Compile Data Set for Download or QSAR

Found 74 hits with Last Name = 'whitney-pickett' and Initial = 'c'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352059 (CHEMBL1824026) Show SMILES Cc1cc(nn1C[C@@H](O)CN)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 |r| Show InChI InChI=1S/C22H31ClN4O3/c1-15-10-20(26-27(15)13-17(28)12-24)16-6-7-19(23)18(11-16)21(29)25-14-22(30)8-4-2-3-5-9-22/h6-7,10-11,17,28,30H,2-5,8-9,12-14,24H2,1H3,(H,25,29)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptake				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344738 ((S)-2-chloro-5-(4-(2-hydroxy-3-methoxypropyl)-3,5-...) Show SMILES COC[C@@H](O)Cn1c(=O)cnn(-c2ccc(Cl)c(c2)C(=O)NCC2(O)CCCCCC2)c1=O |r| Show InChI InChI=1S/C22H29ClN4O6/c1-33-13-16(28)12-26-19(29)11-25-27(21(26)31)15-6-7-18(23)17(10-15)20(30)24-14-22(32)8-4-2-3-5-9-22/h6-7,10-11,16,28,32H,2-5,8-9,12-14H2,1H3,(H,24,30)/t16-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL-1beta release by ELISA in presence of...				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352039 (CHEMBL1823817) Show SMILES COC[C@H](O)Cn1c(=O)cnn(-c2ccc(Cl)c(c2)C(=O)NCC2(O)CCCCCC2)c1=O |r| Show InChI InChI=1S/C22H29ClN4O6/c1-33-13-16(28)12-26-19(29)11-25-27(21(26)31)15-6-7-18(23)17(10-15)20(30)24-14-22(32)8-4-2-3-5-9-22/h6-7,10-11,16,28,32H,2-5,8-9,12-14H2,1H3,(H,24,30)/t16-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344738 ((S)-2-chloro-5-(4-(2-hydroxy-3-methoxypropyl)-3,5-...) Show SMILES COC[C@@H](O)Cn1c(=O)cnn(-c2ccc(Cl)c(c2)C(=O)NCC2(O)CCCCCC2)c1=O |r| Show InChI InChI=1S/C22H29ClN4O6/c1-33-13-16(28)12-26-19(29)11-25-27(21(26)31)15-6-7-18(23)17(10-15)20(30)24-14-22(32)8-4-2-3-5-9-22/h6-7,10-11,16,28,32H,2-5,8-9,12-14H2,1H3,(H,24,30)/t16-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release by ELISA				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352059 (CHEMBL1824026) Show SMILES Cc1cc(nn1C[C@@H](O)CN)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 |r| Show InChI InChI=1S/C22H31ClN4O3/c1-15-10-20(26-27(15)13-17(28)12-24)16-6-7-19(23)18(11-16)21(29)25-14-22(30)8-4-2-3-5-9-22/h6-7,10-11,17,28,30H,2-5,8-9,12-14,24H2,1H3,(H,25,29)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352059 (CHEMBL1824026) Show SMILES Cc1cc(nn1C[C@@H](O)CN)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 |r| Show InChI InChI=1S/C22H31ClN4O3/c1-15-10-20(26-27(15)13-17(28)12-24)16-6-7-19(23)18(11-16)21(29)25-14-22(30)8-4-2-3-5-9-22/h6-7,10-11,17,28,30H,2-5,8-9,12-14,24H2,1H3,(H,25,29)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL-1beta release				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352058 (CHEMBL560241) Show SMILES Cc1cc(n[nH]1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C19H24ClN3O2/c1-13-10-17(23-22-13)14-6-7-16(20)15(11-14)18(24)21-12-19(25)8-4-2-3-5-9-19/h6-7,10-11,25H,2-5,8-9,12H2,1H3,(H,21,24)(H,22,23)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptake				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352060 (CHEMBL1824027) Show SMILES Cc1cc(nn1C[C@H](O)CN)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 |r| Show InChI InChI=1S/C22H31ClN4O3/c1-15-10-20(26-27(15)13-17(28)12-24)16-6-7-19(23)18(11-16)21(29)25-14-22(30)8-4-2-3-5-9-22/h6-7,10-11,17,28,30H,2-5,8-9,12-14,24H2,1H3,(H,25,29)/t17-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptake				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344738 ((S)-2-chloro-5-(4-(2-hydroxy-3-methoxypropyl)-3,5-...) Show SMILES COC[C@@H](O)Cn1c(=O)cnn(-c2ccc(Cl)c(c2)C(=O)NCC2(O)CCCCCC2)c1=O |r| Show InChI InChI=1S/C22H29ClN4O6/c1-33-13-16(28)12-26-19(29)11-25-27(21(26)31)15-6-7-18(23)17(10-15)20(30)24-14-22(32)8-4-2-3-5-9-22/h6-7,10-11,16,28,32H,2-5,8-9,12-14H2,1H3,(H,24,30)/t16-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced YOPRO-1 uptake				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352052 (CHEMBL1824020) Show SMILES Cc1nc(cs1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C19H23ClN2O2S/c1-13-22-17(11-25-13)14-6-7-16(20)15(10-14)18(23)21-12-19(24)8-4-2-3-5-9-19/h6-7,10-11,24H,2-5,8-9,12H2,1H3,(H,21,23)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptake				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352058 (CHEMBL560241) Show SMILES Cc1cc(n[nH]1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C19H24ClN3O2/c1-13-10-17(23-22-13)14-6-7-16(20)15(11-14)18(24)21-12-19(25)8-4-2-3-5-9-19/h6-7,10-11,25H,2-5,8-9,12H2,1H3,(H,21,24)(H,22,23)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352060 (CHEMBL1824027) Show SMILES Cc1cc(nn1C[C@H](O)CN)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 |r| Show InChI InChI=1S/C22H31ClN4O3/c1-15-10-20(26-27(15)13-17(28)12-24)16-6-7-19(23)18(11-16)21(29)25-14-22(30)8-4-2-3-5-9-22/h6-7,10-11,17,28,30H,2-5,8-9,12-14,24H2,1H3,(H,25,29)/t17-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352060 (CHEMBL1824027) Show SMILES Cc1cc(nn1C[C@H](O)CN)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 |r| Show InChI InChI=1S/C22H31ClN4O3/c1-15-10-20(26-27(15)13-17(28)12-24)16-6-7-19(23)18(11-16)21(29)25-14-22(30)8-4-2-3-5-9-22/h6-7,10-11,17,28,30H,2-5,8-9,12-14,24H2,1H3,(H,25,29)/t17-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL-1beta release				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352055 (CHEMBL549618) Show SMILES OC1(CNC(=O)c2cc(ccc2Cl)-c2cc[nH]n2)CCCCCC1 Show InChI InChI=1S/C18H22ClN3O2/c19-15-6-5-13(16-7-10-21-22-16)11-14(15)17(23)20-12-18(24)8-3-1-2-4-9-18/h5-7,10-11,24H,1-4,8-9,12H2,(H,20,23)(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptake				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344734 (2-chloro-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(...) Show SMILES OC1(CNC(=O)c2cc(ccc2Cl)-n2ncc(=O)[nH]c2=O)CCCCCC1 Show InChI InChI=1S/C18H21ClN4O4/c19-14-6-5-12(23-17(26)22-15(24)10-21-23)9-13(14)16(25)20-11-18(27)7-3-1-2-4-8-18/h5-6,9-10,27H,1-4,7-8,11H2,(H,20,25)(H,22,24,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced YOPRO-1 uptake				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344737 (2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(4-(2-...) Show SMILES COCCn1c(=O)cnn(-c2ccc(Cl)c(c2)C(=O)NCC2(O)CCCCCC2)c1=O Show InChI InChI=1S/C21H27ClN4O5/c1-31-11-10-25-18(27)13-24-26(20(25)29)15-6-7-17(22)16(12-15)19(28)23-14-21(30)8-4-2-3-5-9-21/h6-7,12-13,30H,2-5,8-11,14H2,1H3,(H,23,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release by ELISA				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352061 (CHEMBL1824022) Show SMILES