Found 2 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50317496
((R)-2-((4-(biphenyl-4-yloxy)phenoxy)methyl)piperid...)Show SMILES C(Oc1ccc(Oc2ccc(cc2)-c2ccccc2)cc1)[C@H]1CCCCN1 |r| Show InChI InChI=1S/C24H25NO2/c1-2-6-19(7-3-1)20-9-11-23(12-10-20)27-24-15-13-22(14-16-24)26-18-21-8-4-5-17-25-21/h1-3,6-7,9-16,21,25H,4-5,8,17-18H2/t21-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISA |
Bioorg Med Chem Lett 20: 2851-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.047 BindingDB Entry DOI: 10.7270/Q2CC10VD |
More data for this Ligand-Target Pair | |
Leukotriene A-4 hydrolase
(Homo sapiens (Human)) | BDBM50317496
((R)-2-((4-(biphenyl-4-yloxy)phenoxy)methyl)piperid...)Show SMILES C(Oc1ccc(Oc2ccc(cc2)-c2ccccc2)cc1)[C@H]1CCCCN1 |r| Show InChI InChI=1S/C24H25NO2/c1-2-6-19(7-3-1)20-9-11-23(12-10-20)27-24-15-13-22(14-16-24)26-18-21-8-4-5-17-25-21/h1-3,6-7,9-16,21,25H,4-5,8,17-18H2/t21-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MS |
Bioorg Med Chem Lett 20: 2851-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.047 BindingDB Entry DOI: 10.7270/Q2CC10VD |
More data for this Ligand-Target Pair | |