Found 4 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50143693
(8-{2-[4-(2-Bromo-phenyl)-piperazin-1-yl]-ethyl}-8-...)Show SMILES Brc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C21H28BrN3O2/c22-17-5-1-2-6-18(17)24-12-9-23(10-13-24)11-14-25-19(26)15-21(16-20(25)27)7-3-4-8-21/h1-2,5-6H,3-4,7-16H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati s.p.a.
Curated by ChEMBL
| Assay Description Binding affinity to human 5-hydroxytryptamine 1A receptor was measured using [3H]-8-hydroxy-2-(di-n-propylamine) tetraline [3H]-8-OH-DPAT) as radioli... |
J Med Chem 47: 1900-18 (2004)
Article DOI: 10.1021/jm030944+ BindingDB Entry DOI: 10.7270/Q23F4P35 |
More data for this Ligand-Target Pair | |
Alpha-1D adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50143693
(8-{2-[4-(2-Bromo-phenyl)-piperazin-1-yl]-ethyl}-8-...)Show SMILES Brc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C21H28BrN3O2/c22-17-5-1-2-6-18(17)24-12-9-23(10-13-24)11-14-25-19(26)15-21(16-20(25)27)7-3-4-8-21/h1-2,5-6H,3-4,7-16H2 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati s.p.a.
Curated by ChEMBL
| Assay Description Binding affinity to the adrenergic receptor alpha-1D of rat aorta |
J Med Chem 47: 1900-18 (2004)
Article DOI: 10.1021/jm030944+ BindingDB Entry DOI: 10.7270/Q23F4P35 |
More data for this Ligand-Target Pair | |
Alpha-1B adrenergic receptor
(Homo sapiens (Human)) | BDBM50143693
(8-{2-[4-(2-Bromo-phenyl)-piperazin-1-yl]-ethyl}-8-...)Show SMILES Brc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C21H28BrN3O2/c22-17-5-1-2-6-18(17)24-12-9-23(10-13-24)11-14-25-19(26)15-21(16-20(25)27)7-3-4-8-21/h1-2,5-6H,3-4,7-16H2 | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 122 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati s.p.a.
Curated by ChEMBL
| Assay Description Binding affinity constant against alpha-1B adrenergic receptor of guinea pig spleen |
J Med Chem 47: 1900-18 (2004)
Article DOI: 10.1021/jm030944+ BindingDB Entry DOI: 10.7270/Q23F4P35 |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50143693
(8-{2-[4-(2-Bromo-phenyl)-piperazin-1-yl]-ethyl}-8-...)Show SMILES Brc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 Show InChI InChI=1S/C21H28BrN3O2/c22-17-5-1-2-6-18(17)24-12-9-23(10-13-24)11-14-25-19(26)15-21(16-20(25)27)7-3-4-8-21/h1-2,5-6H,3-4,7-16H2 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 376 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Recordati s.p.a.
Curated by ChEMBL
| Assay Description In vitro binding affinity towards alpha-1A adrenergic receptor through displacement of [3H]-prazosin in epididymal rat vas deferens. |
J Med Chem 47: 1900-18 (2004)
Article DOI: 10.1021/jm030944+ BindingDB Entry DOI: 10.7270/Q23F4P35 |
More data for this Ligand-Target Pair | |