COc1ccc(nn1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C20H24ClN3O3/c1-27-18-9-8-17(23-24-18)14-6-7-16(21)15(12-14)19(25)22-13-20(26)10-4-2-3-5-11-20/h6-9,12,26H,2-5,10-11,13H2,1H3,(H,22,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptake				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50318005 (2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(5-met...) Show SMILES Cc1ccc(nc1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C21H25ClN2O2/c1-15-6-9-19(23-13-15)16-7-8-18(22)17(12-16)20(25)24-14-21(26)10-4-2-3-5-11-21/h6-9,12-13,26H,2-5,10-11,14H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptake				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344736 (2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(4-iso...) Show SMILES CC(C)Cn1c(=O)cnn(-c2ccc(Cl)c(c2)C(=O)NCC2(O)CCCCCC2)c1=O Show InChI InChI=1S/C22H29ClN4O4/c1-15(2)13-26-19(28)12-25-27(21(26)30)16-7-8-18(23)17(11-16)20(29)24-14-22(31)9-5-3-4-6-10-22/h7-8,11-12,15,31H,3-6,9-10,13-14H2,1-2H3,(H,24,29)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release by ELISA				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344748 (2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(4-met...) Show SMILES Cn1c(=O)cnn(-c2ccc(Cl)c(c2)C(=O)NCC2(O)CCCCCC2)c1=O Show InChI InChI=1S/C19H23ClN4O4/c1-23-16(25)11-22-24(18(23)27)13-6-7-15(20)14(10-13)17(26)21-12-19(28)8-4-2-3-5-9-19/h6-7,10-11,28H,2-5,8-9,12H2,1H3,(H,21,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release by ELISA				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344737 (2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(4-(2-...) Show SMILES COCCn1c(=O)cnn(-c2ccc(Cl)c(c2)C(=O)NCC2(O)CCCCCC2)c1=O Show InChI InChI=1S/C21H27ClN4O5/c1-31-11-10-25-18(27)13-24-26(20(25)29)15-6-7-17(22)16(12-15)19(28)23-14-21(30)8-4-2-3-5-9-21/h6-7,12-13,30H,2-5,8-11,14H2,1H3,(H,23,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL-1beta release by ELISA in presence of...				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344734 (2-chloro-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(...) Show SMILES OC1(CNC(=O)c2cc(ccc2Cl)-n2ncc(=O)[nH]c2=O)CCCCCC1 Show InChI InChI=1S/C18H21ClN4O4/c19-14-6-5-12(23-17(26)22-15(24)10-21-23)9-13(14)16(25)20-11-18(27)7-3-1-2-4-8-18/h5-6,9-10,27H,1-4,7-8,11H2,(H,20,25)(H,22,24,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release by ELISA				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344735 (2-chloro-5-(4-ethyl-3,5-dioxo-4,5-dihydro-1,2,4-tr...) Show SMILES CCn1c(=O)cnn(-c2ccc(Cl)c(c2)C(=O)NCC2(O)CCCCCC2)c1=O Show InChI InChI=1S/C20H25ClN4O4/c1-2-24-17(26)12-23-25(19(24)28)14-7-8-16(21)15(11-14)18(27)22-13-20(29)9-5-3-4-6-10-20/h7-8,11-12,29H,2-6,9-10,13H2,1H3,(H,22,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release by ELISA				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50318005 (2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(5-met...) Show SMILES Cc1ccc(nc1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C21H25ClN2O2/c1-15-6-9-19(23-13-15)16-7-8-18(22)17(12-16)20(25)24-14-21(26)10-4-2-3-5-11-21/h6-9,12-13,26H,2-5,10-11,14H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352040 (CHEMBL1823818) Show SMILES Cc1ccc(nc1)-c1ccc(Cl)c(c1)C(=O)NCCc1ccccc1Cl Show InChI InChI=1S/C21H18Cl2N2O/c1-14-6-9-20(25-13-14)16-7-8-19(23)17(12-16)21(26)24-11-10-15-4-2-3-5-18(15)22/h2-9,12-13H,10-11H2,1H3,(H,24,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352058 (CHEMBL560241) Show SMILES Cc1cc(n[nH]1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C19H24ClN3O2/c1-13-10-17(23-22-13)14-6-7-16(20)15(11-14)18(24)21-12-19(25)8-4-2-3-5-9-19/h6-7,10-11,25H,2-5,8-9,12H2,1H3,(H,21,24)(H,22,23)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	121	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL-1beta release				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352055 (CHEMBL549618) Show SMILES OC1(CNC(=O)c2cc(ccc2Cl)-c2cc[nH]n2)CCCCCC1 Show InChI InChI=1S/C18H22ClN3O2/c19-15-6-5-13(16-7-10-21-22-16)11-14(15)17(23)20-12-18(24)8-3-1-2-4-9-18/h5-7,10-11,24H,1-4,8-9,12H2,(H,20,23)(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352054 (CHEMBL1824023) Show SMILES OC1(CNC(=O)c2cc(ccc2Cl)-c2ccc(=O)[nH]n2)CCCCCC1 Show InChI InChI=1S/C19H22ClN3O3/c20-15-6-5-13(16-7-8-17(24)23-22-16)11-14(15)18(25)21-12-19(26)9-3-1-2-4-10-19/h5-8,11,26H,1-4,9-10,12H2,(H,21,25)(H,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptake				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344735 (2-chloro-5-(4-ethyl-3,5-dioxo-4,5-dihydro-1,2,4-tr...) Show SMILES CCn1c(=O)cnn(-c2ccc(Cl)c(c2)C(=O)NCC2(O)CCCCCC2)c1=O Show InChI InChI=1S/C20H25ClN4O4/c1-2-24-17(26)12-23-25(19(24)28)14-7-8-16(21)15(11-14)18(27)22-13-20(29)9-5-3-4-6-10-20/h7-8,11-12,29H,2-6,9-10,13H2,1H3,(H,22,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	185	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL-1beta release by ELISA in presence of...				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344736 (2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(4-iso...) Show SMILES CC(C)Cn1c(=O)cnn(-c2ccc(Cl)c(c2)C(=O)NCC2(O)CCCCCC2)c1=O Show InChI InChI=1S/C22H29ClN4O4/c1-15(2)13-26-19(28)12-25-27(21(26)30)16-7-8-18(23)17(11-16)20(29)24-14-22(31)9-5-3-4-6-10-22/h7-8,11-12,15,31H,3-6,9-10,13-14H2,1-2H3,(H,24,29)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL-1beta release by ELISA in presence of...				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352056 (CHEMBL1824024) Show SMILES Cn1ccc(n1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C19H24ClN3O2/c1-23-11-8-17(22-23)14-6-7-16(20)15(12-14)18(24)21-13-19(25)9-4-2-3-5-10-19/h6-8,11-12,25H,2-5,9-10,13H2,1H3,(H,21,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	238	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352053 (CHEMBL1824021) Show SMILES OC1(CNC(=O)c2cc(ccc2Cl)-c2cnoc2)CCCCCC1 Show InChI InChI=1S/C18H21ClN2O3/c19-16-6-5-13(14-10-21-24-11-14)9-15(16)17(22)20-12-18(23)7-3-1-2-4-8-18/h5-6,9-11,23H,1-4,7-8,12H2,(H,20,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352048 (CHEMBL1824016) Show SMILES Cc1ccc(nn1)-c1ccc(Cl)c(c1)C(=O)NCCc1ccccc1Cl Show InChI InChI=1S/C20H17Cl2N3O/c1-13-6-9-19(25-24-13)15-7-8-18(22)16(12-15)20(26)23-11-10-14-4-2-3-5-17(14)21/h2-9,12H,10-11H2,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352057 (CHEMBL1824025) Show SMILES Cn1nccc1-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C19H24ClN3O2/c1-23-17(8-11-22-23)14-6-7-16(20)15(12-14)18(24)21-13-19(25)9-4-2-3-5-10-19/h6-8,11-12,25H,2-5,9-10,13H2,1H3,(H,21,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	