Marvin 2D Structure

The following exact ligands are found in BindingDB

Wt: 420.4 BDBM365245

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 1 hit in this display   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM365245 (US9868720, No. 143 | [2-((2R,5R)-2,5-Dimethyl- pyr...) Show SMILES C[C@@H]1CC[C@@H](C)N1c1nc(Nc2cc(ccn2)C(F)(F)F)cc(n1)C1CCNCC1 |r| Show InChI InChI=1S/C21H27F3N6/c1-13-3-4-14(2)30(13)20-27-17(15-5-8-25-9-6-15)12-19(29-20)28-18-11-16(7-10-26-18)21(22,23)24/h7,10-15,25H,3-6,8-9H2,1-2H3,(H,26,27,28,29)/t13-,14-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	10.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description DLK kinase reactions (20 μL) containing 5 nM N-terminally GST-tagged DLK (catalytic domain amino acid 1-520) (Carna Bioscience), 40 nM N-termina...				J Med Chem 50: 3515-27 (2007) BindingDB Entry DOI: 10.7270/Q2J38VWN
					More data for this Ligand-Target Pair