Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-C chemokine receptor type 5
(Homo sapiens (Human)) | BDBM50441751
(CHEMBL2435893)Show SMILES CC(CCNC(=O)c1c(C)ncnc1C)N1CCC(CC1)N1C(CN(C2CCCCC2)C1=O)c1cccc(F)c1 Show InChI InChI=1S/C31H43FN6O2/c1-21(12-15-33-30(39)29-22(2)34-20-35-23(29)3)36-16-13-27(14-17-36)38-28(24-8-7-9-25(32)18-24)19-37(31(38)40)26-10-5-4-6-11-26/h7-9,18,20-21,26-28H,4-6,10-17,19H2,1-3H3,(H,33,39) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated f... |
J Med Chem 56: 8049-65 (2013)
Article DOI: 10.1021/jm401101p
BindingDB Entry DOI: 10.7270/Q2445NX3 |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 5
(Homo sapiens (Human)) | BDBM50441751
(CHEMBL2435893)Show SMILES CC(CCNC(=O)c1c(C)ncnc1C)N1CCC(CC1)N1C(CN(C2CCCCC2)C1=O)c1cccc(F)c1 Show InChI InChI=1S/C31H43FN6O2/c1-21(12-15-33-30(39)29-22(2)34-20-35-23(29)3)36-16-13-27(14-17-36)38-28(24-8-7-9-25(32)18-24)19-37(31(38)40)26-10-5-4-6-11-26/h7-9,18,20-21,26-28H,4-6,10-17,19H2,1-3H3,(H,33,39) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Displacement of [125I]-RANTES from CCR5 (unknown origin) expressed in HEK293F cell membranes after 45 mins by microbeta jet liquid scintillation coun... |
J Med Chem 56: 8049-65 (2013)
Article DOI: 10.1021/jm401101p
BindingDB Entry DOI: 10.7270/Q2445NX3 |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 5
(Homo sapiens (Human)) | BDBM50441751
(CHEMBL2435893)Show SMILES CC(CCNC(=O)c1c(C)ncnc1C)N1CCC(CC1)N1C(CN(C2CCCCC2)C1=O)c1cccc(F)c1 Show InChI InChI=1S/C31H43FN6O2/c1-21(12-15-33-30(39)29-22(2)34-20-35-23(29)3)36-16-13-27(14-17-36)38-28(24-8-7-9-25(32)18-24)19-37(31(38)40)26-10-5-4-6-11-26/h7-9,18,20-21,26-28H,4-6,10-17,19H2,1-3H3,(H,33,39) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV... |
J Med Chem 56: 8049-65 (2013)
Article DOI: 10.1021/jm401101p
BindingDB Entry DOI: 10.7270/Q2445NX3 |
More data for this
Ligand-Target Pair | |