266	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in HEK293 cells assessed as inhibition of ATP-induced YO-PRO-1 uptake				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352061 (CHEMBL1824022) Show SMILES COc1ccc(nn1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C20H24ClN3O3/c1-27-18-9-8-17(23-24-18)14-6-7-16(21)15(12-14)19(25)22-13-20(26)10-4-2-3-5-11-20/h6-9,12,26H,2-5,10-11,13H2,1H3,(H,22,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352052 (CHEMBL1824020) Show SMILES Cc1nc(cs1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C19H23ClN2O2S/c1-13-22-17(11-25-13)14-6-7-16(20)15(10-14)18(23)21-12-19(24)8-4-2-3-5-9-19/h6-7,10-11,24H,2-5,8-9,12H2,1H3,(H,21,23)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344733 (2-chloro-N-(2-chlorophenethyl)-5-(3,5-dioxo-4,5-di...) Show SMILES Clc1ccccc1CCNC(=O)c1cc(ccc1Cl)-n1ncc(=O)[nH]c1=O Show InChI InChI=1S/C18H14Cl2N4O3/c19-14-4-2-1-3-11(14)7-8-21-17(26)13-9-12(5-6-15(13)20)24-18(27)23-16(25)10-22-24/h1-6,9-10H,7-8H2,(H,21,26)(H,23,25,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release by ELISA				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344733 (2-chloro-N-(2-chlorophenethyl)-5-(3,5-dioxo-4,5-di...) Show SMILES Clc1ccccc1CCNC(=O)c1cc(ccc1Cl)-n1ncc(=O)[nH]c1=O Show InChI InChI=1S/C18H14Cl2N4O3/c19-14-4-2-1-3-11(14)7-8-21-17(26)13-9-12(5-6-15(13)20)24-18(27)23-16(25)10-22-24/h1-6,9-10H,7-8H2,(H,21,26)(H,23,25,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced YOPRO-1 uptake				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344733 (2-chloro-N-(2-chlorophenethyl)-5-(3,5-dioxo-4,5-di...) Show SMILES Clc1ccccc1CCNC(=O)c1cc(ccc1Cl)-n1ncc(=O)[nH]c1=O Show InChI InChI=1S/C18H14Cl2N4O3/c19-14-4-2-1-3-11(14)7-8-21-17(26)13-9-12(5-6-15(13)20)24-18(27)23-16(25)10-22-24/h1-6,9-10H,7-8H2,(H,21,26)(H,23,25,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344747 (2-chloro-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(...) Show SMILES OC1(CNC(=O)c2cc(ccc2Cl)-n2ncc(=O)[nH]c2=O)CCCCC1 Show InChI InChI=1S/C17H19ClN4O4/c18-13-5-4-11(22-16(25)21-14(23)9-20-22)8-12(13)15(24)19-10-17(26)6-2-1-3-7-17/h4-5,8-9,26H,1-3,6-7,10H2,(H,19,24)(H,21,23,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release by ELISA				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352056 (CHEMBL1824024) Show SMILES Cn1ccc(n1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C19H24ClN3O2/c1-23-11-8-17(22-23)14-6-7-16(20)15(12-14)18(24)21-13-19(25)9-4-2-3-5-10-19/h6-8,11-12,25H,2-5,9-10,13H2,1H3,(H,21,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL-1beta release				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344734 (2-chloro-5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(...) Show SMILES OC1(CNC(=O)c2cc(ccc2Cl)-n2ncc(=O)[nH]c2=O)CCCCCC1 Show InChI InChI=1S/C18H21ClN4O4/c19-14-6-5-12(23-17(26)22-15(24)10-21-23)9-13(14)16(25)20-11-18(27)7-3-1-2-4-8-18/h5-6,9-10,27H,1-4,7-8,11H2,(H,20,25)(H,22,24,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	447	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL-1beta release by ELISA in presence of...				