Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM132395
(US8841312, 141)Show SMILES C(N1CCOCC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 Show InChI InChI=1S/C24H27N7O/c1-2-4-18(3-1)31-21-15-25-8-7-19(21)20-14-27-24(29-23(20)31)28-22-6-5-17(13-26-22)16-30-9-11-32-12-10-30/h5-8,13-15,18H,1-4,9-12,16H2,(H,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 6
(Homo sapiens (Human)) | BDBM132395
(US8841312, 141)Show SMILES C(N1CCOCC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 Show InChI InChI=1S/C24H27N7O/c1-2-4-18(3-1)31-21-15-25-8-7-19(21)20-14-27-24(29-23(20)31)28-22-6-5-17(13-26-22)16-30-9-11-32-12-10-30/h5-8,13-15,18H,1-4,9-12,16H2,(H,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this Ligand-Target Pair | |