Compile Data Set for Download or QSAR

Found 276 hits with Last Name = 'toschi' and Initial = 'l'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458963 ((4-{[2-(4-Bromophenyl)imidazo[,2-a]pyridin-3-yl]me...) Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CCN(CC1)C(=O)C1CCCC1 Show InChI InChI=1S/C24H27BrN4O/c25-20-10-8-18(9-11-20)23-21(29-12-4-3-7-22(29)26-23)17-27-13-15-28(16-14-27)24(30)19-5-1-2-6-19/h3-4,7-12,19H,1-2,5-6,13-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.04	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458968 (US10759794, Example 47) Show SMILES COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Br)cc2)CC1 Show InChI InChI=1S/C25H24BrN5O2/c1-33-23-7-4-5-20(27-23)25(32)30-15-13-29(14-16-30)17-21-24(18-8-10-19(26)11-9-18)28-22-6-2-3-12-31(21)22/h2-12H,13-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM458964 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) Show SMILES Clc1ccc(cc1)-c1nc2ccccn2c1CN1CCN(CC1)C(=O)C1CCCC1 Show InChI InChI=1S/C24H27ClN4O/c25-20-10-8-18(9-11-20)23-21(29-12-4-3-7-22(29)26-23)17-27-13-15-28(16-14-27)24(30)19-5-1-2-6-19/h3-4,7-12,19H,1-2,5-6,13-17H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM459034 (US10759794, Example 72) Show SMILES COc1ccc(C)c(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C26H26ClN5O2/c1-18-6-11-23(34-2)29-24(18)26(33)31-15-13-30(14-16-31)17-21-25(19-7-9-20(27)10-8-19)28-22-5-3-4-12-32(21)22/h3-12H,13-17H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM458965 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) Show SMILES COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C25H24ClN5O2/c1-33-23-7-4-5-20(27-23)25(32)30-15-13-29(14-16-30)17-21-24(18-8-10-19(26)11-9-18)28-22-6-2-3-12-31(21)22/h2-12H,13-17H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM458969 (US10759794, Example 54) Show SMILES CC(C)c1ccc(cc1)-c1nc2ccccn2c1CN1CCN(CC1)C(=O)C1CCCC1 Show InChI InChI=1S/C27H34N4O/c1-20(2)21-10-12-22(13-11-21)26-24(31-14-6-5-9-25(31)28-26)19-29-15-17-30(18-16-29)27(32)23-7-3-4-8-23/h5-6,9-14,20,23H,3-4,7-8,15-19H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM413565 (US10414765, Example 49) Show SMILES COc1ccc(C)c(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1 Show InChI InChI=1S/C28H28ClN5O2/c1-18-6-11-25(36-2)31-26(18)28(35)33-15-20-13-32(14-21(20)16-33)17-23-27(19-7-9-22(29)10-8-19)30-24-5-3-4-12-34(23)24/h3-12,20-21H,13-17H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...				US Patent US10414765 (2019) BindingDB Entry DOI: 10.7270/Q2QJ7KNV
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM458968 (US10759794, Example 47) Show SMILES COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Br)cc2)CC1 Show InChI InChI=1S/C25H24BrN5O2/c1-33-23-7-4-5-20(27-23)25(32)30-15-13-29(14-16-30)17-21-24(18-8-10-19(26)11-9-18)28-22-6-2-3-12-31(21)22/h2-12H,13-17H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.90	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM459030 ((4-{[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl]...) Show SMILES COc1ccc(F)c(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C25H23ClFN5O2/c1-34-22-10-9-19(27)24(29-22)25(33)31-14-12-30(13-15-31)16-20-23(17-5-7-18(26)8-6-17)28-21-4-2-3-11-32(20)21/h2-11H,12-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458967 (US10759794, Example 39) Show SMILES CC(C)Oc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C27H28ClN5O2/c1-19(2)35-25-8-5-6-22(29-25)27(34)32-16-14-31(15-17-32)18-23-26(20-9-11-21(28)12-10-20)30-24-7-3-4-13-33(23)24/h3-13,19H,14-18H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM458963 ((4-{[2-(4-Bromophenyl)imidazo[,2-a]pyridin-3-yl]me...) Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CCN(CC1)C(=O)C1CCCC1 Show InChI InChI=1S/C24H27BrN4O/c25-20-10-8-18(9-11-20)23-21(29-12-4-3-7-22(29)26-23)17-27-13-15-28(16-14-27)24(30)19-5-1-2-6-19/h3-4,7-12,19H,1-2,5-6,13-17H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM459036 (US10759794, Example 74) Show SMILES COc1ccc(C)c(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Br)cc2)CC1 Show InChI InChI=1S/C26H26BrN5O2/c1-18-6-11-23(34-2)29-24(18)26(33)31-15-13-30(14-16-31)17-21-25(19-7-9-20(27)10-8-19)28-22-5-3-4-12-32(21)22/h3-12H,13-17H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.10	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM413514 (US10414765, Example 17) Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1 Show InChI InChI=1S/C28H27ClN4O2/c1-35-24-6-4-5-20(13-24)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(19-8-10-23(29)11-9-19)30-26-7-2-3-12-33(25)26/h2-13,21-22H,14-18H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...				US Patent US10414765 (2019) BindingDB Entry DOI: 10.7270/Q2QJ7KNV
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM459029 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) Show SMILES FC(F)(F)Oc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C25H21ClF3N5O2/c26-18-9-7-17(8-10-18)23-20(34-11-2-1-5-21(34)31-23)16-32-12-14-33(15-13-32)24(35)19-4-3-6-22(30-19)36-25(27,28)29/h1-11H,12-16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM458966 ((4-{[2-(4-Bromophenyl)imidazo [1,2-a]pyridin-3-yl]...) Show SMILES Fc1ccccc1C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Br)cc2)CC1 Show InChI InChI=1S/C25H22BrFN4O/c26-19-10-8-18(9-11-19)24-22(31-12-4-3-7-23(31)28-24)17-29-13-15-30(16-14-29)25(32)20-5-1-2-6-21(20)27/h1-12H,13-17H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM459008 (US10759794, Example 43) Show SMILES COc1ccc(Cl)c(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C25H23Cl2N5O2/c1-34-22-10-9-19(27)24(29-22)25(33)31-14-12-30(13-15-31)16-20-23(17-5-7-18(26)8-6-17)28-21-4-2-3-11-32(20)21/h2-11H,12-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM459031 ((4-{[2-(4-Cyclopropylphenyl)imidazo[1,2-a]pyridin-...) Show SMILES Fc1ccccc1C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(cc2)C2CC2)CC1 Show InChI InChI=1S/C28H27FN4O/c29-24-6-2-1-5-23(24)28(34)32-17-15-31(16-18-32)19-25-27(30-26-7-3-4-14-33(25)26)22-12-10-21(11-13-22)20-8-9-20/h1-7,10-14,20H,8-9,15-19H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM459007 (US10759794, Example 42) Show SMILES COc1ccc(Br)c(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C25H23BrClN5O2/c1-34-22-10-9-19(26)24(29-22)25(33)31-14-12-30(13-15-31)16-20-23(17-5-7-18(27)8-6-17)28-21-4-2-3-11-32(20)21/h2-11H,12-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM458967 (US10759794, Example 39) Show SMILES CC(C)Oc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C27H28ClN5O2/c1-19(2)35-25-8-5-6-22(29-25)27(34)32-16-14-31(15-17-32)18-23-26(20-9-11-21(28)12-10-20)30-24-7-3-4-13-33(23)24/h3-13,19H,14-18H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.4	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458993 (US10759794, Example 28) Show SMILES CCOc1ccccc1C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C27H27ClN4O2/c1-2-34-24-8-4-3-7-22(24)27(33)31-17-15-30(16-18-31)19-23-26(20-10-12-21(28)13-11-20)29-25-9-5-6-14-32(23)25/h3-14H,2,15-19H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458966 ((4-{[2-(4-Bromophenyl)imidazo [1,2-a]pyridin-3-yl]...) Show SMILES Fc1ccccc1C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Br)cc2)CC1 Show InChI