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There are 21 purchasable compounds for target: HGK5

Wt: 94.1
BDBM10458
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Wt: 344.8
BDBM31774
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Wt: 216.1
BDBM50067880
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Wt: 304.4
BDBM50083523
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Wt: 429.5
BDBM50098785
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Wt: 465.5
BDBM50123508
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Wt: 247.3
BDBM50125528
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Wt: 236.2
BDBM50145066
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Wt: 206.1
BDBM50145057
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Wt: 270.2
BDBM50185446
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Wt: 350.3
BDBM50279106
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Wt: 344.8
BDBM50279107
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Wt: 242.3
BDBM50293327
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Wt: 420.4
BDBM50331409
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Wt: 361.3
BDBM50331444
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Displayed 1 to 15 (of 21 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 10458,31774,50067880,50083523,50098785,50123508,50125528,50145066,50145057,50185446,50279106,50279107,50293327,50331409,50331444   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50083523
PNG
((1-Benzyl-1H-quinolin-4-ylidene)-pentyl-amine | CH...)
Show SMILES CCCCC\N=c1/ccn(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C21H24N2/c1-2-3-9-15-22-20-14-16-23(17-18-10-5-4-6-11-18)21-13-8-7-12-19(20)21/h4-8,10-14,16H,2-3,9,15,17H2,1H3/b22-20+
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n/an/a 200n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Displacement of [125I]- ChTX from human T cell voltage-gated potassium channel subunit Kv1.3


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50098785
PNG
(4-Benzhydryloxymethyl-1-[3-(4-methoxy-phenyl)-prop...)
Show SMILES COc1ccc(CCCN2CCC(COC(c3ccccc3)c3ccccc3)CC2)cc1
Show InChI InChI=1S/C29H35NO2/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27/h2-7,10-17,25,29H,8-9,18-23H2,1H3
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n/an/a 200n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of Kv1.3 expressed in mouse L929 cells exposed to depolarizing step pulses from -80 mV to +40 mV by whole cell patch clamp method


Bioorg Med Chem Lett 22: 7106-9 (2012)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50125528
PNG
(CHEMBL16518 | N-Cyclohexylmethyl-2-methoxy-benzami...)
Show SMILES COc1ccccc1C(=O)NCC1CCCCC1
Show InChI InChI=1S/C15H21NO2/c1-18-14-10-6-5-9-13(14)15(17)16-11-12-7-3-2-4-8-12/h5-6,9-10,12H,2-4,7-8,11H2,1H3,(H,16,17)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Kv1.3 ion channel. Measured in the Rb_Kv assay: [86Rb+] efflux from CHO cells stably transfected with Kv1.3 channel.


Citation and Details
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50145057
PNG
(1-(6-Hydroxy-4-methoxy-benzofuran-5-yl)-ethanone |...)
Show SMILES COc1c(C(C)=O)c(O)cc2occc12
Show InChI InChI=1S/C11H10O4/c1-6(12)10-8(13)5-9-7(3-4-15-9)11(10)14-2/h3-5,13H,1-2H3
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n/an/an/a 1.00E+5n/an/an/an/an/a



Institute of Medical Research Biotechnology Centre

Curated by ChEMBL


Assay Description
Dissociation constant for the blockage of voltage-gated potassium channel subunit Kv1.3 in human lymphocytes


J Med Chem 47: 2326-36 (2004)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM10458
PNG
(4-AP | 4-Aminopyridine 10 | CHEMBL284348 | DALFAMP...)
Show SMILES Nc1ccncc1
Show InChI InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
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n/an/an/a 1.95E+5n/an/an/an/an/a



Institute of Medical Research Biotechnology Centre

Curated by ChEMBL


Assay Description
Dissociation constant for the blockage of voltage-gated potassium channel subunit Kv1.3 in human lymphocytes


J Med Chem 47: 2326-36 (2004)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50145066
PNG
(1-(6-Hydroxy-4,7-dimethoxy-benzofuran-5-yl)-ethano...)
Show SMILES COc1c(O)c(C(C)=O)c(OC)c2ccoc12
Show InChI InChI=1S/C12H12O5/c1-6(13)8-9(14)12(16-3)11-7(4-5-17-11)10(8)15-2/h4-5,14H,1-3H3
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n/an/an/a 5.00E+4n/an/an/an/an/a



Institute of Medical Research Biotechnology Centre

Curated by ChEMBL


Assay Description
Dissociation constant for the blockage of voltage-gated potassium channel subunit Kv1.3 in human lymphocytes


J Med Chem 47: 2326-36 (2004)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50279106
PNG
(4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one | ...)
Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1
Show InChI InChI=1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2
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n/an/a 10n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of cloned Kv1.3 channel (unknown origin) expressed in mammalian cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50279107
PNG
(1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole | C...)
Show SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1cccn1
Show InChI InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
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n/an/a 5.00E+3n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of cloned Kv1.3 channel (unknown origin) expressed in mammalian cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM31774
PNG
(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
Show SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
Show InChI InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
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n/an/a 6.00E+3n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of cloned Kv1.3 channel (unknown origin) expressed in mammalian cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50098785
PNG
(4-Benzhydryloxymethyl-1-[3-(4-methoxy-phenyl)-prop...)
Show SMILES COc1ccc(CCCN2CCC(COC(c3ccccc3)c3ccccc3)CC2)cc1
Show InChI InChI=1S/C29H35NO2/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27/h2-7,10-17,25,29H,8-9,18-23H2,1H3
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n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of human T-cells voltage-gated potassium channel subunit Kv1.3


