Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM2483 ((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540105 (CHEMBL4648558) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate at 2... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50097575 (6-Chloro-4-cyclopropylethynyl-7-hydroxy-4-trifluor...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540104 (CHEMBL4636944) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540105 (CHEMBL4648558) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540106 (CHEMBL3344478) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540107 (CHEMBL4639106) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | 2.58E+4 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540108 (CHEMBL4632958) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540109 (CHEMBL3344474) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540110 (CHEMBL4645070) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM2483 ((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.02E+4 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50097571 ((S)-6-Chloro-4-cyclopropylethynyl-8-hydroxy-4-trif...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50097575 (6-Chloro-4-cyclopropylethynyl-7-hydroxy-4-trifluor...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540105 (CHEMBL4648558) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540108 (CHEMBL4632958) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.41E+4 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540109 (CHEMBL3344474) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50540110 (CHEMBL4645070) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.59E+4 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in presence of substrate by ... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM2483 ((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate at 2... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesterol 24-hydroxylase (Homo sapiens (Human)) | BDBM50097571 ((S)-6-Chloro-4-cyclopropylethynyl-8-hydroxy-4-trif...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a |
Case Western Reserve University Curated by ChEMBL | Assay Description Binding affinity to recombinant human C-terminal 4His-tagged CYP46A1 delta(2 to 50) mutant expressed in Escherichia coli in absence of substrate by U... | J Med Chem 63: 6477-6488 (2020) Article DOI: 10.1021/acs.jmedchem.9b01383 BindingDB Entry DOI: 10.7270/Q2V40ZR6 | |||||||||||
More data for this Ligand-Target Pair |