InChI=1S/C25H22BrFN4O/c26-19-10-8-18(9-11-19)24-22(31-12-4-3-7-23(31)28-24)17-29-13-15-30(16-14-29)25(32)20-5-1-2-6-21(20)27/h1-12H,13-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM459033 (US10759794, Example 71) Show SMILES COc1ccc(C)c(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(cc2)C#N)CC1 Show InChI InChI=1S/C27H26N6O2/c1-19-6-11-24(35-2)30-25(19)27(34)32-15-13-31(14-16-32)18-22-26(21-9-7-20(17-28)8-10-21)29-23-5-3-4-12-33(22)23/h3-12H,13-16,18H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458963 ((4-{[2-(4-Bromophenyl)imidazo[,2-a]pyridin-3-yl]me...) Show SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CCN(CC1)C(=O)C1CCCC1 Show InChI InChI=1S/C24H27BrN4O/c25-20-10-8-18(9-11-20)23-21(29-12-4-3-7-22(29)26-23)17-27-13-15-28(16-14-27)24(30)19-5-1-2-6-19/h3-4,7-12,19H,1-2,5-6,13-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM459035 (US10759794, Example 73) Show SMILES COc1ccc(C)c(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(cc2)C(C)(C)C)CC1 Show InChI InChI=1S/C30H35N5O2/c1-21-9-14-26(37-5)32-27(21)29(36)34-18-16-33(17-19-34)20-24-28(31-25-8-6-7-15-35(24)25)22-10-12-23(13-11-22)30(2,3)4/h6-15H,16-20H2,1-5H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM459009 (US10759794, Example 44) Show SMILES FC(F)Oc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C25H22ClF2N5O2/c26-18-9-7-17(8-10-18)23-20(33-11-2-1-5-21(33)30-23)16-31-12-14-32(15-13-31)24(34)19-4-3-6-22(29-19)35-25(27)28/h1-11,25H,12-16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458968 (US10759794, Example 47) Show SMILES COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Br)cc2)CC1 Show InChI InChI=1S/C25H24BrN5O2/c1-33-23-7-4-5-20(27-23)25(32)30-15-13-29(14-16-30)17-21-24(18-8-10-19(26)11-9-18)28-22-6-2-3-12-31(21)22/h2-12H,13-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458964 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) Show SMILES Clc1ccc(cc1)-c1nc2ccccn2c1CN1CCN(CC1)C(=O)C1CCCC1 Show InChI InChI=1S/C24H27ClN4O/c25-20-10-8-18(9-11-20)23-21(29-12-4-3-7-22(29)26-23)17-27-13-15-28(16-14-27)24(30)19-5-1-2-6-19/h3-4,7-12,19H,1-2,5-6,13-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM413514 (US10414765, Example 17) Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1 Show InChI InChI=1S/C28H27ClN4O2/c1-35-24-6-4-5-20(13-24)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(19-8-10-23(29)11-9-19)30-26-7-2-3-12-33(25)26/h2-13,21-22H,14-18H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	21.8	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...				US Patent US10414765 (2019) BindingDB Entry DOI: 10.7270/Q2QJ7KNV
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458964 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) Show SMILES Clc1ccc(cc1)-c1nc2ccccn2c1CN1CCN(CC1)C(=O)C1CCCC1 Show InChI InChI=1S/C24H27ClN4O/c25-20-10-8-18(9-11-20)23-21(29-12-4-3-7-22(29)26-23)17-27-13-15-28(16-14-27)24(30)19-5-1-2-6-19/h3-4,7-12,19H,1-2,5-6,13-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.8	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458965 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) Show SMILES COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C25H24ClN5O2/c1-33-23-7-4-5-20(27-23)25(32)30-15-13-29(14-16-30)17-21-24(18-8-10-19(26)11-9-18)28-22-6-2-3-12-31(21)22/h2-12H,13-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.9	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458965 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) Show SMILES COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C25H24ClN5O2/c1-33-23-7-4-5-20(27-23)25(32)30-15-13-29(14-16-30)17-21-24(18-8-10-19(26)11-9-18)28-22-6-2-3-12-31(21)22/h2-12H,13-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM459004 (US10759794, Example 38) Show