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Compile Data Set for Download or QSAR

Found 71 hits with Last Name = 'treyer' and Initial = 'a'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50559193
PNG
(CHEMBL4749352)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1[C@@H](C)COC[C@H]1C |r|
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3.60n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50559197
PNG
(CHEMBL4741511)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOCC1(C)C |r|
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4.70n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50559194
PNG
(CHEMBL4777159)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1[C@@H](C)COC[C@@H]1C |r|
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6.40n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50469476
PNG
(CHEMBL4287799)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOCC1 |r|
Show InChI InChI=1S/C18H23F2N7O2/c1-11-10-29-7-4-27(11)18-24-16(13-9-22-14(21)8-12(13)15(19)20)23-17(25-18)26-2-5-28-6-3-26/h8-9,11,15H,2-7,10H2,1H3,(H2,21,22)/t11-/m1/s1
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8n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50562004
PNG
(CHEMBL4752187)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3nnc(N)s3)N1CCOC2 |r|
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8.20n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal GST-fused mTOR (1360 to 2549 residues) (unknown origin) by ...


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50559196
PNG
(CHEMBL4792469)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOCC11CCC1 |r|
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11n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50562003
PNG
(CHEMBL4788107)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3ccc(N)nn3)N1CCOC2 |r|
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11n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal GST-fused mTOR (1360 to 2549 residues) (unknown origin) by ...


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50559198
PNG
(CHEMBL4758329)
Show SMILES C[C@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@H]1C |r|
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11n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50562006
PNG
(CHEMBL4741382)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)cc3C(F)F)N1CCOC2 |r|
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12n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal GST-fused mTOR (1360 to 2549 residues) (unknown origin) by ...


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50469477
PNG
(CHEMBL4290128)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@H]1C |r|
Show InChI InChI=1S/C19H25F2N7O2/c1-11-9-29-5-3-27(11)18-24-17(14-8-23-15(22)7-13(14)16(20)21)25-19(26-18)28-4-6-30-10-12(28)2/h7-8,11-12,16H,3-6,9-10H2,1-2H3,(H2,22,23)/t11-,12-/m1/s1
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14n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50562005
PNG
(CHEMBL4762174)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)s3)N1CCOC2 |r|
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15n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal GST-fused mTOR (1360 to 2549 residues) (unknown origin) by ...


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50562007
PNG
(CHEMBL4750095)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)nc3C(F)F)N1CCOC2 |r|
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17n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal His6-tagged p110alpha (unknown origin) by TR-FRET assay


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50559191
PNG
(CHEMBL4749250)
Show SMILES CC[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@H]1C |r|
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18n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50469476
PNG
(CHEMBL4287799)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOCC1 |r|
Show InChI InChI=1S/C18H23F2N7O2/c1-11-10-29-7-4-27(11)18-24-16(13-9-22-14(21)8-12(13)15(19)20)23-17(25-18)26-2-5-28-6-3-26/h8-9,11,15H,2-7,10H2,1H3,(H2,21,22)/t11-/m1/s1
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19n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50559187
PNG
(CHEMBL4764200)
Show SMILES COC[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@H]1C |r|
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23n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50559195
PNG
(CHEMBL4779306)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1[C@H](C)COC[C@H]1C |r|
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25n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50559188
PNG
(CHEMBL4746047)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@@H]1CO |r|
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28n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50559198
PNG
(CHEMBL4758329)
Show SMILES C[C@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@H]1C |r|
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33n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50562010
PNG
(CHEMBL4758575)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)c(c3)C(F)(F)F)N1CCOC2 |r|
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33n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal GST-fused mTOR (1360 to 2549 residues) (unknown origin) by ...


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50562007
PNG
(CHEMBL4750095)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)nc3C(F)F)N1CCOC2 |r|
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34n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal GST-fused mTOR (1360 to 2549 residues) (unknown origin) by ...


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50559192
PNG
(CHEMBL4753323)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@H]1C |r|
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42n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50559189
PNG
(CHEMBL4783277)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@H]1CO |r|
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50n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50562009
PNG
(CHEMBL4744965)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)nc3C(F)(F)F)N1CCOC2 |r|
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55n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal His6-tagged p110alpha (unknown origin) by TR-FRET assay


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50562002
PNG
(CHEMBL4795980)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3nc(N)ns3)N1CCOC2 |r|
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58n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal GST-fused mTOR (1360 to 2549 residues) (unknown origin) by ...


