Found 13 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-T1/Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CDK9/cyclin T expressed in insect cells assessed as incorporation of [gamma-33P]-ATP in to pRB fragment (773 to 928) ... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CDK2/cyclin A assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation c... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CDK5/p25 assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation counti... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity at NOP receptor in Swiss mouse vas deferens by [35S]GTP-gamma-S binding assay |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Activity at human B2 receptor transfected in CHO cells assessed as ability to antagonize BK-induced inositol-phosphate accumulation |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity at human M3 receptor assessed as inhibition of carbachol binding |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist potency at human bradykinin B2 receptor assessed as effect on inositol monophosphate accumulation in CHOdhfr- cells |
Citation and Details
|
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | MMDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity against adrenergic Alpha-1D receptor in rat thoracic aorta assessed as noradrenaline-induced response |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Homo sapiens (Human)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Activity at M3 muscarinic receptor in guinea pig assessed as effect on carbachol-induced trachea contraction |
Citation and Details
|
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli assessed as assessed as incorporation of [gamma-33P]-ATP into myelin bas... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Homo sapiens (Human)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description Inhibition of CLK1 |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform alpha
(Sus scrofa) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation counting |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase 3
(Plasmodium falciparum (isolate 3D7)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | KEGG
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description Inhibition of Plasmodium falciparum GSK3 |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024 BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this Ligand-Target Pair | |