Found 3 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50074173
(CHEMBL349041 | Furan-2-ylmethyl-{(S)-1-[2-(5-[1,2,...)Show SMILES C(Cc1c[nH]c2ccc(cc12)-n1cnnc1)N1CC[C@@H](CNCc2ccco2)C1 Show InChI InChI=1S/C22H26N6O/c1-2-20(29-9-1)13-23-11-17-5-7-27(14-17)8-6-18-12-24-22-4-3-19(10-21(18)22)28-15-25-26-16-28/h1-4,9-10,12,15-17,23-24H,5-8,11,13-14H2/t17-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck, Sharp and Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells |
J Med Chem 42: 677-90 (1999)
Article DOI: 10.1021/jm9805687 BindingDB Entry DOI: 10.7270/Q23777W5 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1B
(Homo sapiens (Human)) | BDBM50074173
(CHEMBL349041 | Furan-2-ylmethyl-{(S)-1-[2-(5-[1,2,...)Show SMILES C(Cc1c[nH]c2ccc(cc12)-n1cnnc1)N1CC[C@@H](CNCc2ccco2)C1 Show InChI InChI=1S/C22H26N6O/c1-2-20(29-9-1)13-23-11-17-5-7-27(14-17)8-6-18-12-24-22-4-3-19(10-21(18)22)28-15-25-26-16-28/h1-4,9-10,12,15-17,23-24H,5-8,11,13-14H2/t17-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck, Sharp and Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [3H]-5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells |
J Med Chem 42: 677-90 (1999)
Article DOI: 10.1021/jm9805687 BindingDB Entry DOI: 10.7270/Q23777W5 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50074173
(CHEMBL349041 | Furan-2-ylmethyl-{(S)-1-[2-(5-[1,2,...)Show SMILES C(Cc1c[nH]c2ccc(cc12)-n1cnnc1)N1CC[C@@H](CNCc2ccco2)C1 Show InChI InChI=1S/C22H26N6O/c1-2-20(29-9-1)13-23-11-17-5-7-27(14-17)8-6-18-12-24-22-4-3-19(10-21(18)22)28-15-25-26-16-28/h1-4,9-10,12,15-17,23-24H,5-8,11,13-14H2/t17-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a |
Merck, Sharp and Dohme Research Laboratories
Curated by ChEMBL
| Assay Description Stimulation of [35S]-GTP-gammaS, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor |
J Med Chem 42: 677-90 (1999)
Article DOI: 10.1021/jm9805687 BindingDB Entry DOI: 10.7270/Q23777W5 |
More data for this Ligand-Target Pair | |