Found 2 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM132488
(US8841312, 237)Show SMILES C(c1cccs1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12 Show InChI InChI=1S/C24H23N7S/c1-2-18(32-11-1)16-31-21-12-24(28-14-20(21)19-5-6-26-15-22(19)31)29-23-4-3-17(13-27-23)30-9-7-25-8-10-30/h1-6,11-15,25H,7-10,16H2,(H,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 6
(Homo sapiens (Human)) | BDBM132488
(US8841312, 237)Show SMILES C(c1cccs1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12 Show InChI InChI=1S/C24H23N7S/c1-2-18(32-11-1)16-31-21-12-24(28-14-20(21)19-5-6-26-15-22(19)31)29-23-4-3-17(13-27-23)30-9-7-25-8-10-30/h1-6,11-15,25H,7-10,16H2,(H,27,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 131 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Amgen Inc.
US Patent
| Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr... |
US Patent US8841312 (2014)
BindingDB Entry DOI: 10.7270/Q2H41Q4H |
More data for this
Ligand-Target Pair | |