Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Coagulation factor XI
(Homo sapiens (Human)) | BDBM241471
(US9409908, 103 | US9951071, Example 103)Show SMILES C[C@@H]1CCC[C@H](N2CCC(=CC2=O)c2c(F)ccc(Cl)c2F)c2cc(ccn2)-c2ccc(Nc3nnc(o3)-c3ccco3)cc2NC1=O |r,c:9| Show InChI InChI=1S/C35H29ClF2N6O4/c1-19-4-2-5-28(44-14-12-21(17-30(44)45)31-25(37)10-9-24(36)32(31)38)27-16-20(11-13-39-27)23-8-7-22(18-26(23)41-33(19)46)40-35-43-42-34(48-35)29-6-3-15-47-29/h3,6-11,13,15-19,28H,2,4-5,12,14H2,1H3,(H,40,43)(H,41,46)/t19-,28+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| 6.13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl
| Assay Description
Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake... |
J Med Chem 51: 487-501 (2008)
BindingDB Entry DOI: 10.7270/Q2R78HKQ |
More data for this
Ligand-Target Pair | |
Coagulation factor IX
(Homo sapiens (Human)) | BDBM241471
(US9409908, 103 | US9951071, Example 103)Show SMILES C[C@@H]1CCC[C@H](N2CCC(=CC2=O)c2c(F)ccc(Cl)c2F)c2cc(ccn2)-c2ccc(Nc3nnc(o3)-c3ccco3)cc2NC1=O |r,c:9| Show InChI InChI=1S/C35H29ClF2N6O4/c1-19-4-2-5-28(44-14-12-21(17-30(44)45)31-25(37)10-9-24(36)32(31)38)27-16-20(11-13-39-27)23-8-7-22(18-26(23)41-33(19)46)40-35-43-42-34(48-35)29-6-3-15-47-29/h3,6-11,13,15-19,28H,2,4-5,12,14H2,1H3,(H,40,43)(H,41,46)/t19-,28+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 6.13 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake... |
US Patent US9409908 (2016)
BindingDB Entry DOI: 10.7270/Q27943K8 |
More data for this
Ligand-Target Pair | |
Plasma kallikrein
(Homo sapiens (Human)) | BDBM241471
(US9409908, 103 | US9951071, Example 103)Show SMILES C[C@@H]1CCC[C@H](N2CCC(=CC2=O)c2c(F)ccc(Cl)c2F)c2cc(ccn2)-c2ccc(Nc3nnc(o3)-c3ccco3)cc2NC1=O |r,c:9| Show InChI InChI=1S/C35H29ClF2N6O4/c1-19-4-2-5-28(44-14-12-21(17-30(44)45)31-25(37)10-9-24(36)32(31)38)27-16-20(11-13-39-27)23-8-7-22(18-26(23)41-33(19)46)40-35-43-42-34(48-35)29-6-3-15-47-29/h3,6-11,13,15-19,28H,2,4-5,12,14H2,1H3,(H,40,43)(H,41,46)/t19-,28+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences Srl
| Assay Description
Plasma kallikrein determinations were made in 0.1 M sodium phosphate buffer at a pH of 7.5 containing 0.1-0.2 M sodium chloride and 0.5% PEG 8000. De... |
J Med Chem 51: 487-501 (2008)
BindingDB Entry DOI: 10.7270/Q2R78HKQ |
More data for this
Ligand-Target Pair | |
Plasma kallikrein
(Homo sapiens (Human)) | BDBM241471
(US9409908, 103 | US9951071, Example 103)Show SMILES C[C@@H]1CCC[C@H](N2CCC(=CC2=O)c2c(F)ccc(Cl)c2F)c2cc(ccn2)-c2ccc(Nc3nnc(o3)-c3ccco3)cc2NC1=O |r,c:9| Show InChI InChI=1S/C35H29ClF2N6O4/c1-19-4-2-5-28(44-14-12-21(17-30(44)45)31-25(37)10-9-24(36)32(31)38)27-16-20(11-13-39-27)23-8-7-22(18-26(23)41-33(19)46)40-35-43-42-34(48-35)29-6-3-15-47-29/h3,6-11,13,15-19,28H,2,4-5,12,14H2,1H3,(H,40,43)(H,41,46)/t19-,28+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 13 | -46.8 | n/a | n/a | n/a | n/a | n/a | n/a | 37 |
Bristol-Myers Squibb Company
US Patent
| Assay Description
Plasma kallikrein determinations were made in 0.1 M sodium phosphate buffer at a pH of 7.5 containing 0.1-0.2 M sodium chloride and 0.5% PEG 8000. De... |
US Patent US9409908 (2016)
BindingDB Entry DOI: 10.7270/Q27943K8 |
More data for this
Ligand-Target Pair | |