Found 6 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM168946
(US9079866, 347 | US9079866, 352 | US9745328, Compo...)Show SMILES C[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1ccc(N)nc1 |r| Show InChI InChI=1S/C20H20FN3O3S/c1-13(12-25)24-28(26,27)19-5-3-2-4-17(19)14-6-8-16(18(21)10-14)15-7-9-20(22)23-11-15/h2-11,13,24-25H,12H2,1H3,(H2,22,23)/t13-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9079866 (2015)
BindingDB Entry DOI: 10.7270/Q2FF3R3Q |
More data for this
Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM168946
(US9079866, 347 | US9079866, 352 | US9745328, Compo...)Show SMILES C[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1ccc(N)nc1 |r| Show InChI InChI=1S/C20H20FN3O3S/c1-13(12-25)24-28(26,27)19-5-3-2-4-17(19)14-6-8-16(18(21)10-14)15-7-9-20(22)23-11-15/h2-11,13,24-25H,12H2,1H3,(H2,22,23)/t13-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9884878 (2018)
BindingDB Entry DOI: 10.7270/Q2R78H8P |
More data for this
Ligand-Target Pair | |
Flap endonuclease 1
(Homo sapiens (Human)) | BDBM168946
(US9079866, 347 | US9079866, 352 | US9745328, Compo...)Show SMILES C[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1ccc(N)nc1 |r| Show InChI InChI=1S/C20H20FN3O3S/c1-13(12-25)24-28(26,27)19-5-3-2-4-17(19)14-6-8-16(18(21)10-14)15-7-9-20(22)23-11-15/h2-11,13,24-25H,12H2,1H3,(H2,22,23)/t13-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma... |
US Patent US9745328 (2017)
BindingDB Entry DOI: 10.7270/Q2H13446 |
More data for this
Ligand-Target Pair | |
Flap endonuclease 1
(Homo sapiens (Human)) | BDBM168946
(US9079866, 347 | US9079866, 352 | US9745328, Compo...)Show SMILES C[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1ccc(N)nc1 |r| Show InChI InChI=1S/C20H20FN3O3S/c1-13(12-25)24-28(26,27)19-5-3-2-4-17(19)14-6-8-16(18(21)10-14)15-7-9-20(22)23-11-15/h2-11,13,24-25H,12H2,1H3,(H2,22,23)/t13-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma... |
US Patent US9745328 (2017)
BindingDB Entry DOI: 10.7270/Q2H13446 |
More data for this
Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM168946
(US9079866, 347 | US9079866, 352 | US9745328, Compo...)Show SMILES C[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1ccc(N)nc1 |r| Show InChI InChI=1S/C20H20FN3O3S/c1-13(12-25)24-28(26,27)19-5-3-2-4-17(19)14-6-8-16(18(21)10-14)15-7-9-20(22)23-11-15/h2-11,13,24-25H,12H2,1H3,(H2,22,23)/t13-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9079866 (2015)
BindingDB Entry DOI: 10.7270/Q2FF3R3Q |
More data for this
Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM168946
(US9079866, 347 | US9079866, 352 | US9745328, Compo...)Show SMILES C[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1ccc(N)nc1 |r| Show InChI InChI=1S/C20H20FN3O3S/c1-13(12-25)24-28(26,27)19-5-3-2-4-17(19)14-6-8-16(18(21)10-14)15-7-9-20(22)23-11-15/h2-11,13,24-25H,12H2,1H3,(H2,22,23)/t13-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai... |
US Patent US9884878 (2018)
BindingDB Entry DOI: 10.7270/Q2R78H8P |
More data for this
Ligand-Target Pair | |