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352045 (CHEMBL1824011) Show SMILES Clc1ccc(nc1)-c1ccc(Cl)c(c1)C(=O)NCCc1ccccc1Cl Show InChI InChI=1S/C20H15Cl3N2O/c21-15-6-8-19(25-12-15)14-5-7-18(23)16(11-14)20(26)24-10-9-13-3-1-2-4-17(13)22/h1-8,11-12H,9-10H2,(H,24,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352049 (CHEMBL1824017) Show SMILES COc1ccc(nn1)-c1ccc(Cl)c(c1)C(=O)NCCc1ccccc1Cl Show InChI InChI=1S/C20H17Cl2N3O2/c1-27-19-9-8-18(24-25-19)14-6-7-17(22)15(12-14)20(26)23-11-10-13-4-2-3-5-16(13)21/h2-9,12H,10-11H2,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352051 (CHEMBL1824019) Show SMILES OC1(CNC(=O)c2cc(ccc2Cl)-c2c[nH]cn2)CCCCCC1 Show InChI InChI=1S/C18H22ClN3O2/c19-15-6-5-13(16-10-20-12-22-16)9-14(15)17(23)21-11-18(24)7-3-1-2-4-8-18/h5-6,9-10,12,24H,1-4,7-8,11H2,(H,20,22)(H,21,23)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352061 (CHEMBL1824022) Show SMILES COc1ccc(nn1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C20H24ClN3O3/c1-27-18-9-8-17(23-24-18)14-6-7-16(21)15(12-14)19(25)22-13-20(26)10-4-2-3-5-11-20/h6-9,12,26H,2-5,10-11,13H2,1H3,(H,22,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL-1beta release				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50318005 (2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(5-met...) Show SMILES Cc1ccc(nc1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 Show InChI InChI=1S/C21H25ClN2O2/c1-15-6-9-19(23-13-15)16-7-8-18(22)17(12-16)20(25)24-14-21(26)10-4-2-3-5-11-21/h6-9,12-13,26H,2-5,10-11,14H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	514	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL-1beta release				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352055 (CHEMBL549618) Show SMILES OC1(CNC(=O)c2cc(ccc2Cl)-c2cc[nH]n2)CCCCCC1 Show InChI InChI=1S/C18H22ClN3O2/c19-15-6-5-13(16-7-10-21-22-16)11-14(15)17(23)20-12-18(24)8-3-1-2-4-9-18/h5-7,10-11,24H,1-4,8-9,12H2,(H,20,23)(H,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-stimulated human whole blood assessed as inhibition of ATP-induced IL-1beta release				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50352047 (CHEMBL1824015) Show SMILES CC(O)c1ccc(nc1)-c1ccc(Cl)c(c1)C(=O)NCCc1ccccc1Cl Show InChI InChI=1S/C22H20Cl2N2O2/c1-14(27)17-7-9-21(26-13-17)16-6-8-20(24)18(12-16)22(28)25-11-10-15-4-2-3-5-19(15)23/h2-9,12-14,27H,10-11H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	668	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7R expressed in LPS-activated human monocytes assessed as inhibition of ATP-induced IL-1beta release in presence of low ser...				Bioorg Med Chem Lett 21: 5475-9 (2011) Article DOI: 10.1016/j.bmcl.2011.06.117 BindingDB Entry DOI: 10.7270/Q2PC32RF
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50344739 (5-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)-N...) Show SMILES Cc1ccc(cc1C(=O)NCC1(O)CCCCCC1)-n1ncc(=O)[nH]c1=O Show InChI InChI=1S/C19H24N4O4/c1-13-6-7-14(23-18(26)22-16(24)11-21-23)10-15(13)17(25)20-12-19(27)8-4-2-3-5-9-19/h6-7,10-11,27H,2-5,8-9,12H2,1H3,(H,20,25)(H,22,24,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release by ELISA				Bioorg Med Chem Lett 21: 3708-11 (2011) Article DOI: 10.1016/j.bmcl.2011.04.077 BindingDB Entry DOI: 10.7270/Q2B27VMG
					More data for this Ligand-Target Pair

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