Found 6 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50506125
(CHEMBL4517518)Show SMILES Nc1nc2[nH]c(C3CC3)c(Cc3cccc(Cl)c3)c(=O)n2n1 Show InChI InChI=1S/C15H14ClN5O/c16-10-3-1-2-8(6-10)7-11-12(9-4-5-9)18-15-19-14(17)20-21(15)13(11)22/h1-3,6,9H,4-5,7H2,(H3,17,18,19,20) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CCR2-RA-[R] from human CCR2 expressed in human U2OS cells incubated for 2 hrs by scintillation spectrometric method |
J Med Chem 62: 11035-11053 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00742
BindingDB Entry DOI: 10.7270/Q2QR51DD |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50506125
(CHEMBL4517518)Show SMILES Nc1nc2[nH]c(C3CC3)c(Cc3cccc(Cl)c3)c(=O)n2n1 Show InChI InChI=1S/C15H14ClN5O/c16-10-3-1-2-8(6-10)7-11-12(9-4-5-9)18-15-19-14(17)20-21(15)13(11)22/h1-3,6,9H,4-5,7H2,(H3,17,18,19,20) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CCR2-RA-[R] from human CCR2 expressed in human U2OS cells incubated for 2 hrs by scintillation spectrometric method |
J Med Chem 62: 11035-11053 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00742
BindingDB Entry DOI: 10.7270/Q2QR51DD |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50506125
(CHEMBL4517518)Show SMILES Nc1nc2[nH]c(C3CC3)c(Cc3cccc(Cl)c3)c(=O)n2n1 Show InChI InChI=1S/C15H14ClN5O/c16-10-3-1-2-8(6-10)7-11-12(9-4-5-9)18-15-19-14(17)20-21(15)13(11)22/h1-3,6,9H,4-5,7H2,(H3,17,18,19,20) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description
Antagonist activity at human TEV cleavage site-linked CCR2b expressed in human U2OS cells harboring beta-lactamase reporter gene assessed as inhibiti... |
J Med Chem 62: 11035-11053 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00742
BindingDB Entry DOI: 10.7270/Q2QR51DD |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50506125
(CHEMBL4517518)Show SMILES Nc1nc2[nH]c(C3CC3)c(Cc3cccc(Cl)c3)c(=O)n2n1 Show InChI InChI=1S/C15H14ClN5O/c16-10-3-1-2-8(6-10)7-11-12(9-4-5-9)18-15-19-14(17)20-21(15)13(11)22/h1-3,6,9H,4-5,7H2,(H3,17,18,19,20) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2b in human THP1 cells assessed as inhibition of human MCP1 induced calcium flux by fluo-4 dye based fluorescence assay |
J Med Chem 62: 11035-11053 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00742
BindingDB Entry DOI: 10.7270/Q2QR51DD |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 5
(Homo sapiens (Human)) | BDBM50506125
(CHEMBL4517518)Show SMILES Nc1nc2[nH]c(C3CC3)c(Cc3cccc(Cl)c3)c(=O)n2n1 Show InChI InChI=1S/C15H14ClN5O/c16-10-3-1-2-8(6-10)7-11-12(9-4-5-9)18-15-19-14(17)20-21(15)13(11)22/h1-3,6,9H,4-5,7H2,(H3,17,18,19,20) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 575 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description
Antagonist activity at human TEV cleavage site-linked CCR5 expressed in human U2OS cells harboring beta-lactamase reporter gene assessed as inhibitio... |
J Med Chem 62: 11035-11053 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00742
BindingDB Entry DOI: 10.7270/Q2QR51DD |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 5
(Homo sapiens (Human)) | BDBM50506125
(CHEMBL4517518)Show SMILES Nc1nc2[nH]c(C3CC3)c(Cc3cccc(Cl)c3)c(=O)n2n1 Show InChI InChI=1S/C15H14ClN5O/c16-10-3-1-2-8(6-10)7-11-12(9-4-5-9)18-15-19-14(17)20-21(15)13(11)22/h1-3,6,9H,4-5,7H2,(H3,17,18,19,20) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 575 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description
Antagonist activity at human TEV cleavage site-linked CCR5 expressed in human U2OS cells harboring beta-lactamase reporter gene assessed as inhibitio... |
J Med Chem 62: 11035-11053 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00742
BindingDB Entry DOI: 10.7270/Q2QR51DD |
More data for this
Ligand-Target Pair | |