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21 molecules are shown

Wt: 316.3
BDBM50331454Purchase		Wt: 334.3
BDBM50331458Purchase		Wt: 219.3
BDBM50401658Purchase		Wt: 381.5
BDBM50401665Purchase		Wt: 452.5
BDBM50401672Purchase
Wt: 4026.7
BDBM50115814
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50331454,50331458,50401658,50401665,50401672,50115814   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mu-type opioid receptor


(Homo sapiens (Human))		BDBM50401672
PNG
(DIPHENOXYLATE)
Show SMILES CCOC(=O)C1(CCN(CCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C30H32N2O2/c1-2-34-28(33)29(25-12-6-3-7-13-25)18-21-32(22-19-29)23-20-30(24-31,26-14-8-4-9-15-26)27-16-10-5-11-17-27/h3-17H,2,18-23H2,1H3
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 12n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cell membrane incubated for 60 mins by radioligand binding assay

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00611
BindingDB Entry DOI: 10.7270/Q2N301V5
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 3


(Homo sapiens (Human))		BDBM50115814
PNG
(CHEMBL3609062)
Show SMILES [H][C@@]12CCCN1C(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@H](CC(O)=O)NC(=O)[C@@]([H])(NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@]1([H])CSSC[C@]3([H])NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CSSC[C@]([H])(NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@H](CCCCN)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC |r|
Show InChI InChI=1S/C169H274N52O48S7/c1-13-85(5)127-160(262)204-112(70-126(233)234)150(252)219-132(91(11)229)164(266)217-128(86(6)14-2)165(267)221-63-34-47-123(221)159(261)198-100(42-24-29-58-173)140(242)206-114(74-223)151(253)193-104(46-33-62-186-169(181)182)141(243)210-121-81-274-273-79-119-156(258)195-102(44-31-60-184-167(177)178)136(238)191-101(43-25-30-59-174)144(246)218-131(90(10)228)163(265)213-117(135(237)187-72-125(232)215-129(88(8)226)162(264)214-122(166(268)269)82-276-275-80-120(157(259)216-127)212-154(256)113(73-222)205-134(236)97(175)39-21-26-55-170)77-271-272-78-118(209-142(244)105(52-53-124(176)231)196-146(248)108(66-92-35-17-15-18-36-92)199-133(235)87(7)189-161(263)130(89(9)227)220-158(121)260)155(257)194-99(41-23-28-57-172)138(240)203-111(69-95-71-183-83-188-95)149(251)208-115(75-224)152(254)197-106(54-64-270-12)143(245)190-98(40-22-27-56-171)137(239)201-110(68-94-48-50-96(230)51-49-94)147(249)192-103(45-32-61-185-168(179)180)139(241)200-107(65-84(3)4)145(247)207-116(76-225)153(255)202-109(148(250)211-119)67-93-37-19-16-20-38-93/h15-20,35-38,48-51,71,83-91,97-123,127-132,222-230H,13-14,21-34,39-47,52-70,72-82,170-175H2,1-12H3,(H2,176,231)(H,183,188)(H,187,237)(H,189,263)(H,190,245)(H,191,238)(H,192,249)(H,193,253)(H,194,257)(H,195,258)(H,196,248)(H,197,254)(H,198,261)(H,199,235)(H,200,241)(H,201,239)(H,202,255)(H,203,240)(H,204,262)(H,205,236)(H,206,242)(H,207,247)(H,208,251)(H,209,244)(H,210,243)(H,211,250)(H,212,256)(H,213,265)(H,214,264)(H,215,232)(H,216,259)(H,217,266)(H,218,246)(H,219,252)(H,220,260)(H,233,234)(H,268,269)(H4,177,178,184)(H4,179,180,185)(H4,181,182,186)/t85-,86-,87-,88+,89+,90+,91+,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,127-,128-,129-,130-,131-,132-/m0/s1
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n/an/a 0.154n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human Kv1.3 expressed in CHOK1 cells assessed as inhibition of potassium currents after 10 mins by IonWorks Quattro patch clam...

