SMILES String Search

Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 500.1
BDBM50333129

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 30 hits in this display
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars		420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepacivirus C)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmasset, Inc. Curated by ChEMBL					Assay Description Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation counting				Antimicrob Agents Chemother 52: 458-64 (2008) Article DOI: 10.1128/aac.01184-07 BindingDB Entry DOI: 10.7270/Q21N83Z9
Pharmasset, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	96	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	96	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase in HCV genotype 6a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase in HCV genotype 6a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase in HCV genotype 3a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase in HCV genotype 3a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase in HCV genotype 5a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase in HCV genotype 5a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase in HCV genotype 4a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase in HCV genotype 4a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck & Co. Curated by ChEMBL					Assay Description Inhibition of wild-type HCV genotype 1b BK NS5B Cdelta55 RNA dependent RNA polymerase using RNA as substrate after 1 hr in presence of NTPs by [33P]-...				Bioorg Med Chem Lett 27: 5349-5352 (2017) Article DOI: 10.1016/j.bmcl.2017.06.064 BindingDB Entry DOI: 10.7270/Q2W95CSJ
Merck & Co. Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase S282T mutant in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
RNA-directed RNA polymerase (Hepatitis C virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of NS5B polymerase S282T mutant in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysis				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Genome polyprotein (Dengue virus)	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institute for Tropical Diseases Curated by ChEMBL					Assay Description Inhibition of Dengue virus RdRp activity using 5'-(TCAG)20(TCCAAG)14(TCAG)20-3' as template measured after 120 mins				Bioorg Med Chem Lett 28: 2324-2327 (2018) Article DOI: 10.1016/j.bmcl.2018.04.069 BindingDB Entry DOI: 10.7270/Q24T6MWH
Novartis Institute for Tropical Diseases Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase beta (Homo sapiens (Human))	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase beta using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysis				J Med Chem 60: 5424-5437 (2017) Article DOI: 10.1021/acs.jmedchem.7b00067 BindingDB Entry DOI: 10.7270/Q2BZ6873
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase alpha using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP...				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase alpha using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP...				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase beta (Homo sapiens (Human))	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP ...				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Competitive inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis)				J Med Chem 60: 5424-5437 (2017) Article DOI: 10.1021/acs.jmedchem.7b00067 BindingDB Entry DOI: 10.7270/Q2BZ6873
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase beta (Homo sapiens (Human))	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Emory University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase beta using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP ...				J Med Chem 62: 1859-1874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01300 BindingDB Entry DOI: 10.7270/Q2M048WP
Emory University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
DNA-directed RNA polymerase II subunit RPB1 (Homo sapiens (Human))	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
303A College Road East Curated by ChEMBL					Assay Description Inhibition of human RNA polymerase 2				Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S
303A College Road East Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase alpha catalytic subunit (Homo sapiens (Human))	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
303A College Road East Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...				Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S
303A College Road East Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase beta (Homo sapiens (Human))	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
303A College Road East Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase beta assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper binding...				Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S
303A College Road East Curated by ChEMBL					More data for this Ligand-Target Pair
DNA polymerase subunit gamma-1 (Homo sapiens (Human))	BDBM50333129 (((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
303A College Road East Curated by ChEMBL					Assay Description Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...				Antimicrob Agents Chemother 54: 3187-96 (2010) Article DOI: 10.1128/AAC.00399-10 BindingDB Entry DOI: 10.7270/Q2G1614S
303A College Road East Curated by ChEMBL					More data for this Ligand-Target Pair