SMILES FC(F)(F)COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C26H23ClF3N5O2/c27-19-9-7-18(8-10-19)24-21(35-11-2-1-5-22(35)32-24)16-33-12-14-34(15-13-33)25(36)20-4-3-6-23(31-20)37-17-26(28,29)30/h1-11H,12-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM413513 (US10414765, Example 10) Show SMILES COc1cccc(c1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Br)cc3)CC2C1 Show InChI InChI=1S/C28H27BrN4O2/c1-35-24-6-4-5-20(13-24)28(34)32-16-21-14-31(15-22(21)17-32)18-25-27(19-8-10-23(29)11-9-19)30-26-7-2-3-12-33(25)26/h2-13,21-22H,14-18H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	31.2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...				US Patent US10414765 (2019) BindingDB Entry DOI: 10.7270/Q2QJ7KNV
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458969 (US10759794, Example 54) Show SMILES CC(C)c1ccc(cc1)-c1nc2ccccn2c1CN1CCN(CC1)C(=O)C1CCCC1 Show InChI InChI=1S/C27H34N4O/c1-20(2)21-10-12-22(13-11-21)26-24(31-14-6-5-9-25(31)28-26)19-29-15-17-30(18-16-29)27(32)23-7-3-4-8-23/h5-6,9-14,20,23H,3-4,7-8,15-19H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	38.2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM459029 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) Show SMILES FC(F)(F)Oc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C25H21ClF3N5O2/c26-18-9-7-17(8-10-18)23-20(34-11-2-1-5-21(34)31-23)16-32-12-14-33(15-13-32)24(35)19-4-3-6-22(30-19)36-25(27,28)29/h1-11H,12-16H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM413516 (US10414765, Example 25) Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1 Show InChI InChI=1S/C30H33N5O2/c1-20(2)21-10-12-22(13-11-21)29-26(35-14-5-4-8-27(35)32-29)19-33-15-23-17-34(18-24(23)16-33)30(36)25-7-6-9-28(31-25)37-3/h4-14,20,23-24H,15-19H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	44.1	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...				US Patent US10414765 (2019) BindingDB Entry DOI: 10.7270/Q2QJ7KNV
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM458970 (US10759794, Example 55) Show SMILES COc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(cc2)C(C)C)CC1 Show InChI InChI=1S/C28H31N5O2/c1-20(2)21-10-12-22(13-11-21)27-24(33-14-5-4-8-25(33)30-27)19-31-15-17-32(18-16-31)28(34)23-7-6-9-26(29-23)35-3/h4-14,20H,15-19H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458966 ((4-{[2-(4-Bromophenyl)imidazo [1,2-a]pyridin-3-yl]...) Show SMILES Fc1ccccc1C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Br)cc2)CC1 Show InChI InChI=1S/C25H22BrFN4O/c26-19-10-8-18(9-11-19)24-22(31-12-4-3-7-23(31)28-24)17-29-13-15-30(16-14-29)25(32)20-5-1-2-6-21(20)27/h1-12H,13-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458985 (US10759794, Example 20) Show SMILES COc1ccccc1C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C26H25ClN4O2/c1-33-23-7-3-2-6-21(23)26(32)30-16-14-29(15-17-30)18-22-25(19-9-11-20(27)12-10-19)28-24-8-4-5-13-31(22)24/h2-13H,14-18H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458967 (US10759794, Example 39) Show SMILES CC(C)Oc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C27H28ClN5O2/c1-19(2)35-25-8-5-6-22(29-25)27(34)32-16-14-31(15-17-32)18-23-26(20-9-11-21(28)12-10-20)30-24-7-3-4-13-33(23)24/h3-13,19H,14-18H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM413512 (US10414765, Example 4 | [5-{[2-(4-Chlorophenyl)imi...) Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(Cl)cc3)CC2C1 Show InChI InChI=1S/C27H26ClN5O2/c1-35-25-7-4-5-22(29-25)27(34)32-15-19-13-31(14-20(19)16-32)17-23-26(18-8-10-21(28)11-9-18)30-24-6-2-3-12-33(23)24/h2-12,19-20H,13-17H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	59.9	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...				US Patent US10414765 (2019) BindingDB Entry DOI: 10.7270/Q2QJ7KNV
