Found 4 hits in this display Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM50122250
(CHEMBL3617642)Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1cccc(c1)C#N |r| Show InChI InChI=1S/C20H16ClN5O2/c1-13-11-25(17-4-2-3-14(7-17)9-22)20(27)18-8-16(24-26(13)18)12-28-19-6-5-15(21)10-23-19/h2-8,10,13H,11-12H2,1H3/t13-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 825 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay |
J Med Chem 58: 7485-500 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01005
BindingDB Entry DOI: 10.7270/Q2H9970P |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM50122250
(CHEMBL3617642)Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1cccc(c1)C#N |r| Show InChI InChI=1S/C20H16ClN5O2/c1-13-11-25(17-4-2-3-14(7-17)9-22)20(27)18-8-16(24-26(13)18)12-28-19-6-5-15(21)10-23-19/h2-8,10,13H,11-12H2,1H3/t13-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 832 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assay |
J Med Chem 58: 7485-500 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01005
BindingDB Entry DOI: 10.7270/Q2H9970P |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50122250
(CHEMBL3617642)Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1cccc(c1)C#N |r| Show InChI InChI=1S/C20H16ClN5O2/c1-13-11-25(17-4-2-3-14(7-17)9-22)20(27)18-8-16(24-26(13)18)12-28-19-6-5-15(21)10-23-19/h2-8,10,13H,11-12H2,1H3/t13-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assay |
J Med Chem 58: 7485-500 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01005
BindingDB Entry DOI: 10.7270/Q2H9970P |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50122250
(CHEMBL3617642)Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccc(Cl)cn3)nn12)c1cccc(c1)C#N |r| Show InChI InChI=1S/C20H16ClN5O2/c1-13-11-25(17-4-2-3-14(7-17)9-22)20(27)18-8-16(24-26(13)18)12-28-19-6-5-15(21)10-23-19/h2-8,10,13H,11-12H2,1H3/t13-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assay |
J Med Chem 58: 7485-500 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01005
BindingDB Entry DOI: 10.7270/Q2H9970P |
More data for this
Ligand-Target Pair | |