Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-C chemokine receptor type 5
(Homo sapiens (Human)) | BDBM50441740
(CHEMBL2435895)Show SMILES COC(=O)c1cccc(c1)C1CN(C2CCCCC2)C(=O)N1C1CCN(CC1)C(C)CCNC(=O)c1c(C)ncnc1C Show InChI InChI=1S/C33H46N6O4/c1-22(13-16-34-31(40)30-23(2)35-21-36-24(30)3)37-17-14-28(15-18-37)39-29(25-9-8-10-26(19-25)32(41)43-4)20-38(33(39)42)27-11-6-5-7-12-27/h8-10,19,21-22,27-29H,5-7,11-18,20H2,1-4H3,(H,34,40) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR5 (unknown origin) expressed in HEK293F cell membranes assessed as inhibition of RANTES-induced calcium flux preincubated f... |
J Med Chem 56: 8049-65 (2013)
Article DOI: 10.1021/jm401101p
BindingDB Entry DOI: 10.7270/Q2445NX3 |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 5
(Homo sapiens (Human)) | BDBM50441740
(CHEMBL2435895)Show SMILES COC(=O)c1cccc(c1)C1CN(C2CCCCC2)C(=O)N1C1CCN(CC1)C(C)CCNC(=O)c1c(C)ncnc1C Show InChI InChI=1S/C33H46N6O4/c1-22(13-16-34-31(40)30-23(2)35-21-36-24(30)3)37-17-14-28(15-18-37)39-29(25-9-8-10-26(19-25)32(41)43-4)20-38(33(39)42)27-11-6-5-7-12-27/h8-10,19,21-22,27-29H,5-7,11-18,20H2,1-4H3,(H,34,40) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 176 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Displacement of [125I]-RANTES from CCR5 (unknown origin) expressed in HEK293F cell membranes after 45 mins by microbeta jet liquid scintillation coun... |
J Med Chem 56: 8049-65 (2013)
Article DOI: 10.1021/jm401101p
BindingDB Entry DOI: 10.7270/Q2445NX3 |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 5
(Homo sapiens (Human)) | BDBM50441740
(CHEMBL2435895)Show SMILES COC(=O)c1cccc(c1)C1CN(C2CCCCC2)C(=O)N1C1CCN(CC1)C(C)CCNC(=O)c1c(C)ncnc1C Show InChI InChI=1S/C33H46N6O4/c1-22(13-16-34-31(40)30-23(2)35-21-36-24(30)3)37-17-14-28(15-18-37)39-29(25-9-8-10-26(19-25)32(41)43-4)20-38(33(39)42)27-11-6-5-7-12-27/h8-10,19,21-22,27-29H,5-7,11-18,20H2,1-4H3,(H,34,40) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 347 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description
Inhibition of CCR5 (unknown origin) expressed in human HeLa cells assessed as inhibition of interaction of CHO cells expressing HIV-1 JRFLenv and HIV... |
J Med Chem 56: 8049-65 (2013)
Article DOI: 10.1021/jm401101p
BindingDB Entry DOI: 10.7270/Q2445NX3 |
More data for this
Ligand-Target Pair | |