Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 359.3 BDBM50342894

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dual specificity protein kinase CLK4 (Homo sapiens (Human))	BDBM50342894 (CHEMBL1515868 | N-(2-(1H-imidazol-4-yl)ethyl)-6-(b...) Show SMILES C(Cc1cnc[nH]1)Nc1ncnc2ccc(cc12)-c1ccc2OCOc2c1 Show InChI InChI=1S/C20H17N5O2/c1-3-17-16(7-13(1)14-2-4-18-19(8-14)27-12-26-18)20(25-11-24-17)22-6-5-15-9-21-10-23-15/h1-4,7-11H,5-6,12H2,(H,21,23)(H,22,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	161	n/a	n/a	n/a	n/a	n/a	n/a
National Human Genome Research Institute Curated by ChEMBL					Assay Description Inhibition of Clk4 kinase using ATP as substrate by 33P radiolabelled kinase assay				Bioorg Med Chem Lett 21: 3152-8 (2011) Article DOI: 10.1016/j.bmcl.2011.02.114 BindingDB Entry DOI: 10.7270/Q2J67H83
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (Homo sapiens (Human))	BDBM50342894 (CHEMBL1515868 | N-(2-(1H-imidazol-4-yl)ethyl)-6-(b...) Show SMILES C(Cc1cnc[nH]1)Nc1ncnc2ccc(cc12)-c1ccc2OCOc2c1 Show InChI InChI=1S/C20H17N5O2/c1-3-17-16(7-13(1)14-2-4-18-19(8-14)27-12-26-18)20(25-11-24-17)22-6-5-15-9-21-10-23-15/h1-4,7-11H,5-6,12H2,(H,21,23)(H,22,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	541	n/a	n/a	n/a	n/a	n/a	n/a
National Human Genome Research Institute Curated by ChEMBL					Assay Description Inhibition of Dyrk1A kinase using ATP as substrate by 33P radiolabelled kinase assay				Bioorg Med Chem Lett 21: 3152-8 (2011) Article DOI: 10.1016/j.bmcl.2011.02.114 BindingDB Entry DOI: 10.7270/Q2J67H83
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1 (Homo sapiens (Human))	BDBM50342894 (CHEMBL1515868 | N-(2-(1H-imidazol-4-yl)ethyl)-6-(b...) Show SMILES C(Cc1cnc[nH]1)Nc1ncnc2ccc(cc12)-c1ccc2OCOc2c1 Show InChI InChI=1S/C20H17N5O2/c1-3-17-16(7-13(1)14-2-4-18-19(8-14)27-12-26-18)20(25-11-24-17)22-6-5-15-9-21-10-23-15/h1-4,7-11H,5-6,12H2,(H,21,23)(H,22,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	931	n/a	n/a	n/a	n/a	n/a	n/a
National Human Genome Research Institute Curated by ChEMBL					Assay Description Inhibition of Clk1 kinase using ATP as substrate by 33P radiolabelled kinase assay				Bioorg Med Chem Lett 21: 3152-8 (2011) Article DOI: 10.1016/j.bmcl.2011.02.114 BindingDB Entry DOI: 10.7270/Q2J67H83
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK2 (Homo sapiens (Human))	BDBM50342894 (CHEMBL1515868 | N-(2-(1H-imidazol-4-yl)ethyl)-6-(b...) Show SMILES C(Cc1cnc[nH]1)Nc1ncnc2ccc(cc12)-c1ccc2OCOc2c1 Show InChI InChI=1S/C20H17N5O2/c1-3-17-16(7-13(1)14-2-4-18-19(8-14)27-12-26-18)20(25-11-24-17)22-6-5-15-9-21-10-23-15/h1-4,7-11H,5-6,12H2,(H,21,23)(H,22,24,25)	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Human Genome Research Institute Curated by ChEMBL					Assay Description Inhibition of Clk2 kinase using ATP as substrate by 33P radiolabelled kinase assay				Bioorg Med Chem Lett 21: 3152-8 (2011) Article DOI: 10.1016/j.bmcl.2011.02.114 BindingDB Entry DOI: 10.7270/Q2J67H83
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Homo sapiens (Human))	BDBM50342894 (CHEMBL1515868 | N-(2-(1H-imidazol-4-yl)ethyl)-6-(b...) Show SMILES C(Cc1cnc[nH]1)Nc1ncnc2ccc(cc12)-c1ccc2OCOc2c1 Show InChI InChI=1S/C20H17N5O2/c1-3-17-16(7-13(1)14-2-4-18-19(8-14)27-12-26-18)20(25-11-24-17)22-6-5-15-9-21-10-23-15/h1-4,7-11H,5-6,12H2,(H,21,23)(H,22,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Human Genome Research Institute Curated by ChEMBL					Assay Description Inhibition of Dyrk1B kinase using ATP as substrate by 33P radiolabelled kinase assay				Bioorg Med Chem Lett 21: 3152-8 (2011) Article DOI: 10.1016/j.bmcl.2011.02.114 BindingDB Entry DOI: 10.7270/Q2J67H83
					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK3 (Homo sapiens (Human))	BDBM50342894 (CHEMBL1515868 | N-(2-(1H-imidazol-4-yl)ethyl)-6-(b...) Show SMILES C(Cc1cnc[nH]1)Nc1ncnc2ccc(cc12)-c1ccc2OCOc2c1 Show InChI InChI=1S/C20H17N5O2/c1-3-17-16(7-13(1)14-2-4-18-19(8-14)27-12-26-18)20(25-11-24-17)22-6-5-15-9-21-10-23-15/h1-4,7-11H,5-6,12H2,(H,21,23)(H,22,24,25)	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Human Genome Research Institute Curated by ChEMBL					Assay Description Inhibition of Clk3 kinase using ATP as substrate by 33P radiolabelled kinase assay				Bioorg Med Chem Lett 21: 3152-8 (2011) Article DOI: 10.1016/j.bmcl.2011.02.114 BindingDB Entry DOI: 10.7270/Q2J67H83
					More data for this Ligand-Target Pair