J Med Chem 58: 6784-802 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00495
BindingDB Entry DOI: 10.7270/Q22V2HWG
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 1


(Homo sapiens (Human))		BDBM50115814
PNG
(CHEMBL3609062)
Show SMILES [H][C@@]12CCCN1C(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@H](CC(O)=O)NC(=O)[C@@]([H])(NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@]1([H])CSSC[C@]3([H])NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CSSC[C@]([H])(NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@H](CCCCN)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC |r|
Show InChI InChI=1S/C169H274N52O48S7/c1-13-85(5)127-160(262)204-112(70-126(233)234)150(252)219-132(91(11)229)164(266)217-128(86(6)14-2)165(267)221-63-34-47-123(221)159(261)198-100(42-24-29-58-173)140(242)206-114(74-223)151(253)193-104(46-33-62-186-169(181)182)141(243)210-121-81-274-273-79-119-156(258)195-102(44-31-60-184-167(177)178)136(238)191-101(43-25-30-59-174)144(246)218-131(90(10)228)163(265)213-117(135(237)187-72-125(232)215-129(88(8)226)162(264)214-122(166(268)269)82-276-275-80-120(157(259)216-127)212-154(256)113(73-222)205-134(236)97(175)39-21-26-55-170)77-271-272-78-118(209-142(244)105(52-53-124(176)231)196-146(248)108(66-92-35-17-15-18-36-92)199-133(235)87(7)189-161(263)130(89(9)227)220-158(121)260)155(257)194-99(41-23-28-57-172)138(240)203-111(69-95-71-183-83-188-95)149(251)208-115(75-224)152(254)197-106(54-64-270-12)143(245)190-98(40-22-27-56-171)137(239)201-110(68-94-48-50-96(230)51-49-94)147(249)192-103(45-32-61-185-168(179)180)139(241)200-107(65-84(3)4)145(247)207-116(76-225)153(255)202-109(148(250)211-119)67-93-37-19-16-20-38-93/h15-20,35-38,48-51,71,83-91,97-123,127-132,222-230H,13-14,21-34,39-47,52-70,72-82,170-175H2,1-12H3,(H2,176,231)(H,183,188)(H,187,237)(H,189,263)(H,190,245)(H,191,238)(H,192,249)(H,193,253)(H,194,257)(H,195,258)(H,196,248)(H,197,254)(H,198,261)(H,199,235)(H,200,241)(H,201,239)(H,202,255)(H,203,240)(H,204,262)(H,205,236)(H,206,242)(H,207,247)(H,208,251)(H,209,244)(H,210,243)(H,211,250)(H,212,256)(H,213,265)(H,214,264)(H,215,232)(H,216,259)(H,217,266)(H,218,246)(H,219,252)(H,220,260)(H,233,234)(H,268,269)(H4,177,178,184)(H4,179,180,185)(H4,181,182,186)/t85-,86-,87-,88+,89+,90+,91+,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,127-,128-,129-,130-,131-,132-/m0/s1
PDB
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n/an/a 0.00300n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human Kv1.1 expressed in HEK293 cells assessed as inhibition of potassium currents after 10 mins by IonWorks Quattro patch cla...

J Med Chem 58: 6784-802 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00495
BindingDB Entry DOI: 10.7270/Q22V2HWG
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 3