Bioorg Med Chem Lett 7: 1047-1052 (1997)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50067880
PNG
(4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one | 4-me...)
Show SMILES COc1c2ccoc2cc2oc(=O)ccc12
Show InChI InChI=1S/C12H8O4/c1-14-12-7-2-3-11(13)16-10(7)6-9-8(12)4-5-15-9/h2-6H,1H3
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n/an/a 1.01E+5n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Kv1.3 potassium channel expressed in mouse L929 cells by whole cell patch clamp


Eur J Med Chem 44: 1838-52 (2009)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50279106
PNG
(4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one | ...)
Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1
Show InChI InChI=1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2
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n/an/a 2n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Kv1.3 potassium channel expressed in mouse L929 cells by whole cell patch clamp


Eur J Med Chem 44: 1838-52 (2009)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50293327
PNG
(1,1'[1,4-Butanediyl(oxy)]bis-benzene | CHEMBL56254...)
Show SMILES C(CCOc1ccccc1)COc1ccccc1
Show InChI InChI=1S/C16H18O2/c1-3-9-15(10-4-1)17-13-7-8-14-18-16-11-5-2-6-12-16/h1-6,9-12H,7-8,13-14H2
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Inhibition of Kv1.3 potassium channel expressed in mouse L929 cells by whole cell patch clamp


Eur J Med Chem 44: 1838-52 (2009)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50331409
PNG
(Benzoic acid 3-[(1,1-dioxo-1H-1lambda*6*-benzo[d]i...)
Show SMILES O=C(OCCCN(C1=NS(=O)(=O)c2ccccc12)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H20N2O4S/c26-23(18-10-3-1-4-11-18)29-17-9-16-25(19-12-5-2-6-13-19)22-20-14-7-8-15-21(20)30(27,28)24-22/h1-8,10-15H,9,16-17H2
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n/an/a 1.03E+3n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel Kv1.3 expressed in CGE22 cells by patch clamp assay


Bioorg Med Chem Lett 20: 6983-8 (2010)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50185446
PNG
((E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop...)
Show SMILES COc1cc(O)cc(O)c1C(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+
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n/an/a 740n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel Kv1.3 expressed in CGE22 cells by patch clamp assay


Bioorg Med Chem Lett 20: 6983-8 (2010)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50331444
PNG
(CHEMBL1289297 | N-[3-(1,1-Dioxo-1H-1lambda*6*-benz...)
Show SMILES Fc1ccc(cc1)C(=O)NCCCN=C1NS(=O)(=O)c2ccccc12
Show InChI InChI=1S/C17H16FN3O3S/c18-13-8-6-12(7-9-13)17(22)20-11-3-10-19-16-14-4-1-2-5-15(14)25(23,24)21-16/h1-2,4-9H,3,10-11H2,(H,19,21)(H,20,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel Kv1.3 expressed in CGE22 cells by patch clamp assay


Bioorg Med Chem Lett 20: 6983-8 (2010)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50185446
PNG
((E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop...)
Show SMILES COc1cc(O)cc(O)c1C(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+
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n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel Kv1.3 expressed in L929 cells by whole-cell patch clamp assay


Bioorg Med Chem Lett 20: 6983-8 (2010)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50279106
PNG
(4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one | ...)
Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1
Show InChI InChI=1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2
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n/an/a 740n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Kv1.3 ion channel expressed in CGE22 cells


Bioorg Med Chem Lett 20: 6989-92 (2010)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50279106
PNG
(4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one | ...)
Show SMILES O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1
Show InChI InChI=1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2
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n/an/a 2n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of Kv1.3 expressed in mouse L929 cells exposed to depolarizing step pulses from -80 mV to +40 mV by whole cell patch clamp method


Bioorg Med Chem Lett 22: 7106-9 (2012)

More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (Human))
BDBM50123508
PNG
(CHEMBL148159 | [2'-(2-Pyridin-2-yl-ethylcarbamoyl)...)
Show SMILES O=C(NCc1ccccc1-c1ccccc1C(=O)NCCc1ccccn1)OCc1ccccc1
Show InChI InChI=1S/C29H27N3O3/c33-28(31-19-17-24-13-8-9-18-30-24)27-16-7-6-15-26(27)25-14-5-4-12-23(25)20-32-29(34)35-21-22-10-2-1-3-11-22/h1-16,18H,17,19-21H2,(H,31,33)(H,32,34)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.3 expressed in Xenopus oocytes


J Med Chem 46: 486-98 (2003)

More data for this
Ligand-Target Pair