Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50089353
(CHEMBL3577942)Show SMILES CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@H](NC(=O)c2cc(ccc2NC(=O)NCC)C(F)(F)F)C1=O)N(C)C(C)C |r| Show InChI InChI=1S/C28H42F3N5O3/c1-6-8-18-15-20(35(5)17(3)4)10-12-24(18)36-14-13-23(26(36)38)33-25(37)21-16-19(28(29,30)31)9-11-22(21)34-27(39)32-7-2/h9,11,16-18,20,23-24H,6-8,10,12-15H2,1-5H3,(H,33,37)(H2,32,34,39)/t18-,20-,23+,24+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Antagonist activity against CCR2 in human PBMC assessed as inhibition of MCP1-induced chemotaxis at 37 degC |
ACS Med Chem Lett 6: 439-44 (2015)
Article DOI: 10.1021/ml500505q
BindingDB Entry DOI: 10.7270/Q2668FWM |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50089353
(CHEMBL3577942)Show SMILES CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@H](NC(=O)c2cc(ccc2NC(=O)NCC)C(F)(F)F)C1=O)N(C)C(C)C |r| Show InChI InChI=1S/C28H42F3N5O3/c1-6-8-18-15-20(35(5)17(3)4)10-12-24(18)36-14-13-23(26(36)38)33-25(37)21-16-19(28(29,30)31)9-11-22(21)34-27(39)32-7-2/h9,11,16-18,20,23-24H,6-8,10,12-15H2,1-5H3,(H,33,37)(H2,32,34,39)/t18-,20-,23+,24+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | 25 |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Inhibition of [125I]hMCP1 binding to CCR2 in human PBMC incubated for 30 mins at room temperature |
ACS Med Chem Lett 6: 439-44 (2015)
Article DOI: 10.1021/ml500505q
BindingDB Entry DOI: 10.7270/Q2668FWM |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 5
(Homo sapiens (Human)) | BDBM50089353
(CHEMBL3577942)Show SMILES CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@H](NC(=O)c2cc(ccc2NC(=O)NCC)C(F)(F)F)C1=O)N(C)C(C)C |r| Show InChI InChI=1S/C28H42F3N5O3/c1-6-8-18-15-20(35(5)17(3)4)10-12-24(18)36-14-13-23(26(36)38)33-25(37)21-16-19(28(29,30)31)9-11-22(21)34-27(39)32-7-2/h9,11,16-18,20,23-24H,6-8,10,12-15H2,1-5H3,(H,33,37)(H2,32,34,39)/t18-,20-,23+,24+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Inhibition of [125I]MCP1-beta binding to CCR5 in human HT1080 cell membranes incubated for 4 to 6 hrs |
ACS Med Chem Lett 6: 439-44 (2015)
Article DOI: 10.1021/ml500505q
BindingDB Entry DOI: 10.7270/Q2668FWM |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50089353
(CHEMBL3577942)Show SMILES CCC[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@H](NC(=O)c2cc(ccc2NC(=O)NCC)C(F)(F)F)C1=O)N(C)C(C)C |r| Show InChI InChI=1S/C28H42F3N5O3/c1-6-8-18-15-20(35(5)17(3)4)10-12-24(18)36-14-13-23(26(36)38)33-25(37)21-16-19(28(29,30)31)9-11-22(21)34-27(39)32-7-2/h9,11,16-18,20,23-24H,6-8,10,12-15H2,1-5H3,(H,33,37)(H2,32,34,39)/t18-,20-,23+,24+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
Curated by ChEMBL
| Assay Description
Inhibition of human ERG expressed in HEK293 cells assessed as reduction in peak tail current at holding potential of 80 mV to +20 mV by whole cell pa... |
ACS Med Chem Lett 6: 439-44 (2015)
Article DOI: 10.1021/ml500505q
BindingDB Entry DOI: 10.7270/Q2668FWM |
More data for this
Ligand-Target Pair | |