Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase kinase kinase 12
(Homo sapiens (Human)) | BDBM50271218
(CHEMBL3714987)Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(OC(F)F)c1)C1COC1 |r| Show InChI InChI=1S/C20H25F2N5O2/c1-10(2)27-16(18-13-6-26(7-14(13)18)12-8-28-9-12)4-15(25-27)11-3-17(29-20(21)22)19(23)24-5-11/h3-5,10,12-14,18,20H,6-9H2,1-2H3,(H2,23,24)/t13-,14+,18+ | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi AppTec Co., Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to N-terminally GST-tagged wild type human DLK (1 to 520 residues) expressed in sf21 insect cells using N-terminally His-tagged MKK4... |
J Med Chem 60: 8083-8102 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 12
(Homo sapiens (Human)) | BDBM50271218
(CHEMBL3714987)Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c(OC(F)F)c1)C1COC1 |r| Show InChI InChI=1S/C20H25F2N5O2/c1-10(2)27-16(18-13-6-26(7-14(13)18)12-8-28-9-12)4-15(25-27)11-3-17(29-20(21)22)19(23)24-5-11/h3-5,10,12-14,18,20H,6-9H2,1-2H3,(H2,23,24)/t13-,14+,18+ | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 328 | n/a | n/a | n/a | n/a | n/a | n/a |
WuXi AppTec Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of doxycycline inducible human DLK transfected in HEK293 cells assessed as JNK phosphorylation after 5.5 hrs by Hoechst-33342 staining-bas... |
J Med Chem 60: 8083-8102 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K |
More data for this Ligand-Target Pair | |