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50559190
PNG
(CHEMBL4757223)
Show SMILES CC[C@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@H]1C |r|
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63n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50559191
PNG
(CHEMBL4749250)
Show SMILES CC[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@H]1C |r|
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65n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50559190
PNG
(CHEMBL4757223)
Show SMILES CC[C@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@H]1C |r|
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67n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50559186
PNG
(CHEMBL4752162)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1C2CC1COC2 |r|
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73n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in ...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50562008
PNG
(CHEMBL4755158)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)cc3C(F)(F)F)N1CCOC2 |r|
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118n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal GST-fused mTOR (1360 to 2549 residues) (unknown origin) by ...


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50562006
PNG
(CHEMBL4741382)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)cc3C(F)F)N1CCOC2 |r|
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232n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal His6-tagged p110alpha (unknown origin) by TR-FRET assay


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50559194
PNG
(CHEMBL4777159)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1[C@@H](C)COC[C@@H]1C |r|
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233n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM50562009
PNG
(CHEMBL4744965)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)nc3C(F)(F)F)N1CCOC2 |r|
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249n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal GST-fused mTOR (1360 to 2549 residues) (unknown origin) by ...


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50562008
PNG
(CHEMBL4755158)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)cc3C(F)(F)F)N1CCOC2 |r|
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272n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal His6-tagged p110alpha (unknown origin) by TR-FRET assay


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50559193
PNG
(CHEMBL4749352)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1[C@@H](C)COC[C@H]1C |r|
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287n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50559196
PNG
(CHEMBL4792469)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOCC11CCC1 |r|
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404n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50559197
PNG
(CHEMBL4741511)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOCC1(C)C |r|
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469n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50469477
PNG
(CHEMBL4290128)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@H]1C |r|
Show InChI InChI=1S/C19H25F2N7O2/c1-11-9-29-5-3-27(11)18-24-17(14-8-23-15(22)7-13(14)16(20)21)25-19(26-18)28-4-6-30-10-12(28)2/h7-8,11-12,16H,3-6,9-10H2,1-2H3,(H2,22,23)/t11-,12-/m1/s1
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469n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50562002
PNG
(CHEMBL4795980)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3nc(N)ns3)N1CCOC2 |r|
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806n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal His6-tagged p110alpha (unknown origin) by TR-FRET assay


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50562003
PNG
(CHEMBL4788107)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3ccc(N)nn3)N1CCOC2 |r|
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847n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal His6-tagged p110alpha (unknown origin) by TR-FRET assay


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50559186
PNG
(CHEMBL4752162)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1C2CC1COC2 |r|
PDB

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>1.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50559187
PNG
(CHEMBL4764200)
Show SMILES COC[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@H]1C |r|
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>1.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50559188
PNG
(CHEMBL4746047)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@@H]1CO |r|
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>1.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50559189
PNG
(CHEMBL4783277)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@H]1CO |r|
PDB

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>1.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50559192
PNG
(CHEMBL4753323)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOC[C@H]1C |r|
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>1.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50559195
PNG
(CHEMBL4779306)
Show SMILES C[C@@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1[C@H](C)COC[C@H]1C |r|
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>1.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal His-tagged p110alpha/p85alpha expressed in baculoviru...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c00620
BindingDB Entry DOI: 10.7270/Q2SN0DNS
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50562004
PNG
(CHEMBL4752187)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3nnc(N)s3)N1CCOC2 |r|
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1.55E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal His6-tagged p110alpha (unknown origin) by TR-FRET assay


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50562005
PNG
(CHEMBL4762174)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)s3)N1CCOC2 |r|
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2.49E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal His6-tagged p110alpha (unknown origin) by TR-FRET assay


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50562010
PNG
(CHEMBL4758575)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)c(c3)C(F)(F)F)N1CCOC2 |r|
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>2.00E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant N-terminal His6-tagged p110alpha (unknown origin) by TR-FRET assay


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Target of rapamycin complex subunit LST8


(Homo sapiens)
BDBM50562006
PNG
(CHEMBL4741382)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3cnc(N)cc3C(F)F)N1CCOC2 |r|
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n/an/a 67n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of mTORC1 in human A2058 cells assessed as reduction in S6 ribosomal protein phosphorylation at Ser235/236 residues incubated for 1 hr by ...


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
Target of rapamycin complex subunit LST8


(Homo sapiens)
BDBM50562004
PNG
(CHEMBL4752187)
Show SMILES [H][C@]12Cc3c(nc(nc3N3CCOC[C@H]3C)-c3nnc(N)s3)N1CCOC2 |r|
PDB

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n/an/a 80n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of mTORC1 in human A2058 cells assessed as reduction in S6 ribosomal protein phosphorylation at Ser235/236 residues incubated for 1 hr by ...


Citation and Details

Article DOI: 10.1039/d0md00408a
BindingDB Entry DOI: 10.7270/Q25T3Q6Z
More data for this
Ligand-Target Pair
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