(Homo sapiens (Human))		BDBM50115814
PNG
(CHEMBL3609062)
Show SMILES [H][C@@]12CCCN1C(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@H](CC(O)=O)NC(=O)[C@@]([H])(NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@]1([H])CSSC[C@]3([H])NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CSSC[C@]([H])(NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@H](CCCCN)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC |r|
Show InChI InChI=1S/C169H274N52O48S7/c1-13-85(5)127-160(262)204-112(70-126(233)234)150(252)219-132(91(11)229)164(266)217-128(86(6)14-2)165(267)221-63-34-47-123(221)159(261)198-100(42-24-29-58-173)140(242)206-114(74-223)151(253)193-104(46-33-62-186-169(181)182)141(243)210-121-81-274-273-79-119-156(258)195-102(44-31-60-184-167(177)178)136(238)191-101(43-25-30-59-174)144(246)218-131(90(10)228)163(265)213-117(135(237)187-72-125(232)215-129(88(8)226)162(264)214-122(166(268)269)82-276-275-80-120(157(259)216-127)212-154(256)113(73-222)205-134(236)97(175)39-21-26-55-170)77-271-272-78-118(209-142(244)105(52-53-124(176)231)196-146(248)108(66-92-35-17-15-18-36-92)199-133(235)87(7)189-161(263)130(89(9)227)220-158(121)260)155(257)194-99(41-23-28-57-172)138(240)203-111(69-95-71-183-83-188-95)149(251)208-115(75-224)152(254)197-106(54-64-270-12)143(245)190-98(40-22-27-56-171)137(239)201-110(68-94-48-50-96(230)51-49-94)147(249)192-103(45-32-61-185-168(179)180)139(241)200-107(65-84(3)4)145(247)207-116(76-225)153(255)202-109(148(250)211-119)67-93-37-19-16-20-38-93/h15-20,35-38,48-51,71,83-91,97-123,127-132,222-230H,13-14,21-34,39-47,52-70,72-82,170-175H2,1-12H3,(H2,176,231)(H,183,188)(H,187,237)(H,189,263)(H,190,245)(H,191,238)(H,192,249)(H,193,253)(H,194,257)(H,195,258)(H,196,248)(H,197,254)(H,198,261)(H,199,235)(H,200,241)(H,201,239)(H,202,255)(H,203,240)(H,204,262)(H,205,236)(H,206,242)(H,207,247)(H,208,251)(H,209,244)(H,210,243)(H,211,250)(H,212,256)(H,213,265)(H,214,264)(H,215,232)(H,216,259)(H,217,266)(H,218,246)(H,219,252)(H,220,260)(H,233,234)(H,268,269)(H4,177,178,184)(H4,179,180,185)(H4,181,182,186)/t85-,86-,87-,88+,89+,90+,91+,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,127-,128-,129-,130-,131-,132-/m0/s1
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n/an/a 0.0360n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at Kv1.3 in human whole blood assessed as inhibition of thapsigargin-induced IL-2 secretion incubated for 30 prior to thapsigargi...

J Med Chem 58: 6784-802 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00495
BindingDB Entry DOI: 10.7270/Q22V2HWG
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 3


(Homo sapiens (Human))		BDBM50331458
PNG
(4-(4-phenylbutoxy)-7H-furo[3,2-g]chromen-7-one | 5...)
Show SMILES O=c1ccc2c(OCCCCc3ccccc3)c3ccoc3cc2o1
Show InChI InChI=1S/C21H18O4/c22-20-10-9-16-19(25-20)14-18-17(11-13-23-18)21(16)24-12-5-4-8-15-6-2-1-3-7-15/h1-3,6-7,9-11,13-14H,4-5,8,12H2
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n/an/a 724n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel Kv1.3 expressed in CGE22 cells by patch clamp assay

Bioorg Med Chem Lett 20: 6983-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.132
BindingDB Entry DOI: 10.7270/Q2N58MMS
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 3


(Homo sapiens (Human))		BDBM50401658
PNG
(CHEMBL2205333)
Show SMILES OC1CCN(CCCc2ccccc2)CC1
Show InChI InChI=1S/C14H21NO/c16-14-8-11-15(12-9-14)10-4-7-13-5-2-1-3-6-13/h1-3,5-6,14,16H,4,7-12H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of Kv1.3 expressed in mouse L929 cells exposed to depolarizing step pulses from -80 mV to +40 mV by whole cell patch clamp method

Bioorg Med Chem Lett 22: 7106-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.080
BindingDB Entry DOI: 10.7270/Q2CV4JXW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 3


(Homo sapiens (Human))		BDBM50401665
PNG
(CHEMBL2205326)
Show SMILES N#CC(CCN1CCN(CC1)c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H27N3/c27-22-26(23-10-4-1-5-11-23,24-12-6-2-7-13-24)16-17-28-18-20-29(21-19-28)25-14-8-3-9-15-25/h1-15H,16-21H2
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n/an/a 1.86E+3n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of Kv1.3 expressed in mouse L929 cells exposed to depolarizing step pulses from -80 mV to +40 mV by whole cell patch clamp method

Bioorg Med Chem Lett 22: 7106-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.080
BindingDB Entry DOI: 10.7270/Q2CV4JXW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 3


(Homo sapiens (Human))		BDBM50401672
PNG
(DIPHENOXYLATE)
Show SMILES CCOC(=O)C1(CCN(CCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C30H32N2O2/c1-2-34-28(33)29(25-12-6-3-7-13-25)18-21-32(22-19-29)23-20-30(24-31,26-14-8-4-9-15-26)27-16-10-5-11-17-27/h3-17H,2,18-23H2,1H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of Kv1.3 expressed in mouse L929 cells exposed to depolarizing step pulses from -80 mV to +40 mV by whole cell patch clamp method

