Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
17-beta-hydroxysteroid dehydrogenase type 3
(Rattus norvegicus) | BDBM50528383
(CHEMBL4445467)Show SMILES [H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])c3ccc(CCN4CC(C)N(CC4C)S(=O)(=O)c4ccccc4C(F)(F)F)cc3CC[C@@]21[H] |r| Show InChI InChI=1S/C33H41F3N2O3S/c1-21-20-38(42(40,41)30-7-5-4-6-29(30)33(34,35)36)22(2)19-37(21)17-15-23-8-10-25-24(18-23)9-11-27-26(25)14-16-32(3)28(27)12-13-31(32)39/h4-8,10,18,21-22,26-28H,9,11-17,19-20H2,1-3H3/t21?,22?,26-,27-,28+,32+/m1/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
CHU de Queb£c-Research Center
Curated by ChEMBL
| Assay Description
Inhibition of 17beta-HSD3 in Sprague-Dawley rat testes microsomal fraction assessed as reduction in [14C]-testosterone formation from [14C]-4-androst... |
J Med Chem 62: 7070-7088 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00624
BindingDB Entry DOI: 10.7270/Q2B56P6P |
More data for this
Ligand-Target Pair | |
17-beta-hydroxysteroid dehydrogenase type 3
(Homo sapiens (Human)) | BDBM50528383
(CHEMBL4445467)Show SMILES [H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])c3ccc(CCN4CC(C)N(CC4C)S(=O)(=O)c4ccccc4C(F)(F)F)cc3CC[C@@]21[H] |r| Show InChI InChI=1S/C33H41F3N2O3S/c1-21-20-38(42(40,41)30-7-5-4-6-29(30)33(34,35)36)22(2)19-37(21)17-15-23-8-10-25-24(18-23)9-11-27-26(25)14-16-32(3)28(27)12-13-31(32)39/h4-8,10,18,21-22,26-28H,9,11-17,19-20H2,1-3H3/t21?,22?,26-,27-,28+,32+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
CHU de Queb£c-Research Center
Curated by ChEMBL
| Assay Description
Inhibition of 17beta-HSD3 (unknown origin) expressed in human LNCAP cells assessed as reduction in [14C]-testosterone formation from [14C]-4-androste... |
J Med Chem 62: 7070-7088 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00624
BindingDB Entry DOI: 10.7270/Q2B56P6P |
More data for this
Ligand-Target Pair | |