23-13-10-20(11-14-23)19-32-16-6-3-7-17-32/h2,4-5,8-15,18,26H,3,6-7,16-17,19H2,1H3,(H,31,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50279080
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 |
Cancer Res 68: 4774-82 (2008)
Article DOI: 10.1158/0008-5472.CAN-07-6307 BindingDB Entry DOI: 10.7270/Q26M3715 |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50279080
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50279045
((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C(=O)N(C)C)cc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C28H28N4O4/c1-31(2)28(35)32(3)17-18-10-13-21(14-11-18)29-25(19-8-6-5-7-9-19)24-22-15-12-20(27(34)36-4)16-23(22)30-26(24)33/h5-16,24H,17H2,1-4H3,(H,30,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50279198
((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H29N3O3/c1-35-29(34)22-12-15-24-25(18-22)31-28(33)26(24)27(21-8-4-2-5-9-21)30-23-13-10-20(11-14-23)19-32-16-6-3-7-17-32/h2,4-5,8-15,18,26H,3,6-7,16-17,19H2,1H3,(H,31,33) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human PDGFRalpha |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50279237
((Z)-3-{[4-(N-Acetyl-dimethylcarbamoylmethyl-amino)...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CC(=O)N(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H28N4O5/c1-18(34)33(17-25(35)32(2)3)22-13-11-21(12-14-22)30-27(19-8-6-5-7-9-19)26-23-15-10-20(29(37)38-4)16-24(23)31-28(26)36/h5-16,26H,17H2,1-4H3,(H,31,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50279236
((Z)-3-({4-[(2-Imidazol-1-yl-acetyl)methylamino]-ph...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)Cn3ccnc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H25N5O4/c1-33(25(35)17-34-15-14-30-18-34)22-11-9-21(10-12-22)31-27(19-6-4-3-5-7-19)26-23-13-8-20(29(37)38-2)16-24(23)32-28(26)36/h3-16,18,26H,17H2,1-2H3,(H,32,36) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR1 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50279080
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
| Assay Description Inhibition of human PDGFRalpha |
Cancer Res 68: 4774-82 (2008)
Article DOI: 10.1158/0008-5472.CAN-07-6307 BindingDB Entry DOI: 10.7270/Q26M3715 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50279269
((Z)-3-({4-[(3-Dimethylaminopropyl)-methyl-carbamoy...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)C(=O)N(C)CCN(C)C)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H30N4O4/c1-32(2)16-17-33(3)28(35)20-10-13-22(14-11-20)30-26(19-8-6-5-7-9-19)25-23-15-12-21(29(36)37-4)18-24(23)31-27(25)34/h5-15,18,25H,16-17H2,1-4H3,(H,31,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR3 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50279237
((Z)-3-{[4-(N-Acetyl-dimethylcarbamoylmethyl-amino)...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CC(=O)N(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C29H28N4O5/c1-18(34)33(17-25(35)32(2)3)22-13-11-21(12-14-22)30-27(19-8-6-5-7-9-19)26-23-15-10-20(29(37)38-4)16-24(23)31-28(26)36/h5-16,26H,17H2,1-4H3,(H,31,36) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR1 |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50279045
((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C(=O)N(C)C)cc3)c3ccccc3)C(=O)Nc2c1 |w:10.10| Show InChI InChI=1S/C28H28N4O4/c1-31(2)28(35)32(3)17-18-10-13-21(14-11-18)29-25(19-8-6-5-7-9-19)24-22-15-12-20(27(34)36-4)16-23(22)30-26(24)33/h5-16,24H,17H2,1-4H3,(H,30,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
| Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells |
J Med Chem 52: 4466-80 (2009)
Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS |
More data for this Ligand-Target Pair | |