Found 5 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cytochrome b-245 heavy chain
(Homo sapiens (Human)) | BDBM50497260
(CHEMBL3347567)Show SMILES [H][C@@]12CC(C)(C)[C@@]([H])([C@H](CC(C)=C)N1CCCCC)c1c(cccc21)-c1ccc(Cl)c(Cl)c1 |r,TLB:20:19:3.2:13.8,9:8:3.2:24.19,THB:14:13:3.2:24.19| Show InChI InChI=1S/C28H35Cl2N/c1-6-7-8-14-31-24(15-18(2)3)27-26-20(19-12-13-22(29)23(30)16-19)10-9-11-21(26)25(31)17-28(27,4)5/h9-13,16,24-25,27H,2,6-8,14-15,17H2,1,3-5H3/t24-,25-,27-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh
Curated by ChEMBL
| Assay Description Inhibition of full length human NOX2 transfected in COS 22 cells assessed as inhibition of Phorbol 12-myristate 13-acetate-stimulated ROS generation ... |
Medchemcomm 4: 1085-1092 (2013)
Article DOI: 10.1039/c3md00061c BindingDB Entry DOI: 10.7270/Q2J38WJK |
More data for this Ligand-Target Pair | |
NADPH oxidase 4
(Homo sapiens (Human)) | BDBM50497260
(CHEMBL3347567)Show SMILES [H][C@@]12CC(C)(C)[C@@]([H])([C@H](CC(C)=C)N1CCCCC)c1c(cccc21)-c1ccc(Cl)c(Cl)c1 |r,TLB:20:19:3.2:13.8,9:8:3.2:24.19,THB:14:13:3.2:24.19| Show InChI InChI=1S/C28H35Cl2N/c1-6-7-8-14-31-24(15-18(2)3)27-26-20(19-12-13-22(29)23(30)16-19)10-9-11-21(26)25(31)17-28(27,4)5/h9-13,16,24-25,27H,2,6-8,14-15,17H2,1,3-5H3/t24-,25-,27-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh
Curated by ChEMBL
| Assay Description Inhibition of full length human NOX4 transfected in COS 22 cells assessed as inhibition of Phorbol 12-myristate 13-acetate-stimulated ROS generation ... |
Medchemcomm 4: 1085-1092 (2013)
Article DOI: 10.1039/c3md00061c BindingDB Entry DOI: 10.7270/Q2J38WJK |
More data for this Ligand-Target Pair | |
NADPH oxidase 5
(Homo sapiens (Human)) | BDBM50497260
(CHEMBL3347567)Show SMILES [H][C@@]12CC(C)(C)[C@@]([H])([C@H](CC(C)=C)N1CCCCC)c1c(cccc21)-c1ccc(Cl)c(Cl)c1 |r,TLB:20:19:3.2:13.8,9:8:3.2:24.19,THB:14:13:3.2:24.19| Show InChI InChI=1S/C28H35Cl2N/c1-6-7-8-14-31-24(15-18(2)3)27-26-20(19-12-13-22(29)23(30)16-19)10-9-11-21(26)25(31)17-28(27,4)5/h9-13,16,24-25,27H,2,6-8,14-15,17H2,1,3-5H3/t24-,25-,27-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh
Curated by ChEMBL
| Assay Description Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assa... |
Medchemcomm 4: 1085-1092 (2013)
Article DOI: 10.1039/c3md00061c BindingDB Entry DOI: 10.7270/Q2J38WJK |
More data for this Ligand-Target Pair | |
NADPH oxidase 1
(Homo sapiens (Human)) | BDBM50497260
(CHEMBL3347567)Show SMILES [H][C@@]12CC(C)(C)[C@@]([H])([C@H](CC(C)=C)N1CCCCC)c1c(cccc21)-c1ccc(Cl)c(Cl)c1 |r,TLB:20:19:3.2:13.8,9:8:3.2:24.19,THB:14:13:3.2:24.19| Show InChI InChI=1S/C28H35Cl2N/c1-6-7-8-14-31-24(15-18(2)3)27-26-20(19-12-13-22(29)23(30)16-19)10-9-11-21(26)25(31)17-28(27,4)5/h9-13,16,24-25,27H,2,6-8,14-15,17H2,1,3-5H3/t24-,25-,27-/m0/s1 | KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh
Curated by ChEMBL
| Assay Description Inhibition of full length human NOX1 transfected in COS 22 cells assessed as inhibition of Phorbol 12-myristate 13-acetate-stimulated ROS generation ... |
Medchemcomm 4: 1085-1092 (2013)
Article DOI: 10.1039/c3md00061c BindingDB Entry DOI: 10.7270/Q2J38WJK |
More data for this Ligand-Target Pair | |
Cytochrome b-245 heavy chain
(Homo sapiens (Human)) | BDBM50497260
(CHEMBL3347567)Show SMILES [H][C@@]12CC(C)(C)[C@@]([H])([C@H](CC(C)=C)N1CCCCC)c1c(cccc21)-c1ccc(Cl)c(Cl)c1 |r,TLB:20:19:3.2:13.8,9:8:3.2:24.19,THB:14:13:3.2:24.19| Show InChI InChI=1S/C28H35Cl2N/c1-6-7-8-14-31-24(15-18(2)3)27-26-20(19-12-13-22(29)23(30)16-19)10-9-11-21(26)25(31)17-28(27,4)5/h9-13,16,24-25,27H,2,6-8,14-15,17H2,1,3-5H3/t24-,25-,27-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh
Curated by ChEMBL
| Assay Description Inhibition of full length human NOX2 transfected in COS 22 cells assessed as inhibition of Phorbol 12-myristate 13-acetate-stimulated ROS generation ... |
Medchemcomm 4: 1085-1092 (2013)
Article DOI: 10.1039/c3md00061c BindingDB Entry DOI: 10.7270/Q2J38WJK |
More data for this Ligand-Target Pair | |