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM459003 (US10759794, Example 37) Show SMILES Clc1ccc(cc1)-c1nc2ccccn2c1CN1CCN(CC1)C(=O)c1ccccc1Cl Show InChI InChI=1S/C25H22Cl2N4O/c26-19-10-8-18(9-11-19)24-22(31-12-4-3-7-23(31)28-24)17-29-13-15-30(16-14-29)25(32)20-5-1-2-6-21(20)27/h1-12H,13-17H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM413516 (US10414765, Example 25) Show SMILES COc1cccc(n1)C(=O)N1CC2CN(Cc3c(nc4ccccn34)-c3ccc(cc3)C(C)C)CC2C1 Show InChI InChI=1S/C30H33N5O2/c1-20(2)21-10-12-22(13-11-21)29-26(35-14-5-4-8-27(35)32-29)19-33-15-23-17-34(18-24(23)16-33)30(36)25-7-6-9-28(31-25)37-3/h4-14,20,23-24H,15-19H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	62.2	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description In Vitro Electrophysiological Analysis of the Human TASK-1 and TASK-3 Channels Via Two-Electrode Voltage Clamp Technique in Xenopus laevis OocytesSub...				US Patent US10414765 (2019) BindingDB Entry DOI: 10.7270/Q2QJ7KNV
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM459000 (US10759794, Example 34) Show SMILES CC(C)c1ccccc1C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C28H29ClN4O/c1-20(2)23-7-3-4-8-24(23)28(34)32-17-15-31(16-18-32)19-25-27(21-10-12-22(29)13-11-21)30-26-9-5-6-14-33(25)26/h3-14,20H,15-19H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM458964 ((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...) Show SMILES Clc1ccc(cc1)-c1nc2ccccn2c1CN1CCN(CC1)C(=O)C1CCCC1 Show InChI InChI=1S/C24H27ClN4O/c25-20-10-8-18(9-11-20)23-21(29-12-4-3-7-22(29)26-23)17-27-13-15-28(16-14-27)24(30)19-5-1-2-6-19/h3-4,7-12,19H,1-2,5-6,13-17H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM459010 (US10759794, Example 45) Show SMILES CCOc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C26H26ClN5O2/c1-2-34-24-8-5-6-21(28-24)26(33)31-16-14-30(15-17-31)18-22-25(19-9-11-20(27)12-10-19)29-23-7-3-4-13-32(22)23/h3-13H,2,14-18H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM459031 ((4-{[2-(4-Cyclopropylphenyl)imidazo[1,2-a]pyridin-...) Show SMILES Fc1ccccc1C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(cc2)C2CC2)CC1 Show InChI InChI=1S/C28H27FN4O/c29-24-6-2-1-5-23(24)28(34)32-17-15-31(16-18-32)19-25-27(30-26-7-3-4-14-33(25)26)22-12-10-21(11-13-22)20-8-9-20/h1-7,10-14,20H,8-9,15-19H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM459036 (US10759794, Example 74) Show SMILES COc1ccc(C)c(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Br)cc2)CC1 Show InChI InChI=1S/C26H26BrN5O2/c1-18-6-11-23(34-2)29-24(18)26(33)31-15-13-30(14-16-31)17-21-25(19-7-9-20(27)10-8-19)28-22-5-3-4-12-32(21)22/h3-12H,13-17H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 9 (Homo sapiens (Human))	BDBM458977 (US10759794, Example 12) Show SMILES COc1ccccc1C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Br)cc2)CC1 Show InChI InChI=1S/C26H25BrN4O2/c1-33-23-7-3-2-6-21(23)26(32)30-16-14-29(15-17-30)18-22-25(19-9-11-20(27)12-10-19)28-24-8-4-5-13-31(22)24/h2-13H,14-18H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair
Potassium channel subfamily K member 3 (Homo sapiens (Human))	BDBM459034 (US10759794, Example 72) Show SMILES COc1ccc(C)c(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1 Show InChI InChI=1S/C26H26ClN5O2/c1-18-6-11-23(34-2)29-24(18)26(33)31-15-13-30(14-16-31)17-21-25(19-7-9-20(27)10-8-19)28-22-5-3-4-12-32(21)22/h3-12H,13-17H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...				US Patent US10759794 (2020) BindingDB Entry DOI: 10.7270/Q2KK9FW6
					More data for this Ligand-Target Pair

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