Bioorg Med Chem Lett 22: 7106-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.09.080
BindingDB Entry DOI: 10.7270/Q2CV4JXW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 3


(Homo sapiens (Human))		BDBM50115814
PNG
(CHEMBL3609062)
Show SMILES [H][C@@]12CCCN1C(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@H](CC(O)=O)NC(=O)[C@@]([H])(NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@]1([H])CSSC[C@]3([H])NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](C)NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CSSC[C@]([H])(NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@H](CCCCN)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC2=O)[C@@H](C)O)[C@@H](C)O)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC |r|
Show InChI InChI=1S/C169H274N52O48S7/c1-13-85(5)127-160(262)204-112(70-126(233)234)150(252)219-132(91(11)229)164(266)217-128(86(6)14-2)165(267)221-63-34-47-123(221)159(261)198-100(42-24-29-58-173)140(242)206-114(74-223)151(253)193-104(46-33-62-186-169(181)182)141(243)210-121-81-274-273-79-119-156(258)195-102(44-31-60-184-167(177)178)136(238)191-101(43-25-30-59-174)144(246)218-131(90(10)228)163(265)213-117(135(237)187-72-125(232)215-129(88(8)226)162(264)214-122(166(268)269)82-276-275-80-120(157(259)216-127)212-154(256)113(73-222)205-134(236)97(175)39-21-26-55-170)77-271-272-78-118(209-142(244)105(52-53-124(176)231)196-146(248)108(66-92-35-17-15-18-36-92)199-133(235)87(7)189-161(263)130(89(9)227)220-158(121)260)155(257)194-99(41-23-28-57-172)138(240)203-111(69-95-71-183-83-188-95)149(251)208-115(75-224)152(254)197-106(54-64-270-12)143(245)190-98(40-22-27-56-171)137(239)201-110(68-94-48-50-96(230)51-49-94)147(249)192-103(45-32-61-185-168(179)180)139(241)200-107(65-84(3)4)145(247)207-116(76-225)153(255)202-109(148(250)211-119)67-93-37-19-16-20-38-93/h15-20,35-38,48-51,71,83-91,97-123,127-132,222-230H,13-14,21-34,39-47,52-70,72-82,170-175H2,1-12H3,(H2,176,231)(H,183,188)(H,187,237)(H,189,263)(H,190,245)(H,191,238)(H,192,249)(H,193,253)(H,194,257)(H,195,258)(H,196,248)(H,197,254)(H,198,261)(H,199,235)(H,200,241)(H,201,239)(H,202,255)(H,203,240)(H,204,262)(H,205,236)(H,206,242)(H,207,247)(H,208,251)(H,209,244)(H,210,243)(H,211,250)(H,212,256)(H,213,265)(H,214,264)(H,215,232)(H,216,259)(H,217,266)(H,218,246)(H,219,252)(H,220,260)(H,233,234)(H,268,269)(H4,177,178,184)(H4,179,180,185)(H4,181,182,186)/t85-,86-,87-,88+,89+,90+,91+,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,127-,128-,129-,130-,131-,132-/m0/s1
PDB
MMDB

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UniProtKB/SwissProt

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CHEMBL
PC cid
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UniChem

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PubMed
n/an/a 0.0730n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at Kv1.3 in human whole blood assessed as inhibition of thapsigargin-induced IFN-gamma secretion incubated for 30 prior to thapsi...

J Med Chem 58: 6784-802 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00495
BindingDB Entry DOI: 10.7270/Q22V2HWG
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 3


(Homo sapiens (Human))		BDBM50331454
PNG
(3-[(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-y...)
Show SMILES OCCCN(C1=NS(=O)(=O)c2ccccc12)c1ccccc1 |t:5|
Show InChI InChI=1S/C16H16N2O3S/c19-12-6-11-18(13-7-2-1-3-8-13)16-14-9-4-5-10-15(14)22(20,21)17-16/h1-5,7-10,19H,6,11-12H2
PDB
MMDB

Reactome pathway
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UniProtKB/SwissProt

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CHEMBL
PC cid
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UniChem

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Article
PubMed
n/an/a 5.01E+3n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel Kv1.3 expressed in CGE22 cells by patch clamp assay

Bioorg Med Chem Lett 20: 6983-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.132
BindingDB Entry DOI: 10.7270/Q2N58MMS
More data for this
Ligand-Target Pair