Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM17722
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 18 | 3-phen...)Show SMILES C(Cc1ccncc1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1 Show InChI InChI=1S/C33H34N4O2/c1-3-7-26(8-4-1)30-31-29(35-19-15-25-13-17-34-18-14-25)16-20-36-33(31)39-32(30)27-9-11-28(12-10-27)38-24-23-37-21-5-2-6-22-37/h1,3-4,7-14,16-18,20H,2,5-6,15,19,21-24H2,(H,35,36) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
| Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all... |
Bioorg Med Chem Lett 17: 2299-304 (2007)
Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9 |
More data for this
Ligand-Target Pair | |
Activated CDC42 kinase 1
(Homo sapiens (Human)) | BDBM17722
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 18 | 3-phen...)Show SMILES C(Cc1ccncc1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1 Show InChI InChI=1S/C33H34N4O2/c1-3-7-26(8-4-1)30-31-29(35-19-15-25-13-17-34-18-14-25)16-20-36-33(31)39-32(30)27-9-11-28(12-10-27)38-24-23-37-21-5-2-6-22-37/h1,3-4,7-14,16-18,20H,2,5-6,15,19,21-24H2,(H,35,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
| Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all... |
Bioorg Med Chem Lett 17: 2299-304 (2007)
Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM17722
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 18 | 3-phen...)Show SMILES C(Cc1ccncc1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1 Show InChI InChI=1S/C33H34N4O2/c1-3-7-26(8-4-1)30-31-29(35-19-15-25-13-17-34-18-14-25)16-20-36-33(31)39-32(30)27-9-11-28(12-10-27)38-24-23-37-21-5-2-6-22-37/h1,3-4,7-14,16-18,20H,2,5-6,15,19,21-24H2,(H,35,36) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen
| Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all... |
Bioorg Med Chem Lett 17: 2299-304 (2007)
Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM17722
(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 18 | 3-phen...)Show SMILES C(Cc1ccncc1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCCC2)cc1 Show InChI InChI=1S/C33H34N4O2/c1-3-7-26(8-4-1)30-31-29(35-19-15-25-13-17-34-18-14-25)16-20-36-33(31)39-32(30)27-9-11-28(12-10-27)38-24-23-37-21-5-2-6-22-37/h1,3-4,7-14,16-18,20H,2,5-6,15,19,21-24H2,(H,35,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen
| Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all... |
Bioorg Med Chem Lett 17: 2299-304 (2007)
Article DOI: 10.1016/j.bmcl.2007.01.048
BindingDB Entry DOI: 10.7270/Q2X34VQ9 |
More data for this
Ligand-Target Pair | |