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Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 281.3
BDBM50317491

Wt: 281.3
BDBM50317493

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM50317493 ((R)-2-((4-benzylphenoxy)methyl)piperidine \| CHEMBL...) Show SMILES C(Oc1ccc(Cc2ccccc2)cc1)[C@H]1CCCCN1 \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc. Curated by ChEMBL					Assay Description Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISA				Bioorg Med Chem Lett 20: 2851-4 (2010) Article DOI: 10.1016/j.bmcl.2010.03.047 BindingDB Entry DOI: 10.7270/Q2CC10VD
deCODE Chemistry, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM50317493 ((R)-2-((4-benzylphenoxy)methyl)piperidine \| CHEMBL...) Show SMILES C(Oc1ccc(Cc2ccccc2)cc1)[C@H]1CCCCN1 \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MS				Bioorg Med Chem Lett 20: 2851-4 (2010) Article DOI: 10.1016/j.bmcl.2010.03.047 BindingDB Entry DOI: 10.7270/Q2CC10VD
deCODE Chemistry, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM50317491 ((R/S)-2-((4-benzylphenoxy)methyl)piperidine \| CHEM...) Show SMILES C(Oc1ccc(Cc2ccccc2)cc1)C1CCCCN1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc. Curated by ChEMBL					Assay Description Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISA				Bioorg Med Chem Lett 20: 2851-4 (2010) Article DOI: 10.1016/j.bmcl.2010.03.047 BindingDB Entry DOI: 10.7270/Q2CC10VD
deCODE Chemistry, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM50317491 ((R/S)-2-((4-benzylphenoxy)methyl)piperidine \| CHEM...) Show SMILES C(Oc1ccc(Cc2ccccc2)cc1)C1CCCCN1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
deCODE Chemistry, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MS				Bioorg Med Chem Lett 20: 2851-4 (2010) Article DOI: 10.1016/j.bmcl.2010.03.047 BindingDB Entry DOI: 10.7270/Q2CC10VD
deCODE Chemistry, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair