Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM25013 (4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50313650 (8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50022549 (CHEMBL3299032) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 30 mins by scintillation counting analysis in presence of 100 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50022551 (CHEMBL3298512) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50022559 (CHEMBL3298516) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50022564 (CHEMBL3298929) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50022562 (CHEMBL3298792) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.61E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50022561 (CHEMBL3298611) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.47E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM50493688 (CHEMBL2435181) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of human topoisomerase 2 using relaxed pBR322 as substrate after 10 mins by decatenation assay | Bioorg Med Chem Lett 23: 5874-7 (2013) Article DOI: 10.1016/j.bmcl.2013.08.094 BindingDB Entry DOI: 10.7270/Q2NK3HZ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50022565 (CHEMBL3298930) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50022560 (CHEMBL3298610) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50022558 (CHEMBL3298515) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50022557 (CHEMBL3298514) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50022552 (CHEMBL3298513) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM50022563 (CHEMBL3298928) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATP | ACS Med Chem Lett 5: 462-7 (2014) Article DOI: 10.1021/ml500088x BindingDB Entry DOI: 10.7270/Q2VT1TNG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM50493691 (CHEMBL2435185) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.49E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of human topoisomerase 2 using relaxed pBR322 as substrate after 10 mins by decatenation assay | Bioorg Med Chem Lett 23: 5874-7 (2013) Article DOI: 10.1016/j.bmcl.2013.08.094 BindingDB Entry DOI: 10.7270/Q2NK3HZ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM50493692 (CHEMBL2435183) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of human topoisomerase 2 using relaxed pBR322 as substrate after 10 mins by decatenation assay | Bioorg Med Chem Lett 23: 5874-7 (2013) Article DOI: 10.1016/j.bmcl.2013.08.094 BindingDB Entry DOI: 10.7270/Q2NK3HZ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM50493689 (CHEMBL2435182) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of human topoisomerase 2 using relaxed pBR322 as substrate after 10 mins by decatenation assay | Bioorg Med Chem Lett 23: 5874-7 (2013) Article DOI: 10.1016/j.bmcl.2013.08.094 BindingDB Entry DOI: 10.7270/Q2NK3HZ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM50493690 (CHEMBL2435180) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of human topoisomerase 2 using relaxed pBR322 as substrate after 10 mins by decatenation assay | Bioorg Med Chem Lett 23: 5874-7 (2013) Article DOI: 10.1016/j.bmcl.2013.08.094 BindingDB Entry DOI: 10.7270/Q2NK3HZ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 2-alpha (Homo sapiens (Human)) | BDBM50493687 (CHEMBL2435184) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Inhibition of human topoisomerase 2 using relaxed pBR322 as substrate after 10 mins by decatenation assay | Bioorg Med Chem Lett 23: 5874-7 (2013) Article DOI: 10.1016/j.bmcl.2013.08.094 BindingDB Entry DOI: 10.7270/Q2NK3HZ8 | |||||||||||
More data for this Ligand-Target Pair |