Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prothrombin (Homo sapiens (Human)) | BDBM50075822 ((S)-N-[1-(1-Amino-isoquinolin-6-ylmethyl)-2-oxo-2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
NV Organon Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against thrombin | Bioorg Med Chem Lett 9: 685-90 (1999) BindingDB Entry DOI: 10.7270/Q2KK9C89 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease 1 (Homo sapiens (Human)) | BDBM50037996 (1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimido...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 169 | n/a | n/a | n/a | n/a | n/a | n/a |
NV Organon Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against trypsin | Bioorg Med Chem Lett 9: 685-90 (1999) BindingDB Entry DOI: 10.7270/Q2KK9C89 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50450929 (CHEMBL2029143 | CHEMBL3142450) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem | PubMed | n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemistry Curated by ChEMBL | Assay Description In vitro anti-thrombin activity was determined | Bioorg Med Chem Lett 9: 2013-8 (1999) BindingDB Entry DOI: 10.7270/Q26H4HXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Antithrombin-III (Homo sapiens (Human)) | BDBM50037996 (1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimido...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemistry Curated by ChEMBL | Assay Description Antithrombin III (ATIII)-mediated anti-Xa activity was determined | Bioorg Med Chem Lett 9: 2013-8 (1999) BindingDB Entry DOI: 10.7270/Q26H4HXG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50037996 (1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimido...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
NV Organon Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against thrombin | Bioorg Med Chem Lett 9: 685-90 (1999) BindingDB Entry DOI: 10.7270/Q2KK9C89 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50075824 (Aminoisoquinoline derivative | CHEMBL351865) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NV Organon Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against thrombin | Bioorg Med Chem Lett 9: 685-90 (1999) BindingDB Entry DOI: 10.7270/Q2KK9C89 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50075826 (CHEMBL350114 | N-[1-(1-Amino-isoquinolin-6-ylmethy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NV Organon Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against thrombin | Bioorg Med Chem Lett 9: 685-90 (1999) BindingDB Entry DOI: 10.7270/Q2KK9C89 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50075823 (CHEMBL159435 | N-[1-(1-Amino-isoquinolin-6-ylmethy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 5.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NV Organon Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against thrombin | Bioorg Med Chem Lett 9: 685-90 (1999) BindingDB Entry DOI: 10.7270/Q2KK9C89 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease 1 (Homo sapiens (Human)) | BDBM50075823 (CHEMBL159435 | N-[1-(1-Amino-isoquinolin-6-ylmethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.55E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
NV Organon Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against trypsin | Bioorg Med Chem Lett 9: 685-90 (1999) BindingDB Entry DOI: 10.7270/Q2KK9C89 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50075825 (CHEMBL162185 | N-[1-(1-Amino-isoquinolin-6-ylmethy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.57E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
NV Organon Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against thrombin | Bioorg Med Chem Lett 9: 685-90 (1999) BindingDB Entry DOI: 10.7270/Q2KK9C89 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease 1 (Homo sapiens (Human)) | BDBM50075822 ((S)-N-[1-(1-Amino-isoquinolin-6-ylmethyl)-2-oxo-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.78E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
NV Organon Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against trypsin | Bioorg Med Chem Lett 9: 685-90 (1999) BindingDB Entry DOI: 10.7270/Q2KK9C89 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50037996 (1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimido...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | n/a | n/a | 750 | n/a | n/a | n/a | n/a |
Institute of Chemistry Curated by ChEMBL | Assay Description Effective concentration against thrombin was determined | Bioorg Med Chem Lett 9: 2013-8 (1999) BindingDB Entry DOI: 10.7270/Q26H4HXG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |