Found 3 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-secretase 1
(Homo sapiens (Human)) | BDBM258302
(US9493485, 9-143)Show SMILES C[C@@]1(CC2(CCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F |r,c:10| Show InChI InChI=1S/C20H20F2N4OS/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >7.50E+3 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Imago Pharmaceuticals, Inc.
US Patent
| Assay Description
BACE1 activity can be assessed in an AlphaScreenŽ assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially di... |
US Patent US9493485 (2016)
BindingDB Entry DOI: 10.7270/Q25B01DD |
More data for this
Ligand-Target Pair | |
Cathepsin D
(Homo sapiens (Human)) | BDBM258302
(US9493485, 9-143)Show SMILES C[C@@]1(CC2(CCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F |r,c:10| Show InChI InChI=1S/C20H20F2N4OS/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | 4.5 | 37 |
Imago Pharmaceuticals, Inc.
US Patent
| Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ... |
US Patent US9493485 (2016)
BindingDB Entry DOI: 10.7270/Q25B01DD |
More data for this
Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM258302
(US9493485, 9-143)Show SMILES C[C@@]1(CC2(CCC2)SC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F |r,c:10| Show InChI InChI=1S/C20H20F2N4OS/c1-19(11-20(7-2-8-20)28-18(23)26-19)14-9-13(4-5-15(14)22)25-17(27)16-6-3-12(21)10-24-16/h3-6,9-10H,2,7-8,11H2,1H3,(H2,23,26)(H,25,27)/t19-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.18E+4 | n/a | n/a | n/a | n/a | 4.5 | 37 |
Imago Pharmaceuticals, Inc.
US Patent
| Assay Description
Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ... |
US Patent US9493485 (2016)
BindingDB Entry DOI: 10.7270/Q25B01DD |
More data for this
Ligand-Target Pair | |